Multiple Layers of CDK5R1 Regulation in Alzheimer’s Disease Implicate Long Non-Coding RNAs Article Swipe
Marco Spreafico
,
Barbara Grillo
,
Francesco Rusconi
,
Elena Battaglioli
,
Marco Venturin
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3390/ijms19072022
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3390/ijms19072022
Cyclin-dependent kinase 5 regulatory subunit 1 (CDK5R1) gene encodes for p35, the main activator of Cyclin-dependent kinase 5 (CDK5). The active p35/CDK5 complex is involved in numerous aspects of brain development and function, and its deregulation is closely associated to Alzheimer’s disease (AD) onset and progression. We recently showed that miR-15/107 family can negatively regulate CDK5R1 expression modifying mRNA stability. Interestingly, miRNAs belonging to miR-15/107 family are downregulated in AD brain while CDK5R1 is upregulated. Long non-coding RNAs (lncRNAs) are emerging as master regulators of gene expression, including miRNAs, and their dysregulation has been implicated in the pathogenesis of AD. Here, we evaluated the existence of an additional layer of CDK5R1 expression regulation provided by lncRNAs. In particular, we focused on three lncRNAs potentially regulating CDK5R1 expression levels, based on existing data: NEAT1, HOTAIR, and MALAT1. We demonstrated that NEAT1 and HOTAIR negatively regulate CDK5R1 mRNA levels, while MALAT1 has a positive effect. We also showed that all three lncRNAs positively control miR-15/107 family of miRNAs. Moreover, we evaluated the expression of NEAT1, HOTAIR, and MALAT1 in AD and control brain tissues. Interestingly, NEAT1 displayed increased expression levels in temporal cortex and hippocampus of AD patients. Interestingly, we observed a strong positive correlation between CDK5R1 and NEAT1 expression levels in brain tissues, suggesting a possible neuroprotective role of NEAT1 in AD to compensate for increased CDK5R1 levels. Overall, our work provides evidence of another level of CDK5R1 expression regulation mediated by lncRNAs and points to NEAT1 as a biomarker, as well as a potential pharmacological target for AD therapy.
Related Topics
Concepts
MALAT1
Biology
HOTAIR
microRNA
Long non-coding RNA
Kinase
Regulation of gene expression
Cyclin-dependent kinase 5
Neuroprotection
Gene expression
Cell biology
Gene
Downregulation and upregulation
Genetics
Neuroscience
Cyclin-dependent kinase 2
Protein kinase A
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms19072022
- https://www.mdpi.com/1422-0067/19/7/2022/pdf?version=1531314584
- OA Status
- gold
- Cited By
- 75
- References
- 48
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2829797152
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2829797152Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/ijms19072022Digital Object Identifier
- Title
-
Multiple Layers of CDK5R1 Regulation in Alzheimer’s Disease Implicate Long Non-Coding RNAsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-07-11Full publication date if available
- Authors
-
Marco Spreafico, Barbara Grillo, Francesco Rusconi, Elena Battaglioli, Marco VenturinList of authors in order
- Landing page
-
https://doi.org/10.3390/ijms19072022Publisher landing page
- PDF URL
-
https://www.mdpi.com/1422-0067/19/7/2022/pdf?version=1531314584Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1422-0067/19/7/2022/pdf?version=1531314584Direct OA link when available
- Concepts
-
MALAT1, Biology, HOTAIR, microRNA, Long non-coding RNA, Kinase, Regulation of gene expression, Cyclin-dependent kinase 5, Neuroprotection, Gene expression, Cell biology, Gene, Downregulation and upregulation, Genetics, Neuroscience, Cyclin-dependent kinase 2, Protein kinase ATop concepts (fields/topics) attached by OpenAlex
- Cited by
-
75Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 5, 2024: 8, 2023: 8, 2022: 18, 2021: 13Per-year citation counts (last 5 years)
- References (count)
-
48Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W2829797152 |
|---|---|
| doi | https://doi.org/10.3390/ijms19072022 |
| ids.doi | https://doi.org/10.3390/ijms19072022 |
| ids.mag | 2829797152 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/29997370 |
| ids.openalex | https://openalex.org/W2829797152 |
| fwci | 3.25729481 |
| mesh[0].qualifier_ui | Q000235 |
| mesh[0].descriptor_ui | D000544 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | genetics |
| mesh[0].descriptor_name | Alzheimer Disease |
| mesh[1].qualifier_ui | Q000378 |
| mesh[1].descriptor_ui | D000544 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | metabolism |
| mesh[1].descriptor_name | Alzheimer Disease |
| mesh[2].qualifier_ui | Q000473 |
| mesh[2].descriptor_ui | D000544 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | pathology |
