Myocardial Ischemia-Reperfusion and Diabetes: Lessons Learned From Bedside to Bench Article Swipe
Maya Dia
,
Alexandre Paccalet
,
Bruno Pillot
,
Christelle Léon
,
Michel Ovize
,
Claire Crola Da Silva
,
Thomas Bochaton
,
M. Paillard
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fcvm.2021.660698
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fcvm.2021.660698
In front of the failure to translate from bench to bedside cardioprotective drugs against myocardial ischemia-reperfusion, research scientists are currently revising their animal models. Owing to its growing incidence nowadays, type 2 diabetes (T2D) represents one of the main risk factors of co-morbidities in myocardial infarction. However, discrepancies exist between reported animal and human studies. Our aim was here to compare the impact of diabetes on cell death after cardiac ischemia-reperfusion in a human cohort of ST-elevation myocardial infarction (STEMI) patients with a diet-induced mouse model of T2D, using a high-fat high-sucrose diet for 16 weeks (HFHSD). Interestingly, a small fraction (<14%) of patients undergoing a myocardial infarct were diabetic, but treated, and did not show a bigger infarct size when compared to non-diabetic patients. On the contrary, HFHSD mice displayed an increased infarct size after an in vivo cardiac ischemia-reperfusion, together with an increased cell death after an in vitro hypoxia-reoxygenation on isolated cardiomyocytes. To mimic the diabetic patients' medication profile, 6 weeks of oral gavage with Metformin was performed in the HFHSD mouse group. Metformin treatment of the HFHSD mice led to a similar extent of lower cell death after hypoxia-reoxygenation as in the standard diet group, compared to the HFHSD cardiomyocytes. Altogether, our data highlight that due to their potential protective effect, anti-diabetic medications should be included in pre-clinical study of cardioprotective approaches. Moreover, since diabetic patients represent only a minor fraction of the STEMI patients, diabetic animal models may not be the most suitable translatable model to humans, unlike aging that appears as a common feature of all infarcted patients.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fcvm.2021.660698
- https://www.frontiersin.org/articles/10.3389/fcvm.2021.660698/pdf
- OA Status
- gold
- Cited By
- 7
- References
- 26
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3148009538
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3148009538Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fcvm.2021.660698Digital Object Identifier
- Title
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Myocardial Ischemia-Reperfusion and Diabetes: Lessons Learned From Bedside to BenchWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
-
2021-03-26Full publication date if available
- Authors
-
Maya Dia, Alexandre Paccalet, Bruno Pillot, Christelle Léon, Michel Ovize, Claire Crola Da Silva, Thomas Bochaton, M. PaillardList of authors in order
- Landing page
-
https://doi.org/10.3389/fcvm.2021.660698Publisher landing page
- PDF URL
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https://www.frontiersin.org/articles/10.3389/fcvm.2021.660698/pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.frontiersin.org/articles/10.3389/fcvm.2021.660698/pdfDirect OA link when available
- Concepts
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Medicine, Myocardial infarction, Diabetes mellitus, Metformin, Ischemia, Cardiology, Cardioprotection, Internal medicine, Hypoxia (environmental), Infarction, Animal studies, Endocrinology, Chemistry, Organic chemistry, OxygenTop concepts (fields/topics) attached by OpenAlex
- Cited by
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7Total citation count in OpenAlex
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2025: 3, 2022: 4Per-year citation counts (last 5 years)
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26Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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