Myeloperoxidase impairs mucociliary transport on human airway epithelium Article Swipe
Allison Boboltz
,
Vaidehi Rathi
,
Sahana Kumar
,
Gregg A. Duncan
,
Gregg A. Duncan
,
Allison Boboltz
,
Vaidehi Rathi
,
Sahana Kumar
,
Gregg A. Duncan
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.11.17.688903
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.11.17.688903
Dampening neutrophil-driven inflammation in the airways remains a challenge in treating cystic fibrosis (CF) lung disease. Myeloperoxidase (MPO) is a neutrophilic enzyme that produces reactive oxygen species and is highly concentrated in CF sputum samples. Greater MPO concentrations have been previously correlated with increased mucus plugging in bronchiectasis, suggesting that the enzyme could impair mucociliary transport. MPO reacts competitively with either thiocyanate (SCN - ) or chloride (Cl - ) in the airways to catalyze the production of hypothiocyanous acid (HOSCN) or hypochlorous acid (HOCl), respectively. HOCl has proved in prior studies to be extremely cytotoxic, while HOSCN can drastically reduce cytotoxicity. The concentration of SCN - in the airways is largely dependent on transport by the cystic fibrosis transmembrane conductance regulator (CFTR) protein, which is dysfunctional in individuals with CF and causes low SCN - concentrations. CFTR modulator therapies likely raise the concentration of SCN - and enhance the production of HOSCN in the airways. We found that MPO inhibits mucociliary transport in vitro in regardless of SCN - concentrations primarily due to increasing the macromolecular components and effective viscosity of airway surface liquid. The impairment of mucus clearance by MPO was similar to neutrophil elastase (NE), another neutrophilic granular enzyme that damages the host tissues and induces the secretion of mucin proteins by the airway epithelium. Overall, these findings identify MPO as a therapeutic target to resolve deficits in airway clearance function in CF and other related muco-obstructive lung diseases.
Related Topics
Concepts
Cystic fibrosis
Myeloperoxidase
Mucociliary clearance
Mucus
Chemistry
Cystic fibrosis transmembrane conductance regulator
Mucin
Respiratory epithelium
Hypochlorous acid
Elastase
Lung
Neutrophil elastase
Airway
Sputum
Inflammation
Immunology
Biochemistry
Enzyme
Secretion
Reactive oxygen species
Granulocyte
Apyrase
Epithelium
Intracellular
Cell biology
Transmembrane protein
Fibrosis
Respiratory system
Metadata
- Type
- article
- Landing Page
- https://doi.org/10.1101/2025.11.17.688903
- https://www.biorxiv.org/content/biorxiv/early/2025/11/18/2025.11.17.688903.full.pdf
- OA Status
- green
- References
- 56
- OpenAlex ID
- https://openalex.org/W7105885965
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W7105885965Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2025.11.17.688903Digital Object Identifier
- Title
-
Myeloperoxidase impairs mucociliary transport on human airway epitheliumWork title
- Type
-
articleOpenAlex work type
- Publication year
-
2025Year of publication
- Publication date
-
2025-11-18Full publication date if available
- Authors
-
Allison Boboltz, Vaidehi Rathi, Sahana Kumar, Gregg A. Duncan, Gregg A. Duncan, Allison Boboltz, Vaidehi Rathi, Sahana Kumar, Gregg A. DuncanList of authors in order
- Landing page
-
https://doi.org/10.1101/2025.11.17.688903Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2025/11/18/2025.11.17.688903.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2025/11/18/2025.11.17.688903.full.pdfDirect OA link when available
- Concepts
-
Cystic fibrosis, Myeloperoxidase, Mucociliary clearance, Mucus, Chemistry, Cystic fibrosis transmembrane conductance regulator, Mucin, Respiratory epithelium, Hypochlorous acid, Elastase, Lung, Neutrophil elastase, Airway, Sputum, Inflammation, Immunology, Biochemistry, Enzyme, Secretion, Reactive oxygen species, Granulocyte, Apyrase, Epithelium, Intracellular, Cell biology, Transmembrane protein, Fibrosis, Respiratory systemTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
56Number of works referenced by this work
Full payload
| id | https://openalex.org/W7105885965 |
|---|---|
| doi | https://doi.org/10.1101/2025.11.17.688903 |
| ids.doi | https://doi.org/10.1101/2025.11.17.688903 |
| ids.openalex | https://openalex.org/W7105885965 |
| fwci | 0.0 |
| type | article |
| title | Myeloperoxidase impairs mucociliary transport on human airway epithelium |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T11597 |
| topics[0].field.id | https://openalex.org/fields/24 |
| topics[0].field.display_name | Immunology and Microbiology |
| topics[0].score | 0.6774945855140686 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2403 |
| topics[0].subfield.display_name | Immunology |
| topics[0].display_name | Neutrophil, Myeloperoxidase and Oxidative Mechanisms |
| topics[1].id | https://openalex.org/T10665 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.1695118099451065 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2740 |
| topics[1].subfield.display_name | Pulmonary and Respiratory Medicine |
| topics[1].display_name | Cystic Fibrosis Research Advances |
| topics[2].id | https://openalex.org/T10051 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.018218206241726875 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2737 |
| topics[2].subfield.display_name | Physiology |
| topics[2].display_name | Asthma and respiratory diseases |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C2776938444 |
| concepts[0].level | 2 |
| concepts[0].score | 0.8663982152938843 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q178194 |
| concepts[0].display_name | Cystic fibrosis |
| concepts[1].id | https://openalex.org/C203565725 |
| concepts[1].level | 3 |
| concepts[1].score | 0.8389132618904114 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q420012 |
| concepts[1].display_name | Myeloperoxidase |
| concepts[2].id | https://openalex.org/C114682108 |
| concepts[2].level | 3 |
| concepts[2].score | 0.8343077898025513 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q1952044 |
| concepts[2].display_name | Mucociliary clearance |
| concepts[3].id | https://openalex.org/C2777312293 |
| concepts[3].level | 2 |
| concepts[3].score | 0.6967712044715881 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q3649349 |
| concepts[3].display_name | Mucus |
| concepts[4].id | https://openalex.org/C185592680 |
| concepts[4].level | 0 |
| concepts[4].score | 0.693565845489502 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[4].display_name | Chemistry |
| concepts[5].id | https://openalex.org/C2778428886 |
| concepts[5].level | 3 |
| concepts[5].score | 0.6474626660346985 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q420470 |
| concepts[5].display_name | Cystic fibrosis transmembrane conductance regulator |
| concepts[6].id | https://openalex.org/C179264091 |
| concepts[6].level | 2 |
| concepts[6].score | 0.548140823841095 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q410862 |
| concepts[6].display_name | Mucin |
| concepts[7].id | https://openalex.org/C87568996 |
| concepts[7].level | 3 |
| concepts[7].score | 0.5343960523605347 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q1428754 |
| concepts[7].display_name | Respiratory epithelium |
| concepts[8].id | https://openalex.org/C2780908991 |
| concepts[8].level | 2 |
| concepts[8].score | 0.5269762277603149 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q407318 |
| concepts[8].display_name | Hypochlorous acid |
| concepts[9].id | https://openalex.org/C2781044401 |
| concepts[9].level | 3 |
| concepts[9].score | 0.5269573330879211 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q418897 |
| concepts[9].display_name | Elastase |
| concepts[10].id | https://openalex.org/C2777714996 |
| concepts[10].level | 2 |
| concepts[10].score | 0.5211395025253296 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q7886 |
| concepts[10].display_name | Lung |
| concepts[11].id | https://openalex.org/C2776317360 |
| concepts[11].level | 3 |
| concepts[11].score | 0.45465314388275146 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q14905648 |
| concepts[11].display_name | Neutrophil elastase |
| concepts[12].id | https://openalex.org/C105922876 |
| concepts[12].level | 2 |
| concepts[12].score | 0.4502154290676117 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q1423981 |
| concepts[12].display_name | Airway |
| concepts[13].id | https://openalex.org/C2776301714 |
| concepts[13].level | 3 |
| concepts[13].score | 0.4312289357185364 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q259346 |
| concepts[13].display_name | Sputum |
| concepts[14].id | https://openalex.org/C2776914184 |
| concepts[14].level | 2 |
| concepts[14].score | 0.408392995595932 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q101991 |
| concepts[14].display_name | Inflammation |
| concepts[15].id | https://openalex.org/C203014093 |
| concepts[15].level | 1 |
| concepts[15].score | 0.39132454991340637 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[15].display_name | Immunology |
| concepts[16].id | https://openalex.org/C55493867 |
| concepts[16].level | 1 |
| concepts[16].score | 0.3662929832935333 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[16].display_name | Biochemistry |
| concepts[17].id | https://openalex.org/C181199279 |
| concepts[17].level | 2 |
| concepts[17].score | 0.36289817094802856 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q8047 |
| concepts[17].display_name | Enzyme |
| concepts[18].id | https://openalex.org/C49039625 |
| concepts[18].level | 2 |
| concepts[18].score | 0.3583064079284668 |
| concepts[18].wikidata | https://www.wikidata.org/wiki/Q84230 |
| concepts[18].display_name | Secretion |
| concepts[19].id | https://openalex.org/C48349386 |
| concepts[19].level | 2 |
| concepts[19].score | 0.3400432765483856 |
| concepts[19].wikidata | https://www.wikidata.org/wiki/Q424361 |
| concepts[19].display_name | Reactive oxygen species |
| concepts[20].id | https://openalex.org/C2777983669 |
| concepts[20].level | 2 |
| concepts[20].score | 0.33415457606315613 |
| concepts[20].wikidata | https://www.wikidata.org/wiki/Q223143 |
| concepts[20].display_name | Granulocyte |
| concepts[21].id | https://openalex.org/C2779508331 |
| concepts[21].level | 3 |
| concepts[21].score | 0.3225466012954712 |
| concepts[21].wikidata | https://www.wikidata.org/wiki/Q24770179 |
| concepts[21].display_name | Apyrase |
| concepts[22].id | https://openalex.org/C529295009 |
| concepts[22].level | 2 |
| concepts[22].score | 0.31644871830940247 |
| concepts[22].wikidata | https://www.wikidata.org/wiki/Q41301 |
| concepts[22].display_name | Epithelium |
| concepts[23].id | https://openalex.org/C79879829 |
| concepts[23].level | 2 |
| concepts[23].score | 0.2915782630443573 |
| concepts[23].wikidata | https://www.wikidata.org/wiki/Q5571762 |
| concepts[23].display_name | Intracellular |
| concepts[24].id | https://openalex.org/C95444343 |
| concepts[24].level | 1 |
| concepts[24].score | 0.27746593952178955 |
| concepts[24].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[24].display_name | Cell biology |
| concepts[25].id | https://openalex.org/C24530287 |
| concepts[25].level | 3 |
| concepts[25].score | 0.27245450019836426 |
| concepts[25].wikidata | https://www.wikidata.org/wiki/Q424204 |
| concepts[25].display_name | Transmembrane protein |
| concepts[26].id | https://openalex.org/C2780559512 |
| concepts[26].level | 2 |
| concepts[26].score | 0.26176226139068604 |
| concepts[26].wikidata | https://www.wikidata.org/wiki/Q605709 |
| concepts[26].display_name | Fibrosis |
| concepts[27].id | https://openalex.org/C534529494 |
| concepts[27].level | 2 |
| concepts[27].score | 0.2552557587623596 |
| concepts[27].wikidata | https://www.wikidata.org/wiki/Q7891 |
| concepts[27].display_name | Respiratory system |
| keywords[0].id | https://openalex.org/keywords/cystic-fibrosis |
| keywords[0].score | 0.8663982152938843 |
| keywords[0].display_name | Cystic fibrosis |
| keywords[1].id | https://openalex.org/keywords/myeloperoxidase |
| keywords[1].score | 0.8389132618904114 |
| keywords[1].display_name | Myeloperoxidase |
| keywords[2].id | https://openalex.org/keywords/mucociliary-clearance |
| keywords[2].score | 0.8343077898025513 |
| keywords[2].display_name | Mucociliary clearance |
| keywords[3].id | https://openalex.org/keywords/mucus |
| keywords[3].score | 0.6967712044715881 |
| keywords[3].display_name | Mucus |
| keywords[4].id | https://openalex.org/keywords/cystic-fibrosis-transmembrane-conductance-regulator |
| keywords[4].score | 0.6474626660346985 |
| keywords[4].display_name | Cystic fibrosis transmembrane conductance regulator |
| keywords[5].id | https://openalex.org/keywords/mucin |
| keywords[5].score | 0.548140823841095 |
| keywords[5].display_name | Mucin |
| keywords[6].id | https://openalex.org/keywords/respiratory-epithelium |
| keywords[6].score | 0.5343960523605347 |
| keywords[6].display_name | Respiratory epithelium |
| keywords[7].id | https://openalex.org/keywords/hypochlorous-acid |
| keywords[7].score | 0.5269762277603149 |
| keywords[7].display_name | Hypochlorous acid |
| keywords[8].id | https://openalex.org/keywords/elastase |
| keywords[8].score | 0.5269573330879211 |
| keywords[8].display_name | Elastase |
| language | |
| locations[0].id | doi:10.1101/2025.11.17.688903 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4306402567 |
| locations[0].source.issn | |
| locations[0].source.type | repository |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | |
| locations[0].source.is_core | False |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| locations[0].source.host_organization | https://openalex.org/I2750212522 |
| locations[0].source.host_organization_name | Cold Spring Harbor Laboratory |
| locations[0].source.host_organization_lineage | https://openalex.org/I2750212522 |
| locations[0].license | cc-by-nc |
| locations[0].pdf_url | https://www.biorxiv.org/content/biorxiv/early/2025/11/18/2025.11.17.688903.full.pdf |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.1101/2025.11.17.688903 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A4309959145 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-4203-5928 |
| authorships[0].author.display_name | Allison Boboltz |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I66946132 |
| authorships[0].affiliations[0].raw_affiliation_string | University of Maryland at College Park |
| authorships[0].institutions[0].id | https://openalex.org/I66946132 |
| authorships[0].institutions[0].ror | https://ror.org/https://ror.org/047s2c258 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I66946132 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | University of Maryland, College Park |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Allison Boboltz |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | University of Maryland at College Park |
| authorships[1].author.id | https://openalex.org/A5117391476 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Vaidehi Rathi |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I66946132 |
| authorships[1].affiliations[0].raw_affiliation_string | University of Maryland at College Park |
| authorships[1].institutions[0].id | https://openalex.org/I66946132 |
| authorships[1].institutions[0].ror | https://ror.org/https://ror.org/047s2c258 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I66946132 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | University of Maryland, College Park |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Vaidehi Rathi |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | University of Maryland at College Park |
| authorships[2].author.id | https://openalex.org/A2766010464 |
| authorships[2].author.orcid | https://orcid.org/0000-0001-8367-7591 |
| authorships[2].author.display_name | Sahana Kumar |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I66946132 |
| authorships[2].affiliations[0].raw_affiliation_string | University of Maryland at College Park |
| authorships[2].institutions[0].id | https://openalex.org/I66946132 |
| authorships[2].institutions[0].ror | https://ror.org/https://ror.org/047s2c258 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I66946132 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | University of Maryland, College Park |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Sahana Kumar |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | University of Maryland at College Park |
| authorships[3].author.id | https://openalex.org/A2114997640 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-6811-1327 |
| authorships[3].author.display_name | Gregg A. Duncan |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I66946132 |
| authorships[3].affiliations[0].raw_affiliation_string | University of Maryland at College Park |
| authorships[3].institutions[0].id | https://openalex.org/I66946132 |
| authorships[3].institutions[0].ror | https://ror.org/https://ror.org/047s2c258 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I66946132 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | University of Maryland, College Park |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Gregg A. Duncan |
| authorships[3].is_corresponding | True |
| authorships[3].raw_affiliation_strings | University of Maryland at College Park |
| authorships[4].author.id | https://openalex.org/A2114997640 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-6811-1327 |
| authorships[4].author.display_name | Gregg A. Duncan |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I66946132 |
| authorships[4].affiliations[0].raw_affiliation_string | University of Maryland at College Park |
| authorships[4].institutions[0].id | https://openalex.org/I66946132 |
| authorships[4].institutions[0].ror | https://ror.org/https://ror.org/047s2c258 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I66946132 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | University of Maryland, College Park |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Gregg A Duncan |
| authorships[4].is_corresponding | True |
| authorships[4].raw_affiliation_strings | University of Maryland at College Park |
| authorships[5].author.id | https://openalex.org/A4309959145 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-4203-5928 |
| authorships[5].author.display_name | Allison Boboltz |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Allison Boboltz |
| authorships[5].is_corresponding | False |
| authorships[6].author.id | https://openalex.org/A5117391476 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Vaidehi Rathi |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Vaidehi Rathi |
| authorships[6].is_corresponding | False |
| authorships[7].author.id | https://openalex.org/A2766010464 |
| authorships[7].author.orcid | https://orcid.org/0000-0001-8367-7591 |
| authorships[7].author.display_name | Sahana Kumar |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Sahana Kumar |
| authorships[7].is_corresponding | False |
| authorships[8].author.id | https://openalex.org/A2114997640 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-6811-1327 |
| authorships[8].author.display_name | Gregg A. Duncan |
| authorships[8].author_position | last |
| authorships[8].raw_author_name | Gregg A Duncan |
| authorships[8].is_corresponding | False |
| has_content.pdf | True |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.biorxiv.org/content/biorxiv/early/2025/11/18/2025.11.17.688903.full.pdf |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-11-18T00:00:00 |
| display_name | Myeloperoxidase impairs mucociliary transport on human airway epithelium |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-23T05:10:03.516525 |
| primary_topic.id | https://openalex.org/T11597 |
| primary_topic.field.id | https://openalex.org/fields/24 |
| primary_topic.field.display_name | Immunology and Microbiology |
| primary_topic.score | 0.6774945855140686 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2403 |
| primary_topic.subfield.display_name | Immunology |
| primary_topic.display_name | Neutrophil, Myeloperoxidase and Oxidative Mechanisms |
| cited_by_count | 0 |
| locations_count | 1 |
| best_oa_location.id | doi:10.1101/2025.11.17.688903 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4306402567 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| best_oa_location.source.host_organization | https://openalex.org/I2750212522 |
| best_oa_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| best_oa_location.license | cc-by-nc |
| best_oa_location.pdf_url | https://www.biorxiv.org/content/biorxiv/early/2025/11/18/2025.11.17.688903.full.pdf |
| best_oa_location.version | acceptedVersion |
| best_oa_location.raw_type | posted-content |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.1101/2025.11.17.688903 |
| primary_location.id | doi:10.1101/2025.11.17.688903 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4306402567 |
| primary_location.source.issn | |
| primary_location.source.type | repository |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | |
| primary_location.source.is_core | False |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| primary_location.source.host_organization | https://openalex.org/I2750212522 |
| primary_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| primary_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| primary_location.license | cc-by-nc |
| primary_location.pdf_url | https://www.biorxiv.org/content/biorxiv/early/2025/11/18/2025.11.17.688903.full.pdf |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.1101/2025.11.17.688903 |
| publication_date | 2025-11-18 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W4388120536, https://openalex.org/W1993373985, https://openalex.org/W3093959511, https://openalex.org/W2945205984, https://openalex.org/W2561617930, https://openalex.org/W2792366526, https://openalex.org/W2049527513, https://openalex.org/W2139417815, https://openalex.org/W1919879546, https://openalex.org/W2099168702, https://openalex.org/W2070256030, https://openalex.org/W1768117386, https://openalex.org/W1602489512, https://openalex.org/W4241759281, https://openalex.org/W4381853172, https://openalex.org/W4392055738, https://openalex.org/W2947002727, https://openalex.org/W4210526629, https://openalex.org/W4213206634, https://openalex.org/W3010302032, https://openalex.org/W2124843402, https://openalex.org/W2007415402, https://openalex.org/W2034006178, https://openalex.org/W2085700147, https://openalex.org/W1976040793, https://openalex.org/W2111118550, https://openalex.org/W2793332372, https://openalex.org/W2041277135, https://openalex.org/W2030723292, https://openalex.org/W2010872501, https://openalex.org/W2130318026, https://openalex.org/W2091633325, https://openalex.org/W4309958358, https://openalex.org/W4402797335, https://openalex.org/W2099547846, https://openalex.org/W1991281501, https://openalex.org/W2104928971, https://openalex.org/W2133361303, https://openalex.org/W2054704409, https://openalex.org/W2144292013, https://openalex.org/W2061065484, https://openalex.org/W2038327024, https://openalex.org/W2055347946, https://openalex.org/W1977725157, https://openalex.org/W4414311749, https://openalex.org/W2152495682, https://openalex.org/W2092177169, https://openalex.org/W4289755125, https://openalex.org/W3041944498, https://openalex.org/W3000701487, https://openalex.org/W2043293314, https://openalex.org/W4386476371, https://openalex.org/W4399772686, https://openalex.org/W4414351910, https://openalex.org/W2548660947, https://openalex.org/W2006947947 |
| referenced_works_count | 56 |
| abstract_inverted_index.) | 65, 70 |
| abstract_inverted_index.- | 64, 69, 107, 136, 147, 170 |
| abstract_inverted_index.a | 8, 20, 225 |
| abstract_inverted_index.CF | 33, 131, 236 |
| abstract_inverted_index.We | 157 |
| abstract_inverted_index.as | 224 |
| abstract_inverted_index.be | 94 |
| abstract_inverted_index.by | 116, 191, 215 |
| abstract_inverted_index.in | 4, 10, 32, 47, 71, 90, 108, 128, 154, 164, 166, 231, 235 |
| abstract_inverted_index.is | 19, 29, 111, 126 |
| abstract_inverted_index.of | 78, 105, 145, 152, 168, 182, 188, 212 |
| abstract_inverted_index.on | 114 |
| abstract_inverted_index.or | 66, 82 |
| abstract_inverted_index.to | 74, 93, 174, 195, 228 |
| abstract_inverted_index.(Cl | 68 |
| abstract_inverted_index.MPO | 37, 57, 160, 192, 223 |
| abstract_inverted_index.SCN | 106, 135, 146, 169 |
| abstract_inverted_index.The | 103, 186 |
| abstract_inverted_index.and | 28, 132, 148, 179, 208, 237 |
| abstract_inverted_index.can | 99 |
| abstract_inverted_index.due | 173 |
| abstract_inverted_index.has | 88 |
| abstract_inverted_index.low | 134 |
| abstract_inverted_index.the | 5, 51, 72, 76, 109, 117, 143, 150, 155, 176, 205, 210, 216 |
| abstract_inverted_index.was | 193 |
| abstract_inverted_index.(CF) | 14 |
| abstract_inverted_index.(SCN | 63 |
| abstract_inverted_index.CFTR | 138 |
| abstract_inverted_index.HOCl | 87 |
| abstract_inverted_index.acid | 80, 84 |
| abstract_inverted_index.been | 40 |
| abstract_inverted_index.have | 39 |
| abstract_inverted_index.host | 206 |
| abstract_inverted_index.lung | 15, 241 |
| abstract_inverted_index.that | 23, 50, 159, 203 |
| abstract_inverted_index.with | 43, 60, 130 |
| abstract_inverted_index.(MPO) | 18 |
| abstract_inverted_index.(NE), | 198 |
| abstract_inverted_index.HOSCN | 98, 153 |
| abstract_inverted_index.could | 53 |
| abstract_inverted_index.found | 158 |
| abstract_inverted_index.mucin | 213 |
| abstract_inverted_index.mucus | 45, 189 |
| abstract_inverted_index.other | 238 |
| abstract_inverted_index.prior | 91 |
| abstract_inverted_index.raise | 142 |
| abstract_inverted_index.these | 220 |
| abstract_inverted_index.vitro | 165 |
| abstract_inverted_index.which | 125 |
| abstract_inverted_index.while | 97 |
| abstract_inverted_index.(CFTR) | 123 |
| abstract_inverted_index.airway | 183, 217, 232 |
| abstract_inverted_index.causes | 133 |
| abstract_inverted_index.cystic | 12, 118 |
| abstract_inverted_index.either | 61 |
| abstract_inverted_index.enzyme | 22, 52, 202 |
| abstract_inverted_index.highly | 30 |
| abstract_inverted_index.impair | 54 |
| abstract_inverted_index.likely | 141 |
| abstract_inverted_index.oxygen | 26 |
| abstract_inverted_index.proved | 89 |
| abstract_inverted_index.reacts | 58 |
| abstract_inverted_index.reduce | 101 |
| abstract_inverted_index.sputum | 34 |
| abstract_inverted_index.target | 227 |
| abstract_inverted_index.(HOCl), | 85 |
| abstract_inverted_index.(HOSCN) | 81 |
| abstract_inverted_index.Greater | 36 |
| abstract_inverted_index.airways | 6, 73, 110 |
| abstract_inverted_index.another | 199 |
| abstract_inverted_index.damages | 204 |
| abstract_inverted_index.enhance | 149 |
| abstract_inverted_index.induces | 209 |
| abstract_inverted_index.largely | 112 |
| abstract_inverted_index.liquid. | 185 |
| abstract_inverted_index.related | 239 |
| abstract_inverted_index.remains | 7 |
| abstract_inverted_index.resolve | 229 |
| abstract_inverted_index.similar | 194 |
| abstract_inverted_index.species | 27 |
| abstract_inverted_index.studies | 92 |
| abstract_inverted_index.surface | 184 |
| abstract_inverted_index.tissues | 207 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Overall, | 219 |
| abstract_inverted_index.airways. | 156 |
| abstract_inverted_index.catalyze | 75 |
| abstract_inverted_index.chloride | 67 |
| abstract_inverted_index.deficits | 230 |
| abstract_inverted_index.disease. | 16 |
| abstract_inverted_index.elastase | 197 |
| abstract_inverted_index.fibrosis | 13, 119 |
| abstract_inverted_index.findings | 221 |
| abstract_inverted_index.function | 234 |
| abstract_inverted_index.granular | 201 |
| abstract_inverted_index.identify | 222 |
| abstract_inverted_index.inhibits | 161 |
| abstract_inverted_index.plugging | 46 |
| abstract_inverted_index.produces | 24 |
| abstract_inverted_index.protein, | 124 |
| abstract_inverted_index.proteins | 214 |
| abstract_inverted_index.reactive | 25 |
| abstract_inverted_index.samples. | 35 |
| abstract_inverted_index.treating | 11 |
| abstract_inverted_index.Dampening | 1 |
| abstract_inverted_index.challenge | 9 |
| abstract_inverted_index.clearance | 190, 233 |
| abstract_inverted_index.dependent | 113 |
| abstract_inverted_index.diseases. | 242 |
| abstract_inverted_index.effective | 180 |
| abstract_inverted_index.extremely | 95 |
| abstract_inverted_index.increased | 44 |
| abstract_inverted_index.modulator | 139 |
| abstract_inverted_index.primarily | 172 |
| abstract_inverted_index.regulator | 122 |
| abstract_inverted_index.secretion | 211 |
| abstract_inverted_index.therapies | 140 |
| abstract_inverted_index.transport | 115, 163 |
| abstract_inverted_index.viscosity | 181 |
| abstract_inverted_index.components | 178 |
| abstract_inverted_index.correlated | 42 |
| abstract_inverted_index.cytotoxic, | 96 |
| abstract_inverted_index.impairment | 187 |
| abstract_inverted_index.increasing | 175 |
| abstract_inverted_index.neutrophil | 196 |
| abstract_inverted_index.previously | 41 |
| abstract_inverted_index.production | 77, 151 |
| abstract_inverted_index.regardless | 167 |
| abstract_inverted_index.suggesting | 49 |
| abstract_inverted_index.transport. | 56 |
| abstract_inverted_index.conductance | 121 |
| abstract_inverted_index.drastically | 100 |
| abstract_inverted_index.epithelium. | 218 |
| abstract_inverted_index.individuals | 129 |
| abstract_inverted_index.mucociliary | 55, 162 |
| abstract_inverted_index.therapeutic | 226 |
| abstract_inverted_index.thiocyanate | 62 |
| abstract_inverted_index.concentrated | 31 |
| abstract_inverted_index.hypochlorous | 83 |
| abstract_inverted_index.inflammation | 3 |
| abstract_inverted_index.neutrophilic | 21, 200 |
| abstract_inverted_index.competitively | 59 |
| abstract_inverted_index.concentration | 104, 144 |
| abstract_inverted_index.cytotoxicity. | 102 |
| abstract_inverted_index.dysfunctional | 127 |
| abstract_inverted_index.respectively. | 86 |
| abstract_inverted_index.transmembrane | 120 |
| abstract_inverted_index.concentrations | 38, 171 |
| abstract_inverted_index.macromolecular | 177 |
| abstract_inverted_index.Myeloperoxidase | 17 |
| abstract_inverted_index.bronchiectasis, | 48 |
| abstract_inverted_index.concentrations. | 137 |
| abstract_inverted_index.hypothiocyanous | 79 |
| abstract_inverted_index.muco-obstructive | 240 |
| abstract_inverted_index.neutrophil-driven | 2 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| citation_normalized_percentile.value | 0.72048093 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |