Multiscale three-dimensional imaging of intact human organs down to the cellular scale using hierarchical phase-contrast tomography Article Swipe
Claire Walsh
,
Paul Tafforeau
,
Willi L. Wagner
,
Daniyal J. Jafree
,
Alexandre Bellier
,
Christopher Werlein
,
Mark Kühnel
,
Elodie Boller
,
Simon Walker‐Samuel
,
Jan Lukas Robertus
,
David A. Long
,
Joseph Jacob
,
Sebastian Marussi
,
Emmeline Brown
,
Natalie Holroyd
,
Danny Jonigk
,
Maximilian Ackermann
,
Peter Lee
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.02.03.429481
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.02.03.429481
Human organs are complex, three-dimensional and multiscale systems. Spatially mapping the human body down through its hierarchy, from entire organs to their individual functional units and specialised cells, is a major obstacle to fully understanding health and disease. To meet this challenge, we developed hierarchical phase-contrast tomography (HiP-CT), an X-ray phase propagation technique utilising the European Synchrotron Radiation Facility’s Extremely Brilliant Source: the world’s first high-energy 4 th generation X-ray source. HiP-CT enabled three-dimensional and non-destructive imaging at near-micron resolution in soft tissues at one hundred thousand times the voxel size whilst maintaining the organ’s structure. We applied HiP-CT to image five intact human parenchymal organs: brain, lung, heart, kidney and spleen. These were hierarchically assessed with HiP-CT, providing a structural overview of the whole organ alongside detail of the organ’s individual functional units and cells. The potential applications of HiP-CT were demonstrated through quantification and morphometry of glomeruli in an intact human kidney, and identification of regional changes to the architecture of the air-tissue interface and alveolar morphology in the lung of a deceased COVID-19 patient. Overall, we show that HiP-CT is a powerful tool which can provide a comprehensive picture of structural information for whole intact human organs, encompassing precise details on functional units and their constituent cells to better understand human health and disease.
Related Topics
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2021.02.03.429481
- https://www.biorxiv.org/content/biorxiv/early/2021/02/03/2021.02.03.429481.full.pdf
- OA Status
- green
- Cited By
- 9
- References
- 70
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3128321497
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3128321497Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2021.02.03.429481Digital Object Identifier
- Title
-
Multiscale three-dimensional imaging of intact human organs down to the cellular scale using hierarchical phase-contrast tomographyWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-02-03Full publication date if available
- Authors
-
Claire Walsh, Paul Tafforeau, Willi L. Wagner, Daniyal J. Jafree, Alexandre Bellier, Christopher Werlein, Mark Kühnel, Elodie Boller, Simon Walker‐Samuel, Jan Lukas Robertus, David A. Long, Joseph Jacob, Sebastian Marussi, Emmeline Brown, Natalie Holroyd, Danny Jonigk, Maximilian Ackermann, Peter LeeList of authors in order
- Landing page
-
https://doi.org/10.1101/2021.02.03.429481Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2021/02/03/2021.02.03.429481.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2021/02/03/2021.02.03.429481.full.pdfDirect OA link when available
- Concepts
-
Voxel, Tomography, Radiology, Medicine, Pathology, Biomedical engineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
9Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 2, 2022: 2, 2021: 5Per-year citation counts (last 5 years)
- References (count)
-
70Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3128321497 |
|---|---|
| doi | https://doi.org/10.1101/2021.02.03.429481 |
| ids.doi | https://doi.org/10.1101/2021.02.03.429481 |
| ids.mag | 3128321497 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/33564772 |
| ids.openalex | https://openalex.org/W3128321497 |
| fwci | 2.26453679 |
| type | preprint |
| title | Multiscale three-dimensional imaging of intact human organs down to the cellular scale using hierarchical phase-contrast tomography |
| awards[0].id | https://openalex.org/G2496641717 |
| awards[0].funder_id | https://openalex.org/F4320334626 |
| awards[0].display_name | |
| awards[0].funder_award_id | MR/S007687/1 |
| awards[0].funder_display_name | Medical Research Council |
| awards[1].id | https://openalex.org/G2030465100 |
| awards[1].funder_id | https://openalex.org/F4320334626 |
| awards[1].display_name | |
| awards[1].funder_award_id | MR/R025673/1 |
| awards[1].funder_display_name | Medical Research Council |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T11183 |
| topics[0].field.id | https://openalex.org/fields/31 |
| topics[0].field.display_name | Physics and Astronomy |
| topics[0].score | 0.9952999949455261 |
| topics[0].domain.id | https://openalex.org/domains/3 |
| topics[0].domain.display_name | Physical Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/3108 |
| topics[0].subfield.display_name | Radiation |
| topics[0].display_name | Advanced X-ray Imaging Techniques |
| topics[1].id | https://openalex.org/T10522 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9818000197410583 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2741 |
| topics[1].subfield.display_name | Radiology, Nuclear Medicine and Imaging |
| topics[1].display_name | Medical Imaging Techniques and Applications |
| topics[2].id | https://openalex.org/T11885 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9721999764442444 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2741 |
