Multiscale mapping of transcriptomic signatures for cardiotoxic drugs Article Swipe
Jens Hansen
,
Yuguang Xiong
,
Priyanka Dhanan
,
Bin Hu
,
Arjun Singh Yadaw
,
Gomathi Jayaraman
,
Rosa E. Tolentino
,
Yibang Chen
,
Kristin G. Beaumont
,
Robert Sebra
,
D. Vidović
,
Stephan C. Schürer
,
Joseph Goldfarb
,
James M. Gallo
,
Marc R. Birtwistle
,
Eric A. Sobie
,
Evren U. Azeloglu
,
Seth Berger
,
Angel Chan
,
Christoph Schaniel
,
Nicole Dubois
,
Ravi Iyengar
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.11.02.466774
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.11.02.466774
Drug-induced gene expression profiles can identify potential mechanisms of toxicity. We focused on obtaining signatures for cardiotoxicity of FDA-approved tyrosine kinase inhibitors (TKIs) in human induced pluripotent stem cell-derived cardiomyocytes. Using bulk transcriptomics profiles, we applied singular value decomposition to identify drug-selective patterns in cell lines obtained from multiple healthy human subjects. Cellular pathways affected by highly cardiotoxic TKIs include energy metabolism, contractile, and extracellular matrix dynamics. Projecting these pathways to single cell expression profiles indicates that TKI responses can be evoked in both cardiomyocytes and fibroblasts. Whole genome sequences of the cell lines, using outlier responses enabled us to correctly reidentify a genomic variant associated with anthracycline cardiotoxicity and predict genomic variants potentially associated with TKI cardiotoxicity. We conclude that mRNA expression profiles when integrated with publicly available genomic, pathway, and single cell transcriptomic datasets, provide multiscale predictive understanding of cardiotoxicity for drug development and patient stratification. One sentence summary Genes, pathways, and cell types of the human heart associated with antineoplastic drug cardiotoxicity.
Related Topics
Concepts
Cardiotoxicity
Transcriptome
Biology
Computational biology
Gene expression profiling
Induced pluripotent stem cell
Bioinformatics
Gene expression
Pharmacology
Gene
Genetics
Embryonic stem cell
Chemotherapy
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2021.11.02.466774
- https://www.biorxiv.org/content/biorxiv/early/2023/03/14/2021.11.02.466774.full.pdf
- OA Status
- green
- Cited By
- 2
- References
- 100
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3213454058
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3213454058Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2021.11.02.466774Digital Object Identifier
- Title
-
Multiscale mapping of transcriptomic signatures for cardiotoxic drugsWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-11-04Full publication date if available
- Authors
-
Jens Hansen, Yuguang Xiong, Priyanka Dhanan, Bin Hu, Arjun Singh Yadaw, Gomathi Jayaraman, Rosa E. Tolentino, Yibang Chen, Kristin G. Beaumont, Robert Sebra, D. Vidović, Stephan C. Schürer, Joseph Goldfarb, James M. Gallo, Marc R. Birtwistle, Eric A. Sobie, Evren U. Azeloglu, Seth Berger, Angel Chan, Christoph Schaniel, Nicole Dubois, Ravi IyengarList of authors in order
- Landing page
-
https://doi.org/10.1101/2021.11.02.466774Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2023/03/14/2021.11.02.466774.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2023/03/14/2021.11.02.466774.full.pdfDirect OA link when available
- Concepts
-
Cardiotoxicity, Transcriptome, Biology, Computational biology, Gene expression profiling, Induced pluripotent stem cell, Bioinformatics, Gene expression, Pharmacology, Gene, Genetics, Embryonic stem cell, ChemotherapyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 1Per-year citation counts (last 5 years)
- References (count)
-
100Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3213454058 |
|---|---|
| doi | https://doi.org/10.1101/2021.11.02.466774 |
| ids.doi | https://doi.org/10.1101/2021.11.02.466774 |
| ids.mag | 3213454058 |
| ids.openalex | https://openalex.org/W3213454058 |
| fwci | 0.17743932 |
| type | preprint |
| title | Multiscale mapping of transcriptomic signatures for cardiotoxic drugs |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T11535 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9778000116348267 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2705 |
| topics[0].subfield.display_name | Cardiology and Cardiovascular Medicine |
| topics[0].display_name | Chemotherapy-induced cardiotoxicity and mitigation |
| topics[1].id | https://openalex.org/T10621 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9688000082969666 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Gene Regulatory Network Analysis |
| topics[2].id | https://openalex.org/T10505 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9684000015258789 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | Pluripotent Stem Cells Research |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C2778233292 |
| concepts[0].level | 3 |
| concepts[0].score | 0.9149880409240723 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q2118956 |
| concepts[0].display_name | Cardiotoxicity |
| concepts[1].id | https://openalex.org/C162317418 |
| concepts[1].level | 4 |
| concepts[1].score | 0.6999549269676208 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q252857 |
| concepts[1].display_name | Transcriptome |
| concepts[2].id | https://openalex.org/C86803240 |
| concepts[2].level | 0 |
| concepts[2].score | 0.5577777624130249 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[2].display_name | Biology |
| concepts[3].id | https://openalex.org/C70721500 |
| concepts[3].level | 1 |
| concepts[3].score | 0.5234215259552002 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q177005 |
| concepts[3].display_name | Computational biology |
| concepts[4].id | https://openalex.org/C18431079 |
| concepts[4].level | 4 |
| concepts[4].score | 0.43625587224960327 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q1502169 |
| concepts[4].display_name | Gene expression profiling |
| concepts[5].id | https://openalex.org/C107459253 |
| concepts[5].level | 4 |
| concepts[5].score | 0.4268523156642914 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q674925 |
| concepts[5].display_name | Induced pluripotent stem cell |
| concepts[6].id | https://openalex.org/C60644358 |
| concepts[6].level | 1 |
| concepts[6].score | 0.3678826093673706 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q128570 |
| concepts[6].display_name | Bioinformatics |
| concepts[7].id | https://openalex.org/C150194340 |
| concepts[7].level | 3 |
| concepts[7].score | 0.36710256338119507 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q26972 |
| concepts[7].display_name | Gene expression |
| concepts[8].id | https://openalex.org/C98274493 |
| concepts[8].level | 1 |
| concepts[8].score | 0.333631694316864 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q128406 |
| concepts[8].display_name | Pharmacology |
| concepts[9].id | https://openalex.org/C104317684 |
| concepts[9].level | 2 |
| concepts[9].score | 0.33186429738998413 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[9].display_name | Gene |
| concepts[10].id | https://openalex.org/C54355233 |
| concepts[10].level | 1 |
| concepts[10].score | 0.23576965928077698 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[10].display_name | Genetics |
| concepts[11].id | https://openalex.org/C145103041 |
| concepts[11].level | 3 |
| concepts[11].score | 0.0 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q1151519 |
| concepts[11].display_name | Embryonic stem cell |
| concepts[12].id | https://openalex.org/C2776694085 |
| concepts[12].level | 2 |
| concepts[12].score | 0.0 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q974135 |
| concepts[12].display_name | Chemotherapy |
| keywords[0].id | https://openalex.org/keywords/cardiotoxicity |
| keywords[0].score | 0.9149880409240723 |
| keywords[0].display_name | Cardiotoxicity |
| keywords[1].id | https://openalex.org/keywords/transcriptome |
| keywords[1].score | 0.6999549269676208 |
| keywords[1].display_name | Transcriptome |
| keywords[2].id | https://openalex.org/keywords/biology |
| keywords[2].score | 0.5577777624130249 |
| keywords[2].display_name | Biology |
| keywords[3].id | https://openalex.org/keywords/computational-biology |
| keywords[3].score | 0.5234215259552002 |
| keywords[3].display_name | Computational biology |
| keywords[4].id | https://openalex.org/keywords/gene-expression-profiling |
| keywords[4].score | 0.43625587224960327 |
| keywords[4].display_name | Gene expression profiling |
| keywords[5].id | https://openalex.org/keywords/induced-pluripotent-stem-cell |
| keywords[5].score | 0.4268523156642914 |
| keywords[5].display_name | Induced pluripotent stem cell |
| keywords[6].id | https://openalex.org/keywords/bioinformatics |
| keywords[6].score | 0.3678826093673706 |
| keywords[6].display_name | Bioinformatics |
| keywords[7].id | https://openalex.org/keywords/gene-expression |
| keywords[7].score | 0.36710256338119507 |
| keywords[7].display_name | Gene expression |
| keywords[8].id | https://openalex.org/keywords/pharmacology |
| keywords[8].score | 0.333631694316864 |
| keywords[8].display_name | Pharmacology |
| keywords[9].id | https://openalex.org/keywords/gene |
| keywords[9].score | 0.33186429738998413 |
| keywords[9].display_name | Gene |
| keywords[10].id | https://openalex.org/keywords/genetics |
| keywords[10].score | 0.23576965928077698 |
| keywords[10].display_name | Genetics |
| language | en |
| locations[0].id | doi:10.1101/2021.11.02.466774 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4306402567 |
| locations[0].source.issn | |
| locations[0].source.type | repository |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | |
| locations[0].source.is_core | False |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| locations[0].source.host_organization | https://openalex.org/I2750212522 |
| locations[0].source.host_organization_name | Cold Spring Harbor Laboratory |
| locations[0].source.host_organization_lineage | https://openalex.org/I2750212522 |
| locations[0].license | |
| locations[0].pdf_url | https://www.biorxiv.org/content/biorxiv/early/2023/03/14/2021.11.02.466774.full.pdf |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.1101/2021.11.02.466774 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5102892482 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-1362-6534 |
| authorships[0].author.display_name | Jens Hansen |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I98704320 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 1009, USA |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I98704320 |
| authorships[0].affiliations[1].raw_affiliation_string | Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| authorships[0].institutions[0].id | https://openalex.org/I98704320 |
| authorships[0].institutions[0].ror | https://ror.org/04a9tmd77 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I1320796813, https://openalex.org/I98704320 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | Icahn School of Medicine at Mount Sinai |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Jens Hansen |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 1009, USA, Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| authorships[1].author.id | https://openalex.org/A5073397841 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-5221-6266 |
| authorships[1].author.display_name | Yuguang Xiong |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I98704320 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 1009, USA |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I98704320 |
| authorships[1].affiliations[1].raw_affiliation_string | Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| authorships[1].institutions[0].id | https://openalex.org/I98704320 |
| authorships[1].institutions[0].ror | https://ror.org/04a9tmd77 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I1320796813, https://openalex.org/I98704320 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | Icahn School of Medicine at Mount Sinai |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Yuguang Xiong |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 1009, USA, Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| authorships[2].author.id | https://openalex.org/A5047302589 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Priyanka Dhanan |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I98704320 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 1009, USA |
| authorships[2].affiliations[1].institution_ids | https://openalex.org/I98704320 |
| authorships[2].affiliations[1].raw_affiliation_string | Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| authorships[2].institutions[0].id | https://openalex.org/I98704320 |
| authorships[2].institutions[0].ror | https://ror.org/04a9tmd77 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I1320796813, https://openalex.org/I98704320 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | Icahn School of Medicine at Mount Sinai |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Priyanka Dhanan |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 1009, USA, Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| authorships[3].author.id | https://openalex.org/A5089000322 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-6316-2830 |
| authorships[3].author.display_name | Bin Hu |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I98704320 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 1009, USA |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I98704320 |
| authorships[3].affiliations[1].raw_affiliation_string | Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| authorships[3].institutions[0].id | https://openalex.org/I98704320 |
| authorships[3].institutions[0].ror | https://ror.org/04a9tmd77 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I1320796813, https://openalex.org/I98704320 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | Icahn School of Medicine at Mount Sinai |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Bin Hu |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 1009, USA, Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| authorships[4].author.id | https://openalex.org/A5045788094 |
| authorships[4].author.orcid | https://orcid.org/0000-0001-6853-7443 |
| authorships[4].author.display_name | Arjun Singh Yadaw |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I98704320 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 1009, USA |
| authorships[4].affiliations[1].institution_ids | https://openalex.org/I98704320 |
| authorships[4].affiliations[1].raw_affiliation_string | Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| authorships[4].institutions[0].id | https://openalex.org/I98704320 |
| authorships[4].institutions[0].ror | https://ror.org/04a9tmd77 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I1320796813, https://openalex.org/I98704320 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | Icahn School of Medicine at Mount Sinai |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Arjun S. Yadaw |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 1009, USA, Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| authorships[5].author.id | https://openalex.org/A5036286368 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Gomathi Jayaraman |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I98704320 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 1009, USA |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I98704320 |
| authorships[5].affiliations[1].raw_affiliation_string | Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| authorships[5].institutions[0].id | https://openalex.org/I98704320 |
| authorships[5].institutions[0].ror | https://ror.org/04a9tmd77 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I1320796813, https://openalex.org/I98704320 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | Icahn School of Medicine at Mount Sinai |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Gomathi Jayaraman |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 1009, USA, Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| authorships[6].author.id | https://openalex.org/A5036786986 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-4261-3230 |
| authorships[6].author.display_name | Rosa E. Tolentino |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I98704320 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 1009, USA |
| authorships[6].affiliations[1].institution_ids | https://openalex.org/I98704320 |
| authorships[6].affiliations[1].raw_affiliation_string | Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| authorships[6].institutions[0].id | https://openalex.org/I98704320 |
| authorships[6].institutions[0].ror | https://ror.org/04a9tmd77 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I1320796813, https://openalex.org/I98704320 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | Icahn School of Medicine at Mount Sinai |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Rosa Tolentino |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 1009, USA, Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| authorships[7].author.id | https://openalex.org/A5083462338 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Yibang Chen |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I98704320 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 1009, USA |
| authorships[7].affiliations[1].institution_ids | https://openalex.org/I98704320 |
| authorships[7].affiliations[1].raw_affiliation_string | Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| authorships[7].institutions[0].id | https://openalex.org/I98704320 |
| authorships[7].institutions[0].ror | https://ror.org/04a9tmd77 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I1320796813, https://openalex.org/I98704320 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | Icahn School of Medicine at Mount Sinai |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Yibang Chen |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 1009, USA, Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| authorships[8].author.id | https://openalex.org/A5026912903 |
| authorships[8].author.orcid | https://orcid.org/0000-0003-3075-9977 |
| authorships[8].author.display_name | Kristin G. Beaumont |
| authorships[8].countries | US |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I98704320 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA |
| authorships[8].institutions[0].id | https://openalex.org/I98704320 |
| authorships[8].institutions[0].ror | https://ror.org/04a9tmd77 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I1320796813, https://openalex.org/I98704320 |
| authorships[8].institutions[0].country_code | US |
| authorships[8].institutions[0].display_name | Icahn School of Medicine at Mount Sinai |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Kristin G. Beaumont |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA |
| authorships[9].author.id | https://openalex.org/A5076788078 |
| authorships[9].author.orcid | https://orcid.org/0000-0001-9267-2426 |
| authorships[9].author.display_name | Robert Sebra |
| authorships[9].countries | US |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I98704320 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA |
| authorships[9].institutions[0].id | https://openalex.org/I98704320 |
| authorships[9].institutions[0].ror | https://ror.org/04a9tmd77 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I1320796813, https://openalex.org/I98704320 |
| authorships[9].institutions[0].country_code | US |
| authorships[9].institutions[0].display_name | Icahn School of Medicine at Mount Sinai |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Robert Sebra |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA |
| authorships[10].author.id | https://openalex.org/A5028217875 |
| authorships[10].author.orcid | https://orcid.org/0000-0001-9798-2108 |
| authorships[10].author.display_name | D. Vidović |
| authorships[10].countries | US |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I145608581 |
| authorships[10].affiliations[0].raw_affiliation_string | Institute for Data Science and Computing, University of Miami, Coral Gables, FL 3316, USA |
| authorships[10].institutions[0].id | https://openalex.org/I145608581 |
| authorships[10].institutions[0].ror | https://ror.org/02dgjyy92 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I145608581 |
| authorships[10].institutions[0].country_code | US |
| authorships[10].institutions[0].display_name | University of Miami |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Dusica Vidovic |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Institute for Data Science and Computing, University of Miami, Coral Gables, FL 3316, USA |
| authorships[11].author.id | https://openalex.org/A5013636406 |
| authorships[11].author.orcid | https://orcid.org/0000-0001-7180-0978 |
| authorships[11].author.display_name | Stephan C. Schürer |
| authorships[11].countries | US |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I145608581 |
| authorships[11].affiliations[0].raw_affiliation_string | Institute for Data Science and Computing, University of Miami, Coral Gables, FL 3316, USA |
| authorships[11].institutions[0].id | https://openalex.org/I145608581 |
| authorships[11].institutions[0].ror | https://ror.org/02dgjyy92 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I145608581 |
| authorships[11].institutions[0].country_code | US |
| authorships[11].institutions[0].display_name | University of Miami |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Stephan C. Schürer |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Institute for Data Science and Computing, University of Miami, Coral Gables, FL 3316, USA |
| authorships[12].author.id | https://openalex.org/A5012898979 |
| authorships[12].author.orcid | |
| authorships[12].author.display_name | Joseph Goldfarb |
| authorships[12].countries | US |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I98704320 |
| authorships[12].affiliations[0].raw_affiliation_string | Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 1009, USA |
| authorships[12].affiliations[1].institution_ids | https://openalex.org/I98704320 |
| authorships[12].affiliations[1].raw_affiliation_string | Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| authorships[12].institutions[0].id | https://openalex.org/I98704320 |
| authorships[12].institutions[0].ror | https://ror.org/04a9tmd77 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I1320796813, https://openalex.org/I98704320 |
| authorships[12].institutions[0].country_code | US |
| authorships[12].institutions[0].display_name | Icahn School of Medicine at Mount Sinai |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Joseph Goldfarb |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 1009, USA, Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| authorships[13].author.id | https://openalex.org/A5056500955 |
| authorships[13].author.orcid | |
| authorships[13].author.display_name | James M. Gallo |
| authorships[13].countries | US |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I98704320 |
| authorships[13].affiliations[0].raw_affiliation_string | Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 1009, USA |
| authorships[13].affiliations[1].institution_ids | https://openalex.org/I98704320 |
| authorships[13].affiliations[1].raw_affiliation_string | Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| authorships[13].affiliations[2].institution_ids | https://openalex.org/I63190737 |
| authorships[13].affiliations[2].raw_affiliation_string | School of Pharmacy and Pharmaceutical Sciences, University of Buffalo SUNY System, Buffalo NY 14260 |
| authorships[13].institutions[0].id | https://openalex.org/I98704320 |
| authorships[13].institutions[0].ror | https://ror.org/04a9tmd77 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I1320796813, https://openalex.org/I98704320 |
| authorships[13].institutions[0].country_code | US |
| authorships[13].institutions[0].display_name | Icahn School of Medicine at Mount Sinai |
| authorships[13].institutions[1].id | https://openalex.org/I63190737 |
| authorships[13].institutions[1].ror | https://ror.org/01y64my43 |
| authorships[13].institutions[1].type | education |
| authorships[13].institutions[1].lineage | https://openalex.org/I63190737 |
| authorships[13].institutions[1].country_code | US |
| authorships[13].institutions[1].display_name | University at Buffalo, State University of New York |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | James Gallo |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 1009, USA, Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA, School of Pharmacy and Pharmaceutical Sciences, University of Buffalo SUNY System, Buffalo NY 14260 |
| authorships[14].author.id | https://openalex.org/A5089614989 |
| authorships[14].author.orcid | https://orcid.org/0000-0002-0341-0705 |
| authorships[14].author.display_name | Marc R. Birtwistle |
| authorships[14].countries | US |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I98704320 |
| authorships[14].affiliations[0].raw_affiliation_string | Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 1009, USA |
| authorships[14].affiliations[1].institution_ids | https://openalex.org/I98704320 |
| authorships[14].affiliations[1].raw_affiliation_string | Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| authorships[14].affiliations[2].institution_ids | https://openalex.org/I8078737 |
| authorships[14].affiliations[2].raw_affiliation_string | Chemical and Biomolecular Engineering, Clemson University, Clemson, SC, 2934, USA |
| authorships[14].institutions[0].id | https://openalex.org/I8078737 |
| authorships[14].institutions[0].ror | https://ror.org/037s24f05 |
| authorships[14].institutions[0].type | education |
| authorships[14].institutions[0].lineage | https://openalex.org/I8078737 |
| authorships[14].institutions[0].country_code | US |
| authorships[14].institutions[0].display_name | Clemson University |
| authorships[14].institutions[1].id | https://openalex.org/I98704320 |
| authorships[14].institutions[1].ror | https://ror.org/04a9tmd77 |
| authorships[14].institutions[1].type | education |
| authorships[14].institutions[1].lineage | https://openalex.org/I1320796813, https://openalex.org/I98704320 |
| authorships[14].institutions[1].country_code | US |
| authorships[14].institutions[1].display_name | Icahn School of Medicine at Mount Sinai |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Marc R. Birtwistle |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Chemical and Biomolecular Engineering, Clemson University, Clemson, SC, 2934, USA, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 1009, USA, Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| authorships[15].author.id | https://openalex.org/A5000485841 |
| authorships[15].author.orcid | https://orcid.org/0000-0001-7327-8538 |
| authorships[15].author.display_name | Eric A. Sobie |
| authorships[15].countries | US |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I98704320 |
| authorships[15].affiliations[0].raw_affiliation_string | Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 1009, USA |
| authorships[15].affiliations[1].institution_ids | https://openalex.org/I98704320 |
| authorships[15].affiliations[1].raw_affiliation_string | Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| authorships[15].institutions[0].id | https://openalex.org/I98704320 |
| authorships[15].institutions[0].ror | https://ror.org/04a9tmd77 |
| authorships[15].institutions[0].type | education |
| authorships[15].institutions[0].lineage | https://openalex.org/I1320796813, https://openalex.org/I98704320 |
| authorships[15].institutions[0].country_code | US |
| authorships[15].institutions[0].display_name | Icahn School of Medicine at Mount Sinai |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Eric A. Sobie |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 1009, USA, Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| authorships[16].author.id | https://openalex.org/A5024546157 |
| authorships[16].author.orcid | https://orcid.org/0000-0001-6137-109X |
| authorships[16].author.display_name | Evren U. Azeloglu |
| authorships[16].countries | US |
| authorships[16].affiliations[0].institution_ids | https://openalex.org/I98704320 |
| authorships[16].affiliations[0].raw_affiliation_string | Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 1009, USA |
| authorships[16].affiliations[1].institution_ids | https://openalex.org/I98704320 |
| authorships[16].affiliations[1].raw_affiliation_string | Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| authorships[16].affiliations[2].institution_ids | https://openalex.org/I98704320 |
| authorships[16].affiliations[2].raw_affiliation_string | Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New, York, NY 10029, USA |
| authorships[16].institutions[0].id | https://openalex.org/I98704320 |
| authorships[16].institutions[0].ror | https://ror.org/04a9tmd77 |
| authorships[16].institutions[0].type | education |
| authorships[16].institutions[0].lineage | https://openalex.org/I1320796813, https://openalex.org/I98704320 |
| authorships[16].institutions[0].country_code | US |
| authorships[16].institutions[0].display_name | Icahn School of Medicine at Mount Sinai |
| authorships[16].author_position | middle |
| authorships[16].raw_author_name | Evren U. Azeloglu |
| authorships[16].is_corresponding | False |
| authorships[16].raw_affiliation_strings | Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New, York, NY 10029, USA, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 1009, USA, Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| authorships[17].author.id | https://openalex.org/A5082197380 |
| authorships[17].author.orcid | https://orcid.org/0000-0001-7517-4302 |
| authorships[17].author.display_name | Seth Berger |
| authorships[17].countries | US |
| authorships[17].affiliations[0].institution_ids | https://openalex.org/I193531525 |
| authorships[17].affiliations[0].raw_affiliation_string | Departments of Pediatrics and Genomics & Precision Medicine, George Washington University School of medicine and Health Sciences, Washington DC USA, 20012 |
| authorships[17].institutions[0].id | https://openalex.org/I193531525 |
| authorships[17].institutions[0].ror | https://ror.org/00y4zzh67 |
| authorships[17].institutions[0].type | education |
| authorships[17].institutions[0].lineage | https://openalex.org/I193531525 |
| authorships[17].institutions[0].country_code | US |
| authorships[17].institutions[0].display_name | George Washington University |
| authorships[17].author_position | middle |
| authorships[17].raw_author_name | Seth Berger |
| authorships[17].is_corresponding | False |
| authorships[17].raw_affiliation_strings | Departments of Pediatrics and Genomics & Precision Medicine, George Washington University School of medicine and Health Sciences, Washington DC USA, 20012 |
| authorships[18].author.id | https://openalex.org/A5088970707 |
| authorships[18].author.orcid | https://orcid.org/0000-0002-5788-333X |
| authorships[18].author.display_name | Angel Chan |
| authorships[18].countries | US |
| authorships[18].affiliations[0].institution_ids | https://openalex.org/I98704320 |
| authorships[18].affiliations[0].raw_affiliation_string | Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 1009, USA |
| authorships[18].affiliations[1].institution_ids | https://openalex.org/I1334819555 |
| authorships[18].affiliations[1].raw_affiliation_string | Cardiology Division, Department of Medicine, Memorial Sloan Kettering Cancer Center New York NY 10065 |
| authorships[18].affiliations[2].institution_ids | https://openalex.org/I98704320 |
| authorships[18].affiliations[2].raw_affiliation_string | Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| authorships[18].institutions[0].id | https://openalex.org/I98704320 |
| authorships[18].institutions[0].ror | https://ror.org/04a9tmd77 |
| authorships[18].institutions[0].type | education |
| authorships[18].institutions[0].lineage | https://openalex.org/I1320796813, https://openalex.org/I98704320 |
| authorships[18].institutions[0].country_code | US |
| authorships[18].institutions[0].display_name | Icahn School of Medicine at Mount Sinai |
| authorships[18].institutions[1].id | https://openalex.org/I1334819555 |
| authorships[18].institutions[1].ror | https://ror.org/02yrq0923 |
| authorships[18].institutions[1].type | healthcare |
| authorships[18].institutions[1].lineage | https://openalex.org/I1334819555 |
| authorships[18].institutions[1].country_code | US |
| authorships[18].institutions[1].display_name | Memorial Sloan Kettering Cancer Center |
| authorships[18].author_position | middle |
| authorships[18].raw_author_name | Angel Chan |
| authorships[18].is_corresponding | False |
| authorships[18].raw_affiliation_strings | Cardiology Division, Department of Medicine, Memorial Sloan Kettering Cancer Center New York NY 10065, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 1009, USA, Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| authorships[19].author.id | https://openalex.org/A5061728175 |
| authorships[19].author.orcid | https://orcid.org/0000-0002-1343-4858 |
| authorships[19].author.display_name | Christoph Schaniel |
| authorships[19].countries | US |
| authorships[19].affiliations[0].institution_ids | https://openalex.org/I98704320 |
| authorships[19].affiliations[0].raw_affiliation_string | Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| authorships[19].affiliations[1].institution_ids | https://openalex.org/I98704320 |
| authorships[19].affiliations[1].raw_affiliation_string | Department of Medicine, Division of Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 029, USA |
| authorships[19].institutions[0].id | https://openalex.org/I98704320 |
| authorships[19].institutions[0].ror | https://ror.org/04a9tmd77 |
| authorships[19].institutions[0].type | education |
| authorships[19].institutions[0].lineage | https://openalex.org/I1320796813, https://openalex.org/I98704320 |
| authorships[19].institutions[0].country_code | US |
| authorships[19].institutions[0].display_name | Icahn School of Medicine at Mount Sinai |
| authorships[19].author_position | middle |
| authorships[19].raw_author_name | Christoph Schaniel |
| authorships[19].is_corresponding | False |
| authorships[19].raw_affiliation_strings | Department of Medicine, Division of Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 029, USA, Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| authorships[20].author.id | https://openalex.org/A5075487555 |
| authorships[20].author.orcid | https://orcid.org/0000-0002-8467-3004 |
| authorships[20].author.display_name | Nicole Dubois |
| authorships[20].countries | US |
| authorships[20].affiliations[0].institution_ids | https://openalex.org/I98704320 |
| authorships[20].affiliations[0].raw_affiliation_string | Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| authorships[20].affiliations[1].institution_ids | https://openalex.org/I98704320 |
| authorships[20].affiliations[1].raw_affiliation_string | Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA |
| authorships[20].institutions[0].id | https://openalex.org/I98704320 |
| authorships[20].institutions[0].ror | https://ror.org/04a9tmd77 |
| authorships[20].institutions[0].type | education |
| authorships[20].institutions[0].lineage | https://openalex.org/I1320796813, https://openalex.org/I98704320 |
| authorships[20].institutions[0].country_code | US |
| authorships[20].institutions[0].display_name | Icahn School of Medicine at Mount Sinai |
| authorships[20].author_position | middle |
| authorships[20].raw_author_name | Nicole C. Dubois |
| authorships[20].is_corresponding | False |
| authorships[20].raw_affiliation_strings | Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| authorships[21].author.id | https://openalex.org/A5065778793 |
| authorships[21].author.orcid | https://orcid.org/0000-0002-7814-0180 |
| authorships[21].author.display_name | Ravi Iyengar |
| authorships[21].countries | US |
| authorships[21].affiliations[0].institution_ids | https://openalex.org/I98704320 |
| authorships[21].affiliations[0].raw_affiliation_string | Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 1009, USA |
| authorships[21].affiliations[1].institution_ids | https://openalex.org/I98704320 |
| authorships[21].affiliations[1].raw_affiliation_string | Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| authorships[21].institutions[0].id | https://openalex.org/I98704320 |
| authorships[21].institutions[0].ror | https://ror.org/04a9tmd77 |
| authorships[21].institutions[0].type | education |
| authorships[21].institutions[0].lineage | https://openalex.org/I1320796813, https://openalex.org/I98704320 |
| authorships[21].institutions[0].country_code | US |
| authorships[21].institutions[0].display_name | Icahn School of Medicine at Mount Sinai |
| authorships[21].author_position | last |
| authorships[21].raw_author_name | Ravi Iyengar |
| authorships[21].is_corresponding | True |
| authorships[21].raw_affiliation_strings | Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 1009, USA, Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 0029, USA |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.biorxiv.org/content/biorxiv/early/2023/03/14/2021.11.02.466774.full.pdf |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Multiscale mapping of transcriptomic signatures for cardiotoxic drugs |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11535 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9778000116348267 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2705 |
| primary_topic.subfield.display_name | Cardiology and Cardiovascular Medicine |
| primary_topic.display_name | Chemotherapy-induced cardiotoxicity and mitigation |
| related_works | https://openalex.org/W2160554962, https://openalex.org/W4387676337, https://openalex.org/W2809246414, https://openalex.org/W4395004229, https://openalex.org/W2413304296, https://openalex.org/W4400409060, https://openalex.org/W2558121798, https://openalex.org/W2531392656, https://openalex.org/W1554565168, https://openalex.org/W2073305407 |
| cited_by_count | 2 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 1 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 1 |
| locations_count | 1 |
| best_oa_location.id | doi:10.1101/2021.11.02.466774 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4306402567 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| best_oa_location.source.host_organization | https://openalex.org/I2750212522 |
| best_oa_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| best_oa_location.license | |
| best_oa_location.pdf_url | https://www.biorxiv.org/content/biorxiv/early/2023/03/14/2021.11.02.466774.full.pdf |
| best_oa_location.version | acceptedVersion |
| best_oa_location.raw_type | posted-content |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.1101/2021.11.02.466774 |
| primary_location.id | doi:10.1101/2021.11.02.466774 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4306402567 |
| primary_location.source.issn | |
| primary_location.source.type | repository |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | |
| primary_location.source.is_core | False |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| primary_location.source.host_organization | https://openalex.org/I2750212522 |
| primary_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| primary_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| primary_location.license | |
| primary_location.pdf_url | https://www.biorxiv.org/content/biorxiv/early/2023/03/14/2021.11.02.466774.full.pdf |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.1101/2021.11.02.466774 |
| publication_date | 2021-11-04 |
| publication_year | 2021 |
| referenced_works | https://openalex.org/W2160637457, https://openalex.org/W2889260491, https://openalex.org/W2270164524, https://openalex.org/W2115702862, https://openalex.org/W2132267388, https://openalex.org/W2010992635, https://openalex.org/W2893095295, https://openalex.org/W2107967209, https://openalex.org/W2622073064, https://openalex.org/W2587938050, https://openalex.org/W2944807100, https://openalex.org/W4283390936, https://openalex.org/W4283257569, https://openalex.org/W2227148039, https://openalex.org/W3210475056, https://openalex.org/W950232622, https://openalex.org/W1978565988, https://openalex.org/W1577233398, https://openalex.org/W2036309159, https://openalex.org/W2767891136, https://openalex.org/W201203793, https://openalex.org/W2258287796, https://openalex.org/W2955020690, https://openalex.org/W4249844369, https://openalex.org/W2472460501, https://openalex.org/W2146704115, https://openalex.org/W3088401235, https://openalex.org/W2951457638, https://openalex.org/W2885431007, https://openalex.org/W4291020751, https://openalex.org/W3160863677, https://openalex.org/W2791137884, https://openalex.org/W2556701428, https://openalex.org/W2167989424, https://openalex.org/W4306928328, https://openalex.org/W3112871281, https://openalex.org/W3004111091, https://openalex.org/W4210943401, https://openalex.org/W2166960103, https://openalex.org/W3196189025, https://openalex.org/W2113698123, https://openalex.org/W2899841238, https://openalex.org/W2102199009, https://openalex.org/W2256402734, https://openalex.org/W3133859624, https://openalex.org/W2385169442, https://openalex.org/W3200835841, https://openalex.org/W2942468352, https://openalex.org/W4280537470, https://openalex.org/W4224324891, https://openalex.org/W2131273916, https://openalex.org/W3023537913, https://openalex.org/W3122115907, https://openalex.org/W3088384582, https://openalex.org/W2563937758, https://openalex.org/W2948758642, https://openalex.org/W2087107619, https://openalex.org/W2949350745, https://openalex.org/W2169456326, https://openalex.org/W2950464315, https://openalex.org/W2114104545, https://openalex.org/W2148541040, https://openalex.org/W2949460307, https://openalex.org/W2996171578, https://openalex.org/W2098023402, https://openalex.org/W2149248356, https://openalex.org/W2345356016, https://openalex.org/W3013813739, https://openalex.org/W1974605412, https://openalex.org/W2765175017, https://openalex.org/W2010406941, https://openalex.org/W1928323158, https://openalex.org/W2966885573, https://openalex.org/W2144221808, https://openalex.org/W1989538619, https://openalex.org/W4283264522, https://openalex.org/W3129013634, https://openalex.org/W2136208974, https://openalex.org/W4281680663, https://openalex.org/W2132942669, https://openalex.org/W2528073309, https://openalex.org/W2054656573, https://openalex.org/W2022759861, https://openalex.org/W2070341655, https://openalex.org/W4281751330, https://openalex.org/W1999197334, https://openalex.org/W4210762050, https://openalex.org/W1969614725, https://openalex.org/W2176043226, https://openalex.org/W2307551625, https://openalex.org/W4287881844, https://openalex.org/W2099388546, https://openalex.org/W2951619538, https://openalex.org/W2294886889, https://openalex.org/W1549051302, https://openalex.org/W2026096252, https://openalex.org/W2129256542, https://openalex.org/W2892635078, https://openalex.org/W4017451, https://openalex.org/W1991077525 |
| referenced_works_count | 100 |
| abstract_inverted_index.a | 103 |
| abstract_inverted_index.We | 11, 119 |
| abstract_inverted_index.be | 81 |
| abstract_inverted_index.by | 56 |
| abstract_inverted_index.in | 24, 44, 83 |
| abstract_inverted_index.of | 9, 18, 91, 141, 157 |
| abstract_inverted_index.on | 13 |
| abstract_inverted_index.to | 40, 71, 100 |
| abstract_inverted_index.us | 99 |
| abstract_inverted_index.we | 35 |
| abstract_inverted_index.One | 149 |
| abstract_inverted_index.TKI | 78, 117 |
| abstract_inverted_index.and | 64, 86, 110, 132, 146, 154 |
| abstract_inverted_index.can | 5, 80 |
| abstract_inverted_index.for | 16, 143 |
| abstract_inverted_index.the | 92, 158 |
| abstract_inverted_index.TKIs | 59 |
| abstract_inverted_index.both | 84 |
| abstract_inverted_index.bulk | 32 |
| abstract_inverted_index.cell | 45, 73, 93, 134, 155 |
| abstract_inverted_index.drug | 144, 164 |
| abstract_inverted_index.from | 48 |
| abstract_inverted_index.gene | 2 |
| abstract_inverted_index.mRNA | 122 |
| abstract_inverted_index.stem | 28 |
| abstract_inverted_index.that | 77, 121 |
| abstract_inverted_index.when | 125 |
| abstract_inverted_index.with | 107, 116, 127, 162 |
| abstract_inverted_index.Using | 31 |
| abstract_inverted_index.Whole | 88 |
| abstract_inverted_index.heart | 160 |
| abstract_inverted_index.human | 25, 51, 159 |
| abstract_inverted_index.lines | 46 |
| abstract_inverted_index.these | 69 |
| abstract_inverted_index.types | 156 |
| abstract_inverted_index.using | 95 |
| abstract_inverted_index.value | 38 |
| abstract_inverted_index.(TKIs) | 23 |
| abstract_inverted_index.Genes, | 152 |
| abstract_inverted_index.energy | 61 |
| abstract_inverted_index.evoked | 82 |
| abstract_inverted_index.genome | 89 |
| abstract_inverted_index.highly | 57 |
| abstract_inverted_index.kinase | 21 |
| abstract_inverted_index.lines, | 94 |
| abstract_inverted_index.matrix | 66 |
| abstract_inverted_index.single | 72, 133 |
| abstract_inverted_index.applied | 36 |
| abstract_inverted_index.enabled | 98 |
| abstract_inverted_index.focused | 12 |
| abstract_inverted_index.genomic | 104, 112 |
| abstract_inverted_index.healthy | 50 |
| abstract_inverted_index.include | 60 |
| abstract_inverted_index.induced | 26 |
| abstract_inverted_index.outlier | 96 |
| abstract_inverted_index.patient | 147 |
| abstract_inverted_index.predict | 111 |
| abstract_inverted_index.provide | 137 |
| abstract_inverted_index.summary | 151 |
| abstract_inverted_index.variant | 105 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Cellular | 53 |
| abstract_inverted_index.affected | 55 |
| abstract_inverted_index.conclude | 120 |
| abstract_inverted_index.genomic, | 130 |
| abstract_inverted_index.identify | 6, 41 |
| abstract_inverted_index.multiple | 49 |
| abstract_inverted_index.obtained | 47 |
| abstract_inverted_index.pathway, | 131 |
| abstract_inverted_index.pathways | 54, 70 |
| abstract_inverted_index.patterns | 43 |
| abstract_inverted_index.profiles | 4, 75, 124 |
| abstract_inverted_index.publicly | 128 |
| abstract_inverted_index.sentence | 150 |
| abstract_inverted_index.singular | 37 |
| abstract_inverted_index.tyrosine | 20 |
| abstract_inverted_index.variants | 113 |
| abstract_inverted_index.available | 129 |
| abstract_inverted_index.correctly | 101 |
| abstract_inverted_index.datasets, | 136 |
| abstract_inverted_index.dynamics. | 67 |
| abstract_inverted_index.indicates | 76 |
| abstract_inverted_index.obtaining | 14 |
| abstract_inverted_index.pathways, | 153 |
| abstract_inverted_index.potential | 7 |
| abstract_inverted_index.profiles, | 34 |
| abstract_inverted_index.responses | 79, 97 |
| abstract_inverted_index.sequences | 90 |
| abstract_inverted_index.subjects. | 52 |
| abstract_inverted_index.toxicity. | 10 |
| abstract_inverted_index.Projecting | 68 |
| abstract_inverted_index.associated | 106, 115, 161 |
| abstract_inverted_index.expression | 3, 74, 123 |
| abstract_inverted_index.inhibitors | 22 |
| abstract_inverted_index.integrated | 126 |
| abstract_inverted_index.mechanisms | 8 |
| abstract_inverted_index.multiscale | 138 |
| abstract_inverted_index.predictive | 139 |
| abstract_inverted_index.reidentify | 102 |
| abstract_inverted_index.signatures | 15 |
| abstract_inverted_index.cardiotoxic | 58 |
| abstract_inverted_index.development | 145 |
| abstract_inverted_index.metabolism, | 62 |
| abstract_inverted_index.pluripotent | 27 |
| abstract_inverted_index.potentially | 114 |
| abstract_inverted_index.Drug-induced | 1 |
| abstract_inverted_index.FDA-approved | 19 |
| abstract_inverted_index.cell-derived | 29 |
| abstract_inverted_index.contractile, | 63 |
| abstract_inverted_index.fibroblasts. | 87 |
| abstract_inverted_index.anthracycline | 108 |
| abstract_inverted_index.decomposition | 39 |
| abstract_inverted_index.extracellular | 65 |
| abstract_inverted_index.understanding | 140 |
| abstract_inverted_index.antineoplastic | 163 |
| abstract_inverted_index.cardiomyocytes | 85 |
| abstract_inverted_index.cardiotoxicity | 17, 109, 142 |
| abstract_inverted_index.drug-selective | 42 |
| abstract_inverted_index.transcriptomic | 135 |
| abstract_inverted_index.cardiomyocytes. | 30 |
| abstract_inverted_index.cardiotoxicity. | 118, 165 |
| abstract_inverted_index.stratification. | 148 |
| abstract_inverted_index.transcriptomics | 33 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5065778793, https://openalex.org/A5102892482 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 22 |
| corresponding_institution_ids | https://openalex.org/I98704320 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7200000286102295 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.55186501 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |