Myelin Basic Protein Regulates Primitive and Definitive Neural Stem Cell Proliferation from the Adult Spinal Cord Article Swipe

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Wenjun Xu , Nadia Sachewsky , Ashkan Azimi , Maurita Hung , Andrew Gappasov , Cindi M. Morshead ·

YOU? · · 2016 · Open Access · · DOI: https://doi.org/10.1002/stem.2488

The adult mammalian forebrain comprises two distinct populations of neural stem cells (NSCs): rare, Oct4 positive, primitive NSCs (pNSCs) and definitive NSC (dNSC) which are more abundant and express GFAP. The pNSCs are upstream of the dNSCs in the neural stem cell lineage. Herein we show that pNSC and dNSC populations can also be isolated from the developing and adult spinal cord. Spinal cord derived pNSCs are similarly rare, Oct4 expressing cells that are responsive to leukemia inhibitory factor and dNSCs are 4-5X more abundant and express GFAP. We demonstrate that myelin basic protein (MBP) is inhibitory to both pNSC and dNSC derived colony formation. Similar to what is seen in the adult forebrain following injury, spinal cord injury results in a significant increase in the size of the dNSC and pNSC pools. Hence, both primitive and definitive neural stem cells can be isolated from along the embryonic and adult neuraxis in vivo and their behavior is regulated by MBP and injury.

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Biology Neural stem cell Forebrain Stem cell Spinal cord Cell biology Embryonic stem cell Adult stem cell Myelin Spinal cord injury Myelin basic protein Anatomy Neuroscience Central nervous system Genetics Gene

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Type: article
Language: en
Landing Page: https://doi.org/10.1002/stem.2488
PDF: https://stemcellsjournals.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/stem.2488
OA Status: bronze
Cited By: 23
References: 49
Related Works: 10
OpenAlex ID: https://openalex.org/W2515569276

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DOI: https://doi.org/10.1002/stem.2488

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Title: Myelin Basic Protein Regulates Primitive and Definitive Neural Stem Cell Proliferation from the Adult Spinal Cord

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Type: article

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Language: en

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Publication year: 2016

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Publication date: 2016-08-30

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Authors: Wenjun Xu, Nadia Sachewsky, Ashkan Azimi, Maurita Hung, Andrew Gappasov, Cindi M. Morshead

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Landing page: https://doi.org/10.1002/stem.2488

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Concepts: Biology, Neural stem cell, Forebrain, Stem cell, Spinal cord, Cell biology, Embryonic stem cell, Adult stem cell, Myelin, Spinal cord injury, Myelin basic protein, Anatomy, Neuroscience, Central nervous system, Genetics, Gene

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Cited by: 23

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