N-glycosylation of mouse TRAIL-R restrains TRAIL-induced apoptosis Article Swipe
Yann Estornes
,
Yves Dondelinger
,
Kathrin Weber
,
Inge Bruggeman
,
Adam Peall
,
Marion MacFarlane
,
Serge Lebecque
,
Peter Vandenabeele
,
Mathieu J.M. Bertrand
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1038/s41419-018-0544-7
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1038/s41419-018-0544-7
The sensitivity of cells to death receptor-induced apoptosis is commonly controlled by multiple checkpoints in order to limit induction of excessive or unnecessary death. Although cytotoxic in various cancer cells, tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) does not trigger apoptosis in most non-transformed cells. The molecular nature of the checkpoints that normally protect the cells from TRAIL-induced death are not fully understood. Endoplasmic reticulum (ER) stress has been reported to switch the sensitivity of human cells to the cytotoxic effect of TRAIL, suggesting that this cellular state perturbs some of these protective mechanisms. We found that tunicamycin (TU), but no other ER stress inducers, sensitized mouse fibroblasts and hippocampal neuronal cells to TRAIL-induced apoptosis. Importantly, the sensitization was specific to TRAIL and not caused by differences in ER stress induction. Instead, it relied on the inhibition of N -glycosylation of the mouse TRAIL receptor (mTRAIL-R). Inhibition of N -glycosylation did not alter cell surface expression of mTRAIL-R but enhanced its ability to bind TRAIL, and facilitated mTRAIL-R oligomerization, which resulted in enhanced death-inducing signaling complex (DISC) formation and caspase-8 activation. Remarkably, reconstitution of mTRAIL-R-deficient cells with a version of mTRAIL-R mutated for the three N -glycosylation sites identified in its ectodomain confirmed higher sensitivity to TRAIL-induced apoptosis. Together, our results demonstrate that inhibition of N -glycosylation of mTRAIL-R, and not ER stress induction, sensitizes mouse cells to TRAIL-induced apoptosis. We therefore reveal a new mechanism restraining TRAIL cytotoxicity in mouse cells.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41419-018-0544-7
- https://www.nature.com/articles/s41419-018-0544-7.pdf
- OA Status
- gold
- Cited By
- 24
- References
- 49
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2802319445
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2802319445Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s41419-018-0544-7Digital Object Identifier
- Title
-
N-glycosylation of mouse TRAIL-R restrains TRAIL-induced apoptosisWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-04-26Full publication date if available
- Authors
-
Yann Estornes, Yves Dondelinger, Kathrin Weber, Inge Bruggeman, Adam Peall, Marion MacFarlane, Serge Lebecque, Peter Vandenabeele, Mathieu J.M. BertrandList of authors in order
- Landing page
-
https://doi.org/10.1038/s41419-018-0544-7Publisher landing page
- PDF URL
-
https://www.nature.com/articles/s41419-018-0544-7.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.nature.com/articles/s41419-018-0544-7.pdfDirect OA link when available
- Concepts
-
Apoptosis, Ectodomain, Unfolded protein response, Tunicamycin, Cell biology, Endoplasmic reticulum, Programmed cell death, Cytotoxic T cell, Tumor necrosis factor alpha, Glycosylation, Caspase, Biology, Chemistry, Receptor, Immunology, Biochemistry, In vitroTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
24Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 9, 2023: 1, 2022: 3, 2021: 4Per-year citation counts (last 5 years)
- References (count)
-
49Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W2802319445 |
|---|---|
| doi | https://doi.org/10.1038/s41419-018-0544-7 |
| ids.doi | https://doi.org/10.1038/s41419-018-0544-7 |
| ids.mag | 2802319445 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/29717117 |
| ids.openalex | https://openalex.org/W2802319445 |
| fwci | 0.8568369 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D016475 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | 3T3 Cells |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D000818 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Animals |
| mesh[2].qualifier_ui | Q000187 |
| mesh[2].descriptor_ui | D017209 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | drug effects |
| mesh[2].descriptor_name | Apoptosis |
| mesh[3].qualifier_ui | Q000187 |
| mesh[3].descriptor_ui | D005347 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | drug effects |
| mesh[3].descriptor_name | Fibroblasts |
| mesh[4].qualifier_ui | Q000378 |
| mesh[4].descriptor_ui | D005347 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | metabolism |
| mesh[4].descriptor_name | Fibroblasts |
| mesh[5].qualifier_ui | Q000473 |
| mesh[5].descriptor_ui | D005347 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | pathology |
| mesh[5].descriptor_name | Fibroblasts |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D006031 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Glycosylation |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D057809 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | HEK293 Cells |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D006367 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | HeLa Cells |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D006801 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Humans |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D051379 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Mice |
| mesh[11].qualifier_ui | Q000188 |
| mesh[11].descriptor_ui | D009369 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | drug therapy |
| mesh[11].descriptor_name | Neoplasms |
| mesh[12].qualifier_ui | Q000235 |
| mesh[12].descriptor_ui | D009369 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | genetics |
| mesh[12].descriptor_name | Neoplasms |
| mesh[13].qualifier_ui | Q000378 |
| mesh[13].descriptor_ui | D009369 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | metabolism |
| mesh[13].descriptor_name | Neoplasms |
| mesh[14].qualifier_ui | Q000473 |
| mesh[14].descriptor_ui | D009369 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | pathology |
| mesh[14].descriptor_name | Neoplasms |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D011499 |
| mesh[15].is_major_topic | True |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Protein Processing, Post-Translational |
| mesh[16].qualifier_ui | Q000235 |
| mesh[16].descriptor_ui | D053220 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | genetics |
| mesh[16].descriptor_name | Receptors, TNF-Related Apoptosis-Inducing Ligand |
| mesh[17].qualifier_ui | Q000378 |
| mesh[17].descriptor_ui | D053220 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | metabolism |
| mesh[17].descriptor_name | Receptors, TNF-Related Apoptosis-Inducing Ligand |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D015398 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Signal Transduction |
| mesh[19].qualifier_ui | Q000494 |
| mesh[19].descriptor_ui | D053221 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | pharmacology |
| mesh[19].descriptor_name | TNF-Related Apoptosis-Inducing Ligand |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D016475 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | 3T3 Cells |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D000818 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Animals |
| mesh[22].qualifier_ui | Q000187 |
| mesh[22].descriptor_ui | D017209 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | drug effects |
| mesh[22].descriptor_name | Apoptosis |
| mesh[23].qualifier_ui | Q000187 |
| mesh[23].descriptor_ui | D005347 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | drug effects |
| mesh[23].descriptor_name | Fibroblasts |
| mesh[24].qualifier_ui | Q000378 |
| mesh[24].descriptor_ui | D005347 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | metabolism |
| mesh[24].descriptor_name | Fibroblasts |
| mesh[25].qualifier_ui | Q000473 |
| mesh[25].descriptor_ui | D005347 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | pathology |
| mesh[25].descriptor_name | Fibroblasts |
| mesh[26].qualifier_ui | |
| mesh[26].descriptor_ui | D006031 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | |
| mesh[26].descriptor_name | Glycosylation |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D057809 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | HEK293 Cells |
| mesh[28].qualifier_ui | |
| mesh[28].descriptor_ui | D006367 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | |
| mesh[28].descriptor_name | HeLa Cells |
| mesh[29].qualifier_ui | |
| mesh[29].descriptor_ui | D006801 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | |
| mesh[29].descriptor_name | Humans |
| mesh[30].qualifier_ui | |
| mesh[30].descriptor_ui | D051379 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | |
| mesh[30].descriptor_name | Mice |
| mesh[31].qualifier_ui | Q000188 |
| mesh[31].descriptor_ui | D009369 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | drug therapy |
| mesh[31].descriptor_name | Neoplasms |
| mesh[32].qualifier_ui | Q000235 |
| mesh[32].descriptor_ui | D009369 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | genetics |
| mesh[32].descriptor_name | Neoplasms |
| mesh[33].qualifier_ui | Q000378 |
| mesh[33].descriptor_ui | D009369 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | metabolism |
| mesh[33].descriptor_name | Neoplasms |
| mesh[34].qualifier_ui | Q000473 |
| mesh[34].descriptor_ui | D009369 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | pathology |
| mesh[34].descriptor_name | Neoplasms |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D011499 |
| mesh[35].is_major_topic | True |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | Protein Processing, Post-Translational |
| mesh[36].qualifier_ui | Q000235 |
| mesh[36].descriptor_ui | D053220 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | genetics |
| mesh[36].descriptor_name | Receptors, TNF-Related Apoptosis-Inducing Ligand |
| mesh[37].qualifier_ui | Q000378 |
| mesh[37].descriptor_ui | D053220 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | metabolism |
| mesh[37].descriptor_name | Receptors, TNF-Related Apoptosis-Inducing Ligand |
| mesh[38].qualifier_ui | |
| mesh[38].descriptor_ui | D015398 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | |
| mesh[38].descriptor_name | Signal Transduction |
| mesh[39].qualifier_ui | Q000494 |
| mesh[39].descriptor_ui | D053221 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | pharmacology |
| mesh[39].descriptor_name | TNF-Related Apoptosis-Inducing Ligand |
| mesh[40].qualifier_ui | |
| mesh[40].descriptor_ui | D016475 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | |
| mesh[40].descriptor_name | 3T3 Cells |
| mesh[41].qualifier_ui | |
| mesh[41].descriptor_ui | D000818 |
| mesh[41].is_major_topic | False |
| mesh[41].qualifier_name | |
| mesh[41].descriptor_name | Animals |
| mesh[42].qualifier_ui | Q000187 |
| mesh[42].descriptor_ui | D017209 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | drug effects |
| mesh[42].descriptor_name | Apoptosis |
| mesh[43].qualifier_ui | Q000187 |
| mesh[43].descriptor_ui | D005347 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | drug effects |
| mesh[43].descriptor_name | Fibroblasts |
| mesh[44].qualifier_ui | Q000378 |
| mesh[44].descriptor_ui | D005347 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | metabolism |
| mesh[44].descriptor_name | Fibroblasts |
| mesh[45].qualifier_ui | Q000473 |
| mesh[45].descriptor_ui | D005347 |
| mesh[45].is_major_topic | False |
| mesh[45].qualifier_name | pathology |
| mesh[45].descriptor_name | Fibroblasts |
| mesh[46].qualifier_ui | |
| mesh[46].descriptor_ui | D006031 |
| mesh[46].is_major_topic | False |
| mesh[46].qualifier_name | |
| mesh[46].descriptor_name | Glycosylation |
| mesh[47].qualifier_ui | |
| mesh[47].descriptor_ui | D057809 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | |
| mesh[47].descriptor_name | HEK293 Cells |
| mesh[48].qualifier_ui | |
| mesh[48].descriptor_ui | D006367 |
| mesh[48].is_major_topic | False |
| mesh[48].qualifier_name | |
| mesh[48].descriptor_name | HeLa Cells |
| mesh[49].qualifier_ui | |
| mesh[49].descriptor_ui | D006801 |
| mesh[49].is_major_topic | False |
| mesh[49].qualifier_name | |
| mesh[49].descriptor_name | Humans |
| type | article |
| title | N-glycosylation of mouse TRAIL-R restrains TRAIL-induced apoptosis |
| biblio.issue | 5 |
| biblio.volume | 9 |
| biblio.last_page | 494 |
| biblio.first_page | 494 |
| topics[0].id | https://openalex.org/T10294 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Cell death mechanisms and regulation |
| topics[1].id | https://openalex.org/T11150 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9990000128746033 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1307 |
| topics[1].subfield.display_name | Cell Biology |
| topics[1].display_name | Endoplasmic Reticulum Stress and Disease |
| topics[2].id | https://openalex.org/T10587 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9990000128746033 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2713 |
| topics[2].subfield.display_name | Epidemiology |
| topics[2].display_name | Autophagy in Disease and Therapy |
| is_xpac | False |
| apc_list.value | 2790 |
| apc_list.currency | GBP |
| apc_list.value_usd | 3422 |
| apc_paid.value | 2790 |
| apc_paid.currency | GBP |
| apc_paid.value_usd | 3422 |
| concepts[0].id | https://openalex.org/C190283241 |
| concepts[0].level | 2 |
| concepts[0].score | 0.7530513405799866 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q14599311 |
| concepts[0].display_name | Apoptosis |
| concepts[1].id | https://openalex.org/C1009742 |
| concepts[1].level | 3 |
| concepts[1].score | 0.7049115300178528 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q5333998 |
| concepts[1].display_name | Ectodomain |
| concepts[2].id | https://openalex.org/C139447449 |
| concepts[2].level | 3 |
| concepts[2].score | 0.7028303146362305 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q14633900 |
| concepts[2].display_name | Unfolded protein response |
| concepts[3].id | https://openalex.org/C2777575526 |
| concepts[3].level | 4 |
| concepts[3].score | 0.6864297389984131 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q3542091 |
| concepts[3].display_name | Tunicamycin |
| concepts[4].id | https://openalex.org/C95444343 |
| concepts[4].level | 1 |
| concepts[4].score | 0.6845871806144714 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[4].display_name | Cell biology |
| concepts[5].id | https://openalex.org/C158617107 |
| concepts[5].level | 2 |
| concepts[5].score | 0.6538287401199341 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q79927 |
| concepts[5].display_name | Endoplasmic reticulum |
| concepts[6].id | https://openalex.org/C31573885 |
| concepts[6].level | 3 |
| concepts[6].score | 0.6192781329154968 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q304484 |
| concepts[6].display_name | Programmed cell death |
| concepts[7].id | https://openalex.org/C154317977 |
| concepts[7].level | 3 |
| concepts[7].score | 0.523967981338501 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q376266 |
| concepts[7].display_name | Cytotoxic T cell |
| concepts[8].id | https://openalex.org/C17991360 |
| concepts[8].level | 2 |
| concepts[8].score | 0.4892268180847168 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q21173843 |
| concepts[8].display_name | Tumor necrosis factor alpha |
| concepts[9].id | https://openalex.org/C2777313579 |
| concepts[9].level | 2 |
| concepts[9].score | 0.4856066107749939 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q898365 |
| concepts[9].display_name | Glycosylation |
| concepts[10].id | https://openalex.org/C98424977 |
| concepts[10].level | 4 |
| concepts[10].score | 0.43545064330101013 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q25805 |
| concepts[10].display_name | Caspase |
| concepts[11].id | https://openalex.org/C86803240 |
| concepts[11].level | 0 |
| concepts[11].score | 0.4327634871006012 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[11].display_name | Biology |
| concepts[12].id | https://openalex.org/C185592680 |
| concepts[12].level | 0 |
| concepts[12].score | 0.4158031940460205 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[12].display_name | Chemistry |
| concepts[13].id | https://openalex.org/C170493617 |
| concepts[13].level | 2 |
| concepts[13].score | 0.35330140590667725 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q208467 |
| concepts[13].display_name | Receptor |
| concepts[14].id | https://openalex.org/C203014093 |
| concepts[14].level | 1 |
| concepts[14].score | 0.23433628678321838 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[14].display_name | Immunology |
| concepts[15].id | https://openalex.org/C55493867 |
| concepts[15].level | 1 |
| concepts[15].score | 0.15200775861740112 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[15].display_name | Biochemistry |
| concepts[16].id | https://openalex.org/C202751555 |
| concepts[16].level | 2 |
| concepts[16].score | 0.11721441149711609 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q221681 |
| concepts[16].display_name | In vitro |
| keywords[0].id | https://openalex.org/keywords/apoptosis |
| keywords[0].score | 0.7530513405799866 |
| keywords[0].display_name | Apoptosis |
| keywords[1].id | https://openalex.org/keywords/ectodomain |
| keywords[1].score | 0.7049115300178528 |
| keywords[1].display_name | Ectodomain |
| keywords[2].id | https://openalex.org/keywords/unfolded-protein-response |
| keywords[2].score | 0.7028303146362305 |
| keywords[2].display_name | Unfolded protein response |
| keywords[3].id | https://openalex.org/keywords/tunicamycin |
| keywords[3].score | 0.6864297389984131 |
| keywords[3].display_name | Tunicamycin |
| keywords[4].id | https://openalex.org/keywords/cell-biology |
| keywords[4].score | 0.6845871806144714 |
| keywords[4].display_name | Cell biology |
| keywords[5].id | https://openalex.org/keywords/endoplasmic-reticulum |
| keywords[5].score | 0.6538287401199341 |
| keywords[5].display_name | Endoplasmic reticulum |
| keywords[6].id | https://openalex.org/keywords/programmed-cell-death |
| keywords[6].score | 0.6192781329154968 |
| keywords[6].display_name | Programmed cell death |
| keywords[7].id | https://openalex.org/keywords/cytotoxic-t-cell |
| keywords[7].score | 0.523967981338501 |
| keywords[7].display_name | Cytotoxic T cell |
| keywords[8].id | https://openalex.org/keywords/tumor-necrosis-factor-alpha |
| keywords[8].score | 0.4892268180847168 |
| keywords[8].display_name | Tumor necrosis factor alpha |
| keywords[9].id | https://openalex.org/keywords/glycosylation |
| keywords[9].score | 0.4856066107749939 |
| keywords[9].display_name | Glycosylation |
| keywords[10].id | https://openalex.org/keywords/caspase |
| keywords[10].score | 0.43545064330101013 |
| keywords[10].display_name | Caspase |
| keywords[11].id | https://openalex.org/keywords/biology |
| keywords[11].score | 0.4327634871006012 |
| keywords[11].display_name | Biology |
| keywords[12].id | https://openalex.org/keywords/chemistry |
| keywords[12].score | 0.4158031940460205 |
| keywords[12].display_name | Chemistry |
| keywords[13].id | https://openalex.org/keywords/receptor |
| keywords[13].score | 0.35330140590667725 |
| keywords[13].display_name | Receptor |
| keywords[14].id | https://openalex.org/keywords/immunology |
| keywords[14].score | 0.23433628678321838 |
| keywords[14].display_name | Immunology |
| keywords[15].id | https://openalex.org/keywords/biochemistry |
| keywords[15].score | 0.15200775861740112 |
| keywords[15].display_name | Biochemistry |
| keywords[16].id | https://openalex.org/keywords/in-vitro |
| keywords[16].score | 0.11721441149711609 |
| keywords[16].display_name | In vitro |
| language | en |
| locations[0].id | doi:10.1038/s41419-018-0544-7 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S185208586 |
| locations[0].source.issn | 2041-4889 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2041-4889 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Cell Death and Disease |
| locations[0].source.host_organization | https://openalex.org/P4310319965 |
| locations[0].source.host_organization_name | Springer Nature |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310319965 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.nature.com/articles/s41419-018-0544-7.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Cell Death & Disease |
| locations[0].landing_page_url | https://doi.org/10.1038/s41419-018-0544-7 |
| locations[1].id | pmid:29717117 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Cell death & disease |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/29717117 |
| locations[2].id | pmh:oai:lra.le.ac.uk:2381/45041 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306402365 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | Leicester Research Archive (University of Leicester) |
| locations[2].source.host_organization | https://openalex.org/I153648349 |
| locations[2].source.host_organization_name | University of Leicester |
| locations[2].source.host_organization_lineage | https://openalex.org/I153648349 |
| locations[2].license | cc-by |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Journal Article |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | http://hdl.handle.net/2381/45041 |
| locations[3].id | pmh:oai:europepmc.org:4950171 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306400806 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | Europe PMC (PubMed Central) |
| locations[3].source.host_organization | https://openalex.org/I1303153112 |
| locations[3].source.host_organization_name | European Bioinformatics Institute |
| locations[3].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[3].license | other-oa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/other-oa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | |
| locations[3].landing_page_url | http://europepmc.org/pmc/articles/PMC5931557 |
| locations[4].id | pmh:oai:pubmedcentral.nih.gov:5931557 |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S2764455111 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | PubMed Central |
| locations[4].source.host_organization | https://openalex.org/I1299303238 |
| locations[4].source.host_organization_name | National Institutes of Health |
| locations[4].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[4].license | other-oa |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | Text |
| locations[4].license_id | https://openalex.org/licenses/other-oa |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | Cell Death Dis |
| locations[4].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/5931557 |
| locations[5].id | pmh:oai:archive.ugent.be:8563834 |
| locations[5].is_oa | True |
| locations[5].source.id | https://openalex.org/S4306400477 |
| locations[5].source.issn | |
| locations[5].source.type | repository |
| locations[5].source.is_oa | False |
| locations[5].source.issn_l | |
| locations[5].source.is_core | False |
| locations[5].source.is_in_doaj | False |
| locations[5].source.display_name | Ghent University Academic Bibliography (Ghent University) |
| locations[5].source.host_organization | https://openalex.org/I32597200 |
| locations[5].source.host_organization_name | Ghent University |
| locations[5].source.host_organization_lineage | https://openalex.org/I32597200 |
| locations[5].license | cc-by |
| locations[5].pdf_url | |
| locations[5].version | submittedVersion |
| locations[5].raw_type | journalArticle |
| locations[5].license_id | https://openalex.org/licenses/cc-by |
| locations[5].is_accepted | False |
| locations[5].is_published | False |
| locations[5].raw_source_name | CELL DEATH & DISEASE |
| locations[5].landing_page_url | http://hdl.handle.net/1854/LU-8563834 |
| locations[6].id | pmh:oai:doaj.org/article:6ae69a2e986c489f8e2631be561cadc5 |
| locations[6].is_oa | False |
| locations[6].source.id | https://openalex.org/S4306401280 |
| locations[6].source.issn | |
| locations[6].source.type | repository |
| locations[6].source.is_oa | False |
| locations[6].source.issn_l | |
| locations[6].source.is_core | False |
| locations[6].source.is_in_doaj | False |
| locations[6].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[6].source.host_organization | |
| locations[6].source.host_organization_name | |
| locations[6].source.host_organization_lineage | |
| locations[6].license | |
| locations[6].pdf_url | |
| locations[6].version | submittedVersion |
| locations[6].raw_type | article |
| locations[6].license_id | |
| locations[6].is_accepted | False |
| locations[6].is_published | False |
| locations[6].raw_source_name | Cell Death and Disease, Vol 9, Iss 5, Pp 1-13 (2018) |
| locations[6].landing_page_url | https://doaj.org/article/6ae69a2e986c489f8e2631be561cadc5 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5072490723 |
| authorships[0].author.orcid | https://orcid.org/0000-0003-2687-290X |
| authorships[0].author.display_name | Yann Estornes |
| authorships[0].countries | BE |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210139803 |
| authorships[0].affiliations[0].raw_affiliation_string | VIB Center for Inflammation Research, Technologiepark 927, Zwijnaarde-Ghent, 9052, Belgium |
| authorships[0].institutions[0].id | https://openalex.org/I4210139803 |
| authorships[0].institutions[0].ror | https://ror.org/04q4ydz28 |
| authorships[0].institutions[0].type | facility |
| authorships[0].institutions[0].lineage | https://openalex.org/I2802017950, https://openalex.org/I32597200, https://openalex.org/I4210139803 |
| authorships[0].institutions[0].country_code | BE |
| authorships[0].institutions[0].display_name | VIB-UGent Center for Inflammation Research |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Yann Estornes |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | VIB Center for Inflammation Research, Technologiepark 927, Zwijnaarde-Ghent, 9052, Belgium |
| authorships[1].author.id | https://openalex.org/A5015671418 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-5242-6834 |
| authorships[1].author.display_name | Yves Dondelinger |
| authorships[1].countries | BE |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4210139803 |
| authorships[1].affiliations[0].raw_affiliation_string | VIB Center for Inflammation Research, Technologiepark 927, Zwijnaarde-Ghent, 9052, Belgium |
| authorships[1].institutions[0].id | https://openalex.org/I4210139803 |
| authorships[1].institutions[0].ror | https://ror.org/04q4ydz28 |
| authorships[1].institutions[0].type | facility |
| authorships[1].institutions[0].lineage | https://openalex.org/I2802017950, https://openalex.org/I32597200, https://openalex.org/I4210139803 |
| authorships[1].institutions[0].country_code | BE |
| authorships[1].institutions[0].display_name | VIB-UGent Center for Inflammation Research |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Yves Dondelinger |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | VIB Center for Inflammation Research, Technologiepark 927, Zwijnaarde-Ghent, 9052, Belgium |
| authorships[2].author.id | https://openalex.org/A5049658093 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-1934-923X |
| authorships[2].author.display_name | Kathrin Weber |
| authorships[2].countries | BE |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210139803 |
| authorships[2].affiliations[0].raw_affiliation_string | VIB Center for Inflammation Research, Technologiepark 927, Zwijnaarde-Ghent, 9052, Belgium |
| authorships[2].institutions[0].id | https://openalex.org/I4210139803 |
| authorships[2].institutions[0].ror | https://ror.org/04q4ydz28 |
| authorships[2].institutions[0].type | facility |
| authorships[2].institutions[0].lineage | https://openalex.org/I2802017950, https://openalex.org/I32597200, https://openalex.org/I4210139803 |
| authorships[2].institutions[0].country_code | BE |
| authorships[2].institutions[0].display_name | VIB-UGent Center for Inflammation Research |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Kathrin Weber |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | VIB Center for Inflammation Research, Technologiepark 927, Zwijnaarde-Ghent, 9052, Belgium |
| authorships[3].author.id | https://openalex.org/A5044973225 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Inge Bruggeman |
| authorships[3].countries | BE |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210139803 |
| authorships[3].affiliations[0].raw_affiliation_string | VIB Center for Inflammation Research, Technologiepark 927, Zwijnaarde-Ghent, 9052, Belgium |
| authorships[3].institutions[0].id | https://openalex.org/I4210139803 |
| authorships[3].institutions[0].ror | https://ror.org/04q4ydz28 |
| authorships[3].institutions[0].type | facility |
| authorships[3].institutions[0].lineage | https://openalex.org/I2802017950, https://openalex.org/I32597200, https://openalex.org/I4210139803 |
| authorships[3].institutions[0].country_code | BE |
| authorships[3].institutions[0].display_name | VIB-UGent Center for Inflammation Research |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Inge Bruggeman |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | VIB Center for Inflammation Research, Technologiepark 927, Zwijnaarde-Ghent, 9052, Belgium |
| authorships[4].author.id | https://openalex.org/A5073310329 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Adam Peall |
| authorships[4].countries | GB |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I153648349, https://openalex.org/I4210159948 |
| authorships[4].affiliations[0].raw_affiliation_string | MRC Toxicology Unit, University of Leicester, Lancaster Road, Leicester, LE1 9HN, UK |
| authorships[4].institutions[0].id | https://openalex.org/I4210159948 |
| authorships[4].institutions[0].ror | https://ror.org/05362x394 |
| authorships[4].institutions[0].type | facility |
| authorships[4].institutions[0].lineage | https://openalex.org/I241749, https://openalex.org/I4210087105, https://openalex.org/I4210159948, https://openalex.org/I90344618 |
| authorships[4].institutions[0].country_code | GB |
| authorships[4].institutions[0].display_name | MRC Toxicology Unit |
| authorships[4].institutions[1].id | https://openalex.org/I153648349 |
| authorships[4].institutions[1].ror | https://ror.org/04h699437 |
| authorships[4].institutions[1].type | education |
| authorships[4].institutions[1].lineage | https://openalex.org/I153648349 |
| authorships[4].institutions[1].country_code | GB |
| authorships[4].institutions[1].display_name | University of Leicester |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Adam Peall |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | MRC Toxicology Unit, University of Leicester, Lancaster Road, Leicester, LE1 9HN, UK |
| authorships[5].author.id | https://openalex.org/A5034035769 |
| authorships[5].author.orcid | https://orcid.org/0000-0001-7886-1159 |
| authorships[5].author.display_name | Marion MacFarlane |
| authorships[5].countries | GB |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I153648349, https://openalex.org/I4210159948 |
| authorships[5].affiliations[0].raw_affiliation_string | MRC Toxicology Unit, University of Leicester, Lancaster Road, Leicester, LE1 9HN, UK |
| authorships[5].institutions[0].id | https://openalex.org/I4210159948 |
| authorships[5].institutions[0].ror | https://ror.org/05362x394 |
| authorships[5].institutions[0].type | facility |
| authorships[5].institutions[0].lineage | https://openalex.org/I241749, https://openalex.org/I4210087105, https://openalex.org/I4210159948, https://openalex.org/I90344618 |
| authorships[5].institutions[0].country_code | GB |
| authorships[5].institutions[0].display_name | MRC Toxicology Unit |
| authorships[5].institutions[1].id | https://openalex.org/I153648349 |
| authorships[5].institutions[1].ror | https://ror.org/04h699437 |
| authorships[5].institutions[1].type | education |
| authorships[5].institutions[1].lineage | https://openalex.org/I153648349 |
| authorships[5].institutions[1].country_code | GB |
| authorships[5].institutions[1].display_name | University of Leicester |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Marion MacFarlane |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | MRC Toxicology Unit, University of Leicester, Lancaster Road, Leicester, LE1 9HN, UK |
| authorships[6].author.id | https://openalex.org/A5038103297 |
| authorships[6].author.orcid | https://orcid.org/0000-0003-4006-8061 |
| authorships[6].author.display_name | Serge Lebecque |
| authorships[6].countries | FR |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I100532134, https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I4210105738, https://openalex.org/I4210125048 |
| authorships[6].affiliations[0].raw_affiliation_string | Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, F-69373, France |
| authorships[6].institutions[0].id | https://openalex.org/I4210105738 |
| authorships[6].institutions[0].ror | https://ror.org/01cmnjq37 |
| authorships[6].institutions[0].type | nonprofit |
| authorships[6].institutions[0].lineage | https://openalex.org/I4210105738 |
| authorships[6].institutions[0].country_code | FR |
| authorships[6].institutions[0].display_name | Centre Léon Bérard |
| authorships[6].institutions[1].id | https://openalex.org/I1294671590 |
| authorships[6].institutions[1].ror | https://ror.org/02feahw73 |
| authorships[6].institutions[1].type | government |
| authorships[6].institutions[1].lineage | https://openalex.org/I1294671590 |
| authorships[6].institutions[1].country_code | FR |
| authorships[6].institutions[1].display_name | Centre National de la Recherche Scientifique |
| authorships[6].institutions[2].id | https://openalex.org/I4210125048 |
| authorships[6].institutions[2].ror | https://ror.org/02mgw3155 |
| authorships[6].institutions[2].type | facility |
| authorships[6].institutions[2].lineage | https://openalex.org/I100532134, https://openalex.org/I1294671590, https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I203339264, https://openalex.org/I4210096427, https://openalex.org/I4210105738, https://openalex.org/I4210125048 |
| authorships[6].institutions[2].country_code | FR |
| authorships[6].institutions[2].display_name | Centre de Recherche en Cancérologie de Lyon |
| authorships[6].institutions[3].id | https://openalex.org/I154526488 |
| authorships[6].institutions[3].ror | https://ror.org/02vjkv261 |
| authorships[6].institutions[3].type | government |
| authorships[6].institutions[3].lineage | https://openalex.org/I154526488 |
| authorships[6].institutions[3].country_code | FR |
| authorships[6].institutions[3].display_name | Inserm |
| authorships[6].institutions[4].id | https://openalex.org/I100532134 |
| authorships[6].institutions[4].ror | https://ror.org/029brtt94 |
| authorships[6].institutions[4].type | education |
| authorships[6].institutions[4].lineage | https://openalex.org/I100532134, https://openalex.org/I203339264 |
| authorships[6].institutions[4].country_code | FR |
| authorships[6].institutions[4].display_name | Université Claude Bernard Lyon 1 |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Serge Lebecque |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, F-69373, France |
| authorships[7].author.id | https://openalex.org/A5089113838 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-6669-8822 |
| authorships[7].author.display_name | Peter Vandenabeele |
| authorships[7].countries | BE |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I32597200 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, Zwijnaarde-Ghent, 9052, Belgium |
| authorships[7].institutions[0].id | https://openalex.org/I32597200 |
| authorships[7].institutions[0].ror | https://ror.org/00cv9y106 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I32597200 |
| authorships[7].institutions[0].country_code | BE |
| authorships[7].institutions[0].display_name | Ghent University |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Peter Vandenabeele |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, Zwijnaarde-Ghent, 9052, Belgium |
| authorships[8].author.id | https://openalex.org/A5018449456 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-9000-0626 |
| authorships[8].author.display_name | Mathieu J.M. Bertrand |
| authorships[8].countries | BE |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I32597200 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, Zwijnaarde-Ghent, 9052, Belgium |
| authorships[8].institutions[0].id | https://openalex.org/I32597200 |
| authorships[8].institutions[0].ror | https://ror.org/00cv9y106 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I32597200 |
| authorships[8].institutions[0].country_code | BE |
| authorships[8].institutions[0].display_name | Ghent University |
| authorships[8].author_position | last |
| authorships[8].raw_author_name | Mathieu J. M. Bertrand |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, Zwijnaarde-Ghent, 9052, Belgium |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.nature.com/articles/s41419-018-0544-7.pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | N-glycosylation of mouse TRAIL-R restrains TRAIL-induced apoptosis |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10294 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Cell death mechanisms and regulation |
| related_works | https://openalex.org/W2073846391, https://openalex.org/W4224980520, https://openalex.org/W2917641208, https://openalex.org/W2538224455, https://openalex.org/W4388233975, https://openalex.org/W2129786365, https://openalex.org/W1834296935, https://openalex.org/W2044580921, https://openalex.org/W1507019195, https://openalex.org/W1991026659 |
| cited_by_count | 24 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 3 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 9 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 1 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 3 |
| counts_by_year[4].year | 2021 |
| counts_by_year[4].cited_by_count | 4 |
| counts_by_year[5].year | 2020 |
| counts_by_year[5].cited_by_count | 2 |
| counts_by_year[6].year | 2019 |
| counts_by_year[6].cited_by_count | 2 |
| locations_count | 7 |
| best_oa_location.id | doi:10.1038/s41419-018-0544-7 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S185208586 |
| best_oa_location.source.issn | 2041-4889 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2041-4889 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Cell Death and Disease |
| best_oa_location.source.host_organization | https://openalex.org/P4310319965 |
| best_oa_location.source.host_organization_name | Springer Nature |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310319965 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.nature.com/articles/s41419-018-0544-7.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Cell Death & Disease |
| best_oa_location.landing_page_url | https://doi.org/10.1038/s41419-018-0544-7 |
| primary_location.id | doi:10.1038/s41419-018-0544-7 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S185208586 |
| primary_location.source.issn | 2041-4889 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2041-4889 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Cell Death and Disease |
| primary_location.source.host_organization | https://openalex.org/P4310319965 |
| primary_location.source.host_organization_name | Springer Nature |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310319965 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.nature.com/articles/s41419-018-0544-7.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Cell Death & Disease |
| primary_location.landing_page_url | https://doi.org/10.1038/s41419-018-0544-7 |
| publication_date | 2018-04-26 |
| publication_year | 2018 |
| referenced_works | https://openalex.org/W1988779395, https://openalex.org/W2017578232, https://openalex.org/W2092508425, https://openalex.org/W1980919524, https://openalex.org/W2113505777, https://openalex.org/W2102986716, https://openalex.org/W1484817497, https://openalex.org/W2007718868, https://openalex.org/W2290145688, https://openalex.org/W2096186936, https://openalex.org/W2333319155, https://openalex.org/W2012173926, https://openalex.org/W1971895570, https://openalex.org/W2088264970, https://openalex.org/W2135416318, https://openalex.org/W2047931877, https://openalex.org/W1984937904, https://openalex.org/W2154102072, https://openalex.org/W2039805273, https://openalex.org/W1977603207, https://openalex.org/W2105266786, https://openalex.org/W2059912335, https://openalex.org/W2146825351, https://openalex.org/W2124992697, https://openalex.org/W2126000912, https://openalex.org/W2075101741, https://openalex.org/W2077948125, https://openalex.org/W2031293873, https://openalex.org/W2563040416, https://openalex.org/W2067256617, https://openalex.org/W2078016121, https://openalex.org/W1965364089, https://openalex.org/W2072660479, https://openalex.org/W2395580257, https://openalex.org/W2081695451, https://openalex.org/W980126877, https://openalex.org/W2149369491, https://openalex.org/W2146796201, https://openalex.org/W1988991871, https://openalex.org/W2586706543, https://openalex.org/W1970011233, https://openalex.org/W2120881405, https://openalex.org/W1963848568, https://openalex.org/W2463605899, https://openalex.org/W2475188541, https://openalex.org/W2047064467, https://openalex.org/W2086405876, https://openalex.org/W2023875360, https://openalex.org/W1978497677 |
| referenced_works_count | 49 |
| abstract_inverted_index.N | 139, 149, 196, 216 |
| abstract_inverted_index.a | 188, 234 |
| abstract_inverted_index.ER | 103, 129, 222 |
| abstract_inverted_index.We | 95, 231 |
| abstract_inverted_index.by | 12, 126 |
| abstract_inverted_index.in | 15, 27, 42, 128, 172, 200, 240 |
| abstract_inverted_index.is | 9 |
| abstract_inverted_index.it | 133 |
| abstract_inverted_index.no | 101 |
| abstract_inverted_index.of | 3, 20, 49, 75, 82, 91, 138, 141, 148, 157, 184, 190, 215, 218 |
| abstract_inverted_index.on | 135 |
| abstract_inverted_index.or | 22 |
| abstract_inverted_index.to | 5, 17, 71, 78, 113, 121, 163, 206, 228 |
| abstract_inverted_index.The | 1, 46 |
| abstract_inverted_index.and | 109, 123, 166, 179, 220 |
| abstract_inverted_index.are | 60 |
| abstract_inverted_index.but | 100, 159 |
| abstract_inverted_index.did | 151 |
| abstract_inverted_index.for | 193 |
| abstract_inverted_index.has | 68 |
| abstract_inverted_index.its | 161, 201 |
| abstract_inverted_index.new | 235 |
| abstract_inverted_index.not | 39, 61, 124, 152, 221 |
| abstract_inverted_index.our | 210 |
| abstract_inverted_index.the | 50, 55, 73, 79, 117, 136, 142, 194 |
| abstract_inverted_index.was | 119 |
| abstract_inverted_index.(ER) | 66 |
| abstract_inverted_index.been | 69 |
| abstract_inverted_index.bind | 164 |
| abstract_inverted_index.cell | 154 |
| abstract_inverted_index.does | 38 |
| abstract_inverted_index.from | 57 |
| abstract_inverted_index.most | 43 |
| abstract_inverted_index.some | 90 |
| abstract_inverted_index.that | 52, 85, 97, 213 |
| abstract_inverted_index.this | 86 |
| abstract_inverted_index.with | 187 |
| abstract_inverted_index.(TU), | 99 |
| abstract_inverted_index.TRAIL | 122, 144, 238 |
| abstract_inverted_index.alter | 153 |
| abstract_inverted_index.cells | 4, 56, 77, 112, 186, 227 |
| abstract_inverted_index.death | 6, 59 |
| abstract_inverted_index.found | 96 |
| abstract_inverted_index.fully | 62 |
| abstract_inverted_index.human | 76 |
| abstract_inverted_index.limit | 18 |
| abstract_inverted_index.mouse | 107, 143, 226, 241 |
| abstract_inverted_index.order | 16 |
| abstract_inverted_index.other | 102 |
| abstract_inverted_index.sites | 198 |
| abstract_inverted_index.state | 88 |
| abstract_inverted_index.these | 92 |
| abstract_inverted_index.three | 195 |
| abstract_inverted_index.tumor | 31 |
| abstract_inverted_index.which | 170 |
| abstract_inverted_index.(DISC) | 177 |
| abstract_inverted_index.TRAIL, | 83, 165 |
| abstract_inverted_index.cancer | 29 |
| abstract_inverted_index.caused | 125 |
| abstract_inverted_index.cells, | 30 |
| abstract_inverted_index.cells. | 45, 242 |
| abstract_inverted_index.death. | 24 |
| abstract_inverted_index.effect | 81 |
| abstract_inverted_index.factor | 33 |
| abstract_inverted_index.higher | 204 |
| abstract_inverted_index.ligand | 36 |
| abstract_inverted_index.nature | 48 |
| abstract_inverted_index.relied | 134 |
| abstract_inverted_index.reveal | 233 |
| abstract_inverted_index.stress | 67, 104, 130, 223 |
| abstract_inverted_index.switch | 72 |
| abstract_inverted_index.(TRAIL) | 37 |
| abstract_inverted_index.ability | 162 |
| abstract_inverted_index.complex | 176 |
| abstract_inverted_index.mutated | 192 |
| abstract_inverted_index.protect | 54 |
| abstract_inverted_index.results | 211 |
| abstract_inverted_index.surface | 155 |
| abstract_inverted_index.trigger | 40 |
| abstract_inverted_index.various | 28 |
| abstract_inverted_index.version | 189 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Although | 25 |
| abstract_inverted_index.Instead, | 132 |
| abstract_inverted_index.cellular | 87 |
| abstract_inverted_index.commonly | 10 |
| abstract_inverted_index.enhanced | 160, 173 |
| abstract_inverted_index.mTRAIL-R | 158, 168, 191 |
| abstract_inverted_index.multiple | 13 |
| abstract_inverted_index.necrosis | 32 |
| abstract_inverted_index.neuronal | 111 |
| abstract_inverted_index.normally | 53 |
| abstract_inverted_index.perturbs | 89 |
| abstract_inverted_index.receptor | 145 |
| abstract_inverted_index.reported | 70 |
| abstract_inverted_index.resulted | 171 |
| abstract_inverted_index.specific | 120 |
| abstract_inverted_index.Together, | 209 |
| abstract_inverted_index.apoptosis | 8, 41 |
| abstract_inverted_index.caspase-8 | 180 |
| abstract_inverted_index.confirmed | 203 |
| abstract_inverted_index.cytotoxic | 26, 80 |
| abstract_inverted_index.excessive | 21 |
| abstract_inverted_index.formation | 178 |
| abstract_inverted_index.inducers, | 105 |
| abstract_inverted_index.induction | 19 |
| abstract_inverted_index.mTRAIL-R, | 219 |
| abstract_inverted_index.mechanism | 236 |
| abstract_inverted_index.molecular | 47 |
| abstract_inverted_index.reticulum | 65 |
| abstract_inverted_index.signaling | 175 |
| abstract_inverted_index.therefore | 232 |
| abstract_inverted_index.Inhibition | 147 |
| abstract_inverted_index.apoptosis. | 115, 208, 230 |
| abstract_inverted_index.controlled | 11 |
| abstract_inverted_index.ectodomain | 202 |
| abstract_inverted_index.expression | 156 |
| abstract_inverted_index.identified | 199 |
| abstract_inverted_index.induction, | 224 |
| abstract_inverted_index.induction. | 131 |
| abstract_inverted_index.inhibition | 137, 214 |
| abstract_inverted_index.protective | 93 |
| abstract_inverted_index.sensitized | 106 |
| abstract_inverted_index.sensitizes | 225 |
| abstract_inverted_index.suggesting | 84 |
| abstract_inverted_index.(mTRAIL-R). | 146 |
| abstract_inverted_index.Endoplasmic | 64 |
| abstract_inverted_index.Remarkably, | 182 |
| abstract_inverted_index.activation. | 181 |
| abstract_inverted_index.checkpoints | 14, 51 |
| abstract_inverted_index.demonstrate | 212 |
| abstract_inverted_index.differences | 127 |
| abstract_inverted_index.facilitated | 167 |
| abstract_inverted_index.fibroblasts | 108 |
| abstract_inverted_index.hippocampal | 110 |
| abstract_inverted_index.mechanisms. | 94 |
| abstract_inverted_index.restraining | 237 |
| abstract_inverted_index.sensitivity | 2, 74, 205 |
| abstract_inverted_index.tunicamycin | 98 |
| abstract_inverted_index.understood. | 63 |
| abstract_inverted_index.unnecessary | 23 |
| abstract_inverted_index.Importantly, | 116 |
| abstract_inverted_index.cytotoxicity | 239 |
| abstract_inverted_index.(TNF)-related | 34 |
| abstract_inverted_index.TRAIL-induced | 58, 114, 207, 229 |
| abstract_inverted_index.sensitization | 118 |
| abstract_inverted_index.-glycosylation | 140, 150, 197, 217 |
| abstract_inverted_index.death-inducing | 174 |
| abstract_inverted_index.reconstitution | 183 |
| abstract_inverted_index.non-transformed | 44 |
| abstract_inverted_index.oligomerization, | 169 |
| abstract_inverted_index.receptor-induced | 7 |
| abstract_inverted_index.apoptosis-inducing | 35 |
| abstract_inverted_index.mTRAIL-R-deficient | 185 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 89 |
| countries_distinct_count | 3 |
| institutions_distinct_count | 9 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8500000238418579 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.70368355 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |