Nanomaterials‐Mediated Co‐Stimulation of Toll‐Like Receptors and CD40 for Antitumor Immunity Article Swipe
Jinyue Yan
,
Yuebao Zhang
,
Shi Du
,
Xucheng Hou
,
Wenqing Li
,
Chunxi Zeng
,
Chengxiang Zhang
,
Jeffrey K. J. Cheng
,
Binbin Deng
,
David W. McComb
,
Weiyu Zhao
,
Yonger Xue
,
Diana D. Kang
,
Xiaolin Cheng
,
Yizhou Dong
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1002/adma.202207486
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1002/adma.202207486
Toll‐like receptors (TLRs) and CD40‐related signaling pathways represent critical bridges between innate and adaptive immune responses. Here, an immunotherapy regimen that enables co‐stimulation of TLR7/8‐ and CD40‐mediated pathways is developed. TLR7/8 agonist resiquimod (R848) derived amino lipids, RAL1 and RAL2, are synthesized and formulated into RAL‐derived lipid nanoparticles (RAL‐LNPs). The RAL2‐LNPs show efficient CD40 mRNA delivery to DCs both in vitro (90.8 ± 2.7%) and in vivo (61.3 ± 16.4%). When combined with agonistic anti‐CD40 antibody, this approach can produce effective antitumor activities in mouse melanoma tumor models, thereby suppressing tumor growth, prolonging mouse survival, and establishing antitumor memory immunity. Overall, RAL2‐LNPs provide a novel platform toward cancer immunotherapy by integrating innate and adaptive immunity.
Related Topics
Concepts
TLR7
Acquired immune system
CD40
Innate immune system
Cancer immunotherapy
Stimulation
Immunity
Immune system
Receptor
Immunotherapy
Toll-like receptor
Agonist
Biology
Immunology
Cell biology
Cancer research
In vitro
Neuroscience
Cytotoxic T cell
Biochemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/adma.202207486
- OA Status
- green
- Cited By
- 47
- References
- 59
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W4296322253Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/adma.202207486Digital Object Identifier
- Title
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Nanomaterials‐Mediated Co‐Stimulation of Toll‐Like Receptors and CD40 for Antitumor ImmunityWork title
- Type
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articleOpenAlex work type
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enPrimary language
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2022Year of publication
- Publication date
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2022-09-19Full publication date if available
- Authors
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Jinyue Yan, Yuebao Zhang, Shi Du, Xucheng Hou, Wenqing Li, Chunxi Zeng, Chengxiang Zhang, Jeffrey K. J. Cheng, Binbin Deng, David W. McComb, Weiyu Zhao, Yonger Xue, Diana D. Kang, Xiaolin Cheng, Yizhou DongList of authors in order
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https://doi.org/10.1002/adma.202207486Publisher landing page
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.ncbi.nlm.nih.gov/pmc/articles/9691606Direct OA link when available
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TLR7, Acquired immune system, CD40, Innate immune system, Cancer immunotherapy, Stimulation, Immunity, Immune system, Receptor, Immunotherapy, Toll-like receptor, Agonist, Biology, Immunology, Cell biology, Cancer research, In vitro, Neuroscience, Cytotoxic T cell, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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47Total citation count in OpenAlex
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2025: 15, 2024: 19, 2023: 13Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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