Multivariate Assessment of Thyroid, Lipid, and Inflammatory Profiles by HBV Status and Viral Load: Age- and Sex-Specific Findings Article Swipe
Hyeokjun Yun
,
Jong Wan Kim
,
Jae Kyung Kim
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/v17091208
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/v17091208
Chronic hepatitis B virus (HBV) infection may influence extrahepatic systems, including endocrine and lipid regulation. In this cross-sectional study, 186 adults were stratified by HBV DNA status and viral load to examine thyroid function, systemic inflammation, and lipid metabolism, with further analyses by age and sex. Thyroid-stimulating hormone (TSH, a pituitary regulator of thyroid function) levels were significantly lower in HBsAg-positive individuals compared with controls; however, this association was attenuated after stratification by viral load, indicating that the relationship is not unequivocally independent of HBV DNA levels, as free thyroxine (FT4, the circulating thyroid hormone reflecting gland activity) levels remained stable. Lipid profiles displayed demographic-specific patterns: males with high viral load exhibited lower HDL cholesterol, whereas younger HBV-positive individuals showed higher LDL cholesterol. CRP levels were unaffected by HBV status or viral load, aligning with the absence of systemic inflammation in early or inactive disease stages. Age was a major determinant across biomarkers, with complex interactions involving sex and viral load. These findings indicate subtle but clinically relevant extrahepatic effects of HBV infection and underscore the need for personalized monitoring and longitudinal studies to clarify metabolic and cardiovascular implications. These subgroup trends should be interpreted with caution given the absence of BMI, liver enzyme, fibrosis, medication, and comorbidity data in this retrospective cohort.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/v17091208
- https://www.mdpi.com/1999-4915/17/9/1208/pdf?version=1756906406
- OA Status
- gold
- References
- 57
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4413951889
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4413951889Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/v17091208Digital Object Identifier
- Title
-
Multivariate Assessment of Thyroid, Lipid, and Inflammatory Profiles by HBV Status and Viral Load: Age- and Sex-Specific FindingsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-09-03Full publication date if available
- Authors
-
Hyeokjun Yun, Jong Wan Kim, Jae Kyung KimList of authors in order
- Landing page
-
https://doi.org/10.3390/v17091208Publisher landing page
- PDF URL
-
https://www.mdpi.com/1999-4915/17/9/1208/pdf?version=1756906406Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1999-4915/17/9/1208/pdf?version=1756906406Direct OA link when available
- Concepts
-
Multivariate analysis, Multivariate statistics, Viral load, Medicine, Internal medicine, Endocrinology, Physiology, Immunology, Virus, Mathematics, StatisticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
57Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4413951889 |
|---|---|
| doi | https://doi.org/10.3390/v17091208 |
| ids.doi | https://doi.org/10.3390/v17091208 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/41012636 |
| ids.openalex | https://openalex.org/W4413951889 |
| fwci | 0.0 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D008297 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Male |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D019562 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Viral Load |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D005260 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Female |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D000328 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Adult |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D008875 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Middle Aged |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D003430 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Cross-Sectional Studies |
| mesh[7].qualifier_ui | Q000235 |
| mesh[7].descriptor_ui | D006515 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | genetics |
| mesh[7].descriptor_name | Hepatitis B virus |
| mesh[8].qualifier_ui | Q000502 |
| mesh[8].descriptor_ui | D006515 |
| mesh[8].is_major_topic | True |
| mesh[8].qualifier_name | physiology |
| mesh[8].descriptor_name | Hepatitis B virus |
| mesh[9].qualifier_ui | Q000821 |
| mesh[9].descriptor_ui | D019694 |
| mesh[9].is_major_topic | True |
| mesh[9].qualifier_name | virology |
| mesh[9].descriptor_name | Hepatitis B, Chronic |
| mesh[10].qualifier_ui | Q000097 |
| mesh[10].descriptor_ui | D019694 |
| mesh[10].is_major_topic | True |
| mesh[10].qualifier_name | blood |
| mesh[10].descriptor_name | Hepatitis B, Chronic |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D000367 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Age Factors |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D007249 |
| mesh[12].is_major_topic | True |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Inflammation |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D012737 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Sex Factors |
| mesh[14].qualifier_ui | Q000378 |
| mesh[14].descriptor_ui | D013961 |
| mesh[14].is_major_topic | True |
| mesh[14].qualifier_name | metabolism |
| mesh[14].descriptor_name | Thyroid Gland |
| mesh[15].qualifier_ui | Q000097 |
| mesh[15].descriptor_ui | D008055 |
| mesh[15].is_major_topic | True |
| mesh[15].qualifier_name | blood |
| mesh[15].descriptor_name | Lipids |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D050356 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Lipid Metabolism |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D000368 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Aged |
| mesh[18].qualifier_ui | Q000097 |
| mesh[18].descriptor_ui | D004279 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | blood |
| mesh[18].descriptor_name | DNA, Viral |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D055815 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Young Adult |
| mesh[20].qualifier_ui | Q000097 |
| mesh[20].descriptor_ui | D013972 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | blood |
| mesh[20].descriptor_name | Thyrotropin |
| mesh[21].qualifier_ui | Q000097 |
| mesh[21].descriptor_ui | D015415 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | blood |
| mesh[21].descriptor_name | Biomarkers |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D006801 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Humans |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D008297 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Male |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D019562 |
| mesh[24].is_major_topic | True |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | Viral Load |
| mesh[25].qualifier_ui | |
| mesh[25].descriptor_ui | D005260 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | |
| mesh[25].descriptor_name | Female |
| mesh[26].qualifier_ui | |
| mesh[26].descriptor_ui | D000328 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | |
| mesh[26].descriptor_name | Adult |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D008875 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Middle Aged |
| mesh[28].qualifier_ui | |
| mesh[28].descriptor_ui | D003430 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | |
| mesh[28].descriptor_name | Cross-Sectional Studies |
| mesh[29].qualifier_ui | Q000235 |
| mesh[29].descriptor_ui | D006515 |
| mesh[29].is_major_topic | True |
| mesh[29].qualifier_name | genetics |
| mesh[29].descriptor_name | Hepatitis B virus |
| mesh[30].qualifier_ui | Q000502 |
| mesh[30].descriptor_ui | D006515 |
| mesh[30].is_major_topic | True |
| mesh[30].qualifier_name | physiology |
| mesh[30].descriptor_name | Hepatitis B virus |
| mesh[31].qualifier_ui | Q000821 |
| mesh[31].descriptor_ui | D019694 |
| mesh[31].is_major_topic | True |
| mesh[31].qualifier_name | virology |
| mesh[31].descriptor_name | Hepatitis B, Chronic |
| mesh[32].qualifier_ui | Q000097 |
| mesh[32].descriptor_ui | D019694 |
| mesh[32].is_major_topic | True |
| mesh[32].qualifier_name | blood |
| mesh[32].descriptor_name | Hepatitis B, Chronic |
| mesh[33].qualifier_ui | |
| mesh[33].descriptor_ui | D000367 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | |
| mesh[33].descriptor_name | Age Factors |
| mesh[34].qualifier_ui | |
| mesh[34].descriptor_ui | D007249 |
| mesh[34].is_major_topic | True |
| mesh[34].qualifier_name | |
| mesh[34].descriptor_name | Inflammation |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D012737 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | Sex Factors |
| mesh[36].qualifier_ui | Q000378 |
| mesh[36].descriptor_ui | D013961 |
| mesh[36].is_major_topic | True |
| mesh[36].qualifier_name | metabolism |
| mesh[36].descriptor_name | Thyroid Gland |
| mesh[37].qualifier_ui | Q000097 |
| mesh[37].descriptor_ui | D008055 |
| mesh[37].is_major_topic | True |
| mesh[37].qualifier_name | blood |
| mesh[37].descriptor_name | Lipids |
| mesh[38].qualifier_ui | |
| mesh[38].descriptor_ui | D050356 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | |
| mesh[38].descriptor_name | Lipid Metabolism |
| mesh[39].qualifier_ui | |
| mesh[39].descriptor_ui | D000368 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | |
| mesh[39].descriptor_name | Aged |
| mesh[40].qualifier_ui | Q000097 |
| mesh[40].descriptor_ui | D004279 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | blood |
| mesh[40].descriptor_name | DNA, Viral |
| mesh[41].qualifier_ui | |
| mesh[41].descriptor_ui | D055815 |
| mesh[41].is_major_topic | False |
| mesh[41].qualifier_name | |
| mesh[41].descriptor_name | Young Adult |
| mesh[42].qualifier_ui | Q000097 |
| mesh[42].descriptor_ui | D013972 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | blood |
| mesh[42].descriptor_name | Thyrotropin |
| mesh[43].qualifier_ui | Q000097 |
| mesh[43].descriptor_ui | D015415 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | blood |
| mesh[43].descriptor_name | Biomarkers |
| mesh[44].qualifier_ui | |
| mesh[44].descriptor_ui | D006801 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | |
| mesh[44].descriptor_name | Humans |
| mesh[45].qualifier_ui | |
| mesh[45].descriptor_ui | D008297 |
| mesh[45].is_major_topic | False |
| mesh[45].qualifier_name | |
| mesh[45].descriptor_name | Male |
| mesh[46].qualifier_ui | |
| mesh[46].descriptor_ui | D019562 |
| mesh[46].is_major_topic | True |
| mesh[46].qualifier_name | |
| mesh[46].descriptor_name | Viral Load |
| mesh[47].qualifier_ui | |
| mesh[47].descriptor_ui | D005260 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | |
| mesh[47].descriptor_name | Female |
| mesh[48].qualifier_ui | |
| mesh[48].descriptor_ui | D000328 |
| mesh[48].is_major_topic | False |
| mesh[48].qualifier_name | |
| mesh[48].descriptor_name | Adult |
| mesh[49].qualifier_ui | |
| mesh[49].descriptor_ui | D008875 |
| mesh[49].is_major_topic | False |
| mesh[49].qualifier_name | |
| mesh[49].descriptor_name | Middle Aged |
| type | article |
| title | Multivariate Assessment of Thyroid, Lipid, and Inflammatory Profiles by HBV Status and Viral Load: Age- and Sex-Specific Findings |
| biblio.issue | 9 |
| biblio.volume | 17 |
| biblio.last_page | 1208 |
| biblio.first_page | 1208 |
| topics[0].id | https://openalex.org/T10340 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2713 |
| topics[0].subfield.display_name | Epidemiology |
| topics[0].display_name | Hepatitis B Virus Studies |
| topics[1].id | https://openalex.org/T10351 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9998999834060669 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2713 |
| topics[1].subfield.display_name | Epidemiology |
| topics[1].display_name | Liver Disease Diagnosis and Treatment |
| topics[2].id | https://openalex.org/T10151 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9983999729156494 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2721 |
| topics[2].subfield.display_name | Hepatology |
| topics[2].display_name | Hepatitis C virus research |
| is_xpac | False |
| apc_list.value | 2600 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2815 |
| apc_paid.value | 2600 |
| apc_paid.currency | CHF |
| apc_paid.value_usd | 2815 |
| concepts[0].id | https://openalex.org/C38180746 |
| concepts[0].level | 2 |
| concepts[0].score | 0.7186075448989868 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q1952580 |
| concepts[0].display_name | Multivariate analysis |
| concepts[1].id | https://openalex.org/C161584116 |
| concepts[1].level | 2 |
| concepts[1].score | 0.6793268322944641 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q1952580 |
| concepts[1].display_name | Multivariate statistics |
| concepts[2].id | https://openalex.org/C142462285 |
| concepts[2].level | 3 |
| concepts[2].score | 0.6360705494880676 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q2528140 |
| concepts[2].display_name | Viral load |
| concepts[3].id | https://openalex.org/C71924100 |
| concepts[3].level | 0 |
| concepts[3].score | 0.5277830958366394 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[3].display_name | Medicine |
| concepts[4].id | https://openalex.org/C126322002 |
| concepts[4].level | 1 |
| concepts[4].score | 0.5028671622276306 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[4].display_name | Internal medicine |
| concepts[5].id | https://openalex.org/C134018914 |
| concepts[5].level | 1 |
| concepts[5].score | 0.3776731491088867 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q162606 |
| concepts[5].display_name | Endocrinology |
| concepts[6].id | https://openalex.org/C42407357 |
| concepts[6].level | 1 |
| concepts[6].score | 0.3761550784111023 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q521 |
| concepts[6].display_name | Physiology |
| concepts[7].id | https://openalex.org/C203014093 |
| concepts[7].level | 1 |
| concepts[7].score | 0.3245115280151367 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[7].display_name | Immunology |
| concepts[8].id | https://openalex.org/C2522874641 |
| concepts[8].level | 2 |
| concepts[8].score | 0.20870020985603333 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q808 |
| concepts[8].display_name | Virus |
| concepts[9].id | https://openalex.org/C33923547 |
| concepts[9].level | 0 |
| concepts[9].score | 0.1179656982421875 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q395 |
| concepts[9].display_name | Mathematics |
| concepts[10].id | https://openalex.org/C105795698 |
| concepts[10].level | 1 |
| concepts[10].score | 0.09726503491401672 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q12483 |
| concepts[10].display_name | Statistics |
| keywords[0].id | https://openalex.org/keywords/multivariate-analysis |
| keywords[0].score | 0.7186075448989868 |
| keywords[0].display_name | Multivariate analysis |
| keywords[1].id | https://openalex.org/keywords/multivariate-statistics |
| keywords[1].score | 0.6793268322944641 |
| keywords[1].display_name | Multivariate statistics |
| keywords[2].id | https://openalex.org/keywords/viral-load |
| keywords[2].score | 0.6360705494880676 |
| keywords[2].display_name | Viral load |
| keywords[3].id | https://openalex.org/keywords/medicine |
| keywords[3].score | 0.5277830958366394 |
| keywords[3].display_name | Medicine |
| keywords[4].id | https://openalex.org/keywords/internal-medicine |
| keywords[4].score | 0.5028671622276306 |
| keywords[4].display_name | Internal medicine |
| keywords[5].id | https://openalex.org/keywords/endocrinology |
| keywords[5].score | 0.3776731491088867 |
| keywords[5].display_name | Endocrinology |
| keywords[6].id | https://openalex.org/keywords/physiology |
| keywords[6].score | 0.3761550784111023 |
| keywords[6].display_name | Physiology |
| keywords[7].id | https://openalex.org/keywords/immunology |
| keywords[7].score | 0.3245115280151367 |
| keywords[7].display_name | Immunology |
| keywords[8].id | https://openalex.org/keywords/virus |
| keywords[8].score | 0.20870020985603333 |
| keywords[8].display_name | Virus |
| keywords[9].id | https://openalex.org/keywords/mathematics |
| keywords[9].score | 0.1179656982421875 |
| keywords[9].display_name | Mathematics |
| keywords[10].id | https://openalex.org/keywords/statistics |
| keywords[10].score | 0.09726503491401672 |
| keywords[10].display_name | Statistics |
| language | en |
| locations[0].id | doi:10.3390/v17091208 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S55776271 |
| locations[0].source.issn | 1999-4915 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1999-4915 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Viruses |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/1999-4915/17/9/1208/pdf?version=1756906406 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Viruses |
| locations[0].landing_page_url | https://doi.org/10.3390/v17091208 |
| locations[1].id | pmid:41012636 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Viruses |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/41012636 |
| locations[2].id | pmh:oai:doaj.org/article:6fe2d773df8b4967894db98fdd65c3a7 |
| locations[2].is_oa | False |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Viruses, Vol 17, Iss 9, p 1208 (2025) |
| locations[2].landing_page_url | https://doaj.org/article/6fe2d773df8b4967894db98fdd65c3a7 |
| locations[3].id | pmh:oai:europepmc.org:11282812 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306400806 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | Europe PMC (PubMed Central) |
| locations[3].source.host_organization | https://openalex.org/I1303153112 |
| locations[3].source.host_organization_name | European Bioinformatics Institute |
| locations[3].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[3].license | other-oa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/other-oa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | |
| locations[3].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/12474459 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5101267374 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Hyeokjun Yun |
| authorships[0].countries | KR |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I89015989 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Medical Laser, Dankook University School of Medicine, Cheonan-si 31116, Republic of Korea |
| authorships[0].institutions[0].id | https://openalex.org/I89015989 |
| authorships[0].institutions[0].ror | https://ror.org/058pdbn81 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I89015989 |
| authorships[0].institutions[0].country_code | KR |
| authorships[0].institutions[0].display_name | Dankook University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Hyeokjun Yun |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Medical Laser, Dankook University School of Medicine, Cheonan-si 31116, Republic of Korea |
| authorships[1].author.id | https://openalex.org/A5082118533 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-7335-764X |
| authorships[1].author.display_name | Jong Wan Kim |
| authorships[1].countries | KR |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I89015989 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Laboratory Medicine, Dankook University School of Medicine, Cheonan-si 31116, Republic of Korea |
| authorships[1].institutions[0].id | https://openalex.org/I89015989 |
| authorships[1].institutions[0].ror | https://ror.org/058pdbn81 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I89015989 |
| authorships[1].institutions[0].country_code | KR |
| authorships[1].institutions[0].display_name | Dankook University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Jong Wan Kim |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Laboratory Medicine, Dankook University School of Medicine, Cheonan-si 31116, Republic of Korea |
| authorships[2].author.id | https://openalex.org/A5000491897 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-1534-563X |
| authorships[2].author.display_name | Jae Kyung Kim |
| authorships[2].countries | KR |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I89015989 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Biomedical Laboratory Science, Dankook University College of Health Sciences, Cheonan-si 31116, Republic of Korea |
| authorships[2].institutions[0].id | https://openalex.org/I89015989 |
| authorships[2].institutions[0].ror | https://ror.org/058pdbn81 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I89015989 |
| authorships[2].institutions[0].country_code | KR |
| authorships[2].institutions[0].display_name | Dankook University |
| authorships[2].author_position | last |
| authorships[2].raw_author_name | Jae Kyung Kim |
| authorships[2].is_corresponding | True |
| authorships[2].raw_affiliation_strings | Department of Biomedical Laboratory Science, Dankook University College of Health Sciences, Cheonan-si 31116, Republic of Korea |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/1999-4915/17/9/1208/pdf?version=1756906406 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Multivariate Assessment of Thyroid, Lipid, and Inflammatory Profiles by HBV Status and Viral Load: Age- and Sex-Specific Findings |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10340 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2713 |
| primary_topic.subfield.display_name | Epidemiology |
| primary_topic.display_name | Hepatitis B Virus Studies |
| related_works | https://openalex.org/W2406638334, https://openalex.org/W40745829, https://openalex.org/W4318262572, https://openalex.org/W1978357124, https://openalex.org/W1578824628, https://openalex.org/W2032728545, https://openalex.org/W1570805059, https://openalex.org/W4250754046, https://openalex.org/W4243682621, https://openalex.org/W2036849593 |
| cited_by_count | 0 |
| locations_count | 4 |
| best_oa_location.id | doi:10.3390/v17091208 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S55776271 |
| best_oa_location.source.issn | 1999-4915 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1999-4915 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Viruses |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/1999-4915/17/9/1208/pdf?version=1756906406 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Viruses |
| best_oa_location.landing_page_url | https://doi.org/10.3390/v17091208 |
| primary_location.id | doi:10.3390/v17091208 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S55776271 |
| primary_location.source.issn | 1999-4915 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1999-4915 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Viruses |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/1999-4915/17/9/1208/pdf?version=1756906406 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Viruses |
| primary_location.landing_page_url | https://doi.org/10.3390/v17091208 |
| publication_date | 2025-09-03 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W3157206439, https://openalex.org/W4284889996, https://openalex.org/W2089108066, https://openalex.org/W2147283902, https://openalex.org/W3154329346, https://openalex.org/W2886000562, https://openalex.org/W3215476932, https://openalex.org/W3109442209, https://openalex.org/W2735446022, https://openalex.org/W3093907075, https://openalex.org/W4309668644, https://openalex.org/W4387787377, https://openalex.org/W2745897813, https://openalex.org/W4387034484, https://openalex.org/W2573281743, https://openalex.org/W2107471334, https://openalex.org/W2605785536, https://openalex.org/W1998915515, https://openalex.org/W4387787435, https://openalex.org/W4401856361, https://openalex.org/W4377292553, https://openalex.org/W4403176672, https://openalex.org/W2394539415, https://openalex.org/W3198536732, https://openalex.org/W4224112317, https://openalex.org/W2111553711, https://openalex.org/W1996813448, https://openalex.org/W2580143761, https://openalex.org/W2916781358, https://openalex.org/W2089697615, https://openalex.org/W3016754509, https://openalex.org/W4406338465, https://openalex.org/W2067354316, https://openalex.org/W2745980697, https://openalex.org/W3125839615, https://openalex.org/W3207506888, https://openalex.org/W2887103958, https://openalex.org/W4223502545, https://openalex.org/W2018668816, https://openalex.org/W3027504226, https://openalex.org/W2171150690, https://openalex.org/W2713927065, https://openalex.org/W4393932905, https://openalex.org/W2733295083, https://openalex.org/W3133552553, https://openalex.org/W2914376991, https://openalex.org/W4288489177, https://openalex.org/W3134100017, https://openalex.org/W2007697984, https://openalex.org/W1933895714, https://openalex.org/W4226348950, https://openalex.org/W2999327898, https://openalex.org/W4245198918, https://openalex.org/W4229024135, https://openalex.org/W2159443779, https://openalex.org/W3120641366, https://openalex.org/W4391972305 |
| referenced_works_count | 57 |
| abstract_inverted_index.B | 2 |
| abstract_inverted_index.a | 49, 148 |
| abstract_inverted_index.In | 15 |
| abstract_inverted_index.as | 87 |
| abstract_inverted_index.be | 193 |
| abstract_inverted_index.by | 23, 42, 72, 127 |
| abstract_inverted_index.in | 59, 140, 209 |
| abstract_inverted_index.is | 79 |
| abstract_inverted_index.of | 52, 83, 137, 170, 200 |
| abstract_inverted_index.or | 130, 142 |
| abstract_inverted_index.to | 30, 183 |
| abstract_inverted_index.186 | 19 |
| abstract_inverted_index.Age | 146 |
| abstract_inverted_index.CRP | 123 |
| abstract_inverted_index.DNA | 25, 85 |
| abstract_inverted_index.HBV | 24, 84, 128, 171 |
| abstract_inverted_index.HDL | 113 |
| abstract_inverted_index.LDL | 121 |
| abstract_inverted_index.age | 43 |
| abstract_inverted_index.and | 12, 27, 36, 44, 158, 173, 180, 186, 206 |
| abstract_inverted_index.but | 165 |
| abstract_inverted_index.for | 177 |
| abstract_inverted_index.may | 6 |
| abstract_inverted_index.not | 80 |
| abstract_inverted_index.sex | 157 |
| abstract_inverted_index.the | 77, 91, 135, 175, 198 |
| abstract_inverted_index.was | 68, 147 |
| abstract_inverted_index.BMI, | 201 |
| abstract_inverted_index.data | 208 |
| abstract_inverted_index.free | 88 |
| abstract_inverted_index.high | 108 |
| abstract_inverted_index.load | 29, 110 |
| abstract_inverted_index.need | 176 |
| abstract_inverted_index.sex. | 45 |
| abstract_inverted_index.that | 76 |
| abstract_inverted_index.this | 16, 66, 210 |
| abstract_inverted_index.were | 21, 56, 125 |
| abstract_inverted_index.with | 39, 63, 107, 134, 153, 195 |
| abstract_inverted_index.(FT4, | 90 |
| abstract_inverted_index.(HBV) | 4 |
| abstract_inverted_index.(TSH, | 48 |
| abstract_inverted_index.Lipid | 101 |
| abstract_inverted_index.These | 161, 189 |
| abstract_inverted_index.after | 70 |
| abstract_inverted_index.early | 141 |
| abstract_inverted_index.given | 197 |
| abstract_inverted_index.gland | 96 |
| abstract_inverted_index.lipid | 13, 37 |
| abstract_inverted_index.liver | 202 |
| abstract_inverted_index.load, | 74, 132 |
| abstract_inverted_index.load. | 160 |
| abstract_inverted_index.lower | 58, 112 |
| abstract_inverted_index.major | 149 |
| abstract_inverted_index.males | 106 |
| abstract_inverted_index.viral | 28, 73, 109, 131, 159 |
| abstract_inverted_index.virus | 3 |
| abstract_inverted_index.across | 151 |
| abstract_inverted_index.adults | 20 |
| abstract_inverted_index.higher | 120 |
| abstract_inverted_index.levels | 55, 98, 124 |
| abstract_inverted_index.should | 192 |
| abstract_inverted_index.showed | 119 |
| abstract_inverted_index.status | 26, 129 |
| abstract_inverted_index.study, | 18 |
| abstract_inverted_index.subtle | 164 |
| abstract_inverted_index.trends | 191 |
| abstract_inverted_index.Chronic | 0 |
| abstract_inverted_index.absence | 136, 199 |
| abstract_inverted_index.caution | 196 |
| abstract_inverted_index.clarify | 184 |
| abstract_inverted_index.cohort. | 212 |
| abstract_inverted_index.complex | 154 |
| abstract_inverted_index.disease | 144 |
| abstract_inverted_index.effects | 169 |
| abstract_inverted_index.enzyme, | 203 |
| abstract_inverted_index.examine | 31 |
| abstract_inverted_index.further | 40 |
| abstract_inverted_index.hormone | 47, 94 |
| abstract_inverted_index.levels, | 86 |
| abstract_inverted_index.stable. | 100 |
| abstract_inverted_index.stages. | 145 |
| abstract_inverted_index.studies | 182 |
| abstract_inverted_index.thyroid | 32, 53, 93 |
| abstract_inverted_index.whereas | 115 |
| abstract_inverted_index.younger | 116 |
| abstract_inverted_index.aligning | 133 |
| abstract_inverted_index.analyses | 41 |
| abstract_inverted_index.compared | 62 |
| abstract_inverted_index.findings | 162 |
| abstract_inverted_index.however, | 65 |
| abstract_inverted_index.inactive | 143 |
| abstract_inverted_index.indicate | 163 |
| abstract_inverted_index.profiles | 102 |
| abstract_inverted_index.relevant | 167 |
| abstract_inverted_index.remained | 99 |
| abstract_inverted_index.subgroup | 190 |
| abstract_inverted_index.systemic | 34, 138 |
| abstract_inverted_index.systems, | 9 |
| abstract_inverted_index.activity) | 97 |
| abstract_inverted_index.controls; | 64 |
| abstract_inverted_index.displayed | 103 |
| abstract_inverted_index.endocrine | 11 |
| abstract_inverted_index.exhibited | 111 |
| abstract_inverted_index.fibrosis, | 204 |
| abstract_inverted_index.function) | 54 |
| abstract_inverted_index.function, | 33 |
| abstract_inverted_index.hepatitis | 1 |
| abstract_inverted_index.including | 10 |
| abstract_inverted_index.infection | 5, 172 |
| abstract_inverted_index.influence | 7 |
| abstract_inverted_index.involving | 156 |
| abstract_inverted_index.metabolic | 185 |
| abstract_inverted_index.patterns: | 105 |
| abstract_inverted_index.pituitary | 50 |
| abstract_inverted_index.regulator | 51 |
| abstract_inverted_index.thyroxine | 89 |
| abstract_inverted_index.attenuated | 69 |
| abstract_inverted_index.clinically | 166 |
| abstract_inverted_index.indicating | 75 |
| abstract_inverted_index.monitoring | 179 |
| abstract_inverted_index.reflecting | 95 |
| abstract_inverted_index.stratified | 22 |
| abstract_inverted_index.unaffected | 126 |
| abstract_inverted_index.underscore | 174 |
| abstract_inverted_index.association | 67 |
| abstract_inverted_index.biomarkers, | 152 |
| abstract_inverted_index.circulating | 92 |
| abstract_inverted_index.comorbidity | 207 |
| abstract_inverted_index.determinant | 150 |
| abstract_inverted_index.independent | 82 |
| abstract_inverted_index.individuals | 61, 118 |
| abstract_inverted_index.interpreted | 194 |
| abstract_inverted_index.medication, | 205 |
| abstract_inverted_index.metabolism, | 38 |
| abstract_inverted_index.regulation. | 14 |
| abstract_inverted_index.HBV-positive | 117 |
| abstract_inverted_index.cholesterol, | 114 |
| abstract_inverted_index.cholesterol. | 122 |
| abstract_inverted_index.extrahepatic | 8, 168 |
| abstract_inverted_index.inflammation | 139 |
| abstract_inverted_index.interactions | 155 |
| abstract_inverted_index.longitudinal | 181 |
| abstract_inverted_index.personalized | 178 |
| abstract_inverted_index.relationship | 78 |
| abstract_inverted_index.implications. | 188 |
| abstract_inverted_index.inflammation, | 35 |
| abstract_inverted_index.retrospective | 211 |
| abstract_inverted_index.significantly | 57 |
| abstract_inverted_index.unequivocally | 81 |
| abstract_inverted_index.HBsAg-positive | 60 |
| abstract_inverted_index.cardiovascular | 187 |
| abstract_inverted_index.stratification | 71 |
| abstract_inverted_index.cross-sectional | 17 |
| abstract_inverted_index.Thyroid-stimulating | 46 |
| abstract_inverted_index.demographic-specific | 104 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5000491897 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 3 |
| corresponding_institution_ids | https://openalex.org/I89015989 |
| citation_normalized_percentile.value | 0.49819766 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |