Natural PPARs agonists for the treatment of nonalcoholic fatty liver disease Article Swipe
Jiashu Pan
,
Wenjun Zhou
,
Ruohui Xu
,
Lianjun Xing
,
Guang Ji
,
Yanqi Dang
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1016/j.biopha.2022.113127
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1016/j.biopha.2022.113127
Nonalcoholic fatty liver disease (NAFLD) is a general term for a series of liver diseases including simple steatosis, non-alcoholic steatohepatitis, liver fibrosis, which is closely related to metabolic syndrome. The pathogenesis of NAFLD is relatively complex, which has gradually changed from the previous 'two-hit' hypothesis to the current "multiple hits" hypothesis. However, there is currently no approved treatment for NAFLD in clinic, highlighting the urgent need for drug development. Peroxisome proliferator activated receptors (PPARs) are members of the nuclear receptor superfamily, whose different subtypes have been proved to regulate different stages of NAFLD, thus becoming promising drug targets for NAFLD. As important sources of drug development, natural products have been proven to treat NAFLD through multiple pathways and multiple targets. In this paper, we outline the regulatory role of PPARs in NAFLD, and summarize some natural products that target PPARs to ameliorate NAFLD, in order to provide reference for drug development of NAFLD.
Related Topics
Concepts
Nonalcoholic fatty liver disease
Steatohepatitis
Fatty liver
Steatosis
Medicine
Metabolic syndrome
Bioinformatics
Disease
Drug development
Fibrosis
Chronic liver disease
Internal medicine
Peroxisome proliferator-activated receptor
Drug
Biology
Pharmacology
Receptor
Obesity
Cirrhosis
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.biopha.2022.113127
- OA Status
- gold
- Cited By
- 42
- References
- 112
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4281488956
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4281488956Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.biopha.2022.113127Digital Object Identifier
- Title
-
Natural PPARs agonists for the treatment of nonalcoholic fatty liver diseaseWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-05-20Full publication date if available
- Authors
-
Jiashu Pan, Wenjun Zhou, Ruohui Xu, Lianjun Xing, Guang Ji, Yanqi DangList of authors in order
- Landing page
-
https://doi.org/10.1016/j.biopha.2022.113127Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1016/j.biopha.2022.113127Direct OA link when available
- Concepts
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Nonalcoholic fatty liver disease, Steatohepatitis, Fatty liver, Steatosis, Medicine, Metabolic syndrome, Bioinformatics, Disease, Drug development, Fibrosis, Chronic liver disease, Internal medicine, Peroxisome proliferator-activated receptor, Drug, Biology, Pharmacology, Receptor, Obesity, CirrhosisTop concepts (fields/topics) attached by OpenAlex
- Cited by
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42Total citation count in OpenAlex
- Citations by year (recent)
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2025: 18, 2024: 13, 2023: 10, 2022: 1Per-year citation counts (last 5 years)
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112Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.hypothesis. | 50 |
| abstract_inverted_index.Nonalcoholic | 0 |
| abstract_inverted_index.development, | 105 |
| abstract_inverted_index.development. | 68 |
| abstract_inverted_index.highlighting | 62 |
| abstract_inverted_index.pathogenesis | 30 |
| abstract_inverted_index.proliferator | 70 |
| abstract_inverted_index.superfamily, | 80 |
| abstract_inverted_index.non-alcoholic | 18 |
| abstract_inverted_index.steatohepatitis, | 19 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5027897339, https://openalex.org/A5019124641 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 6 |
| corresponding_institution_ids | https://openalex.org/I4210098460, https://openalex.org/I4210101984 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8399999737739563 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.97827633 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |