Nailfold videocapillaroscopy abnormalities in autoimmune inflammatory myopathy subsets Article Swipe
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· 2025
· Open Access
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· DOI: https://doi.org/10.1093/rheumatology/keaf594
Objectives Nailfold videocapillaroscopy (NVC) alterations have been described in autoimmune inflammatory myopathies (AIM). This study aimed to describe NVC abnormalities in AIM subsets using a clinico-sero-pathological approach. Methods We studied subjects from the Canadian Inflammatory Myopathy Study (CIMS), a prospective AIM cohort. NVC images were acquired using the DS MEDICA Videocap (X200 magnification). Capillary density was scored quantitatively and semi-quantitatively. Ectasias, giant capillaries, ramified capillaries and microhemorrhages were scored as present or absent and with a standardized semi-quantitative scale (0 = none, 1 = ≤33%, 2 = 33–66%, and 3 = ≥66% abnormal capillaries/total capillaries per mm). NVC patterns (i.e. scleroderma early/active/late, scleroderma-like, non-specific, and normal) were described. NVC features and patterns were compared between AIM subsets. Results We included 99 AIM subjects: 41 dermatomyositis, 24 scleromyositis, 16 anti-synthetase syndrome, 7 immune-mediated necrotizing myopathy, 8 inclusion body myositis and 3 polymyositis. 71% were female, and the median disease duration was 1 year [IQR; 0.4–2.8]. The most frequent NVC abnormality was decreased capillary density in dermatomyositis (95%), scleromyositis (92%) and anti-synthetase syndrome (87%). Qualitatively, 44% of subjects had abnormal NVC, 25% non-specific NVC abnormalities, and 30% normal NVC. NVC patterns were not discriminant between dermatomyositis, scleromyositis and anti-synthetase syndrome. NVC abnormalities were absent in immune-mediated necrotizing myopathy, inclusion body myositis and polymyositis. Conclusion Dermatomyositis, scleromyositis and anti-synthetase syndrome showed frequent NVC abnormalities, although no NVC pattern was associated with a particular subset in our study. However, NVC may help distinguish between these subsets and immune-mediated necrotizing myopathy, inclusion body myositis and polymyositis.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/rheumatology/keaf594
- https://academic.oup.com/rheumatology/advance-article-pdf/doi/10.1093/rheumatology/keaf594/65224393/keaf594.pdf
- OA Status
- hybrid
- OpenAlex ID
- https://openalex.org/W7104468690
Raw OpenAlex JSON
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https://openalex.org/W7104468690Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/rheumatology/keaf594Digital Object Identifier
- Title
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Nailfold videocapillaroscopy abnormalities in autoimmune inflammatory myopathy subsetsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
-
2025-11-05Full publication date if available
- Authors
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Valérie Leclair, Thaisa Cotton, Hao Cheng Shen, Claudie Berger, Yves Troyanov, Marie Hudson, Geneviève GygerList of authors in order
- Landing page
-
https://doi.org/10.1093/rheumatology/keaf594Publisher landing page
- PDF URL
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https://academic.oup.com/rheumatology/advance-article-pdf/doi/10.1093/rheumatology/keaf594/65224393/keaf594.pdfDirect link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://academic.oup.com/rheumatology/advance-article-pdf/doi/10.1093/rheumatology/keaf594/65224393/keaf594.pdfDirect OA link when available
- Concepts
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Dermatomyositis, Medicine, Inclusion body myositis, Inflammatory myopathy, Pathology, Myopathy, Myositis, Overlap syndrome, Autoimmune disease, Polymyositis, Dermatology, Abnormality, Internal medicine, AutoantibodyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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