Native and tagged CENP-A histones are functionally inequivalent Article Swipe
Minh Bui
,
Songjoon Baek
,
Reda S. Bentahar
,
Daniël P. Melters
,
Yamini Dalal
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1186/s13072-024-00543-9
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1186/s13072-024-00543-9
Background Over the past several decades, the use of biochemical and fluorescent tags has elucidated mechanistic and cytological processes that would otherwise be impossible. The challenging nature of certain nuclear proteins includes low abundancy, poor antibody recognition, and transient dynamics. One approach to get around those issues is the addition of a peptide or larger protein tag to the target protein to improve enrichment, purification, and visualization. However, many of these studies were done under the assumption that tagged proteins can fully recapitulate native protein function. Results We report that when C-terminally TAP-tagged CENP-A histone variant is introduced, it undergoes altered kinetochore protein binding, differs in post-translational modifications (PTMs), utilizes histone chaperones that differ from that of native CENP-A, and can partially displace native CENP-A in human cells. Additionally, these tagged CENP-A-containing nucleosomes have reduced centromeric incorporation at early G1 phase and poorly associates with linker histone H1.5 compared to native CENP-A nucleosomes. Conclusions These data suggest expressing tagged versions of histone variant CENP-A may result in unexpected utilization of non-native pathways, thereby altering the biological function of the histone variant.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1186/s13072-024-00543-9
- https://epigeneticsandchromatin.biomedcentral.com/counter/pdf/10.1186/s13072-024-00543-9
- OA Status
- gold
- Cited By
- 4
- References
- 69
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4399274729
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- OpenAlex ID
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https://openalex.org/W4399274729Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1186/s13072-024-00543-9Digital Object Identifier
- Title
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Native and tagged CENP-A histones are functionally inequivalentWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-06-02Full publication date if available
- Authors
-
Minh Bui, Songjoon Baek, Reda S. Bentahar, Daniël P. Melters, Yamini DalalList of authors in order
- Landing page
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https://doi.org/10.1186/s13072-024-00543-9Publisher landing page
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https://epigeneticsandchromatin.biomedcentral.com/counter/pdf/10.1186/s13072-024-00543-9Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://epigeneticsandchromatin.biomedcentral.com/counter/pdf/10.1186/s13072-024-00543-9Direct OA link when available
- Concepts
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Histone, Biology, Nucleosome, Computational biology, Linker, Acetylation, Cell biology, Histone code, Function (biology), Protein function, Genetics, DNA, Gene, Operating system, Computer scienceTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
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2025: 3, 2024: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.function | 177 |
| abstract_inverted_index.includes | 32 |
| abstract_inverted_index.proteins | 31, 80 |
| abstract_inverted_index.utilizes | 110 |
| abstract_inverted_index.variant. | 181 |
| abstract_inverted_index.versions | 160 |
| abstract_inverted_index.dynamics. | 40 |
| abstract_inverted_index.function. | 86 |
| abstract_inverted_index.otherwise | 22 |
| abstract_inverted_index.partially | 122 |
| abstract_inverted_index.pathways, | 172 |
| abstract_inverted_index.processes | 19 |
| abstract_inverted_index.transient | 39 |
| abstract_inverted_index.undergoes | 100 |
| abstract_inverted_index.Background | 1 |
| abstract_inverted_index.TAP-tagged | 93 |
| abstract_inverted_index.abundancy, | 34 |
| abstract_inverted_index.associates | 144 |
| abstract_inverted_index.assumption | 77 |
| abstract_inverted_index.biological | 176 |
| abstract_inverted_index.chaperones | 112 |
| abstract_inverted_index.elucidated | 15 |
| abstract_inverted_index.expressing | 158 |
| abstract_inverted_index.non-native | 171 |
| abstract_inverted_index.unexpected | 168 |
| abstract_inverted_index.Conclusions | 154 |
| abstract_inverted_index.biochemical | 10 |
| abstract_inverted_index.centromeric | 136 |
| abstract_inverted_index.challenging | 26 |
| abstract_inverted_index.cytological | 18 |
| abstract_inverted_index.enrichment, | 64 |
| abstract_inverted_index.fluorescent | 12 |
| abstract_inverted_index.impossible. | 24 |
| abstract_inverted_index.introduced, | 98 |
| abstract_inverted_index.kinetochore | 102 |
| abstract_inverted_index.mechanistic | 16 |
| abstract_inverted_index.nucleosomes | 133 |
| abstract_inverted_index.utilization | 169 |
| abstract_inverted_index.C-terminally | 92 |
| abstract_inverted_index.nucleosomes. | 153 |
| abstract_inverted_index.recapitulate | 83 |
| abstract_inverted_index.recognition, | 37 |
| abstract_inverted_index.Additionally, | 129 |
| abstract_inverted_index.incorporation | 137 |
| abstract_inverted_index.modifications | 108 |
| abstract_inverted_index.purification, | 65 |
| abstract_inverted_index.visualization. | 67 |
| abstract_inverted_index.CENP-A-containing | 132 |
| abstract_inverted_index.post-translational | 107 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5062431514 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 5 |
| corresponding_institution_ids | https://openalex.org/I4210140884, https://openalex.org/I4210149717 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/1 |
| sustainable_development_goals[0].score | 0.6499999761581421 |
| sustainable_development_goals[0].display_name | No poverty |
| citation_normalized_percentile.value | 0.79183874 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |