Nanobody Engineered and Photosensitiser Loaded Bacterial Outer Membrane Vesicles Potentiate Antitumour Immunity and Immunotherapy Article Swipe
Peng Xia
,
Chengming Qu
,
Xiaolong Xu
,
Ming Tian
,
Zhifen Li
,
Jingbo Ma
,
Rui Hou
,
Han Li
,
Felix Rückert
,
Tianyu Zhong
,
Liang Zhao
,
Yufeng Yuan
,
Jigang Wang
,
Zhijie Li
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/jev2.70069
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/jev2.70069
Bacterial outer membrane vesicles (OMVs) are promising as antitumour agents, but their clinical application is limited by toxicity concerns and unclear mechanisms. We engineered OMVs with cadherin 17 (CDH17) tumour‐targeting nanobodies, enhancing tumour selectivity and efficacy while reducing adverse effects. These engineered OMVs function as natural stimulator of interferon genes (STING) agonists, activating the cyclic GMP‐AMP synthase (cGAS)‐STING pathway in cancer cells and tumour‐associated macrophages (TAMs). Loading engineered OMVs with photoimmunotherapy photosensitisers further enhanced tumour inhibition and STING activation in TAMs. Combining nanobody‐engineered OMV‐mediated photoimmunotherapy with CD47 blockade effectively suppressed primary and metastatic tumours, establishing sustained antitumour immune memory. This study demonstrates the potential of nanobody‐engineered OMVs as STING agonists and provides insights into novel OMV‐based immunotherapeutic strategies harnessing the innate immune system against cancer. Our findings open new avenues for OMV applications in tumour immunotherapy, offering a promising approach to overcome current limitations in cancer treatment.
Related Topics
Concepts
Immunotherapy
Cancer immunotherapy
Stimulator of interferon genes
Immunogenic cell death
Cancer research
Immune system
Innate immune system
Sting
Biology
Immunology
Aerospace engineering
Engineering
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/jev2.70069
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jev2.70069
- OA Status
- gold
- Cited By
- 8
- References
- 44
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409567739
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4409567739Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/jev2.70069Digital Object Identifier
- Title
-
Nanobody Engineered and Photosensitiser Loaded Bacterial Outer Membrane Vesicles Potentiate Antitumour Immunity and ImmunotherapyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-04-01Full publication date if available
- Authors
-
Peng Xia, Chengming Qu, Xiaolong Xu, Ming Tian, Zhifen Li, Jingbo Ma, Rui Hou, Han Li, Felix Rückert, Tianyu Zhong, Liang Zhao, Yufeng Yuan, Jigang Wang, Zhijie LiList of authors in order
- Landing page
-
https://doi.org/10.1002/jev2.70069Publisher landing page
- PDF URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jev2.70069Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jev2.70069Direct OA link when available
- Concepts
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Immunotherapy, Cancer immunotherapy, Stimulator of interferon genes, Immunogenic cell death, Cancer research, Immune system, Innate immune system, Sting, Biology, Immunology, Aerospace engineering, EngineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
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8Total citation count in OpenAlex
- Citations by year (recent)
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2025: 8Per-year citation counts (last 5 years)
- References (count)
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44Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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