Myositis/Myasthenia after Pembrolizumab in a Bladder Cancer Patient with an Autoimmunity-Associated HLA: Immune–Biological Evaluation and Case Report Article Swipe
Cirino Botta
,
Rita Maria Agostino
,
Vincenzo Dattola
,
Vittoria Cianci
,
Natale Daniele Calandruccio
,
Giovanna Bianco
,
A. Mafodda
,
R. Maisano
,
Eleonora Iuliano
,
Giovanna Orizzonte
,
D Mazzacuva
,
A. Falzea
,
Rita Emilena Saladino
,
Rocco Giannicola
,
Giorgio Restifo
,
Umberto Aguglia
,
Michele Caraglia
,
Pierpaolo Correale
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/ijms22126246
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/ijms22126246
Pembrolizumab (mAb to PD-1) has been recently approved for the therapy of pretreated urothelial cancer. Despite the efficacy, it is often accompanied by unpredictable and sometime severe immune-related (ir) adverse events (AEs). Here, we report the clinical and immune–biological characterization of a patient with a metastatic bladder cancer who developed myositis signs (M) and a myasthenia-like syndrome (MLS) during treatment with pembrolizumab. The patient presented an autoimmunity-associated HLA haplotype (HLA-A*02/HLA-B*08/HLA-C*07/HLA-DRB1*03) and experienced an increase in activated CD8 T-cells along the treatment. The symptomatology regressed after pembrolizumab discontinuation and a pyridostigmine and steroids-based therapy. This is the first report of concurrent M and MLS appearance in cancer patients receiving pembrolizumab. More efforts are needed to define early the risk and the clinical meaning of irAEs in this setting.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms22126246
- https://www.mdpi.com/1422-0067/22/12/6246/pdf?version=1623317577
- OA Status
- gold
- Cited By
- 9
- References
- 49
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3167434565
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3167434565Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/ijms22126246Digital Object Identifier
- Title
-
Myositis/Myasthenia after Pembrolizumab in a Bladder Cancer Patient with an Autoimmunity-Associated HLA: Immune–Biological Evaluation and Case ReportWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-06-10Full publication date if available
- Authors
-
Cirino Botta, Rita Maria Agostino, Vincenzo Dattola, Vittoria Cianci, Natale Daniele Calandruccio, Giovanna Bianco, A. Mafodda, R. Maisano, Eleonora Iuliano, Giovanna Orizzonte, D Mazzacuva, A. Falzea, Rita Emilena Saladino, Rocco Giannicola, Giorgio Restifo, Umberto Aguglia, Michele Caraglia, Pierpaolo CorrealeList of authors in order
- Landing page
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https://doi.org/10.3390/ijms22126246Publisher landing page
- PDF URL
-
https://www.mdpi.com/1422-0067/22/12/6246/pdf?version=1623317577Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/1422-0067/22/12/6246/pdf?version=1623317577Direct OA link when available
- Concepts
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Pembrolizumab, Medicine, Myasthenia gravis, Myositis, Autoimmunity, Immunology, Immunotherapy, Adverse effect, Oncology, Internal medicine, Cancer, Bladder cancer, Immune system, DiscontinuationTop concepts (fields/topics) attached by OpenAlex
- Cited by
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9Total citation count in OpenAlex
- Citations by year (recent)
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2024: 1, 2023: 1, 2022: 2, 2021: 5Per-year citation counts (last 5 years)
- References (count)
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49Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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