Nano(bio)Materials Do Not Affect Macrophage Phenotype—A Study Conducted by the REFINE Project Article Swipe
Christopher David
,
Jolanda P. Vermeulen
,
Sabrina Gioria
,
Rob J. Vandebriel
,
Neill J. Liptrott
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/ijms25105491
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/ijms25105491
Macrophages are well known for their involvement in the biocompatibility, as well as biodistribution, of nano(bio)materials. Although there are a number of rodent cell lines, they may not fully recapitulate primary cell responses, particularly those of human cells. Isolation of tissue-resident macrophages from humans is difficult and may result in insufficient cells with which to determine the possible interaction with nano(bio)materials. Isolation of primary human monocytes and differentiation to monocyte-derived macrophages may provide a useful tool with which to further study these interactions. To that end, we developed a standard operating procedure for this differentiation, as part of the Regulatory Science Framework for Nano(bio)material-based Medical Products and Devices (REFINE) project, and used it to measure the secretion of bioactive molecules from M1 and M2 differentiated monocytes in response to model nano(bio)materials, following an initial assessment of pyrogenic contamination, which may confound potential observations. The SOP was deployed in two partner institutions with broadly similar results. The work presented here shows the utility of this assay but highlights the relevance of donor variability in responses to nano(bio)materials. Whilst donor variability can provide some logistical challenges to the application of such assays, this variability is much closer to the heterogeneous cells that are present in vivo, compared to homogeneous non-human cell lines.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms25105491
- https://www.mdpi.com/1422-0067/25/10/5491/pdf?version=1715952015
- OA Status
- gold
- References
- 43
- Related Works
- 10
- OpenAlex ID
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https://openalex.org/W4397002318Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/ijms25105491Digital Object Identifier
- Title
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Nano(bio)Materials Do Not Affect Macrophage Phenotype—A Study Conducted by the REFINE ProjectWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-05-17Full publication date if available
- Authors
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Christopher David, Jolanda P. Vermeulen, Sabrina Gioria, Rob J. Vandebriel, Neill J. LiptrottList of authors in order
- Landing page
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https://doi.org/10.3390/ijms25105491Publisher landing page
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https://www.mdpi.com/1422-0067/25/10/5491/pdf?version=1715952015Direct link to full text PDF
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1422-0067/25/10/5491/pdf?version=1715952015Direct OA link when available
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Homogeneous, Computational biology, Biodistribution, Cell culture, Biocompatibility, Monocyte, Macrophage, In vivo, Phenotype, Cell type, Cell biology, Cell, Biology, Chemistry, In vitro, Immunology, Biotechnology, Biochemistry, Genetics, Gene, Thermodynamics, Organic chemistry, PhysicsTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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