<title>Abstract</title> <bold>Background: </bold>This study aims to investigate the variations of the naturally occurring antibodies against ASC (NAbs-ASC) among a healthy Chinese population and analyze their correlation with age. <bold>Methods</bold>: This cross-sectional study recruited a total of 97 young, 99 middle-aged, and 108 elderly subjects from the Health Management Department of Daping Hospital, Army Medical University. The study compared the levels of the NAbs-ASC in different age groups and analyzed t…