| mesh[2].descriptor_name | Alzheimer Disease |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D018450 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Disease Progression |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D005786 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Gene Expression Regulation |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D005819 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Genetic Markers |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D006367 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | HeLa Cells |
| mesh[7].qualifier_ui | Q000378 |
| mesh[7].descriptor_ui | D006624 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | metabolism |
| mesh[7].descriptor_name | Hippocampus |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D006801 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Humans |
| mesh[9].qualifier_ui | Q000235 |
| mesh[9].descriptor_ui | D009419 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | genetics |
| mesh[9].descriptor_name | Nerve Tissue Proteins |
| mesh[10].qualifier_ui | Q000378 |
| mesh[10].descriptor_ui | D062085 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | metabolism |
| mesh[10].descriptor_name | RNA, Long Noncoding |
| mesh[11].qualifier_ui | Q000378 |
| mesh[11].descriptor_ui | D013702 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | metabolism |
| mesh[11].descriptor_name | Temporal Lobe |
| mesh[12].qualifier_ui | Q000235 |
| mesh[12].descriptor_ui | D000544 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | genetics |
| mesh[12].descriptor_name | Alzheimer Disease |
| mesh[13].qualifier_ui | Q000378 |
| mesh[13].descriptor_ui | D000544 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | metabolism |
| mesh[13].descriptor_name | Alzheimer Disease |
| mesh[14].qualifier_ui | Q000473 |
| mesh[14].descriptor_ui | D000544 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | pathology |
| mesh[14].descriptor_name | Alzheimer Disease |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D018450 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Disease Progression |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D005786 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Gene Expression Regulation |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D005819 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Genetic Markers |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D006367 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | HeLa Cells |
| mesh[19].qualifier_ui | Q000378 |
| mesh[19].descriptor_ui | D006624 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | metabolism |
| mesh[19].descriptor_name | Hippocampus |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D006801 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Humans |
| mesh[21].qualifier_ui | Q000235 |
| mesh[21].descriptor_ui | D009419 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | genetics |
| mesh[21].descriptor_name | Nerve Tissue Proteins |
| mesh[22].qualifier_ui | Q000378 |
| mesh[22].descriptor_ui | D062085 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | metabolism |
| mesh[22].descriptor_name | RNA, Long Noncoding |
| mesh[23].qualifier_ui | Q000378 |
| mesh[23].descriptor_ui | D013702 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | metabolism |
| mesh[23].descriptor_name | Temporal Lobe |
| type | article |
| title | Multiple Layers of CDK5R1 Regulation in Alzheimer’s Disease Implicate Long Non-Coding RNAs |
| awards[0].id | https://openalex.org/G1180721515 |
| awards[0].funder_id | https://openalex.org/F4320313475 |
| awards[0].display_name | |
| awards[0].funder_award_id | Bando BIOMETRA - Fondi Incentivo alla Ricerca 2015 |
| awards[0].funder_display_name | Università degli Studi di Milano |
| biblio.issue | 7 |
| biblio.volume | 19 |
| biblio.last_page | 2022 |
| biblio.first_page | 2022 |
| topics[0].id | https://openalex.org/T10515 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1306 |
| topics[0].subfield.display_name | Cancer Research |
| topics[0].display_name | Cancer-related molecular mechanisms research |
| topics[1].id | https://openalex.org/T11482 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.998199999332428 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | RNA modifications and cancer |
| topics[2].id | https://openalex.org/T11765 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9966999888420105 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | Circular RNAs in diseases |
| funders[0].id | https://openalex.org/F4320313475 |
| funders[0].ror | https://ror.org/00wjc7c48 |
| funders[0].display_name | Università degli Studi di Milano |
| is_xpac | False |
