Multi‐omics identifies microbiota‐derived deoxycholic acid as a key mediator of blood‐brain barrier dysfunction in Parkinson's disease Article Swipe
Zhe Zhao
,
Jing Chen
,
Yixuan Liu
,
Song Wang
,
Danhua Zhao
,
Chaobo Bai
,
Mei-Fang Wu
,
Gaofei Hu
,
Yiwen Fu
,
Fang Lu
,
Xiaoyi Liu
,
Zheng Zhang
,
Renya Zhan
,
Lemin Zheng
,
Junliang Yuan
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/imt2.70076
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/imt2.70076
The gut microbiota derived from Parkinson's disease patients, enriched in Bacteroides fragilis (B. fragilis) and Phocaeicola vulgatus (P. vulgatus), may promote the elevations of deoxycholic acid, iso-deoxycholic acid, and ursodeoxycholic acid levels in the systemic circulation. The increased serum bile acids, in turn, contribute to the endothelial cell death and pericyte injury possibly through activating interferon alpha response and TGF-β signaling pathways at the blood-brain barrier in the midbrain, ultimately leading to the neurodegeneration and motor deficits in the germ-free mice.
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Multi‐omics identifies microbiota‐derived deoxycholic acid as a key mediator of blood‐brain barrier dysfunction in Parkinson's diseaseWork title
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Zhe Zhao, Jing Chen, Yixuan Liu, Song Wang, Danhua Zhao, Chaobo Bai, Mei-Fang Wu, Gaofei Hu, Yiwen Fu, Fang Lu, Xiaoyi Liu, Zheng Zhang, Renya Zhan, Lemin Zheng, Junliang YuanList of authors in order
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