| topics[2].subfield.display_name | Radiology, Nuclear Medicine and Imaging |
| topics[2].display_name | MRI in cancer diagnosis |
| funders[0].id | https://openalex.org/F4320334626 |
| funders[0].ror | https://ror.org/03x94j517 |
| funders[0].display_name | Medical Research Council |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C54170458 |
| concepts[0].level | 2 |
| concepts[0].score | 0.5359690189361572 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q663554 |
| concepts[0].display_name | Voxel |
| concepts[1].id | https://openalex.org/C163716698 |
| concepts[1].level | 2 |
| concepts[1].score | 0.4977912902832031 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q841267 |
| concepts[1].display_name | Tomography |
| concepts[2].id | https://openalex.org/C126838900 |
| concepts[2].level | 1 |
| concepts[2].score | 0.3708210587501526 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q77604 |
| concepts[2].display_name | Radiology |
| concepts[3].id | https://openalex.org/C71924100 |
| concepts[3].level | 0 |
| concepts[3].score | 0.33431071043014526 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[3].display_name | Medicine |
| concepts[4].id | https://openalex.org/C142724271 |
| concepts[4].level | 1 |
| concepts[4].score | 0.32969599962234497 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[4].display_name | Pathology |
| concepts[5].id | https://openalex.org/C136229726 |
| concepts[5].level | 1 |
| concepts[5].score | 0.321651816368103 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q327092 |
| concepts[5].display_name | Biomedical engineering |
| keywords[0].id | https://openalex.org/keywords/voxel |
| keywords[0].score | 0.5359690189361572 |
| keywords[0].display_name | Voxel |
| keywords[1].id | https://openalex.org/keywords/tomography |
| keywords[1].score | 0.4977912902832031 |
| keywords[1].display_name | Tomography |
| keywords[2].id | https://openalex.org/keywords/radiology |
| keywords[2].score | 0.3708210587501526 |
| keywords[2].display_name | Radiology |
| keywords[3].id | https://openalex.org/keywords/medicine |
| keywords[3].score | 0.33431071043014526 |
| keywords[3].display_name | Medicine |
| keywords[4].id | https://openalex.org/keywords/pathology |
| keywords[4].score | 0.32969599962234497 |
| keywords[4].display_name | Pathology |
| keywords[5].id | https://openalex.org/keywords/biomedical-engineering |
| keywords[5].score | 0.321651816368103 |
| keywords[5].display_name | Biomedical engineering |
| language | en |
| locations[0].id | doi:10.1101/2021.02.03.429481 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4306402567 |
| locations[0].source.issn | |
| locations[0].source.type | repository |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | |
| locations[0].source.is_core | False |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| locations[0].source.host_organization | https://openalex.org/I2750212522 |
| locations[0].source.host_organization_name | Cold Spring Harbor Laboratory |
| locations[0].source.host_organization_lineage | https://openalex.org/I2750212522 |
| locations[0].license | cc-by-nc |
| locations[0].pdf_url | https://www.biorxiv.org/content/biorxiv/early/2021/02/03/2021.02.03.429481.full.pdf |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.1101/2021.02.03.429481 |
| locations[1].id | pmid:33564772 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | bioRxiv : the preprint server for biology |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/33564772 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:7872374 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | bioRxiv |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/7872374 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5056573031 |
| authorships[0].author.orcid | https://orcid.org/0000-0003-3769-3392 |
| authorships[0].author.display_name | Claire Walsh |
| authorships[0].countries | GB |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I45129253 |
| authorships[0].affiliations[0].raw_affiliation_string | Centre for Advanced Biomedical Imaging, University College London, U.K |
| authorships[0].institutions[0].id | https://openalex.org/I45129253 |
| authorships[0].institutions[0].ror | https://ror.org/02jx3x895 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I124357947, https://openalex.org/I45129253 |
| authorships[0].institutions[0].country_code | GB |
| authorships[0].institutions[0].display_name | University College London |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | C. Walsh |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Centre for Advanced Biomedical Imaging, University College London, U.K |
| authorships[1].author.id | https://openalex.org/A5037458493 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-5962-1683 |
| authorships[1].author.display_name | Paul Tafforeau |
| authorships[1].countries | FR |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I2801997478 |
| authorships[1].affiliations[0].raw_affiliation_string | European Synchrotron Radiation Facility, Grenoble, France |
| authorships[1].institutions[0].id | https://openalex.org/I2801997478 |
| authorships[1].institutions[0].ror | https://ror.org/02550n020 |
| authorships[1].institutions[0].type | nonprofit |
| authorships[1].institutions[0].lineage | https://openalex.org/I2801997478 |
| authorships[1].institutions[0].country_code | FR |
| authorships[1].institutions[0].display_name | European Synchrotron Radiation Facility |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | P. Tafforeau |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | European Synchrotron Radiation Facility, Grenoble, France |
| authorships[2].author.id | https://openalex.org/A5036089918 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-2748-5429 |
| authorships[2].author.display_name | Willi L. Wagner |
| authorships[2].countries | DE |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210129183 |
| authorships[2].affiliations[0].raw_affiliation_string | a, bHeidelberg, Germany Translational Lung Research Centre Heidelberg (TLRC), German Lung Research Centre (DZL), Heidelberg, Germany |
| authorships[2].institutions[0].id | https://openalex.org/I4210129183 |
| authorships[2].institutions[0].ror | https://ror.org/03dx11k66 |
| authorships[2].institutions[0].type | facility |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210129183, https://openalex.org/I4411590659 |
| authorships[2].institutions[0].country_code | DE |
| authorships[2].institutions[0].display_name | German Center for Lung Research |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Willi L. Wagner |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | a, bHeidelberg, Germany Translational Lung Research Centre Heidelberg (TLRC), German Lung Research Centre (DZL), Heidelberg, Germany |
| authorships[3].author.id | https://openalex.org/A5089101801 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-8235-0394 |
| authorships[3].author.display_name | Daniyal J. Jafree |
| authorships[3].countries | GB |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I45129253 |
| authorships[3].affiliations[0].raw_affiliation_string | UCL MB/PhD Programme, Faculty of Medical Sciences, University College London, UK |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I2800129641, https://openalex.org/I45129253 |
| authorships[3].affiliations[1].raw_affiliation_string | Developmental Biology and Cancer Programme, Great Ormond Street Institute of Child Health, University College London, UK |
| authorships[3].institutions[0].id | https://openalex.org/I2800129641 |
| authorships[3].institutions[0].ror | https://ror.org/00zn2c847 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I2800129641, https://openalex.org/I2800349819 |
| authorships[3].institutions[0].country_code | GB |
| authorships[3].institutions[0].display_name | Great Ormond Street Hospital |
| authorships[3].institutions[1].id | https://openalex.org/I45129253 |
| authorships[3].institutions[1].ror | https://ror.org/02jx3x895 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I124357947, https://openalex.org/I45129253 |
| authorships[3].institutions[1].country_code | GB |
| authorships[3].institutions[1].display_name | University College London |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | D. J. Jafree |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Developmental Biology and Cancer Programme, Great Ormond Street Institute of Child Health, University College London, UK, UCL MB/PhD Programme, Faculty of Medical Sciences, University College London, UK |
| authorships[4].author.id | https://openalex.org/A5060647208 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-0907-0315 |
| authorships[4].author.display_name | Alexandre Bellier |
| authorships[4].countries | FR |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I899635006 |
| authorships[4].affiliations[0].raw_affiliation_string | French Alps Laboratory of Anatomy (LADAF), Grenoble Alpes University, Grenoble, France |
| authorships[4].institutions[0].id | https://openalex.org/I899635006 |
| authorships[4].institutions[0].ror | https://ror.org/02rx3b187 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I899635006 |
| authorships[4].institutions[0].country_code | FR |
| authorships[4].institutions[0].display_name | Université Grenoble Alpes |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | A. Bellier |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | French Alps Laboratory of Anatomy (LADAF), Grenoble Alpes University, Grenoble, France |
| authorships[5].author.id | https://openalex.org/A5077513006 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-7694-4257 |
| authorships[5].author.display_name | Christopher Werlein |
| authorships[5].countries | DE |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I34809795 |
| authorships[5].affiliations[0].raw_affiliation_string | Institute of Pathology, Hannover Medical School, Hannover, Germany (Carl-Neuberg-Straße 1, 30625 Hannover) |
| authorships[5].institutions[0].id | https://openalex.org/I34809795 |
| authorships[5].institutions[0].ror | https://ror.org/00f2yqf98 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I34809795 |
| authorships[5].institutions[0].country_code | DE |
| authorships[5].institutions[0].display_name | Medizinische Hochschule Hannover |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | C. Werlein |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Institute of Pathology, Hannover Medical School, Hannover, Germany (Carl-Neuberg-Straße 1, 30625 Hannover) |
| authorships[6].author.id | https://openalex.org/A5002390547 |
| authorships[6].author.orcid | https://orcid.org/0000-0003-3558-2576 |
| authorships[6].author.display_name | Mark Kühnel |
| authorships[6].countries | DE |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I34809795 |
| authorships[6].affiliations[0].raw_affiliation_string | Institute of Pathology, Hannover Medical School, Hannover, Germany (Carl-Neuberg-Straße 1, 30625 Hannover) |
| authorships[6].affiliations[1].institution_ids | https://openalex.org/I4210129183 |
| authorships[6].affiliations[1].raw_affiliation_string | Member of the German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH) |
| authorships[6].institutions[0].id | https://openalex.org/I4210129183 |
| authorships[6].institutions[0].ror | https://ror.org/03dx11k66 |
| authorships[6].institutions[0].type | facility |
| authorships[6].institutions[0].lineage | https://openalex.org/I4210129183, https://openalex.org/I4411590659 |
| authorships[6].institutions[0].country_code | DE |
| authorships[6].institutions[0].display_name | German Center for Lung Research |
| authorships[6].institutions[1].id | https://openalex.org/I34809795 |
| authorships[6].institutions[1].ror | https://ror.org/00f2yqf98 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I34809795 |
| authorships[6].institutions[1].country_code | DE |
| authorships[6].institutions[1].display_name | Medizinische Hochschule Hannover |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | M. P. Kühnel |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Institute of Pathology, Hannover Medical School, Hannover, Germany (Carl-Neuberg-Straße 1, 30625 Hannover), Member of the German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH) |
| authorships[7].author.id | https://openalex.org/A5104753016 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-1938-7888 |
| authorships[7].author.display_name | Elodie Boller |
| authorships[7].countries | FR |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I2801997478 |
| authorships[7].affiliations[0].raw_affiliation_string | European Synchrotron Radiation Facility, Grenoble, France |
| authorships[7].institutions[0].id | https://openalex.org/I2801997478 |
| authorships[7].institutions[0].ror | https://ror.org/02550n020 |
| authorships[7].institutions[0].type | nonprofit |
| authorships[7].institutions[0].lineage | https://openalex.org/I2801997478 |
| authorships[7].institutions[0].country_code | FR |
| authorships[7].institutions[0].display_name | European Synchrotron Radiation Facility |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | E. Boller |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | European Synchrotron Radiation Facility, Grenoble, France |
| authorships[8].author.id | https://openalex.org/A5089459978 |
| authorships[8].author.orcid | https://orcid.org/0000-0003-3530-9166 |
| authorships[8].author.display_name | Simon Walker‐Samuel |
| authorships[8].countries | GB |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I45129253 |
| authorships[8].affiliations[0].raw_affiliation_string | Centre for Advanced Biomedical Imaging, University College London, U.K |
| authorships[8].institutions[0].id | https://openalex.org/I45129253 |
| authorships[8].institutions[0].ror | https://ror.org/02jx3x895 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I124357947, https://openalex.org/I45129253 |
| authorships[8].institutions[0].country_code | GB |
| authorships[8].institutions[0].display_name | University College London |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | S. Walker-Samuel |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Centre for Advanced Biomedical Imaging, University College London, U.K |
| authorships[9].author.id | https://openalex.org/A5022991046 |
| authorships[9].author.orcid | https://orcid.org/0000-0003-0433-7965 |
| authorships[9].author.display_name | Jan Lukas Robertus |
| authorships[9].countries | GB |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I2800036501 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Histopathology, Royal Brompton and Harefield NHS Foundation Trust, London, UK |
| authorships[9].affiliations[1].institution_ids | https://openalex.org/I47508984 |
| authorships[9].affiliations[1].raw_affiliation_string | National Heart & Lung Institute, Imperial College London, London, UK |
| authorships[9].institutions[0].id | https://openalex.org/I47508984 |
| authorships[9].institutions[0].ror | https://ror.org/041kmwe10 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I47508984 |
| authorships[9].institutions[0].country_code | GB |
| authorships[9].institutions[0].display_name | Imperial College London |
| authorships[9].institutions[1].id | https://openalex.org/I2800036501 |
| authorships[9].institutions[1].ror | https://ror.org/02218z997 |
| authorships[9].institutions[1].type | healthcare |
| authorships[9].institutions[1].lineage | https://openalex.org/I2800036501 |
| authorships[9].institutions[1].country_code | GB |
| authorships[9].institutions[1].display_name | Royal Brompton & Harefield NHS Foundation Trust |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | J. L. Robertus |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Histopathology, Royal Brompton and Harefield NHS Foundation Trust, London, UK, National Heart & Lung Institute, Imperial College London, London, UK |
| authorships[10].author.id | https://openalex.org/A5060888495 |
| authorships[10].author.orcid | https://orcid.org/0000-0001-6580-3435 |
| authorships[10].author.display_name | David A. Long |
| authorships[10].countries | GB |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I2800129641, https://openalex.org/I45129253 |
| authorships[10].affiliations[0].raw_affiliation_string | Developmental Biology and Cancer Programme, Great Ormond Street Institute of Child Health, University College London, UK |
| authorships[10].institutions[0].id | https://openalex.org/I2800129641 |
| authorships[10].institutions[0].ror | https://ror.org/00zn2c847 |
| authorships[10].institutions[0].type | healthcare |
| authorships[10].institutions[0].lineage | https://openalex.org/I2800129641, https://openalex.org/I2800349819 |
| authorships[10].institutions[0].country_code | GB |
| authorships[10].institutions[0].display_name | Great Ormond Street Hospital |
| authorships[10].institutions[1].id | https://openalex.org/I45129253 |
| authorships[10].institutions[1].ror | https://ror.org/02jx3x895 |
| authorships[10].institutions[1].type | education |
| authorships[10].institutions[1].lineage | https://openalex.org/I124357947, https://openalex.org/I45129253 |
| authorships[10].institutions[1].country_code | GB |
| authorships[10].institutions[1].display_name | University College London |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | D. A. Long |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Developmental Biology and Cancer Programme, Great Ormond Street Institute of Child Health, University College London, UK |
| authorships[11].author.id | https://openalex.org/A5009829456 |
| authorships[11].author.orcid | https://orcid.org/0000-0002-8054-2293 |
| authorships[11].author.display_name | Joseph Jacob |
| authorships[11].countries | GB |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I1340918713, https://openalex.org/I45129253 |
| authorships[11].affiliations[0].raw_affiliation_string | Department of Radiology, University College London Hospitals NHS Foundation Trust, London, UK |
| authorships[11].affiliations[1].institution_ids | https://openalex.org/I45129253 |
| authorships[11].affiliations[1].raw_affiliation_string | Centre for Medical Image Computing, University College London, London, UK |
| authorships[11].institutions[0].id | https://openalex.org/I45129253 |
| authorships[11].institutions[0].ror | https://ror.org/02jx3x895 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I124357947, https://openalex.org/I45129253 |
| authorships[11].institutions[0].country_code | GB |
| authorships[11].institutions[0].display_name | University College London |
| authorships[11].institutions[1].id | https://openalex.org/I1340918713 |
| authorships[11].institutions[1].ror | https://ror.org/042fqyp44 |
| authorships[11].institutions[1].type | healthcare |
| authorships[11].institutions[1].lineage | https://openalex.org/I1340918713 |
| authorships[11].institutions[1].country_code | GB |
| authorships[11].institutions[1].display_name | University College London Hospitals NHS Foundation Trust |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | J. Jacob |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Centre for Medical Image Computing, University College London, London, UK, Department of Radiology, University College London Hospitals NHS Foundation Trust, London, UK |
| authorships[12].author.id | https://openalex.org/A5069577970 |
| authorships[12].author.orcid | https://orcid.org/0000-0003-4537-210X |
| authorships[12].author.display_name | Sebastian Marussi |
| authorships[12].countries | GB |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I45129253 |
| authorships[12].affiliations[0].raw_affiliation_string | Department of Mechanical Engineering University College London, U.K |
| authorships[12].institutions[0].id | https://openalex.org/I45129253 |
| authorships[12].institutions[0].ror | https://ror.org/02jx3x895 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I124357947, https://openalex.org/I45129253 |
| authorships[12].institutions[0].country_code | GB |
| authorships[12].institutions[0].display_name | University College London |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | S. Marussi |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Department of Mechanical Engineering University College London, U.K |
| authorships[13].author.id | https://openalex.org/A5022311239 |
| authorships[13].author.orcid | https://orcid.org/0000-0001-6222-0146 |
| authorships[13].author.display_name | Emmeline Brown |
| authorships[13].countries | GB |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I45129253 |
| authorships[13].affiliations[0].raw_affiliation_string | Centre for Advanced Biomedical Imaging, University College London, U.K |
| authorships[13].institutions[0].id | https://openalex.org/I45129253 |
| authorships[13].institutions[0].ror | https://ror.org/02jx3x895 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I124357947, https://openalex.org/I45129253 |
| authorships[13].institutions[0].country_code | GB |
| authorships[13].institutions[0].display_name | University College London |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | E. Brown |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Centre for Advanced Biomedical Imaging, University College London, U.K |
| authorships[14].author.id | https://openalex.org/A5074988857 |
| authorships[14].author.orcid | https://orcid.org/0000-0001-9174-1346 |
| authorships[14].author.display_name | Natalie Holroyd |
| authorships[14].countries | GB |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I45129253 |
| authorships[14].affiliations[0].raw_affiliation_string | Centre for Advanced Biomedical Imaging, University College London, U.K |
| authorships[14].institutions[0].id | https://openalex.org/I45129253 |
| authorships[14].institutions[0].ror | https://ror.org/02jx3x895 |
| authorships[14].institutions[0].type | education |
| authorships[14].institutions[0].lineage | https://openalex.org/I124357947, https://openalex.org/I45129253 |
| authorships[14].institutions[0].country_code | GB |
| authorships[14].institutions[0].display_name | University College London |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | N. Holroyd |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Centre for Advanced Biomedical Imaging, University College London, U.K |
| authorships[15].author.id | https://openalex.org/A5068639127 |
| authorships[15].author.orcid | https://orcid.org/0000-0002-5251-2281 |
| authorships[15].author.display_name | Danny Jonigk |
| authorships[15].countries | DE |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I34809795 |
| authorships[15].affiliations[0].raw_affiliation_string | Institute of Pathology, Hannover Medical School, Hannover, Germany (Carl-Neuberg-Straße 1, 30625 Hannover) |
| authorships[15].affiliations[1].institution_ids | https://openalex.org/I4210129183 |
| authorships[15].affiliations[1].raw_affiliation_string | Member of the German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH) |
| authorships[15].institutions[0].id | https://openalex.org/I4210129183 |
| authorships[15].institutions[0].ror | https://ror.org/03dx11k66 |
| authorships[15].institutions[0].type | facility |
| authorships[15].institutions[0].lineage | https://openalex.org/I4210129183, https://openalex.org/I4411590659 |
| authorships[15].institutions[0].country_code | DE |
| authorships[15].institutions[0].display_name | German Center for Lung Research |
| authorships[15].institutions[1].id | https://openalex.org/I34809795 |
| authorships[15].institutions[1].ror | https://ror.org/00f2yqf98 |
| authorships[15].institutions[1].type | education |
| authorships[15].institutions[1].lineage | https://openalex.org/I34809795 |
| authorships[15].institutions[1].country_code | DE |
| authorships[15].institutions[1].display_name | Medizinische Hochschule Hannover |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | D. D. Jonigk |
| authorships[15].is_corresponding | True |
| authorships[15].raw_affiliation_strings | Institute of Pathology, Hannover Medical School, Hannover, Germany (Carl-Neuberg-Straße 1, 30625 Hannover), Member of the German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH) |
| authorships[16].author.id | https://openalex.org/A5086646925 |
| authorships[16].author.orcid | https://orcid.org/0000-0001-9996-2477 |
| authorships[16].author.display_name | Maximilian Ackermann |
| authorships[16].countries | DE |
| authorships[16].affiliations[0].institution_ids | https://openalex.org/I197323543, https://openalex.org/I4210094062 |
| authorships[16].affiliations[0].raw_affiliation_string | Institute of Functional and Clinical Anatomy, University Medical Center of the Johannes Gutenberg University Mainz, Mainz |
| authorships[16].institutions[0].id | https://openalex.org/I197323543 |
| authorships[16].institutions[0].ror | https://ror.org/023b0x485 |
| authorships[16].institutions[0].type | education |
| authorships[16].institutions[0].lineage | https://openalex.org/I197323543 |
| authorships[16].institutions[0].country_code | DE |
| authorships[16].institutions[0].display_name | Johannes Gutenberg University Mainz |
| authorships[16].institutions[1].id | https://openalex.org/I4210094062 |
| authorships[16].institutions[1].ror | https://ror.org/00q1fsf04 |
| authorships[16].institutions[1].type | healthcare |
| authorships[16].institutions[1].lineage | https://openalex.org/I4210094062 |
| authorships[16].institutions[1].country_code | DE |
| authorships[16].institutions[1].display_name | University Medical Center of the Johannes Gutenberg University Mainz |
| authorships[16].author_position | middle |
| authorships[16].raw_author_name | M. Ackermann |
| authorships[16].is_corresponding | True |
| authorships[16].raw_affiliation_strings | Institute of Functional and Clinical Anatomy, University Medical Center of the Johannes Gutenberg University Mainz, Mainz |
| authorships[17].author.id | https://openalex.org/A5100354178 |
| authorships[17].author.orcid | https://orcid.org/0000-0002-3898-8881 |
| authorships[17].author.display_name | Peter Lee |
| authorships[17].countries | GB |
| authorships[17].affiliations[0].institution_ids | https://openalex.org/I45129253 |
| authorships[17].affiliations[0].raw_affiliation_string | Department of Mechanical Engineering University College London, U.K |
| authorships[17].institutions[0].id | https://openalex.org/I45129253 |
| authorships[17].institutions[0].ror | https://ror.org/02jx3x895 |
| authorships[17].institutions[0].type | education |
| authorships[17].institutions[0].lineage | https://openalex.org/I124357947, https://openalex.org/I45129253 |
| authorships[17].institutions[0].country_code | GB |
| authorships[17].institutions[0].display_name | University College London |
| authorships[17].author_position | last |
| authorships[17].raw_author_name | P. D. Lee |
| authorships[17].is_corresponding | True |
| authorships[17].raw_affiliation_strings | Department of Mechanical Engineering University College London, U.K |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.biorxiv.org/content/biorxiv/early/2021/02/03/2021.02.03.429481.full.pdf |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Multiscale three-dimensional imaging of intact human organs down to the cellular scale using hierarchical phase-contrast tomography |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11183 |
| primary_topic.field.id | https://openalex.org/fields/31 |
| primary_topic.field.display_name | Physics and Astronomy |
| primary_topic.score | 0.9952999949455261 |
| primary_topic.domain.id | https://openalex.org/domains/3 |
| primary_topic.domain.display_name | Physical Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/3108 |
| primary_topic.subfield.display_name | Radiation |
| primary_topic.display_name | Advanced X-ray Imaging Techniques |
| related_works | https://openalex.org/W3027020613, https://openalex.org/W2016533837, https://openalex.org/W3167885074, https://openalex.org/W2892386716, https://openalex.org/W1998563493, https://openalex.org/W4306164210, https://openalex.org/W4313316311, https://openalex.org/W4362608745, https://openalex.org/W2383143032, https://openalex.org/W2082728368 |
| cited_by_count | 9 |
| counts_by_year[0].year | 2024 |
| counts_by_year[0].cited_by_count | 2 |
| counts_by_year[1].year | 2022 |
| counts_by_year[1].cited_by_count | 2 |
| counts_by_year[2].year | 2021 |
| counts_by_year[2].cited_by_count | 5 |
| locations_count | 3 |
| best_oa_location.id | doi:10.1101/2021.02.03.429481 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4306402567 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| best_oa_location.source.host_organization | https://openalex.org/I2750212522 |
| best_oa_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| best_oa_location.license | cc-by-nc |
| best_oa_location.pdf_url | https://www.biorxiv.org/content/biorxiv/early/2021/02/03/2021.02.03.429481.full.pdf |
| best_oa_location.version | acceptedVersion |
| best_oa_location.raw_type | posted-content |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.1101/2021.02.03.429481 |
| primary_location.id | doi:10.1101/2021.02.03.429481 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4306402567 |
| primary_location.source.issn | |
| primary_location.source.type | repository |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | |
| primary_location.source.is_core | False |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| primary_location.source.host_organization | https://openalex.org/I2750212522 |
| primary_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| primary_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| primary_location.license | cc-by-nc |
| primary_location.pdf_url | https://www.biorxiv.org/content/biorxiv/early/2021/02/03/2021.02.03.429481.full.pdf |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.1101/2021.02.03.429481 |
| publication_date | 2021-02-03 |
| publication_year | 2021 |
| referenced_works | https://openalex.org/W2256829711, https://openalex.org/W3015704836, https://openalex.org/W2602815865, https://openalex.org/W2991971180, https://openalex.org/W2895680199, https://openalex.org/W3005867992, https://openalex.org/W2982697854, https://openalex.org/W2778860560, https://openalex.org/W3007883266, https://openalex.org/W3008693132, https://openalex.org/W2972907726, https://openalex.org/W2772858389, https://openalex.org/W2083146528, https://openalex.org/W2085293532, https://openalex.org/W2977797947, https://openalex.org/W1975063723, https://openalex.org/W1986974937, https://openalex.org/W2788593837, https://openalex.org/W1963483517, https://openalex.org/W1998401010, https://openalex.org/W940073560, https://openalex.org/W2133665775, https://openalex.org/W2960596976, https://openalex.org/W2157202055, https://openalex.org/W2009968854, https://openalex.org/W2196188554, https://openalex.org/W2085343555, https://openalex.org/W1980813421, https://openalex.org/W2017990018, https://openalex.org/W2910188397, https://openalex.org/W2038472491, https://openalex.org/W2097291003, https://openalex.org/W2462369702, https://openalex.org/W2129413091, https://openalex.org/W2206789629, https://openalex.org/W1974557726, https://openalex.org/W2804243750, https://openalex.org/W3080517202, https://openalex.org/W3027918021, https://openalex.org/W3080674218, https://openalex.org/W3007273493, https://openalex.org/W2612519453, https://openalex.org/W2922020904, https://openalex.org/W3125011419, https://openalex.org/W3111279863, https://openalex.org/W3025052660, https://openalex.org/W3018124344, https://openalex.org/W3004890574, https://openalex.org/W3044388039, https://openalex.org/W2345010043, https://openalex.org/W2767128594, https://openalex.org/W3024126428, https://openalex.org/W6780283850, https://openalex.org/W2130509346, https://openalex.org/W2167279371, https://openalex.org/W2467628122, https://openalex.org/W2149242702, https://openalex.org/W2003508313, https://openalex.org/W2586526567, https://openalex.org/W3099559583, https://openalex.org/W2906442564, https://openalex.org/W2126511480, https://openalex.org/W3118627743, https://openalex.org/W3041319886, https://openalex.org/W2791698505, https://openalex.org/W4210955137, https://openalex.org/W2971262600, https://openalex.org/W651660064, https://openalex.org/W4213108508, https://openalex.org/W2551492997 |
| referenced_works_count | 70 |
| abstract_inverted_index.4 | 67 |
| abstract_inverted_index.a | 30, 120, 174, 184, 190 |
| abstract_inverted_index.To | 39 |
| abstract_inverted_index.We | 97 |
| abstract_inverted_index.an | 49, 151 |
| abstract_inverted_index.at | 78, 84 |
| abstract_inverted_index.in | 81, 150, 170 |
| abstract_inverted_index.is | 29, 183 |
| abstract_inverted_index.of | 123, 129, 140, 148, 157, 163, 173, 193 |
| abstract_inverted_index.on | 204 |
| abstract_inverted_index.th | 68 |
| abstract_inverted_index.to | 21, 33, 100, 160, 211 |
| abstract_inverted_index.we | 43, 179 |
| abstract_inverted_index.The | 137 |
| abstract_inverted_index.and | 6, 26, 37, 75, 111, 135, 146, 155, 167, 207, 216 |
| abstract_inverted_index.are | 3 |
| abstract_inverted_index.can | 188 |
| abstract_inverted_index.for | 196 |
| abstract_inverted_index.its | 16 |
| abstract_inverted_index.one | 85 |
| abstract_inverted_index.the | 11, 55, 63, 89, 94, 124, 130, 161, 164, 171 |
| abstract_inverted_index.body | 13 |
| abstract_inverted_index.down | 14 |
| abstract_inverted_index.five | 102 |
| abstract_inverted_index.from | 18 |
| abstract_inverted_index.lung | 172 |
| abstract_inverted_index.meet | 40 |
| abstract_inverted_index.show | 180 |
| abstract_inverted_index.size | 91 |
| abstract_inverted_index.soft | 82 |
| abstract_inverted_index.that | 181 |
| abstract_inverted_index.this | 41 |
| abstract_inverted_index.tool | 186 |
| abstract_inverted_index.were | 114, 142 |
| abstract_inverted_index.with | 117 |
| abstract_inverted_index.Human | 1 |
| abstract_inverted_index.These | 113 |
| abstract_inverted_index.X-ray | 50, 70 |
| abstract_inverted_index.cells | 210 |
| abstract_inverted_index.first | 65 |
| abstract_inverted_index.fully | 34 |
| abstract_inverted_index.human | 12, 104, 153, 199, 214 |
| abstract_inverted_index.image | 101 |
| abstract_inverted_index.lung, | 108 |
| abstract_inverted_index.major | 31 |
| abstract_inverted_index.organ | 126 |
| abstract_inverted_index.phase | 51 |
| abstract_inverted_index.their | 22, 208 |
| abstract_inverted_index.times | 88 |
| abstract_inverted_index.units | 25, 134, 206 |
| abstract_inverted_index.voxel | 90 |
| abstract_inverted_index.which | 187 |
| abstract_inverted_index.whole | 125, 197 |
| abstract_inverted_index.HiP-CT | 72, 99, 141, 182 |
| abstract_inverted_index.better | 212 |
| abstract_inverted_index.brain, | 107 |
| abstract_inverted_index.cells, | 28 |
| abstract_inverted_index.cells. | 136 |
| abstract_inverted_index.detail | 128 |
| abstract_inverted_index.entire | 19 |
| abstract_inverted_index.health | 36, 215 |
| abstract_inverted_index.heart, | 109 |
| abstract_inverted_index.intact | 103, 152, 198 |
| abstract_inverted_index.kidney | 110 |
| abstract_inverted_index.organs | 2, 20 |
| abstract_inverted_index.whilst | 92 |
| abstract_inverted_index.HiP-CT, | 118 |
| abstract_inverted_index.Source: | 62 |
| abstract_inverted_index.applied | 98 |
| abstract_inverted_index.changes | 159 |
| abstract_inverted_index.details | 203 |
| abstract_inverted_index.enabled | 73 |
| abstract_inverted_index.hundred | 86 |
| abstract_inverted_index.imaging | 77 |
| abstract_inverted_index.kidney, | 154 |
| abstract_inverted_index.mapping | 10 |
| abstract_inverted_index.organs, | 200 |
| abstract_inverted_index.organs: | 106 |
| abstract_inverted_index.picture | 192 |
| abstract_inverted_index.precise | 202 |
| abstract_inverted_index.provide | 189 |
| abstract_inverted_index.source. | 71 |
| abstract_inverted_index.spleen. | 112 |
| abstract_inverted_index.through | 15, 144 |
| abstract_inverted_index.tissues | 83 |
| abstract_inverted_index.ABSTRACT | 0 |
| abstract_inverted_index.COVID-19 | 176 |
| abstract_inverted_index.European | 56 |
| abstract_inverted_index.Overall, | 178 |
| abstract_inverted_index.alveolar | 168 |
| abstract_inverted_index.assessed | 116 |
| abstract_inverted_index.complex, | 4 |
| abstract_inverted_index.deceased | 175 |
| abstract_inverted_index.disease. | 38, 217 |
| abstract_inverted_index.obstacle | 32 |
| abstract_inverted_index.overview | 122 |
| abstract_inverted_index.patient. | 177 |
| abstract_inverted_index.powerful | 185 |
| abstract_inverted_index.regional | 158 |
| abstract_inverted_index.systems. | 8 |
| abstract_inverted_index.thousand | 87 |
| abstract_inverted_index.(HiP-CT), | 48 |
| abstract_inverted_index.Brilliant | 61 |
| abstract_inverted_index.Extremely | 60 |
| abstract_inverted_index.Radiation | 58 |
| abstract_inverted_index.Spatially | 9 |
| abstract_inverted_index.alongside | 127 |
| abstract_inverted_index.developed | 44 |
| abstract_inverted_index.glomeruli | 149 |
| abstract_inverted_index.interface | 166 |
| abstract_inverted_index.organ’s | 95, 131 |
| abstract_inverted_index.potential | 138 |
| abstract_inverted_index.providing | 119 |
| abstract_inverted_index.technique | 53 |
| abstract_inverted_index.utilising | 54 |
| abstract_inverted_index.world’s | 64 |
| abstract_inverted_index.air-tissue | 165 |
| abstract_inverted_index.challenge, | 42 |
| abstract_inverted_index.functional | 24, 133, 205 |
| abstract_inverted_index.generation | 69 |
| abstract_inverted_index.hierarchy, | 17 |
| abstract_inverted_index.individual | 23, 132 |
| abstract_inverted_index.morphology | 169 |
| abstract_inverted_index.multiscale | 7 |
| abstract_inverted_index.resolution | 80 |
| abstract_inverted_index.structural | 121, 194 |
| abstract_inverted_index.structure. | 96 |
| abstract_inverted_index.tomography | 47 |
| abstract_inverted_index.understand | 213 |
| abstract_inverted_index.Synchrotron | 57 |
| abstract_inverted_index.constituent | 209 |
| abstract_inverted_index.high-energy | 66 |
| abstract_inverted_index.information | 195 |
| abstract_inverted_index.maintaining | 93 |
| abstract_inverted_index.morphometry | 147 |
| abstract_inverted_index.near-micron | 79 |
| abstract_inverted_index.parenchymal | 105 |
| abstract_inverted_index.propagation | 52 |
| abstract_inverted_index.specialised | 27 |
| abstract_inverted_index.Facility’s | 59 |
| abstract_inverted_index.applications | 139 |
| abstract_inverted_index.architecture | 162 |
| abstract_inverted_index.demonstrated | 143 |
| abstract_inverted_index.encompassing | 201 |
| abstract_inverted_index.hierarchical | 45 |
| abstract_inverted_index.comprehensive | 191 |
| abstract_inverted_index.understanding | 35 |
| abstract_inverted_index.hierarchically | 115 |
| abstract_inverted_index.identification | 156 |
| abstract_inverted_index.phase-contrast | 46 |
| abstract_inverted_index.quantification | 145 |
| abstract_inverted_index.non-destructive | 76 |
| abstract_inverted_index.three-dimensional | 5, 74 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5100354178, https://openalex.org/A5068639127, https://openalex.org/A5086646925 |
| countries_distinct_count | 3 |
| institutions_distinct_count | 18 |
| corresponding_institution_ids | https://openalex.org/I197323543, https://openalex.org/I34809795, https://openalex.org/I4210094062, https://openalex.org/I4210129183, https://openalex.org/I45129253 |
| citation_normalized_percentile.value | 0.8887018 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |