Nanosilibinin ameliorates anxiety, learning impairment and Wnt-β catenin related genes expression deficits in zebrafish model of Autism Spectrum Disorder Article Swipe
Zahra Karimi
,
Asadollah Zarifkar
,
Mehdi Dianatpour
,
Esmaeil Mirzaei
,
Mahintaj Dara
,
Hadi Aligholi
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-1980576/v1
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-1980576/v1
purpose The present study evaluated the effect of Nanosilibinin (as an inhibitor of Wnt signaling pathway), on neurobehavioral and molecular deficits in Valproic acid zebrafish model of Autism Spectrum Disorder. Methods Zebrafish embryos were exposed to Valproic acid (1µM) and Nanosilibinin (100,200 and 500 µM) for 96 h, then survival rate, inattentive and anxiety behavior and the expression of CHD8, CTNNB, GSK3β, LRP6, TNFα, IL1β and BDNF genes were assessed 7 days post fertilization (dpf). Results The results indicated that except 500 µM, other concentrations of Nanosilibinin didn’t have any adverse effect on survival, hatching and morphological development when were used with Valproic acid at the same time. In addition, 100 and 200 µM of Nanosilibinin could ameliorate the anxiety and learning deficit in zebrafish larvae. Real-time analysis revealed that Nanosilibinin prevented raising the expression of a number of genes associated with autism such as CHD8, CTNNB, GSK3 β, LRP6, TNFα, IL1β and BDNF after exposure to Valproic acid. Conclusion In conclusion, Nanosilibinin treatment for the first 96 h of life showed therapeutic effect on an ASD-like phenotype by decreasing anxiety and learning deficits and reduction in expression of number ASD related genes.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-1980576/v1
- https://www.researchsquare.com/article/rs-1980576/latest.pdf
- OA Status
- green
- Cited By
- 1
- References
- 52
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4293149918
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- OpenAlex ID
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https://openalex.org/W4293149918Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-1980576/v1Digital Object Identifier
- Title
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Nanosilibinin ameliorates anxiety, learning impairment and Wnt-β catenin related genes expression deficits in zebrafish model of Autism Spectrum DisorderWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-08-26Full publication date if available
- Authors
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Zahra Karimi, Asadollah Zarifkar, Mehdi Dianatpour, Esmaeil Mirzaei, Mahintaj Dara, Hadi AligholiList of authors in order
- Landing page
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https://doi.org/10.21203/rs.3.rs-1980576/v1Publisher landing page
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https://www.researchsquare.com/article/rs-1980576/latest.pdfDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
- OA URL
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https://www.researchsquare.com/article/rs-1980576/latest.pdfDirect OA link when available
- Concepts
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Zebrafish, Wnt signaling pathway, Valproic Acid, Anxiety, Autism spectrum disorder, Autism, Neurodevelopmental disorder, Psychology, Gene, Medicine, Pharmacology, Biology, Psychiatry, Epilepsy, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2024: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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