Clinical Chemistry • Vol 68 • No 8
Multiplex Fragment Analysis for Flexible Detection of All SARS-CoV-2 Variants of Concern
April 2022 • Andrew E. Clark, Zhaohui Wang, Emily Ostman, Hui Zheng, Huiyu Yao, Brandi L. Cantarel, Mohammed Kanchwala, Chao Xing, Li Chen, Pei Irwin, Yan Xu, Dwi…
Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants continue to emerge, and effective tracking requires rapid return of results. Surveillance of variants is typically performed by whole genome sequencing (WGS), which can be financially prohibitive and requires specialized equipment and bioinformatic expertise. Genotyping approaches are rapid methods for monitoring SARS-CoV-2 variants but require continuous adaptation. Fragment analysis may represent an approach for improved SA…