Nafcillin and Hypokalemia: A Forgotten Adverse Effect Article Swipe
Tambi Isaac
,
Sandrine Matta
,
M. Omar F. Khan
,
Konstantinos Mouskas
,
Roxana Lazarescu
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.7759/cureus.92012
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.7759/cureus.92012
Hypokalemia is a common yet often overlooked electrolyte disturbance in hospitalized patients. Among the various etiologies, drug-induced hypokalemia remains underrecognized. Nafcillin, a beta-lactam antibiotic widely used for methicillin-sensitive Staphylococcus aureus (MSSA) infections, has been infrequently reported as a cause of renal potassium wasting. We present the case of a 67-year-old male hospitalized for MSSA bacteremia complicated by epidural and shoulder abscesses, ultimately requiring extensive surgical interventions and long-term intravenous nafcillin therapy. During his hospital course, the patient developed persistent hypokalemia that was resistant to supplementation. A thorough evaluation excluded gastrointestinal, renal, and endocrine causes. The calculated fractional excretion of potassium (FEK) was 17.7%, indicating renal potassium wasting. The hypokalemia was attributed to nafcillin therapy and managed successfully with aggressive potassium and magnesium repletion. This case highlights nafcillin as a potential but underreported cause of renal potassium wasting. Clinicians should consider nafcillin-induced hypokalemia in patients receiving prolonged therapy, particularly when hypokalemia persists despite adequate supplementation and resolution of other contributing factors. Routine electrolyte monitoring and early intervention can mitigate complications and ensure safe continuation of antibiotic treatment.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.7759/cureus.92012
- https://www.cureus.com/articles/397858-nafcillin-and-hypokalemia-a-forgotten-adverse-effect.pdf
- OA Status
- diamond
- Cited By
- 1
- References
- 6
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- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W4414139448Canonical identifier for this work in OpenAlex
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https://doi.org/10.7759/cureus.92012Digital Object Identifier
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Nafcillin and Hypokalemia: A Forgotten Adverse EffectWork title
- Type
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articleOpenAlex work type
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enPrimary language
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2025Year of publication
- Publication date
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2025-09-10Full publication date if available
- Authors
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Tambi Isaac, Sandrine Matta, M. Omar F. Khan, Konstantinos Mouskas, Roxana LazarescuList of authors in order
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https://doi.org/10.7759/cureus.92012Publisher landing page
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https://www.cureus.com/articles/397858-nafcillin-and-hypokalemia-a-forgotten-adverse-effect.pdfDirect link to full text PDF
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://www.cureus.com/articles/397858-nafcillin-and-hypokalemia-a-forgotten-adverse-effect.pdfDirect OA link when available
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.magnesium | 121 |
| abstract_inverted_index.nafcillin | 69, 112, 126 |
| abstract_inverted_index.patients. | 11 |
| abstract_inverted_index.potassium | 41, 99, 105, 119, 135 |
| abstract_inverted_index.potential | 129 |
| abstract_inverted_index.prolonged | 145 |
| abstract_inverted_index.receiving | 144 |
| abstract_inverted_index.requiring | 62 |
| abstract_inverted_index.resistant | 82 |
| abstract_inverted_index.Clinicians | 137 |
| abstract_inverted_index.Nafcillin, | 20 |
| abstract_inverted_index.abscesses, | 60 |
| abstract_inverted_index.aggressive | 118 |
| abstract_inverted_index.antibiotic | 23, 174 |
| abstract_inverted_index.attributed | 110 |
| abstract_inverted_index.aureus</i> | 29 |
| abstract_inverted_index.bacteremia | 54 |
| abstract_inverted_index.calculated | 95 |
| abstract_inverted_index.evaluation | 87 |
| abstract_inverted_index.fractional | 96 |
| abstract_inverted_index.highlights | 125 |
| abstract_inverted_index.indicating | 103 |
| abstract_inverted_index.monitoring | 162 |
| abstract_inverted_index.overlooked | 6 |
| abstract_inverted_index.persistent | 78 |
| abstract_inverted_index.repletion. | 122 |
| abstract_inverted_index.resolution | 155 |
| abstract_inverted_index.treatment. | 175 |
| abstract_inverted_index.ultimately | 61 |
| abstract_inverted_index.67-year-old | 49 |
| abstract_inverted_index.Hypokalemia | 0 |
| abstract_inverted_index.beta-lactam | 22 |
| abstract_inverted_index.complicated | 55 |
| abstract_inverted_index.disturbance | 8 |
| abstract_inverted_index.electrolyte | 7, 161 |
| abstract_inverted_index.etiologies, | 15 |
| abstract_inverted_index.hypokalemia | 17, 79, 108, 141, 149 |
| abstract_inverted_index.infections, | 31 |
| abstract_inverted_index.intravenous | 68 |
| abstract_inverted_index.continuation | 172 |
| abstract_inverted_index.contributing | 158 |
| abstract_inverted_index.drug-induced | 16 |
| abstract_inverted_index.hospitalized | 10, 51 |
| abstract_inverted_index.infrequently | 34 |
| abstract_inverted_index.intervention | 165 |
| abstract_inverted_index.particularly | 147 |
| abstract_inverted_index.successfully | 116 |
| abstract_inverted_index.complications | 168 |
| abstract_inverted_index.interventions | 65 |
| abstract_inverted_index.underreported | 131 |
| abstract_inverted_index.supplementation | 153 |
| abstract_inverted_index.supplementation. | 84 |
| abstract_inverted_index.underrecognized. | 19 |
| abstract_inverted_index.<i>Staphylococcus | 28 |
| abstract_inverted_index.gastrointestinal, | 89 |
| abstract_inverted_index.nafcillin-induced | 140 |
| abstract_inverted_index.methicillin-sensitive | 27 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 91 |
| countries_distinct_count | 3 |
| institutions_distinct_count | 5 |
| citation_normalized_percentile.value | 0.91682423 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |