Nano‐delivery systems as a promising therapeutic potential for epilepsy: Current status and future perspectives Article Swipe

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Ahmad Movahedpour , Rasul Taghvaeefar , Ali A. Asadi‐Pooya , Yousof Karami , Ronia Tavasolian , Seyyed Hossein Khatami , Elahe Soltani Fard , Sina Taghvimi , Neda Karami , Khojaste Rahimi Jaberi , Mortaza Taheri‐Anganeh , Hassan Ghasemi ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1111/cns.14355

Epilepsy is a common chronic neurological disorder caused by aberrant neuronal electrical activity. Antiseizure medications (ASMs) are the first line of treatment for people with epilepsy (PWE). However, their effectiveness may be limited by their inability to cross the blood–brain barrier (BBB), among many other potential underpinnings for drug resistance in epilepsy. Therefore, there is a need to overcome this issue and, hopefully, improve the effectiveness of ASMs. Recently, synthetic nanoparticle‐based drug delivery systems have received attention for improving the effectiveness of ASMs due to their ability to cross the BBB. Furthermore, exosomes have emerged as a promising generation of drug delivery systems because of their potential benefits over synthetic nanoparticles. In this narrative review, we focus on various synthetic nanoparticles that have been studied to deliver ASMs. Furthermore, the benefits and limitations of each nano‐delivery system have been discussed. Finally, we discuss exosomes as potentially promising delivery tools for treating epilepsy.

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Epilepsy Drug delivery Microvesicles Medicine Narrative review Nanotechnology Intensive care medicine Psychiatry Materials science Biology microRNA Gene Biochemistry

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Type: review
Language: en
Landing Page: https://doi.org/10.1111/cns.14355
PDF: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cns.14355
OA Status: gold
Cited By: 27
References: 93
Related Works: 10
OpenAlex ID: https://openalex.org/W4384401345

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OpenAlex ID: https://openalex.org/W4384401345

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DOI: https://doi.org/10.1111/cns.14355

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Title: Nano‐delivery systems as a promising therapeutic potential for epilepsy: Current status and future perspectives

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Type: review

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Language: en

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Publication year: 2023

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Publication date: 2023-07-14

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Authors: Ahmad Movahedpour, Rasul Taghvaeefar, Ali A. Asadi‐Pooya, Yousof Karami, Ronia Tavasolian, Seyyed Hossein Khatami, Elahe Soltani Fard, Sina Taghvimi, Neda Karami, Khojaste Rahimi Jaberi, Mortaza Taheri‐Anganeh, Hassan Ghasemi

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Landing page: https://doi.org/10.1111/cns.14355

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PDF URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cns.14355

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OA URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cns.14355

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Concepts: Epilepsy, Drug delivery, Microvesicles, Medicine, Narrative review, Nanotechnology, Intensive care medicine, Psychiatry, Materials science, Biology, microRNA, Gene, Biochemistry

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Cited by: 27

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Citations by year (recent): 2025: 11, 2024: 13, 2023: 3

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References (count): 93

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Related works (count): 10

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