Mutations in a translation initiation factor identify the target of a memory-enhancing compound Article Swipe
Yusuke Sekine
,
Alisa Zyryanova
,
Ana Crespillo-Casado
,
Peter M. Fischer
,
Heather P. Harding
,
David Ron
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1126/science.aaa6986
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1126/science.aaa6986
Identification of a memory drug target ISRIB is a potent inhibitor of the integrated stress response (ISR), which involves the activation of eIF2α-specific kinases, phosphorylation of eIF2α, and consequent down-regulation of global translation levels. ISRIB is also a candidate drug for treating certain memory disorders. ISRIB does not prevent eIF2α phosphorylation and must therefore act downstream of this step. Sekine et al. now report that ISRIB reverses the inhibitory effect of eIF2α phosphorylation on the activity of eIF2B, a dedicated guanine nucleotide exchange factor, enhancing its activity independently of phosphorylation (see the Perspective by Hinnebusch). The authors isolated ISRIB-resistant cells and identified a genetic lesion in a short N-terminal region of eIF2Bδ that appears to be responsible for the observed phenotype. Science , this issue p. 1027 ; see also p. 967
Related Topics
Concepts
Integrated stress response
Phosphorylation
eIF2
Guanine nucleotide exchange factor
Translation (biology)
Eukaryotic translation
Biology
Guanine
Kinase
Cell biology
Phenotype
Genetics
Signal transduction
Nucleotide
Gene
Messenger RNA
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1126/science.aaa6986
- https://www.science.org/cms/asset/9904afd8-725e-42a8-a6e1-5023b4ac3b8d/pap.pdf
- OA Status
- bronze
- Cited By
- 228
- References
- 32
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2046278771
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2046278771Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1126/science.aaa6986Digital Object Identifier
- Title
-
Mutations in a translation initiation factor identify the target of a memory-enhancing compoundWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2015Year of publication
- Publication date
-
2015-04-10Full publication date if available
- Authors
-
Yusuke Sekine, Alisa Zyryanova, Ana Crespillo-Casado, Peter M. Fischer, Heather P. Harding, David RonList of authors in order
- Landing page
-
https://doi.org/10.1126/science.aaa6986Publisher landing page
- PDF URL
-
https://www.science.org/cms/asset/9904afd8-725e-42a8-a6e1-5023b4ac3b8d/pap.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://www.science.org/cms/asset/9904afd8-725e-42a8-a6e1-5023b4ac3b8d/pap.pdfDirect OA link when available
- Concepts
-
Integrated stress response, Phosphorylation, eIF2, Guanine nucleotide exchange factor, Translation (biology), Eukaryotic translation, Biology, Guanine, Kinase, Cell biology, Phenotype, Genetics, Signal transduction, Nucleotide, Gene, Messenger RNATop concepts (fields/topics) attached by OpenAlex
- Cited by
-
228Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 16, 2024: 16, 2023: 14, 2022: 10, 2021: 22Per-year citation counts (last 5 years)
- References (count)
-
32Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W2046278771 |
|---|---|
| doi | https://doi.org/10.1126/science.aaa6986 |
| ids.doi | https://doi.org/10.1126/science.aaa6986 |
| ids.mag | 2046278771 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/25858979 |
| ids.openalex | https://openalex.org/W2046278771 |
| fwci | 15.29701173 |
| mesh[0].qualifier_ui | Q000494 |
| mesh[0].descriptor_ui | D000081 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | pharmacology |
| mesh[0].descriptor_name | Acetamides |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D000818 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Animals |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D016466 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | CHO Cells |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D064112 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Clustered Regularly Interspaced Short Palindromic Repeats |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D003412 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Cricetulus |
| mesh[5].qualifier_ui | Q000494 |
| mesh[5].descriptor_ui | D003514 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | pharmacology |
| mesh[5].descriptor_name | Cyclohexylamines |
| mesh[6].qualifier_ui | Q000235 |
| mesh[6].descriptor_ui | D004351 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | genetics |
| mesh[6].descriptor_name | Drug Resistance |
| mesh[7].qualifier_ui | Q000378 |
| mesh[7].descriptor_ui | D015852 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | metabolism |
| mesh[7].descriptor_name | Eukaryotic Initiation Factor-2 |
| mesh[8].qualifier_ui | Q000235 |
| mesh[8].descriptor_ui | D020717 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | genetics |
| mesh[8].descriptor_name | Eukaryotic Initiation Factor-2B |
| mesh[9].qualifier_ui | Q000378 |
| mesh[9].descriptor_ui | D020717 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | metabolism |
| mesh[9].descriptor_name | Eukaryotic Initiation Factor-2B |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D005820 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Genetic Testing |
| mesh[11].qualifier_ui | Q000187 |
| mesh[11].descriptor_ui | D008568 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | drug effects |
| mesh[11].descriptor_name | Memory |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D020125 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Mutation, Missense |
| mesh[13].qualifier_ui | Q000494 |
| mesh[13].descriptor_ui | D018697 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | pharmacology |
| mesh[13].descriptor_name | Nootropic Agents |
| mesh[14].qualifier_ui | Q000187 |
| mesh[14].descriptor_ui | D014176 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | drug effects |
| mesh[14].descriptor_name | Protein Biosynthesis |
| mesh[15].qualifier_ui | Q000187 |
| mesh[15].descriptor_ui | D056811 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | drug effects |
| mesh[15].descriptor_name | Unfolded Protein Response |
| mesh[16].qualifier_ui | Q000276 |
| mesh[16].descriptor_ui | D056811 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | immunology |
| mesh[16].descriptor_name | Unfolded Protein Response |
| mesh[17].qualifier_ui | Q000494 |
| mesh[17].descriptor_ui | D000081 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | pharmacology |
| mesh[17].descriptor_name | Acetamides |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D000818 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Animals |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D016466 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | CHO Cells |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D064112 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Clustered Regularly Interspaced Short Palindromic Repeats |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D003412 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Cricetulus |
| mesh[22].qualifier_ui | Q000494 |
| mesh[22].descriptor_ui | D003514 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | pharmacology |
| mesh[22].descriptor_name | Cyclohexylamines |
| mesh[23].qualifier_ui | Q000235 |
| mesh[23].descriptor_ui | D004351 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | genetics |
| mesh[23].descriptor_name | Drug Resistance |
| mesh[24].qualifier_ui | Q000378 |
| mesh[24].descriptor_ui | D015852 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | metabolism |
| mesh[24].descriptor_name | Eukaryotic Initiation Factor-2 |
| mesh[25].qualifier_ui | Q000235 |
| mesh[25].descriptor_ui | D020717 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | genetics |
| mesh[25].descriptor_name | Eukaryotic Initiation Factor-2B |
| mesh[26].qualifier_ui | Q000378 |
| mesh[26].descriptor_ui | D020717 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | metabolism |
| mesh[26].descriptor_name | Eukaryotic Initiation Factor-2B |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D005820 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Genetic Testing |
| mesh[28].qualifier_ui | Q000187 |
| mesh[28].descriptor_ui | D008568 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | drug effects |
| mesh[28].descriptor_name | Memory |
| mesh[29].qualifier_ui | |
| mesh[29].descriptor_ui | D020125 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | |
| mesh[29].descriptor_name | Mutation, Missense |
| mesh[30].qualifier_ui | Q000494 |
| mesh[30].descriptor_ui | D018697 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | pharmacology |
| mesh[30].descriptor_name | Nootropic Agents |
| mesh[31].qualifier_ui | Q000187 |
| mesh[31].descriptor_ui | D014176 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | drug effects |
| mesh[31].descriptor_name | Protein Biosynthesis |
| mesh[32].qualifier_ui | Q000187 |
| mesh[32].descriptor_ui | D056811 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | drug effects |
| mesh[32].descriptor_name | Unfolded Protein Response |
| mesh[33].qualifier_ui | Q000276 |
| mesh[33].descriptor_ui | D056811 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | immunology |
| mesh[33].descriptor_name | Unfolded Protein Response |
| mesh[34].qualifier_ui | Q000494 |
| mesh[34].descriptor_ui | D000081 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | pharmacology |
| mesh[34].descriptor_name | Acetamides |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D000818 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | Animals |
| mesh[36].qualifier_ui | |
| mesh[36].descriptor_ui | D016466 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | |
| mesh[36].descriptor_name | CHO Cells |
| mesh[37].qualifier_ui | |
| mesh[37].descriptor_ui | D064112 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | |
| mesh[37].descriptor_name | Clustered Regularly Interspaced Short Palindromic Repeats |
| mesh[38].qualifier_ui | |
| mesh[38].descriptor_ui | D003412 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | |
| mesh[38].descriptor_name | Cricetulus |
| mesh[39].qualifier_ui | Q000494 |
| mesh[39].descriptor_ui | D003514 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | pharmacology |
| mesh[39].descriptor_name | Cyclohexylamines |
| mesh[40].qualifier_ui | Q000235 |
| mesh[40].descriptor_ui | D004351 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | genetics |
| mesh[40].descriptor_name | Drug Resistance |
| mesh[41].qualifier_ui | Q000378 |
| mesh[41].descriptor_ui | D015852 |
| mesh[41].is_major_topic | False |
| mesh[41].qualifier_name | metabolism |
| mesh[41].descriptor_name | Eukaryotic Initiation Factor-2 |
| mesh[42].qualifier_ui | Q000235 |
| mesh[42].descriptor_ui | D020717 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | genetics |
| mesh[42].descriptor_name | Eukaryotic Initiation Factor-2B |
| mesh[43].qualifier_ui | Q000378 |
| mesh[43].descriptor_ui | D020717 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | metabolism |
| mesh[43].descriptor_name | Eukaryotic Initiation Factor-2B |
| mesh[44].qualifier_ui | |
| mesh[44].descriptor_ui | D005820 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | |
| mesh[44].descriptor_name | Genetic Testing |
| mesh[45].qualifier_ui | Q000187 |
| mesh[45].descriptor_ui | D008568 |
| mesh[45].is_major_topic | False |
| mesh[45].qualifier_name | drug effects |
| mesh[45].descriptor_name | Memory |
| mesh[46].qualifier_ui | |
| mesh[46].descriptor_ui | D020125 |
| mesh[46].is_major_topic | False |
| mesh[46].qualifier_name | |
| mesh[46].descriptor_name | Mutation, Missense |
| mesh[47].qualifier_ui | Q000494 |
| mesh[47].descriptor_ui | D018697 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | pharmacology |
| mesh[47].descriptor_name | Nootropic Agents |
| mesh[48].qualifier_ui | Q000187 |
| mesh[48].descriptor_ui | D014176 |
| mesh[48].is_major_topic | False |
| mesh[48].qualifier_name | drug effects |
| mesh[48].descriptor_name | Protein Biosynthesis |
| mesh[49].qualifier_ui | Q000187 |
| mesh[49].descriptor_ui | D056811 |
| mesh[49].is_major_topic | False |
| mesh[49].qualifier_name | drug effects |
| mesh[49].descriptor_name | Unfolded Protein Response |
| type | article |
| title | Mutations in a translation initiation factor identify the target of a memory-enhancing compound |
| awards[0].id | https://openalex.org/G4837454053 |
| awards[0].funder_id | https://openalex.org/F4320307874 |
| awards[0].display_name | |
| awards[0].funder_award_id | 084812/Z/08/Z |
| awards[0].funder_display_name | Wellcome |
| biblio.issue | 6238 |
| biblio.volume | 348 |
| biblio.last_page | 1030 |
| biblio.first_page | 1027 |
| topics[0].id | https://openalex.org/T11150 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1307 |
| topics[0].subfield.display_name | Cell Biology |
| topics[0].display_name | Endoplasmic Reticulum Stress and Disease |
| topics[1].id | https://openalex.org/T12610 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9998999834060669 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | RNA regulation and disease |
| topics[2].id | https://openalex.org/T10878 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9991999864578247 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | CRISPR and Genetic Engineering |
| funders[0].id | https://openalex.org/F4320307874 |
| funders[0].ror | https://ror.org/029chgv08 |
| funders[0].display_name | Wellcome |
| funders[1].id | https://openalex.org/F4320323514 |
| funders[1].ror | https://ror.org/05j492n53 |
| funders[1].display_name | Daiichi Sankyo Foundation of Life Science |
| funders[2].id | https://openalex.org/F4320334764 |
| funders[2].ror | https://ror.org/00hhkn466 |
| funders[2].display_name | Japan Society for the Promotion of Science |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C2779638656 |
| concepts[0].level | 5 |
| concepts[0].score | 0.8276287913322449 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q6043166 |
| concepts[0].display_name | Integrated stress response |
| concepts[1].id | https://openalex.org/C11960822 |
| concepts[1].level | 2 |
| concepts[1].score | 0.7721843719482422 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q242736 |
| concepts[1].display_name | Phosphorylation |
| concepts[2].id | https://openalex.org/C93734116 |
| concepts[2].level | 5 |
| concepts[2].score | 0.74125736951828 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q1017133 |
| concepts[2].display_name | eIF2 |
| concepts[3].id | https://openalex.org/C126619667 |
| concepts[3].level | 3 |
| concepts[3].score | 0.6987559795379639 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q901088 |
| concepts[3].display_name | Guanine nucleotide exchange factor |
| concepts[4].id | https://openalex.org/C149364088 |
| concepts[4].level | 4 |
| concepts[4].score | 0.625343382358551 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q185917 |
| concepts[4].display_name | Translation (biology) |
| concepts[5].id | https://openalex.org/C4718897 |
| concepts[5].level | 5 |
| concepts[5].score | 0.49711874127388 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q5408698 |
| concepts[5].display_name | Eukaryotic translation |
| concepts[6].id | https://openalex.org/C86803240 |
| concepts[6].level | 0 |
| concepts[6].score | 0.47672024369239807 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[6].display_name | Biology |
| concepts[7].id | https://openalex.org/C2778301229 |
| concepts[7].level | 4 |
| concepts[7].score | 0.47608983516693115 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q169313 |
| concepts[7].display_name | Guanine |
| concepts[8].id | https://openalex.org/C184235292 |
| concepts[8].level | 2 |
| concepts[8].score | 0.47085636854171753 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q421851 |
| concepts[8].display_name | Kinase |
| concepts[9].id | https://openalex.org/C95444343 |
| concepts[9].level | 1 |
| concepts[9].score | 0.4639906883239746 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[9].display_name | Cell biology |
| concepts[10].id | https://openalex.org/C127716648 |
| concepts[10].level | 3 |
| concepts[10].score | 0.41163209080696106 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q104053 |
| concepts[10].display_name | Phenotype |
| concepts[11].id | https://openalex.org/C54355233 |
| concepts[11].level | 1 |
| concepts[11].score | 0.35719847679138184 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[11].display_name | Genetics |
| concepts[12].id | https://openalex.org/C62478195 |
| concepts[12].level | 2 |
| concepts[12].score | 0.2389325201511383 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q828130 |
| concepts[12].display_name | Signal transduction |
| concepts[13].id | https://openalex.org/C512185932 |
| concepts[13].level | 3 |
| concepts[13].score | 0.22647425532341003 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q28745 |
| concepts[13].display_name | Nucleotide |
| concepts[14].id | https://openalex.org/C104317684 |
| concepts[14].level | 2 |
| concepts[14].score | 0.1552613377571106 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[14].display_name | Gene |
| concepts[15].id | https://openalex.org/C105580179 |
| concepts[15].level | 3 |
| concepts[15].score | 0.0 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q188928 |
| concepts[15].display_name | Messenger RNA |
| keywords[0].id | https://openalex.org/keywords/integrated-stress-response |
| keywords[0].score | 0.8276287913322449 |
| keywords[0].display_name | Integrated stress response |
| keywords[1].id | https://openalex.org/keywords/phosphorylation |
| keywords[1].score | 0.7721843719482422 |
| keywords[1].display_name | Phosphorylation |
| keywords[2].id | https://openalex.org/keywords/eif2 |
| keywords[2].score | 0.74125736951828 |
| keywords[2].display_name | eIF2 |
| keywords[3].id | https://openalex.org/keywords/guanine-nucleotide-exchange-factor |
| keywords[3].score | 0.6987559795379639 |
| keywords[3].display_name | Guanine nucleotide exchange factor |
| keywords[4].id | https://openalex.org/keywords/translation |
| keywords[4].score | 0.625343382358551 |
| keywords[4].display_name | Translation (biology) |
| keywords[5].id | https://openalex.org/keywords/eukaryotic-translation |
| keywords[5].score | 0.49711874127388 |
| keywords[5].display_name | Eukaryotic translation |
| keywords[6].id | https://openalex.org/keywords/biology |
| keywords[6].score | 0.47672024369239807 |
| keywords[6].display_name | Biology |
| keywords[7].id | https://openalex.org/keywords/guanine |
| keywords[7].score | 0.47608983516693115 |
| keywords[7].display_name | Guanine |
| keywords[8].id | https://openalex.org/keywords/kinase |
| keywords[8].score | 0.47085636854171753 |
| keywords[8].display_name | Kinase |
| keywords[9].id | https://openalex.org/keywords/cell-biology |
| keywords[9].score | 0.4639906883239746 |
| keywords[9].display_name | Cell biology |
| keywords[10].id | https://openalex.org/keywords/phenotype |
| keywords[10].score | 0.41163209080696106 |
| keywords[10].display_name | Phenotype |
| keywords[11].id | https://openalex.org/keywords/genetics |
| keywords[11].score | 0.35719847679138184 |
| keywords[11].display_name | Genetics |
| keywords[12].id | https://openalex.org/keywords/signal-transduction |
| keywords[12].score | 0.2389325201511383 |
| keywords[12].display_name | Signal transduction |
| keywords[13].id | https://openalex.org/keywords/nucleotide |
| keywords[13].score | 0.22647425532341003 |
| keywords[13].display_name | Nucleotide |
| keywords[14].id | https://openalex.org/keywords/gene |
| keywords[14].score | 0.1552613377571106 |
| keywords[14].display_name | Gene |
| language | en |
| locations[0].id | doi:10.1126/science.aaa6986 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S3880285 |
| locations[0].source.issn | 0036-8075, 1095-9203 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0036-8075 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Science |
| locations[0].source.host_organization | https://openalex.org/P4310315823 |
| locations[0].source.host_organization_name | American Association for the Advancement of Science |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310315823 |
| locations[0].source.host_organization_lineage_names | American Association for the Advancement of Science |
| locations[0].license | |
| locations[0].pdf_url | https://www.science.org/cms/asset/9904afd8-725e-42a8-a6e1-5023b4ac3b8d/pap.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Science |
| locations[0].landing_page_url | https://doi.org/10.1126/science.aaa6986 |
| locations[1].id | pmid:25858979 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Science (New York, N.Y.) |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/25858979 |
| locations[2].id | pmh:oai:europepmc.org:3630504 |
| locations[2].is_oa | False |
| locations[2].source.id | https://openalex.org/S4306400806 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | Europe PMC (PubMed Central) |
| locations[2].source.host_organization | https://openalex.org/I1303153112 |
| locations[2].source.host_organization_name | European Bioinformatics Institute |
| locations[2].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/4538794 |
| locations[3].id | pmh:oai:nottingham-repository.worktribe.com:1110195 |
| locations[3].is_oa | False |
| locations[3].source.id | https://openalex.org/S4306402481 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | Repository@Nottingham (University of Nottingham) |
| locations[3].source.host_organization | https://openalex.org/I142263535 |
| locations[3].source.host_organization_name | University of Nottingham |
| locations[3].source.host_organization_lineage | https://openalex.org/I142263535 |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Journal Article |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | |
| locations[3].landing_page_url | https://nottingham-repository.worktribe.com/output/1110195 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5078318814 |
| authorships[0].author.orcid | https://orcid.org/0000-0003-0345-1416 |
| authorships[0].author.display_name | Yusuke Sekine |
| authorships[0].countries | GB |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I241749, https://openalex.org/I4210116691, https://openalex.org/I4389425352, https://openalex.org/I87048295 |
| authorships[0].affiliations[0].raw_affiliation_string | University of Cambridge, Cambridge Institute for Medical Research (CIMR), the Wellcome Trust MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0XY, UK. |
| authorships[0].institutions[0].id | https://openalex.org/I4389425352 |
| authorships[0].institutions[0].ror | https://ror.org/05m8dr349 |
| authorships[0].institutions[0].type | facility |
| authorships[0].institutions[0].lineage | https://openalex.org/I241749, https://openalex.org/I2802466933, https://openalex.org/I34931013, https://openalex.org/I4389425352 |
| authorships[0].institutions[0].country_code | |
| authorships[0].institutions[0].display_name | NIHR Cambridge Biomedical Research Centre |
| authorships[0].institutions[1].id | https://openalex.org/I241749 |
| authorships[0].institutions[1].ror | https://ror.org/013meh722 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I241749 |
| authorships[0].institutions[1].country_code | GB |
| authorships[0].institutions[1].display_name | University of Cambridge |
| authorships[0].institutions[2].id | https://openalex.org/I87048295 |
| authorships[0].institutions[2].ror | https://ror.org/029chgv08 |
| authorships[0].institutions[2].type | nonprofit |
| authorships[0].institutions[2].lineage | https://openalex.org/I87048295 |
| authorships[0].institutions[2].country_code | GB |
| authorships[0].institutions[2].display_name | Wellcome Trust |
| authorships[0].institutions[3].id | https://openalex.org/I4210116691 |
| authorships[0].institutions[3].ror | https://ror.org/0264dxb48 |
| authorships[0].institutions[3].type | facility |
| authorships[0].institutions[3].lineage | https://openalex.org/I241749, https://openalex.org/I2802466933, https://openalex.org/I4210087105, https://openalex.org/I4210116691, https://openalex.org/I87048295, https://openalex.org/I90344618 |
| authorships[0].institutions[3].country_code | GB |
| authorships[0].institutions[3].display_name | Wellcome/MRC Institute of Metabolic Science |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Yusuke Sekine |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | University of Cambridge, Cambridge Institute for Medical Research (CIMR), the Wellcome Trust MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0XY, UK. |
| authorships[1].author.id | https://openalex.org/A5002076790 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-9885-6012 |
| authorships[1].author.display_name | Alisa Zyryanova |
| authorships[1].countries | GB |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I241749, https://openalex.org/I4210116691, https://openalex.org/I4389425352, https://openalex.org/I87048295 |
| authorships[1].affiliations[0].raw_affiliation_string | University of Cambridge, Cambridge Institute for Medical Research (CIMR), the Wellcome Trust MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0XY, UK. |
| authorships[1].institutions[0].id | https://openalex.org/I4389425352 |
| authorships[1].institutions[0].ror | https://ror.org/05m8dr349 |
| authorships[1].institutions[0].type | facility |
| authorships[1].institutions[0].lineage | https://openalex.org/I241749, https://openalex.org/I2802466933, https://openalex.org/I34931013, https://openalex.org/I4389425352 |
| authorships[1].institutions[0].country_code | |
| authorships[1].institutions[0].display_name | NIHR Cambridge Biomedical Research Centre |
| authorships[1].institutions[1].id | https://openalex.org/I241749 |
| authorships[1].institutions[1].ror | https://ror.org/013meh722 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I241749 |
| authorships[1].institutions[1].country_code | GB |
| authorships[1].institutions[1].display_name | University of Cambridge |
| authorships[1].institutions[2].id | https://openalex.org/I87048295 |
| authorships[1].institutions[2].ror | https://ror.org/029chgv08 |
| authorships[1].institutions[2].type | nonprofit |
| authorships[1].institutions[2].lineage | https://openalex.org/I87048295 |
| authorships[1].institutions[2].country_code | GB |
| authorships[1].institutions[2].display_name | Wellcome Trust |
| authorships[1].institutions[3].id | https://openalex.org/I4210116691 |
| authorships[1].institutions[3].ror | https://ror.org/0264dxb48 |
| authorships[1].institutions[3].type | facility |
| authorships[1].institutions[3].lineage | https://openalex.org/I241749, https://openalex.org/I2802466933, https://openalex.org/I4210087105, https://openalex.org/I4210116691, https://openalex.org/I87048295, https://openalex.org/I90344618 |
| authorships[1].institutions[3].country_code | GB |
| authorships[1].institutions[3].display_name | Wellcome/MRC Institute of Metabolic Science |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Alisa Zyryanova |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | University of Cambridge, Cambridge Institute for Medical Research (CIMR), the Wellcome Trust MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0XY, UK. |
| authorships[2].author.id | https://openalex.org/A5025998272 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-7230-3188 |
| authorships[2].author.display_name | Ana Crespillo-Casado |
| authorships[2].countries | GB |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I241749, https://openalex.org/I4210116691, https://openalex.org/I4389425352, https://openalex.org/I87048295 |
| authorships[2].affiliations[0].raw_affiliation_string | University of Cambridge, Cambridge Institute for Medical Research (CIMR), the Wellcome Trust MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0XY, UK. |
| authorships[2].institutions[0].id | https://openalex.org/I4389425352 |
| authorships[2].institutions[0].ror | https://ror.org/05m8dr349 |
| authorships[2].institutions[0].type | facility |
| authorships[2].institutions[0].lineage | https://openalex.org/I241749, https://openalex.org/I2802466933, https://openalex.org/I34931013, https://openalex.org/I4389425352 |
| authorships[2].institutions[0].country_code | |
| authorships[2].institutions[0].display_name | NIHR Cambridge Biomedical Research Centre |
| authorships[2].institutions[1].id | https://openalex.org/I241749 |
| authorships[2].institutions[1].ror | https://ror.org/013meh722 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I241749 |
| authorships[2].institutions[1].country_code | GB |
| authorships[2].institutions[1].display_name | University of Cambridge |
| authorships[2].institutions[2].id | https://openalex.org/I87048295 |
| authorships[2].institutions[2].ror | https://ror.org/029chgv08 |
| authorships[2].institutions[2].type | nonprofit |
| authorships[2].institutions[2].lineage | https://openalex.org/I87048295 |
| authorships[2].institutions[2].country_code | GB |
| authorships[2].institutions[2].display_name | Wellcome Trust |
| authorships[2].institutions[3].id | https://openalex.org/I4210116691 |
| authorships[2].institutions[3].ror | https://ror.org/0264dxb48 |
| authorships[2].institutions[3].type | facility |
| authorships[2].institutions[3].lineage | https://openalex.org/I241749, https://openalex.org/I2802466933, https://openalex.org/I4210087105, https://openalex.org/I4210116691, https://openalex.org/I87048295, https://openalex.org/I90344618 |
| authorships[2].institutions[3].country_code | GB |
| authorships[2].institutions[3].display_name | Wellcome/MRC Institute of Metabolic Science |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Ana Crespillo-Casado |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | University of Cambridge, Cambridge Institute for Medical Research (CIMR), the Wellcome Trust MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0XY, UK. |
| authorships[3].author.id | https://openalex.org/A5041852883 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-5866-9271 |
| authorships[3].author.display_name | Peter M. Fischer |
| authorships[3].countries | GB |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I142263535 |
| authorships[3].affiliations[0].raw_affiliation_string | Division of Medicinal Chemistry and Structural Biology, School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK. |
| authorships[3].institutions[0].id | https://openalex.org/I142263535 |
| authorships[3].institutions[0].ror | https://ror.org/01ee9ar58 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I142263535 |
| authorships[3].institutions[0].country_code | GB |
| authorships[3].institutions[0].display_name | University of Nottingham |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Peter M. Fischer |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Division of Medicinal Chemistry and Structural Biology, School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK. |
| authorships[4].author.id | https://openalex.org/A5010360422 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-7359-7974 |
| authorships[4].author.display_name | Heather P. Harding |
| authorships[4].countries | GB |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I241749, https://openalex.org/I4210116691, https://openalex.org/I4389425352, https://openalex.org/I87048295 |
| authorships[4].affiliations[0].raw_affiliation_string | University of Cambridge, Cambridge Institute for Medical Research (CIMR), the Wellcome Trust MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0XY, UK. |
| authorships[4].institutions[0].id | https://openalex.org/I4389425352 |
| authorships[4].institutions[0].ror | https://ror.org/05m8dr349 |
| authorships[4].institutions[0].type | facility |
| authorships[4].institutions[0].lineage | https://openalex.org/I241749, https://openalex.org/I2802466933, https://openalex.org/I34931013, https://openalex.org/I4389425352 |
| authorships[4].institutions[0].country_code | |
| authorships[4].institutions[0].display_name | NIHR Cambridge Biomedical Research Centre |
| authorships[4].institutions[1].id | https://openalex.org/I241749 |
| authorships[4].institutions[1].ror | https://ror.org/013meh722 |
| authorships[4].institutions[1].type | education |
| authorships[4].institutions[1].lineage | https://openalex.org/I241749 |
| authorships[4].institutions[1].country_code | GB |
| authorships[4].institutions[1].display_name | University of Cambridge |
| authorships[4].institutions[2].id | https://openalex.org/I87048295 |
| authorships[4].institutions[2].ror | https://ror.org/029chgv08 |
| authorships[4].institutions[2].type | nonprofit |
| authorships[4].institutions[2].lineage | https://openalex.org/I87048295 |
| authorships[4].institutions[2].country_code | GB |
| authorships[4].institutions[2].display_name | Wellcome Trust |
| authorships[4].institutions[3].id | https://openalex.org/I4210116691 |
| authorships[4].institutions[3].ror | https://ror.org/0264dxb48 |
| authorships[4].institutions[3].type | facility |
| authorships[4].institutions[3].lineage | https://openalex.org/I241749, https://openalex.org/I2802466933, https://openalex.org/I4210087105, https://openalex.org/I4210116691, https://openalex.org/I87048295, https://openalex.org/I90344618 |
| authorships[4].institutions[3].country_code | GB |
| authorships[4].institutions[3].display_name | Wellcome/MRC Institute of Metabolic Science |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Heather P. Harding |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | University of Cambridge, Cambridge Institute for Medical Research (CIMR), the Wellcome Trust MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0XY, UK. |
| authorships[5].author.id | https://openalex.org/A5077934127 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-3014-5636 |
| authorships[5].author.display_name | David Ron |
| authorships[5].countries | GB |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I241749, https://openalex.org/I4210116691, https://openalex.org/I4389425352, https://openalex.org/I87048295 |
| authorships[5].affiliations[0].raw_affiliation_string | University of Cambridge, Cambridge Institute for Medical Research (CIMR), the Wellcome Trust MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0XY, UK. |
| authorships[5].institutions[0].id | https://openalex.org/I4389425352 |
| authorships[5].institutions[0].ror | https://ror.org/05m8dr349 |
| authorships[5].institutions[0].type | facility |
| authorships[5].institutions[0].lineage | https://openalex.org/I241749, https://openalex.org/I2802466933, https://openalex.org/I34931013, https://openalex.org/I4389425352 |
| authorships[5].institutions[0].country_code | |
| authorships[5].institutions[0].display_name | NIHR Cambridge Biomedical Research Centre |
| authorships[5].institutions[1].id | https://openalex.org/I241749 |
| authorships[5].institutions[1].ror | https://ror.org/013meh722 |
| authorships[5].institutions[1].type | education |
| authorships[5].institutions[1].lineage | https://openalex.org/I241749 |
| authorships[5].institutions[1].country_code | GB |
| authorships[5].institutions[1].display_name | University of Cambridge |
| authorships[5].institutions[2].id | https://openalex.org/I87048295 |
| authorships[5].institutions[2].ror | https://ror.org/029chgv08 |
| authorships[5].institutions[2].type | nonprofit |
| authorships[5].institutions[2].lineage | https://openalex.org/I87048295 |
| authorships[5].institutions[2].country_code | GB |
| authorships[5].institutions[2].display_name | Wellcome Trust |
| authorships[5].institutions[3].id | https://openalex.org/I4210116691 |
| authorships[5].institutions[3].ror | https://ror.org/0264dxb48 |
| authorships[5].institutions[3].type | facility |
| authorships[5].institutions[3].lineage | https://openalex.org/I241749, https://openalex.org/I2802466933, https://openalex.org/I4210087105, https://openalex.org/I4210116691, https://openalex.org/I87048295, https://openalex.org/I90344618 |
| authorships[5].institutions[3].country_code | GB |
| authorships[5].institutions[3].display_name | Wellcome/MRC Institute of Metabolic Science |
| authorships[5].author_position | last |
| authorships[5].raw_author_name | David Ron |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | University of Cambridge, Cambridge Institute for Medical Research (CIMR), the Wellcome Trust MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0XY, UK. |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.science.org/cms/asset/9904afd8-725e-42a8-a6e1-5023b4ac3b8d/pap.pdf |
| open_access.oa_status | bronze |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Mutations in a translation initiation factor identify the target of a memory-enhancing compound |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11150 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1307 |
| primary_topic.subfield.display_name | Cell Biology |
| primary_topic.display_name | Endoplasmic Reticulum Stress and Disease |
| related_works | https://openalex.org/W4244792731, https://openalex.org/W4240290525, https://openalex.org/W2948805793, https://openalex.org/W2337516890, https://openalex.org/W4297537233, https://openalex.org/W2905658793, https://openalex.org/W2163944965, https://openalex.org/W2128729736, https://openalex.org/W132148142, https://openalex.org/W2396457105 |
| cited_by_count | 228 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 16 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 16 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 14 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 10 |
| counts_by_year[4].year | 2021 |
| counts_by_year[4].cited_by_count | 22 |
| counts_by_year[5].year | 2020 |
| counts_by_year[5].cited_by_count | 26 |
| counts_by_year[6].year | 2019 |
| counts_by_year[6].cited_by_count | 32 |
| counts_by_year[7].year | 2018 |
| counts_by_year[7].cited_by_count | 31 |
| counts_by_year[8].year | 2017 |
| counts_by_year[8].cited_by_count | 24 |
| counts_by_year[9].year | 2016 |
| counts_by_year[9].cited_by_count | 26 |
| counts_by_year[10].year | 2015 |
| counts_by_year[10].cited_by_count | 11 |
| locations_count | 4 |
| best_oa_location.id | doi:10.1126/science.aaa6986 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S3880285 |
| best_oa_location.source.issn | 0036-8075, 1095-9203 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 0036-8075 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Science |
| best_oa_location.source.host_organization | https://openalex.org/P4310315823 |
| best_oa_location.source.host_organization_name | American Association for the Advancement of Science |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310315823 |
| best_oa_location.source.host_organization_lineage_names | American Association for the Advancement of Science |
| best_oa_location.license | |
| best_oa_location.pdf_url | https://www.science.org/cms/asset/9904afd8-725e-42a8-a6e1-5023b4ac3b8d/pap.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Science |
| best_oa_location.landing_page_url | https://doi.org/10.1126/science.aaa6986 |
| primary_location.id | doi:10.1126/science.aaa6986 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S3880285 |
| primary_location.source.issn | 0036-8075, 1095-9203 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0036-8075 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Science |
| primary_location.source.host_organization | https://openalex.org/P4310315823 |
| primary_location.source.host_organization_name | American Association for the Advancement of Science |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310315823 |
| primary_location.source.host_organization_lineage_names | American Association for the Advancement of Science |
| primary_location.license | |
| primary_location.pdf_url | https://www.science.org/cms/asset/9904afd8-725e-42a8-a6e1-5023b4ac3b8d/pap.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Science |
| primary_location.landing_page_url | https://doi.org/10.1126/science.aaa6986 |
| publication_date | 2015-04-10 |
| publication_year | 2015 |
| referenced_works | https://openalex.org/W2131632095, https://openalex.org/W2118337461, https://openalex.org/W1991999080, https://openalex.org/W2050733310, https://openalex.org/W2010378562, https://openalex.org/W2067040999, https://openalex.org/W2002378374, https://openalex.org/W2161371655, https://openalex.org/W2057635096, https://openalex.org/W2097918049, https://openalex.org/W2410169568, https://openalex.org/W2118337893, https://openalex.org/W2099571525, https://openalex.org/W2093158584, https://openalex.org/W2100472948, https://openalex.org/W2129532016, https://openalex.org/W2165702516, https://openalex.org/W2149112086, https://openalex.org/W2080448503, https://openalex.org/W2102049218, https://openalex.org/W2143258175, https://openalex.org/W1969882218, https://openalex.org/W2079838847, https://openalex.org/W1535827761, https://openalex.org/W2130005269, https://openalex.org/W1977709885, https://openalex.org/W2068854526, https://openalex.org/W2101386223, https://openalex.org/W2013647364, https://openalex.org/W2162076197, https://openalex.org/W645770732, https://openalex.org/W1964184380 |
| referenced_works_count | 32 |
| abstract_inverted_index., | 122 |
| abstract_inverted_index.; | 127 |
| abstract_inverted_index.a | 2, 8, 37, 78, 102, 106 |
| abstract_inverted_index.be | 115 |
| abstract_inverted_index.by | 93 |
| abstract_inverted_index.et | 60 |
| abstract_inverted_index.in | 105 |
| abstract_inverted_index.is | 7, 35 |
| abstract_inverted_index.of | 1, 11, 21, 25, 30, 56, 70, 76, 88, 110 |
| abstract_inverted_index.on | 73 |
| abstract_inverted_index.p. | 125, 130 |
| abstract_inverted_index.to | 114 |
| abstract_inverted_index.967 | 131 |
| abstract_inverted_index.The | 95 |
| abstract_inverted_index.act | 54 |
| abstract_inverted_index.al. | 61 |
| abstract_inverted_index.and | 27, 51, 100 |
| abstract_inverted_index.for | 40, 117 |
| abstract_inverted_index.its | 85 |
| abstract_inverted_index.not | 47 |
| abstract_inverted_index.now | 62 |
| abstract_inverted_index.see | 128 |
| abstract_inverted_index.the | 12, 19, 67, 74, 91, 118 |
| abstract_inverted_index.(see | 90 |
| abstract_inverted_index.1027 | 126 |
| abstract_inverted_index.also | 36, 129 |
| abstract_inverted_index.does | 46 |
| abstract_inverted_index.drug | 4, 39 |
| abstract_inverted_index.must | 52 |
| abstract_inverted_index.that | 64, 112 |
| abstract_inverted_index.this | 57, 123 |
| abstract_inverted_index.ISRIB | 6, 34, 45, 65 |
| abstract_inverted_index.cells | 99 |
| abstract_inverted_index.issue | 124 |
| abstract_inverted_index.short | 107 |
| abstract_inverted_index.step. | 58 |
| abstract_inverted_index.which | 17 |
| abstract_inverted_index.(ISR), | 16 |
| abstract_inverted_index.Sekine | 59 |
| abstract_inverted_index.eIF2B, | 77 |
| abstract_inverted_index.eIF2α | 49, 71 |
| abstract_inverted_index.effect | 69 |
| abstract_inverted_index.global | 31 |
| abstract_inverted_index.lesion | 104 |
| abstract_inverted_index.memory | 3, 43 |
| abstract_inverted_index.potent | 9 |
| abstract_inverted_index.region | 109 |
| abstract_inverted_index.report | 63 |
| abstract_inverted_index.stress | 14 |
| abstract_inverted_index.target | 5 |
| abstract_inverted_index.Science | 121 |
| abstract_inverted_index.appears | 113 |
| abstract_inverted_index.authors | 96 |
| abstract_inverted_index.certain | 42 |
| abstract_inverted_index.eIF2Bδ | 111 |
| abstract_inverted_index.eIF2α, | 26 |
| abstract_inverted_index.factor, | 83 |
| abstract_inverted_index.genetic | 103 |
| abstract_inverted_index.guanine | 80 |
| abstract_inverted_index.levels. | 33 |
| abstract_inverted_index.prevent | 48 |
| abstract_inverted_index.activity | 75, 86 |
| abstract_inverted_index.exchange | 82 |
| abstract_inverted_index.involves | 18 |
| abstract_inverted_index.isolated | 97 |
| abstract_inverted_index.kinases, | 23 |
| abstract_inverted_index.observed | 119 |
| abstract_inverted_index.response | 15 |
| abstract_inverted_index.reverses | 66 |
| abstract_inverted_index.treating | 41 |
| abstract_inverted_index.candidate | 38 |
| abstract_inverted_index.dedicated | 79 |
| abstract_inverted_index.enhancing | 84 |
| abstract_inverted_index.inhibitor | 10 |
| abstract_inverted_index.therefore | 53 |
| abstract_inverted_index.N-terminal | 108 |
| abstract_inverted_index.activation | 20 |
| abstract_inverted_index.consequent | 28 |
| abstract_inverted_index.disorders. | 44 |
| abstract_inverted_index.downstream | 55 |
| abstract_inverted_index.identified | 101 |
| abstract_inverted_index.inhibitory | 68 |
| abstract_inverted_index.integrated | 13 |
| abstract_inverted_index.nucleotide | 81 |
| abstract_inverted_index.phenotype. | 120 |
| abstract_inverted_index.Perspective | 92 |
| abstract_inverted_index.responsible | 116 |
| abstract_inverted_index.translation | 32 |
| abstract_inverted_index.Hinnebusch). | 94 |
| abstract_inverted_index.independently | 87 |
| abstract_inverted_index.Identification | 0 |
| abstract_inverted_index.ISRIB-resistant | 98 |
| abstract_inverted_index.down-regulation | 29 |
| abstract_inverted_index.eIF2α-specific | 22 |
| abstract_inverted_index.phosphorylation | 24, 50, 72, 89 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 99 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 6 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8299999833106995 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.99466018 |
| citation_normalized_percentile.is_in_top_1_percent | True |
| citation_normalized_percentile.is_in_top_10_percent | True |