Nanopore design for exceptional rectification of DNA translocation Article Swipe
Ngan Hoang Pham
,
Yao Yao
,
Chenyu Wen
,
Shiyu Li
,
Shuangshuang Zeng
,
Tomas Nyberg
,
Tuan Tran
,
Daniel Primetzhofer
,
Zhen Zhang
,
Shi‐Li Zhang
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-382666/v1
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-382666/v1
Solid-state nanopores (SSNPs) of on-demand shape and size can facilitate desired sensor performance. However, reproducible production of arrayed nanopores of predefined geometry is yet to demonstrate despite of numerous methods explored. Here, bowl-shape SSNPs combining unique properties of ultrathin membrane and tapering geometry are demonstrated. The bowl-SSNP upper opening is 100-120 nm in diameter, with the bottom opening reaching sub-5 nm. Numerical simulation reveals the formation of multiple electroosmotic vortexes (EOVs) originating from distributed surface charge around the pore-bowl. The EOVs determine, collaboratively with electrophoretic force, how nanoscale objects translocate the bowl-SSNPs. Exceptional rectification with higher frequencies, longer duration and larger amplitude is found when DNA strands translocate downwards from the upper large opening than upwards from the bottom smallest restriction. The rectification is a manifestation of the interplay between electrophoresis and electroosmosis. The resourceful silicon nanofabrication technology is ingeniously shown to enable innovative nanopore designs targeting unprecedented sensor applications.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-382666/v1
- https://www.researchsquare.com/article/rs-382666/v1.pdf?c=1631895492000
- OA Status
- green
- References
- 36
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3154228614
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3154228614Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-382666/v1Digital Object Identifier
- Title
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Nanopore design for exceptional rectification of DNA translocationWork title
- Type
-
preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
-
2021-04-14Full publication date if available
- Authors
-
Ngan Hoang Pham, Yao Yao, Chenyu Wen, Shiyu Li, Shuangshuang Zeng, Tomas Nyberg, Tuan Tran, Daniel Primetzhofer, Zhen Zhang, Shi‐Li ZhangList of authors in order
- Landing page
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https://doi.org/10.21203/rs.3.rs-382666/v1Publisher landing page
- PDF URL
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https://www.researchsquare.com/article/rs-382666/v1.pdf?c=1631895492000Direct link to full text PDF
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.researchsquare.com/article/rs-382666/v1.pdf?c=1631895492000Direct OA link when available
- Concepts
-
Nanopore, Rectification, Chromosomal translocation, Nanopore sequencing, DNA, Nanotechnology, Computational biology, Materials science, Engineering, Biology, Genetics, DNA sequencing, Gene, Electrical engineering, VoltageTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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36Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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