Multiple sclerosis pathogenesis: missing pieces of an old puzzle Article Swipe
Reza Rahmanzadeh
,
Wolfgang Brück
,
Alireza Minagar
,
Mohammad Ali Sahraian
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1515/revneuro-2018-0002
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1515/revneuro-2018-0002
Traditionally, multiple sclerosis (MS) was considered to be a CD4 T cell-mediated CNS autoimmunity, compatible with experimental autoimmune encephalitis model, which can be characterized by focal lesions in the white matter. However, studies of recent decades revealed several missing pieces of MS puzzle and showed that MS pathogenesis is more complex than the traditional view and may include the following: a primary degenerative process (e.g. oligodendroglial pathology), generalized abnormality of normal-appearing brain tissue, pronounced gray matter pathology, involvement of innate immunity, and CD8 T cells and B cells. Here, we review these findings and discuss their implications in MS pathogenesis.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1515/revneuro-2018-0002
- OA Status
- gold
- Cited By
- 22
- References
- 213
- Related Works
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- OpenAlex ID
- https://openalex.org/W2805433833
All OpenAlex metadata
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- OpenAlex ID
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https://openalex.org/W2805433833Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1515/revneuro-2018-0002Digital Object Identifier
- Title
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Multiple sclerosis pathogenesis: missing pieces of an old puzzleWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2018Year of publication
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2018-06-08Full publication date if available
- Authors
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Reza Rahmanzadeh, Wolfgang Brück, Alireza Minagar, Mohammad Ali SahraianList of authors in order
- Landing page
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https://doi.org/10.1515/revneuro-2018-0002Publisher landing page
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://resolver.sub.uni-goettingen.de/purl?gro-2/136962Direct OA link when available
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Pathogenesis, Multiple sclerosis, Pathology, Autoimmunity, White matter, Abnormality, Neuroscience, Neurology, Medicine, Immunology, Biology, Disease, Magnetic resonance imaging, Psychiatry, RadiologyTop concepts (fields/topics) attached by OpenAlex
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22Total citation count in OpenAlex
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2025: 1, 2024: 2, 2023: 3, 2022: 2, 2021: 4Per-year citation counts (last 5 years)
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213Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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