| apc_list.value | 2300 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2490 |
| apc_paid.value | 1559 |
| apc_paid.currency | EUR |
| apc_paid.value_usd | 1681 |
| concepts[0].id | https://openalex.org/C2779134362 |
| concepts[0].level | 5 |
| concepts[0].score | 0.8162771463394165 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q18056223 |
| concepts[0].display_name | MALAT1 |
| concepts[1].id | https://openalex.org/C86803240 |
| concepts[1].level | 0 |
| concepts[1].score | 0.7171498537063599 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[1].display_name | Biology |
| concepts[2].id | https://openalex.org/C2781128886 |
| concepts[2].level | 5 |
| concepts[2].score | 0.6273403167724609 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q18062498 |
| concepts[2].display_name | HOTAIR |
| concepts[3].id | https://openalex.org/C145059251 |
| concepts[3].level | 3 |
| concepts[3].score | 0.5980880260467529 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q310899 |
| concepts[3].display_name | microRNA |
| concepts[4].id | https://openalex.org/C62203573 |
| concepts[4].level | 4 |
| concepts[4].score | 0.5713070034980774 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q15087973 |
| concepts[4].display_name | Long non-coding RNA |
| concepts[5].id | https://openalex.org/C184235292 |
| concepts[5].level | 2 |
| concepts[5].score | 0.46399447321891785 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q421851 |
| concepts[5].display_name | Kinase |
| concepts[6].id | https://openalex.org/C165864922 |
| concepts[6].level | 3 |
| concepts[6].score | 0.4630361497402191 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q411391 |
| concepts[6].display_name | Regulation of gene expression |
| concepts[7].id | https://openalex.org/C121738310 |
| concepts[7].level | 5 |
| concepts[7].score | 0.45947426557540894 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q18248262 |
| concepts[7].display_name | Cyclin-dependent kinase 5 |
| concepts[8].id | https://openalex.org/C25498285 |
| concepts[8].level | 2 |
| concepts[8].score | 0.4262702763080597 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q1981368 |
| concepts[8].display_name | Neuroprotection |
| concepts[9].id | https://openalex.org/C150194340 |
| concepts[9].level | 3 |
| concepts[9].score | 0.4212597608566284 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q26972 |
| concepts[9].display_name | Gene expression |
| concepts[10].id | https://openalex.org/C95444343 |
| concepts[10].level | 1 |
| concepts[10].score | 0.41001370549201965 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[10].display_name | Cell biology |
| concepts[11].id | https://openalex.org/C104317684 |
| concepts[11].level | 2 |
| concepts[11].score | 0.3990788757801056 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[11].display_name | Gene |
| concepts[12].id | https://openalex.org/C127561419 |
| concepts[12].level | 3 |
| concepts[12].score | 0.35388797521591187 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q224527 |
| concepts[12].display_name | Downregulation and upregulation |
| concepts[13].id | https://openalex.org/C54355233 |
| concepts[13].level | 1 |
| concepts[13].score | 0.275492787361145 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[13].display_name | Genetics |
| concepts[14].id | https://openalex.org/C169760540 |
| concepts[14].level | 1 |
| concepts[14].score | 0.1951107680797577 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q207011 |
| concepts[14].display_name | Neuroscience |
| concepts[15].id | https://openalex.org/C82495950 |
| concepts[15].level | 4 |
| concepts[15].score | 0.13940206170082092 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q14911732 |
| concepts[15].display_name | Cyclin-dependent kinase 2 |
| concepts[16].id | https://openalex.org/C97029542 |
| concepts[16].level | 3 |
| concepts[16].score | 0.13351458311080933 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q281417 |
| concepts[16].display_name | Protein kinase A |
| keywords[0].id | https://openalex.org/keywords/malat1 |
| keywords[0].score | 0.8162771463394165 |
| keywords[0].display_name | MALAT1 |
| keywords[1].id | https://openalex.org/keywords/biology |
| keywords[1].score | 0.7171498537063599 |
| keywords[1].display_name | Biology |
| keywords[2].id | https://openalex.org/keywords/hotair |
| keywords[2].score | 0.6273403167724609 |
| keywords[2].display_name | HOTAIR |
| keywords[3].id | https://openalex.org/keywords/microrna |
| keywords[3].score | 0.5980880260467529 |
| keywords[3].display_name | microRNA |
| keywords[4].id | https://openalex.org/keywords/long-non-coding-rna |
| keywords[4].score | 0.5713070034980774 |
| keywords[4].display_name | Long non-coding RNA |
| keywords[5].id | https://openalex.org/keywords/kinase |
| keywords[5].score | 0.46399447321891785 |
| keywords[5].display_name | Kinase |
| keywords[6].id | https://openalex.org/keywords/regulation-of-gene-expression |
| keywords[6].score | 0.4630361497402191 |
| keywords[6].display_name | Regulation of gene expression |
| keywords[7].id | https://openalex.org/keywords/cyclin-dependent-kinase-5 |
| keywords[7].score | 0.45947426557540894 |
| keywords[7].display_name | Cyclin-dependent kinase 5 |
| keywords[8].id | https://openalex.org/keywords/neuroprotection |
| keywords[8].score | 0.4262702763080597 |
| keywords[8].display_name | Neuroprotection |
| keywords[9].id | https://openalex.org/keywords/gene-expression |
| keywords[9].score | 0.4212597608566284 |
| keywords[9].display_name | Gene expression |
| keywords[10].id | https://openalex.org/keywords/cell-biology |
| keywords[10].score | 0.41001370549201965 |
| keywords[10].display_name | Cell biology |
| keywords[11].id | https://openalex.org/keywords/gene |
| keywords[11].score | 0.3990788757801056 |
| keywords[11].display_name | Gene |
| keywords[12].id | https://openalex.org/keywords/downregulation-and-upregulation |
| keywords[12].score | 0.35388797521591187 |
| keywords[12].display_name | Downregulation and upregulation |
| keywords[13].id | https://openalex.org/keywords/genetics |
| keywords[13].score | 0.275492787361145 |
| keywords[13].display_name | Genetics |
| keywords[14].id | https://openalex.org/keywords/neuroscience |
| keywords[14].score | 0.1951107680797577 |
| keywords[14].display_name | Neuroscience |
| keywords[15].id | https://openalex.org/keywords/cyclin-dependent-kinase-2 |
| keywords[15].score | 0.13940206170082092 |
| keywords[15].display_name | Cyclin-dependent kinase 2 |
| keywords[16].id | https://openalex.org/keywords/protein-kinase-a |
| keywords[16].score | 0.13351458311080933 |
| keywords[16].display_name | Protein kinase A |
| language | en |
| locations[0].id | doi:10.3390/ijms19072022 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S10623703 |
| locations[0].source.issn | 1422-0067, 1661-6596 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1422-0067 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | International Journal of Molecular Sciences |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/1422-0067/19/7/2022/pdf?version=1531314584 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | International Journal of Molecular Sciences |
| locations[0].landing_page_url | https://doi.org/10.3390/ijms19072022 |
| locations[1].id | pmid:29997370 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | International journal of molecular sciences |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/29997370 |
| locations[2].id | pmh:oai:air.unimi.it:2434/582183 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306400516 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) |
| locations[2].source.host_organization | https://openalex.org/I189158943 |
| locations[2].source.host_organization_name | University of Milan |
| locations[2].source.host_organization_lineage | https://openalex.org/I189158943 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | info:eu-repo/semantics/article |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | http://hdl.handle.net/2434/582183 |
| locations[3].id | pmh:oai:doaj.org/article:76c9aa8c5abc411c87ec1228ce53ad1f |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306401280 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[3].source.host_organization | |
| locations[3].source.host_organization_name | |
| locations[3].license | cc-by-sa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | article |
| locations[3].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | International Journal of Molecular Sciences, Vol 19, Iss 7, p 2022 (2018) |
| locations[3].landing_page_url | https://doaj.org/article/76c9aa8c5abc411c87ec1228ce53ad1f |
| locations[4].id | pmh:oai:europepmc.org:5035595 |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S4306400806 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | Europe PMC (PubMed Central) |
| locations[4].source.host_organization | https://openalex.org/I1303153112 |
| locations[4].source.host_organization_name | European Bioinformatics Institute |
| locations[4].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[4].license | other-oa |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | Text |
| locations[4].license_id | https://openalex.org/licenses/other-oa |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | |
| locations[4].landing_page_url | http://europepmc.org/pmc/articles/PMC6073344 |
| locations[5].id | pmh:oai:mdpi.com:/1422-0067/19/7/2022/ |
| locations[5].is_oa | True |
| locations[5].source.id | https://openalex.org/S4306400947 |
| locations[5].source.issn | |
| locations[5].source.type | repository |
| locations[5].source.is_oa | True |
| locations[5].source.issn_l | |
| locations[5].source.is_core | False |
| locations[5].source.is_in_doaj | False |
| locations[5].source.display_name | MDPI (MDPI AG) |
| locations[5].source.host_organization | https://openalex.org/I4210097602 |
| locations[5].source.host_organization_name | Multidisciplinary Digital Publishing Institute (Switzerland) |
| locations[5].source.host_organization_lineage | https://openalex.org/I4210097602 |
| locations[5].license | cc-by |
| locations[5].pdf_url | |
| locations[5].version | submittedVersion |
| locations[5].raw_type | Text |
| locations[5].license_id | https://openalex.org/licenses/cc-by |
| locations[5].is_accepted | False |
| locations[5].is_published | False |
| locations[5].raw_source_name | International Journal of Molecular Sciences |
| locations[5].landing_page_url | http://dx.doi.org/10.3390/ijms19072022 |
| locations[6].id | pmh:oai:pubmedcentral.nih.gov:6073344 |
| locations[6].is_oa | True |
| locations[6].source.id | https://openalex.org/S2764455111 |
| locations[6].source.issn | |
| locations[6].source.type | repository |
| locations[6].source.is_oa | False |
| locations[6].source.issn_l | |
| locations[6].source.is_core | False |
| locations[6].source.is_in_doaj | False |
| locations[6].source.display_name | PubMed Central |
| locations[6].source.host_organization | https://openalex.org/I1299303238 |
| locations[6].source.host_organization_name | National Institutes of Health |
| locations[6].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[6].license | other-oa |
| locations[6].pdf_url | |
| locations[6].version | submittedVersion |
| locations[6].raw_type | Text |
| locations[6].license_id | https://openalex.org/licenses/other-oa |
| locations[6].is_accepted | False |
| locations[6].is_published | False |
| locations[6].raw_source_name | Int J Mol Sci |
| locations[6].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/6073344 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5087875349 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-2131-8160 |
| authorships[0].author.display_name | Marco Spreafico |
| authorships[0].countries | IT |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I189158943 |
| authorships[0].affiliations[0].raw_affiliation_string | Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano, Via Fratelli Cervi 93, 20090 Segrate, Italy |
| authorships[0].institutions[0].id | https://openalex.org/I189158943 |
| authorships[0].institutions[0].ror | https://ror.org/00wjc7c48 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I189158943 |
| authorships[0].institutions[0].country_code | IT |
| authorships[0].institutions[0].display_name | University of Milan |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Marco Spreafico |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano, Via Fratelli Cervi 93, 20090 Segrate, Italy |
| authorships[1].author.id | https://openalex.org/A5056541450 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Barbara Grillo |
| authorships[1].countries | IT |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I189158943 |
| authorships[1].affiliations[0].raw_affiliation_string | Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano, Via Fratelli Cervi 93, 20090 Segrate, Italy |
| authorships[1].institutions[0].id | https://openalex.org/I189158943 |
| authorships[1].institutions[0].ror | https://ror.org/00wjc7c48 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I189158943 |
| authorships[1].institutions[0].country_code | IT |
| authorships[1].institutions[0].display_name | University of Milan |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Barbara Grillo |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano, Via Fratelli Cervi 93, 20090 Segrate, Italy |
| authorships[2].author.id | https://openalex.org/A5030831584 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-0500-7845 |
| authorships[2].author.display_name | Francesco Rusconi |
| authorships[2].countries | IT |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I189158943 |
| authorships[2].affiliations[0].raw_affiliation_string | Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano, Via Fratelli Cervi 93, 20090 Segrate, Italy |
| authorships[2].institutions[0].id | https://openalex.org/I189158943 |
| authorships[2].institutions[0].ror | https://ror.org/00wjc7c48 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I189158943 |
| authorships[2].institutions[0].country_code | IT |
| authorships[2].institutions[0].display_name | University of Milan |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Francesco Rusconi |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano, Via Fratelli Cervi 93, 20090 Segrate, Italy |
| authorships[3].author.id | https://openalex.org/A5036052608 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-9168-7212 |
| authorships[3].author.display_name | Elena Battaglioli |
| authorships[3].countries | IT |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I189158943 |
| authorships[3].affiliations[0].raw_affiliation_string | Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano, Via Fratelli Cervi 93, 20090 Segrate, Italy |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I4210113153 |
| authorships[3].affiliations[1].raw_affiliation_string | Istituto di Neuroscienze, CNR, Via Vanvitelli 32, 20129 Milano, Italy |
| authorships[3].institutions[0].id | https://openalex.org/I4210113153 |
| authorships[3].institutions[0].ror | https://ror.org/0240rwx68 |
| authorships[3].institutions[0].type | facility |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210113153, https://openalex.org/I4210155236 |
| authorships[3].institutions[0].country_code | IT |
| authorships[3].institutions[0].display_name | Neuroscience Institute |
| authorships[3].institutions[1].id | https://openalex.org/I189158943 |
| authorships[3].institutions[1].ror | https://ror.org/00wjc7c48 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I189158943 |
| authorships[3].institutions[1].country_code | IT |
| authorships[3].institutions[1].display_name | University of Milan |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Elena Battaglioli |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano, Via Fratelli Cervi 93, 20090 Segrate, Italy, Istituto di Neuroscienze, CNR, Via Vanvitelli 32, 20129 Milano, Italy |
| authorships[4].author.id | https://openalex.org/A5027054002 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-5871-9689 |
| authorships[4].author.display_name | Marco Venturin |
| authorships[4].countries | IT |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I189158943 |
| authorships[4].affiliations[0].raw_affiliation_string | Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano, Via Fratelli Cervi 93, 20090 Segrate, Italy |
| authorships[4].institutions[0].id | https://openalex.org/I189158943 |
| authorships[4].institutions[0].ror | https://ror.org/00wjc7c48 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I189158943 |
| authorships[4].institutions[0].country_code | IT |
| authorships[4].institutions[0].display_name | University of Milan |
| authorships[4].author_position | last |
| authorships[4].raw_author_name | Marco Venturin |
| authorships[4].is_corresponding | True |
| authorships[4].raw_affiliation_strings | Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano, Via Fratelli Cervi 93, 20090 Segrate, Italy |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/1422-0067/19/7/2022/pdf?version=1531314584 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Multiple Layers of CDK5R1 Regulation in Alzheimer’s Disease Implicate Long Non-Coding RNAs |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10515 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1306 |
| primary_topic.subfield.display_name | Cancer Research |
| primary_topic.display_name | Cancer-related molecular mechanisms research |
| related_works | https://openalex.org/W2907010999, https://openalex.org/W2900800457, https://openalex.org/W2764323110, https://openalex.org/W3182691860, https://openalex.org/W4401704840, https://openalex.org/W2808878540, https://openalex.org/W4390239327, https://openalex.org/W3177597305, https://openalex.org/W4200084850, https://openalex.org/W2142344706 |
| cited_by_count | 75 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 5 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 8 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 8 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 18 |
| counts_by_year[4].year | 2021 |
| counts_by_year[4].cited_by_count | 13 |
| counts_by_year[5].year | 2020 |
| counts_by_year[5].cited_by_count | 14 |
| counts_by_year[6].year | 2019 |
| counts_by_year[6].cited_by_count | 6 |
| counts_by_year[7].year | 2018 |
| counts_by_year[7].cited_by_count | 3 |
| locations_count | 7 |
| best_oa_location.id | doi:10.3390/ijms19072022 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S10623703 |
| best_oa_location.source.issn | 1422-0067, 1661-6596 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1422-0067 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | International Journal of Molecular Sciences |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/1422-0067/19/7/2022/pdf?version=1531314584 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | International Journal of Molecular Sciences |
| best_oa_location.landing_page_url | https://doi.org/10.3390/ijms19072022 |
| primary_location.id | doi:10.3390/ijms19072022 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S10623703 |
| primary_location.source.issn | 1422-0067, 1661-6596 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1422-0067 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | International Journal of Molecular Sciences |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/1422-0067/19/7/2022/pdf?version=1531314584 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | International Journal of Molecular Sciences |
| primary_location.landing_page_url | https://doi.org/10.3390/ijms19072022 |
| publication_date | 2018-07-11 |
| publication_year | 2018 |
| referenced_works | https://openalex.org/W2071068165, https://openalex.org/W2096963202, https://openalex.org/W2626841948, https://openalex.org/W1987710088, https://openalex.org/W1954244449, https://openalex.org/W1760380374, https://openalex.org/W6676006000, https://openalex.org/W945743162, https://openalex.org/W2154153860, https://openalex.org/W1971737167, https://openalex.org/W2470925219, https://openalex.org/W412106668, https://openalex.org/W6629495878, https://openalex.org/W2295032943, https://openalex.org/W2218802090, https://openalex.org/W2130313087, https://openalex.org/W2111988174, https://openalex.org/W2124826140, https://openalex.org/W1969161156, https://openalex.org/W4252392290, https://openalex.org/W2134476703, https://openalex.org/W2463633368, https://openalex.org/W2058970225, https://openalex.org/W2068728873, https://openalex.org/W2291638877, https://openalex.org/W6713910826, https://openalex.org/W1895291674, https://openalex.org/W2126504590, https://openalex.org/W1970318365, https://openalex.org/W1490481380, https://openalex.org/W2466016379, https://openalex.org/W1493359429, https://openalex.org/W1914313496, https://openalex.org/W2024715297, https://openalex.org/W2135082409, https://openalex.org/W2136949432, https://openalex.org/W2399348969, https://openalex.org/W2041278398, https://openalex.org/W2039530860, https://openalex.org/W2734671954, https://openalex.org/W2132503351, https://openalex.org/W2105349784, https://openalex.org/W1989057528, https://openalex.org/W2749532133, https://openalex.org/W2268624619, https://openalex.org/W2106571070, https://openalex.org/W2404686943, https://openalex.org/W4214953980 |
| referenced_works_count | 48 |
| abstract_inverted_index.1 | 5 |
| abstract_inverted_index.5 | 2, 17 |
| abstract_inverted_index.a | 150, 199, 213, 247, 252 |
| abstract_inverted_index.AD | 69, 177, 194, 220, 257 |
| abstract_inverted_index.In | 116 |
| abstract_inverted_index.We | 46, 136, 153 |
| abstract_inverted_index.an | 106 |
| abstract_inverted_index.as | 81, 246, 249, 251 |
| abstract_inverted_index.by | 114, 240 |
| abstract_inverted_index.in | 25, 68, 95, 176, 188, 209, 219 |
| abstract_inverted_index.is | 23, 36, 73 |
| abstract_inverted_index.of | 14, 28, 84, 98, 105, 109, 164, 171, 193, 217, 232, 235 |
| abstract_inverted_index.on | 120, 129 |
| abstract_inverted_index.to | 39, 63, 221, 244 |
| abstract_inverted_index.we | 101, 118, 167, 197 |
| abstract_inverted_index.AD. | 99 |
| abstract_inverted_index.The | 19 |
| abstract_inverted_index.all | 157 |
| abstract_inverted_index.and | 31, 33, 44, 89, 134, 140, 174, 178, 191, 205, 242 |
| abstract_inverted_index.are | 66, 79 |
| abstract_inverted_index.can | 52 |
| abstract_inverted_index.for | 9, 223, 256 |
| abstract_inverted_index.has | 92, 149 |
| abstract_inverted_index.its | 34 |
| abstract_inverted_index.our | 228 |
| abstract_inverted_index.the | 11, 96, 103, 169 |
| abstract_inverted_index.(AD) | 42 |
| abstract_inverted_index.Long | 75 |
| abstract_inverted_index.RNAs | 77 |
| abstract_inverted_index.also | 154 |
| abstract_inverted_index.been | 93 |
| abstract_inverted_index.gene | 7, 85 |
| abstract_inverted_index.mRNA | 58, 145 |
| abstract_inverted_index.main | 12 |
| abstract_inverted_index.p35, | 10 |
| abstract_inverted_index.role | 216 |
| abstract_inverted_index.that | 49, 138, 156 |
| abstract_inverted_index.well | 250 |
| abstract_inverted_index.work | 229 |
| abstract_inverted_index.Here, | 100 |
| abstract_inverted_index.NEAT1 | 139, 183, 206, 218, 245 |
| abstract_inverted_index.based | 128 |
| abstract_inverted_index.brain | 29, 70, 180, 210 |
| abstract_inverted_index.data: | 131 |
| abstract_inverted_index.layer | 108 |
| abstract_inverted_index.level | 234 |
| abstract_inverted_index.onset | 43 |
| abstract_inverted_index.their | 90 |
| abstract_inverted_index.three | 121, 158 |
| abstract_inverted_index.while | 71, 147 |
| abstract_inverted_index.CDK5R1 | 55, 72, 110, 125, 144, 204, 225, 236 |
| abstract_inverted_index.HOTAIR | 141 |
| abstract_inverted_index.MALAT1 | 148, 175 |
| abstract_inverted_index.NEAT1, | 132, 172 |
| abstract_inverted_index.active | 20 |
| abstract_inverted_index.cortex | 190 |
| abstract_inverted_index.family | 51, 65, 163 |
| abstract_inverted_index.kinase | 1, 16 |
| abstract_inverted_index.levels | 187, 208 |
| abstract_inverted_index.master | 82 |
| abstract_inverted_index.miRNAs | 61 |
| abstract_inverted_index.points | 243 |
| abstract_inverted_index.showed | 48, 155 |
| abstract_inverted_index.strong | 200 |
| abstract_inverted_index.target | 255 |
| abstract_inverted_index.(CDK5). | 18 |
| abstract_inverted_index.HOTAIR, | 133, 173 |
| abstract_inverted_index.MALAT1. | 135 |
| abstract_inverted_index.another | 233 |
| abstract_inverted_index.aspects | 27 |
| abstract_inverted_index.between | 203 |
| abstract_inverted_index.closely | 37 |
| abstract_inverted_index.complex | 22 |
| abstract_inverted_index.control | 161, 179 |
| abstract_inverted_index.disease | 41 |
| abstract_inverted_index.effect. | 152 |
| abstract_inverted_index.encodes | 8 |
| abstract_inverted_index.focused | 119 |
| abstract_inverted_index.levels, | 127, 146 |
| abstract_inverted_index.levels. | 226 |
| abstract_inverted_index.lncRNAs | 122, 159, 241 |
| abstract_inverted_index.miRNAs, | 88 |
| abstract_inverted_index.miRNAs. | 165 |
| abstract_inverted_index.subunit | 4 |
| abstract_inverted_index.(CDK5R1) | 6 |
| abstract_inverted_index.Overall, | 227 |
| abstract_inverted_index.emerging | 80 |
| abstract_inverted_index.evidence | 231 |
| abstract_inverted_index.existing | 130 |
| abstract_inverted_index.involved | 24 |
| abstract_inverted_index.lncRNAs. | 115 |
| abstract_inverted_index.mediated | 239 |
| abstract_inverted_index.numerous | 26 |
| abstract_inverted_index.observed | 198 |
| abstract_inverted_index.p35/CDK5 | 21 |
| abstract_inverted_index.positive | 151, 201 |
| abstract_inverted_index.possible | 214 |
| abstract_inverted_index.provided | 113 |
| abstract_inverted_index.provides | 230 |
| abstract_inverted_index.recently | 47 |
| abstract_inverted_index.regulate | 54, 143 |
| abstract_inverted_index.temporal | 189 |
| abstract_inverted_index.therapy. | 258 |
| abstract_inverted_index.tissues, | 211 |
| abstract_inverted_index.tissues. | 181 |
| abstract_inverted_index.(lncRNAs) | 78 |
| abstract_inverted_index.Moreover, | 166 |
| abstract_inverted_index.activator | 13 |
| abstract_inverted_index.belonging | 62 |
| abstract_inverted_index.displayed | 184 |
| abstract_inverted_index.evaluated | 102, 168 |
| abstract_inverted_index.existence | 104 |
| abstract_inverted_index.function, | 32 |
| abstract_inverted_index.including | 87 |
| abstract_inverted_index.increased | 185, 224 |
| abstract_inverted_index.modifying | 57 |
| abstract_inverted_index.patients. | 195 |
| abstract_inverted_index.potential | 253 |
| abstract_inverted_index.additional | 107 |
| abstract_inverted_index.associated | 38 |
| abstract_inverted_index.biomarker, | 248 |
| abstract_inverted_index.compensate | 222 |
| abstract_inverted_index.expression | 56, 111, 126, 170, 186, 207, 237 |
| abstract_inverted_index.implicated | 94 |
| abstract_inverted_index.miR-15/107 | 50, 64, 162 |
| abstract_inverted_index.negatively | 53, 142 |
| abstract_inverted_index.non-coding | 76 |
| abstract_inverted_index.positively | 160 |
| abstract_inverted_index.regulating | 124 |
| abstract_inverted_index.regulation | 112, 238 |
| abstract_inverted_index.regulators | 83 |
| abstract_inverted_index.regulatory | 3 |
| abstract_inverted_index.stability. | 59 |
| abstract_inverted_index.suggesting | 212 |
| abstract_inverted_index.correlation | 202 |
| abstract_inverted_index.development | 30 |
| abstract_inverted_index.expression, | 86 |
| abstract_inverted_index.hippocampus | 192 |
| abstract_inverted_index.particular, | 117 |
| abstract_inverted_index.potentially | 123 |
| abstract_inverted_index.demonstrated | 137 |
| abstract_inverted_index.deregulation | 35 |
| abstract_inverted_index.pathogenesis | 97 |
| abstract_inverted_index.progression. | 45 |
| abstract_inverted_index.upregulated. | 74 |
| abstract_inverted_index.Alzheimer’s | 40 |
| abstract_inverted_index.downregulated | 67 |
| abstract_inverted_index.dysregulation | 91 |
| abstract_inverted_index.Interestingly, | 60, 182, 196 |
| abstract_inverted_index.neuroprotective | 215 |
| abstract_inverted_index.pharmacological | 254 |
| abstract_inverted_index.Cyclin-dependent | 0, 15 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 96 |
| corresponding_author_ids | https://openalex.org/A5027054002 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 5 |
| corresponding_institution_ids | https://openalex.org/I189158943 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.550000011920929 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.91747603 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |