Multiple mechanisms of curcumin targeting spinal cord injury Article Swipe
Guangjin Gu
,
Jie Ren
,
Bin Zhu
,
Zhongju Shi
,
Shiqing Feng
,
Zhijian Wei
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.biopha.2023.114224
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.biopha.2023.114224
Spinal cord injury (SCI) is an irreversible disease process with a high disability and mortality rate. After primary spinal cord injury, the secondary injury may occur in sequence, which is composed of ischemia and hypoxia, excitotoxicity, calcium overload, oxidative stress and inflammation, resulting in massive death of parenchymal cells in the injured area, followed by the formation of syringomyelia. Effectively curbing the process of secondary injury can promote nerve repair and improve functional prognosis. As the main active ingredient in turmeric, curcumin can play an important role in reducing inflammation and oxidation, protecting the neurons, and ultimately reducing spinal cord injury. This article reviews the effects of curcumin on the repair of nerve injury, with emphasis on the various mechanisms by which curcumin promotes the treatment of spinal cord injury.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.biopha.2023.114224
- OA Status
- gold
- Cited By
- 28
- References
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- OpenAlex ID
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https://openalex.org/W4316193387Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.biopha.2023.114224Digital Object Identifier
- Title
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Multiple mechanisms of curcumin targeting spinal cord injuryWork title
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reviewOpenAlex work type
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enPrimary language
- Publication year
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2023Year of publication
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2023-01-14Full publication date if available
- Authors
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Guangjin Gu, Jie Ren, Bin Zhu, Zhongju Shi, Shiqing Feng, Zhijian WeiList of authors in order
- Landing page
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https://doi.org/10.1016/j.biopha.2023.114224Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://doi.org/10.1016/j.biopha.2023.114224Direct OA link when available
- Concepts
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Medicine, Excitotoxicity, Curcumin, Spinal cord injury, Spinal cord, Neuroprotection, Inflammation, Hypoxia (environmental), Oxidative stress, Anesthesia, Pharmacology, Immunology, Internal medicine, Glutamate receptor, Receptor, Chemistry, Psychiatry, Organic chemistry, OxygenTop concepts (fields/topics) attached by OpenAlex
- Cited by
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28Total citation count in OpenAlex
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2025: 12, 2024: 8, 2023: 8Per-year citation counts (last 5 years)
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202Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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