Naturally occurring antibodies against ASC decrease during aging Article Swipe
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· 2024
· Open Access
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· DOI: https://doi.org/10.21203/rs.3.rs-5343804/v1
· OA: W4404151340
<title>Abstract</title> <bold>Background: </bold>This study aims to investigate the variations of the naturally occurring antibodies against ASC (NAbs-ASC) among a healthy Chinese population and analyze their correlation with age. <bold>Methods</bold>: This cross-sectional study recruited a total of 97 young, 99 middle-aged, and 108 elderly subjects from the Health Management Department of Daping Hospital, Army Medical University. The study compared the levels of the NAbs-ASC in different age groups and analyzed the correlation between NAbs-ASC and age using Spearman's correlation. Additionally, the study involved plotting NAbs-ASC to evaluate the receiver operating characteristic (ROC) curve for aging. <bold>Results</bold>: NAbs-ASC were widely present in humans.NAbs-ASC levels were significantly lower in the elderly group compared with the young (2421.15ng/L vs. 2849.26 ng/L, p<0.001) and middle-aged groups (2421.15 ng/L vs. 2878.44 ng/L, p<0.001). There was no statistically significant difference in NAbs-ASC levels between the young and middle-aged groups (2849.26 vs. 2878.44, p=0.576). Spearman's correlation analysis indicated a negative correlation between age and NAbs-ASC levels (r=-0.324, p<0.001). ROC curve analysis showed that the area under the curve (AUC) for NAbs-ASC was 0.699 (95% CI: 0.628-0.771, p < 0.001). <bold>Conclusion:</bold> The NAbs-ASC levels were reduced in elderly individuals and are negatively correlated with age. NAbs-ASC may serve as a potential biomarker of aging and aging-related diseases.
