Multiplexed profiling of single-cell extracellular vesicles secretion Article Swipe
YOU?
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· 2019
· Open Access
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· DOI: https://doi.org/10.1073/pnas.1814348116
Significance Extracellular vesicles (EVs) are cell-derived nanosized particles medicating cell−cell communication and transferring biology information molecules like nucleic acids to regulate human health and diseases. Conventional methods for EV surface marker profiling can’t tell the differences in the quantity and phenotypes of EV secretion between cells. To address this need, we developed a microchip platform for profiling an array of surface markers on EVs from large numbers of single cells, enabling more-comprehensive monitoring of cellular communications. Single-cell EV secretion assay led to previously unobserved cell heterogeneity underlying EV secretion, which might open up avenues for studying cell communication and cell microenvironment in both basic and clinical research.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1073/pnas.1814348116
- https://www.pnas.org/content/pnas/116/13/5979.full.pdf
- OA Status
- bronze
- Cited By
- 144
- References
- 45
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2952272517
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2952272517Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1073/pnas.1814348116Digital Object Identifier
- Title
-
Multiplexed profiling of single-cell extracellular vesicles secretionWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2019Year of publication
- Publication date
-
2019-03-11Full publication date if available
- Authors
-
Yahui Ji, Dongyuan Qi, Linmei Li, Haoran Su, Xiaojie Li, Yong Luo, Bo Sun, Fuyin Zhang, Bingcheng Lin, Tingjiao Liu, Yao LuList of authors in order
- Landing page
-
https://doi.org/10.1073/pnas.1814348116Publisher landing page
- PDF URL
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https://www.pnas.org/content/pnas/116/13/5979.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
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https://www.pnas.org/content/pnas/116/13/5979.full.pdfDirect OA link when available
- Concepts
-
Secretion, Cell, Single-cell analysis, Microvesicles, Cell biology, Phenotype, Extracellular vesicle, Extracellular, Biology, Cell culture, Extracellular vesicles, Intracellular, Population, microRNA, Gene, Genetics, Medicine, Biochemistry, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
144Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 20, 2024: 28, 2023: 22, 2022: 20, 2021: 26Per-year citation counts (last 5 years)
- References (count)
-
45Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W2121354606, https://openalex.org/W2080418767, https://openalex.org/W2108375854, https://openalex.org/W1977613047, https://openalex.org/W2054410308, https://openalex.org/W301388723, https://openalex.org/W561419410, https://openalex.org/W1969002010, https://openalex.org/W1987604193, https://openalex.org/W2619475721, https://openalex.org/W2781579322, https://openalex.org/W2700673768, https://openalex.org/W2786202610, https://openalex.org/W2952961321, https://openalex.org/W2159401023, https://openalex.org/W2259481044, https://openalex.org/W2034774921, https://openalex.org/W2779044993, https://openalex.org/W1979792239, https://openalex.org/W2248179576, https://openalex.org/W2135461398, https://openalex.org/W1993140699, https://openalex.org/W2288512038, https://openalex.org/W2415013816, https://openalex.org/W1932219212, https://openalex.org/W2783004471, https://openalex.org/W2088298294, https://openalex.org/W2166180044, https://openalex.org/W2061078277, https://openalex.org/W2168204150, https://openalex.org/W2258410243, https://openalex.org/W2051452288, https://openalex.org/W2766877982, https://openalex.org/W2100634642, https://openalex.org/W2807819616, https://openalex.org/W2304559519, https://openalex.org/W2081896305, https://openalex.org/W2074420452, https://openalex.org/W2863269889, https://openalex.org/W2088049678, https://openalex.org/W2079521303, https://openalex.org/W2605452842, https://openalex.org/W3201763383, https://openalex.org/W1982729887, https://openalex.org/W2598882867 |
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