Mutation Landscape of Base Substitutions, Duplications, and Deletions in the Representative Current Cholera Pandemic Strain Article Swipe
Wen Wei
,
Lifeng Xiong
,
Yuan‐Nong Ye
,
Meng‐Ze Du
,
Yi‐Zhou Gao
,
Kai-Yue Zhang
,
Yan-Ting Jin
,
Zhenglin Yang
,
Po-Chun Wong
,
Susanna K. P. Lau
,
Biao Kan
,
Jun Zhu
,
Patrick C. Y. Woo
,
Feng‐Biao Guo
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1093/gbe/evy151
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1093/gbe/evy151
Pandemic cholera is a major concern for public health because of its high mortality and morbidity. Mutation accumulation (MA) experiments were performed on a representative strain of the current cholera pandemic. Although the base-pair substitution mutation rates in Vibrio cholerae (1.24 × 10-10 per site per generation for wild-type lines and 3.29 × 10-8 for mismatch repair deficient lines) are lower than that previously reported in other bacteria using MA analysis, we discovered specific high rates (8.31 × 10-8 site/generation for wild-type lines and 1.82 × 10-6 for mismatch repair deficient lines) of base duplication or deletion driven by large-scale copy number variations (CNVs). These duplication-deletions are located in two pathogenic islands, IMEX and the large integron island. Each element of these islands has discrepant rate in rapid integration and excision, which provides clues to the pandemicity evolution of V. cholerae. These results also suggest that large-scale structural variants such as CNVs can accumulate rapidly during short-term evolution. Mismatch repair deficient lines exhibit a significantly increased mutation rate in the larger chromosome (Chr1) at specific regions, and this pattern is not observed in wild-type lines. We propose that the high frequency of GATC sites in Chr1 improves the efficiency of MMR, resulting in similar rates of mutation in the wild-type condition. In addition, different mutation rates and spectra were observed in the MA lines under distinct growth conditions, including minimal media, rich media and antibiotic treatments.
Related Topics
Concepts
Biology
Pandemic
Mutation
Strain (injury)
Genetics
Mutation Accumulation
Cholera
Genome
Gene duplication
Evolutionary biology
Coronavirus disease 2019 (COVID-19)
Virology
Gene
Disease
Anatomy
Pathology
Infectious disease (medical specialty)
Medicine
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/gbe/evy151
- https://academic.oup.com/gbe/article-pdf/10/8/2072/25643005/evy151.pdf
- OA Status
- gold
- Cited By
- 9
- References
- 65
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2886598101
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2886598101Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/gbe/evy151Digital Object Identifier
- Title
-
Mutation Landscape of Base Substitutions, Duplications, and Deletions in the Representative Current Cholera Pandemic StrainWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-07-27Full publication date if available
- Authors
-
Wen Wei, Lifeng Xiong, Yuan‐Nong Ye, Meng‐Ze Du, Yi‐Zhou Gao, Kai-Yue Zhang, Yan-Ting Jin, Zhenglin Yang, Po-Chun Wong, Susanna K. P. Lau, Biao Kan, Jun Zhu, Patrick C. Y. Woo, Feng‐Biao GuoList of authors in order
- Landing page
-
https://doi.org/10.1093/gbe/evy151Publisher landing page
- PDF URL
-
https://academic.oup.com/gbe/article-pdf/10/8/2072/25643005/evy151.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://academic.oup.com/gbe/article-pdf/10/8/2072/25643005/evy151.pdfDirect OA link when available
- Concepts
-
Biology, Pandemic, Mutation, Strain (injury), Genetics, Mutation Accumulation, Cholera, Genome, Gene duplication, Evolutionary biology, Coronavirus disease 2019 (COVID-19), Virology, Gene, Disease, Anatomy, Pathology, Infectious disease (medical specialty), MedicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
9Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 1, 2022: 3, 2020: 1, 2019: 3Per-year citation counts (last 5 years)
- References (count)
-
65Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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