Nature Chose Phosphates and Chemists Should Too: How Emerging P(V) Methods Can Augment Existing Strategies Article Swipe
Kyle W. Knouse
,
Dillon T. Flood
,
Julien C. Vantourout
,
Michael A. Schmidt
,
Ivar M. McDonald
,
Martin D. Eastgate
,
Phil S. Baran
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1021/acscentsci.1c00487
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1021/acscentsci.1c00487
Phosphate linkages govern life as we know it. Their unique properties provide the foundation for many natural systems from cell biology and biosynthesis to the backbone of nucleic acids. Phosphates are ideal natural moieties; existing as ionized species in a stable P(V)-oxidation state, they are endowed with high stability but exhibit enzymatically unlockable potential. Despite intense interest in phosphorus catalysis and condensation chemistry, organic chemistry has not fully embraced the potential of P(V) reagents. To be sure, within the world of chemical oligonucleotide synthesis, modern approaches utilize P(III) reagent systems to create phosphate linkages and their analogs. In this Outlook, we present recent studies from our laboratories suggesting that numerous exciting opportunities for P(V) chemistry exist at the nexus of organic synthesis and biochemistry. Applications to the synthesis of stereopure antisense oligonucleotides, cyclic dinucleotides, methylphosphonates, and phosphines are reviewed as well as chemoselective modification to peptides, proteins, and nucleic acids. Finally, an outlook into what may be possible in the future with P(V) chemistry is previewed, suggesting these examples represent just the tip of the iceberg.
Related Topics
Concepts
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1021/acscentsci.1c00487
- https://pubs.acs.org/doi/pdf/10.1021/acscentsci.1c00487
- OA Status
- diamond
- Cited By
- 93
- References
- 108
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3201372641
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3201372641Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1021/acscentsci.1c00487Digital Object Identifier
- Title
-
Nature Chose Phosphates and Chemists Should Too: How Emerging P(V) Methods Can Augment Existing StrategiesWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-09-10Full publication date if available
- Authors
-
Kyle W. Knouse, Dillon T. Flood, Julien C. Vantourout, Michael A. Schmidt, Ivar M. McDonald, Martin D. Eastgate, Phil S. BaranList of authors in order
- Landing page
-
https://doi.org/10.1021/acscentsci.1c00487Publisher landing page
- PDF URL
-
https://pubs.acs.org/doi/pdf/10.1021/acscentsci.1c00487Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
-
https://pubs.acs.org/doi/pdf/10.1021/acscentsci.1c00487Direct OA link when available
- Concepts
-
Chemistry, Nucleic acid, Oligonucleotide, Combinatorial chemistry, Organic synthesis, Nanotechnology, Organic chemistry, Biochemistry, Catalysis, DNA, Materials scienceTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
93Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 20, 2024: 27, 2023: 30, 2022: 15, 2021: 1Per-year citation counts (last 5 years)
- References (count)
-
108Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3201372641 |
|---|---|
| doi | https://doi.org/10.1021/acscentsci.1c00487 |
| ids.doi | https://doi.org/10.1021/acscentsci.1c00487 |
| ids.mag | 3201372641 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/34584948 |
| ids.openalex | https://openalex.org/W3201372641 |
| fwci | 7.11986719 |
| type | review |
| title | Nature Chose Phosphates and Chemists Should Too: How Emerging P(V) Methods Can Augment Existing Strategies |
| awards[0].id | https://openalex.org/G5374570612 |
| awards[0].funder_id | https://openalex.org/F4320337472 |
| awards[0].display_name | |
| awards[0].funder_award_id | UL1 TR002551 |
| awards[0].funder_display_name | National Center for Advancing Translational Sciences |
| awards[1].id | https://openalex.org/G3027912527 |
| awards[1].funder_id | https://openalex.org/F4320337354 |
| awards[1].display_name | |
| awards[1].funder_award_id | GM-118176 |
| awards[1].funder_display_name | National Institute of General Medical Sciences |
| awards[2].id | https://openalex.org/G8981936356 |
| awards[2].funder_id | https://openalex.org/F4320337472 |
| awards[2].display_name | |
| awards[2].funder_award_id | TL1 TR002551 |
| awards[2].funder_display_name | National Center for Advancing Translational Sciences |
| biblio.issue | 9 |
| biblio.volume | 7 |
| biblio.last_page | 1485 |
| biblio.first_page | 1473 |
| topics[0].id | https://openalex.org/T10207 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9991000294685364 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Advanced biosensing and bioanalysis techniques |
| topics[1].id | https://openalex.org/T10432 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9984999895095825 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | DNA and Nucleic Acid Chemistry |
| topics[2].id | https://openalex.org/T11440 |
| topics[2].field.id | https://openalex.org/fields/16 |
| topics[2].field.display_name | Chemistry |
| topics[2].score | 0.9983999729156494 |
| topics[2].domain.id | https://openalex.org/domains/3 |
| topics[2].domain.display_name | Physical Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1605 |
| topics[2].subfield.display_name | Organic Chemistry |
| topics[2].display_name | Click Chemistry and Applications |
| funders[0].id | https://openalex.org/F4320307115 |
| funders[0].ror | https://ror.org/00gtmwv55 |
| funders[0].display_name | Bristol-Myers Squibb |
| funders[1].id | https://openalex.org/F4320337354 |
| funders[1].ror | https://ror.org/04q48ey07 |
| funders[1].display_name | National Institute of General Medical Sciences |
| funders[2].id | https://openalex.org/F4320337472 |
| funders[2].ror | https://ror.org/04pw6fb54 |
| funders[2].display_name | National Center for Advancing Translational Sciences |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C185592680 |
| concepts[0].level | 0 |
| concepts[0].score | 0.6451107263565063 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[0].display_name | Chemistry |
| concepts[1].id | https://openalex.org/C24107716 |
| concepts[1].level | 2 |
| concepts[1].score | 0.5953765511512756 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q123619 |
| concepts[1].display_name | Nucleic acid |
| concepts[2].id | https://openalex.org/C129312508 |
| concepts[2].level | 3 |
| concepts[2].score | 0.5256891250610352 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q133686 |
| concepts[2].display_name | Oligonucleotide |
| concepts[3].id | https://openalex.org/C21951064 |
| concepts[3].level | 1 |
| concepts[3].score | 0.4364590048789978 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q899212 |
| concepts[3].display_name | Combinatorial chemistry |
| concepts[4].id | https://openalex.org/C535685238 |
| concepts[4].level | 3 |
| concepts[4].score | 0.4129767417907715 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q1153832 |
| concepts[4].display_name | Organic synthesis |
| concepts[5].id | https://openalex.org/C171250308 |
| concepts[5].level | 1 |
| concepts[5].score | 0.3645104467868805 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q11468 |
| concepts[5].display_name | Nanotechnology |
| concepts[6].id | https://openalex.org/C178790620 |
| concepts[6].level | 1 |
| concepts[6].score | 0.31712692975997925 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q11351 |
| concepts[6].display_name | Organic chemistry |
| concepts[7].id | https://openalex.org/C55493867 |
| concepts[7].level | 1 |
| concepts[7].score | 0.28014281392097473 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[7].display_name | Biochemistry |
| concepts[8].id | https://openalex.org/C161790260 |
| concepts[8].level | 2 |
| concepts[8].score | 0.2760152220726013 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q82264 |
| concepts[8].display_name | Catalysis |
| concepts[9].id | https://openalex.org/C552990157 |
| concepts[9].level | 2 |
| concepts[9].score | 0.15969428420066833 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7430 |
| concepts[9].display_name | DNA |
| concepts[10].id | https://openalex.org/C192562407 |
| concepts[10].level | 0 |
| concepts[10].score | 0.10832032561302185 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q228736 |
| concepts[10].display_name | Materials science |
| keywords[0].id | https://openalex.org/keywords/chemistry |
| keywords[0].score | 0.6451107263565063 |
| keywords[0].display_name | Chemistry |
| keywords[1].id | https://openalex.org/keywords/nucleic-acid |
| keywords[1].score | 0.5953765511512756 |
| keywords[1].display_name | Nucleic acid |
| keywords[2].id | https://openalex.org/keywords/oligonucleotide |
| keywords[2].score | 0.5256891250610352 |
| keywords[2].display_name | Oligonucleotide |
| keywords[3].id | https://openalex.org/keywords/combinatorial-chemistry |
| keywords[3].score | 0.4364590048789978 |
| keywords[3].display_name | Combinatorial chemistry |
| keywords[4].id | https://openalex.org/keywords/organic-synthesis |
| keywords[4].score | 0.4129767417907715 |
| keywords[4].display_name | Organic synthesis |
| keywords[5].id | https://openalex.org/keywords/nanotechnology |
| keywords[5].score | 0.3645104467868805 |
| keywords[5].display_name | Nanotechnology |
| keywords[6].id | https://openalex.org/keywords/organic-chemistry |
| keywords[6].score | 0.31712692975997925 |
| keywords[6].display_name | Organic chemistry |
| keywords[7].id | https://openalex.org/keywords/biochemistry |
| keywords[7].score | 0.28014281392097473 |
| keywords[7].display_name | Biochemistry |
| keywords[8].id | https://openalex.org/keywords/catalysis |
| keywords[8].score | 0.2760152220726013 |
| keywords[8].display_name | Catalysis |
| keywords[9].id | https://openalex.org/keywords/dna |
| keywords[9].score | 0.15969428420066833 |
| keywords[9].display_name | DNA |
| keywords[10].id | https://openalex.org/keywords/materials-science |
| keywords[10].score | 0.10832032561302185 |
| keywords[10].display_name | Materials science |
| language | en |
| locations[0].id | doi:10.1021/acscentsci.1c00487 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2765035057 |
| locations[0].source.issn | 2374-7943, 2374-7951 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2374-7943 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | ACS Central Science |
| locations[0].source.host_organization | https://openalex.org/P4310320006 |
| locations[0].source.host_organization_name | American Chemical Society |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320006 |
| locations[0].source.host_organization_lineage_names | American Chemical Society |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://pubs.acs.org/doi/pdf/10.1021/acscentsci.1c00487 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | ACS Central Science |
| locations[0].landing_page_url | https://doi.org/10.1021/acscentsci.1c00487 |
| locations[1].id | pmid:34584948 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | ACS central science |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/34584948 |
| locations[2].id | pmh:oai:doaj.org/article:5be940581fe646b0a5177709e009d3a1 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].license | cc-by-sa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | ACS Central Science, Vol 7, Iss 9, Pp 1473-1485 (2021) |
| locations[2].landing_page_url | https://doaj.org/article/5be940581fe646b0a5177709e009d3a1 |
| locations[3].id | pmh:oai:europepmc.org:7361985 |
| locations[3].is_oa | False |
| locations[3].source.id | https://openalex.org/S4306400806 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | Europe PMC (PubMed Central) |
| locations[3].source.host_organization | https://openalex.org/I1303153112 |
| locations[3].source.host_organization_name | European Bioinformatics Institute |
| locations[3].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | |
| locations[3].landing_page_url | http://europepmc.org/pmc/articles/PMC8461637 |
| locations[4].id | pmh:oai:pubmedcentral.nih.gov:8461637 |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S2764455111 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | PubMed Central |
| locations[4].source.host_organization | https://openalex.org/I1299303238 |
| locations[4].source.host_organization_name | National Institutes of Health |
| locations[4].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[4].license | |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | Text |
| locations[4].license_id | |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | ACS Cent Sci |
| locations[4].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/8461637 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5026245761 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-9688-0513 |
| authorships[0].author.display_name | Kyle W. Knouse |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I150209017, https://openalex.org/I40399489, https://openalex.org/I4210140114 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States |
| authorships[0].affiliations[1].raw_affiliation_string | Elsie Biotechnologies, 4955 Directors Place, San Diego, California 92121, United States |
| authorships[0].institutions[0].id | https://openalex.org/I4210140114 |
| authorships[0].institutions[0].ror | https://ror.org/04x9v7g36 |
| authorships[0].institutions[0].type | company |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210140114 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | Scripps (United States) |
| authorships[0].institutions[1].id | https://openalex.org/I150209017 |
| authorships[0].institutions[1].ror | https://ror.org/04v7hvq31 |
| authorships[0].institutions[1].type | facility |
| authorships[0].institutions[1].lineage | https://openalex.org/I150209017, https://openalex.org/I36258959 |
| authorships[0].institutions[1].country_code | US |
| authorships[0].institutions[1].display_name | Scripps Institution of Oceanography |
| authorships[0].institutions[2].id | https://openalex.org/I40399489 |
| authorships[0].institutions[2].ror | https://ror.org/01grq2104 |
| authorships[0].institutions[2].type | nonprofit |
| authorships[0].institutions[2].lineage | https://openalex.org/I40399489 |
| authorships[0].institutions[2].country_code | US |
| authorships[0].institutions[2].display_name | Torrey Pines Institute For Molecular Studies |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Kyle W. Knouse |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States, Elsie Biotechnologies, 4955 Directors Place, San Diego, California 92121, United States |
| authorships[1].author.id | https://openalex.org/A5064376834 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-6600-0287 |
| authorships[1].author.display_name | Dillon T. Flood |
| authorships[1].countries | US |
| authorships[1].affiliations[0].raw_affiliation_string | Elsie Biotechnologies, 4955 Directors Place, San Diego, California 92121, United States |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I150209017, https://openalex.org/I40399489, https://openalex.org/I4210140114 |
| authorships[1].affiliations[1].raw_affiliation_string | Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States |
| authorships[1].institutions[0].id | https://openalex.org/I4210140114 |
| authorships[1].institutions[0].ror | https://ror.org/04x9v7g36 |
| authorships[1].institutions[0].type | company |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210140114 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | Scripps (United States) |
| authorships[1].institutions[1].id | https://openalex.org/I150209017 |
| authorships[1].institutions[1].ror | https://ror.org/04v7hvq31 |
| authorships[1].institutions[1].type | facility |
| authorships[1].institutions[1].lineage | https://openalex.org/I150209017, https://openalex.org/I36258959 |
| authorships[1].institutions[1].country_code | US |
| authorships[1].institutions[1].display_name | Scripps Institution of Oceanography |
| authorships[1].institutions[2].id | https://openalex.org/I40399489 |
| authorships[1].institutions[2].ror | https://ror.org/01grq2104 |
| authorships[1].institutions[2].type | nonprofit |
| authorships[1].institutions[2].lineage | https://openalex.org/I40399489 |
| authorships[1].institutions[2].country_code | US |
| authorships[1].institutions[2].display_name | Torrey Pines Institute For Molecular Studies |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Dillon T. Flood |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States, Elsie Biotechnologies, 4955 Directors Place, San Diego, California 92121, United States |
| authorships[2].author.id | https://openalex.org/A5015990328 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-0602-069X |
| authorships[2].author.display_name | Julien C. Vantourout |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I150209017, https://openalex.org/I40399489, https://openalex.org/I4210140114 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States |
| authorships[2].institutions[0].id | https://openalex.org/I4210140114 |
| authorships[2].institutions[0].ror | https://ror.org/04x9v7g36 |
| authorships[2].institutions[0].type | company |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210140114 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | Scripps (United States) |
| authorships[2].institutions[1].id | https://openalex.org/I150209017 |
| authorships[2].institutions[1].ror | https://ror.org/04v7hvq31 |
| authorships[2].institutions[1].type | facility |
| authorships[2].institutions[1].lineage | https://openalex.org/I150209017, https://openalex.org/I36258959 |
| authorships[2].institutions[1].country_code | US |
| authorships[2].institutions[1].display_name | Scripps Institution of Oceanography |
| authorships[2].institutions[2].id | https://openalex.org/I40399489 |
| authorships[2].institutions[2].ror | https://ror.org/01grq2104 |
| authorships[2].institutions[2].type | nonprofit |
| authorships[2].institutions[2].lineage | https://openalex.org/I40399489 |
| authorships[2].institutions[2].country_code | US |
| authorships[2].institutions[2].display_name | Torrey Pines Institute For Molecular Studies |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Julien C. Vantourout |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States |
| authorships[3].author.id | https://openalex.org/A5082072514 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-4880-2083 |
| authorships[3].author.display_name | Michael A. Schmidt |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210091812 |
| authorships[3].affiliations[0].raw_affiliation_string | Chemical and Synthetic Development, Bristol Myers Squibb, One Squibb Drive, New Brunswick, New Jersey 08903, United States |
| authorships[3].institutions[0].id | https://openalex.org/I4210091812 |
| authorships[3].institutions[0].ror | https://ror.org/00gtmwv55 |
| authorships[3].institutions[0].type | company |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210091812 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | Bristol-Myers Squibb (United States) |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Michael A. Schmidt |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Chemical and Synthetic Development, Bristol Myers Squibb, One Squibb Drive, New Brunswick, New Jersey 08903, United States |
| authorships[4].author.id | https://openalex.org/A5047963982 |
| authorships[4].author.orcid | https://orcid.org/0000-0001-7500-7133 |
| authorships[4].author.display_name | Ivar M. McDonald |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210091812 |
| authorships[4].affiliations[0].raw_affiliation_string | Small Molecule Drug Discovery, Bristol Myers Squibb, 100 Binney Street, Cambridge, Massachusetts 02142, United States |
| authorships[4].institutions[0].id | https://openalex.org/I4210091812 |
| authorships[4].institutions[0].ror | https://ror.org/00gtmwv55 |
| authorships[4].institutions[0].type | company |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210091812 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | Bristol-Myers Squibb (United States) |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Ivar M. Mcdonald |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Small Molecule Drug Discovery, Bristol Myers Squibb, 100 Binney Street, Cambridge, Massachusetts 02142, United States |
| authorships[5].author.id | https://openalex.org/A5029466336 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-6487-3121 |
| authorships[5].author.display_name | Martin D. Eastgate |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I4210091812 |
| authorships[5].affiliations[0].raw_affiliation_string | Chemical and Synthetic Development, Bristol Myers Squibb, One Squibb Drive, New Brunswick, New Jersey 08903, United States |
| authorships[5].institutions[0].id | https://openalex.org/I4210091812 |
| authorships[5].institutions[0].ror | https://ror.org/00gtmwv55 |
| authorships[5].institutions[0].type | company |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210091812 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | Bristol-Myers Squibb (United States) |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Martin D. Eastgate |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Chemical and Synthetic Development, Bristol Myers Squibb, One Squibb Drive, New Brunswick, New Jersey 08903, United States |
| authorships[6].author.id | https://openalex.org/A5051379973 |
| authorships[6].author.orcid | https://orcid.org/0000-0001-9193-9053 |
| authorships[6].author.display_name | Phil S. Baran |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I150209017, https://openalex.org/I40399489, https://openalex.org/I4210140114 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States |
| authorships[6].affiliations[1].raw_affiliation_string | Elsie Biotechnologies, 4955 Directors Place, San Diego, California 92121, United States |
| authorships[6].institutions[0].id | https://openalex.org/I4210140114 |
| authorships[6].institutions[0].ror | https://ror.org/04x9v7g36 |
| authorships[6].institutions[0].type | company |
| authorships[6].institutions[0].lineage | https://openalex.org/I4210140114 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | Scripps (United States) |
| authorships[6].institutions[1].id | https://openalex.org/I150209017 |
| authorships[6].institutions[1].ror | https://ror.org/04v7hvq31 |
| authorships[6].institutions[1].type | facility |
| authorships[6].institutions[1].lineage | https://openalex.org/I150209017, https://openalex.org/I36258959 |
| authorships[6].institutions[1].country_code | US |
| authorships[6].institutions[1].display_name | Scripps Institution of Oceanography |
| authorships[6].institutions[2].id | https://openalex.org/I40399489 |
| authorships[6].institutions[2].ror | https://ror.org/01grq2104 |
| authorships[6].institutions[2].type | nonprofit |
| authorships[6].institutions[2].lineage | https://openalex.org/I40399489 |
| authorships[6].institutions[2].country_code | US |
| authorships[6].institutions[2].display_name | Torrey Pines Institute For Molecular Studies |
| authorships[6].author_position | last |
| authorships[6].raw_author_name | Phil S. Baran |
| authorships[6].is_corresponding | True |
| authorships[6].raw_affiliation_strings | Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States, Elsie Biotechnologies, 4955 Directors Place, San Diego, California 92121, United States |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://pubs.acs.org/doi/pdf/10.1021/acscentsci.1c00487 |
| open_access.oa_status | diamond |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Nature Chose Phosphates and Chemists Should Too: How Emerging P(V) Methods Can Augment Existing Strategies |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10207 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9991000294685364 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Advanced biosensing and bioanalysis techniques |
| related_works | https://openalex.org/W1559747182, https://openalex.org/W2051344354, https://openalex.org/W2081918775, https://openalex.org/W4210761931, https://openalex.org/W2582812828, https://openalex.org/W4367367846, https://openalex.org/W2039817796, https://openalex.org/W2042597707, https://openalex.org/W2072719700, https://openalex.org/W2330226136 |
| cited_by_count | 93 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 20 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 27 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 30 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 15 |
| counts_by_year[4].year | 2021 |
| counts_by_year[4].cited_by_count | 1 |
| locations_count | 5 |
| best_oa_location.id | doi:10.1021/acscentsci.1c00487 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2765035057 |
| best_oa_location.source.issn | 2374-7943, 2374-7951 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2374-7943 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | ACS Central Science |
| best_oa_location.source.host_organization | https://openalex.org/P4310320006 |
| best_oa_location.source.host_organization_name | American Chemical Society |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320006 |
| best_oa_location.source.host_organization_lineage_names | American Chemical Society |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://pubs.acs.org/doi/pdf/10.1021/acscentsci.1c00487 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | ACS Central Science |
| best_oa_location.landing_page_url | https://doi.org/10.1021/acscentsci.1c00487 |
| primary_location.id | doi:10.1021/acscentsci.1c00487 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2765035057 |
| primary_location.source.issn | 2374-7943, 2374-7951 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2374-7943 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | ACS Central Science |
| primary_location.source.host_organization | https://openalex.org/P4310320006 |
| primary_location.source.host_organization_name | American Chemical Society |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320006 |
| primary_location.source.host_organization_lineage_names | American Chemical Society |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://pubs.acs.org/doi/pdf/10.1021/acscentsci.1c00487 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | ACS Central Science |
| primary_location.landing_page_url | https://doi.org/10.1021/acscentsci.1c00487 |
| publication_date | 2021-09-10 |
| publication_year | 2021 |
| referenced_works | https://openalex.org/W4241552450, https://openalex.org/W2135090970, https://openalex.org/W2010440660, https://openalex.org/W3005231892, https://openalex.org/W2064761203, https://openalex.org/W2499895432, https://openalex.org/W1971580698, https://openalex.org/W3006883590, https://openalex.org/W2477940784, https://openalex.org/W2050052511, https://openalex.org/W1881469793, https://openalex.org/W2797692501, https://openalex.org/W1981067442, https://openalex.org/W2069636180, https://openalex.org/W2014974385, https://openalex.org/W2089617243, https://openalex.org/W1984286262, https://openalex.org/W2153772742, https://openalex.org/W2012182437, https://openalex.org/W2015531736, https://openalex.org/W2329543029, https://openalex.org/W1557501498, https://openalex.org/W1641857233, https://openalex.org/W1488936586, https://openalex.org/W2329415690, https://openalex.org/W2318995361, https://openalex.org/W2015916466, https://openalex.org/W2034716970, https://openalex.org/W2019014169, https://openalex.org/W2054615424, https://openalex.org/W1966347067, https://openalex.org/W4242300492, https://openalex.org/W1964571849, https://openalex.org/W2028888693, https://openalex.org/W2040355525, https://openalex.org/W2071301122, https://openalex.org/W2027488963, https://openalex.org/W1947145954, https://openalex.org/W1970673071, https://openalex.org/W1987885238, https://openalex.org/W1973152917, https://openalex.org/W2038346298, https://openalex.org/W4246731605, https://openalex.org/W2077002341, https://openalex.org/W2085465602, https://openalex.org/W1991975352, https://openalex.org/W2037945358, https://openalex.org/W2059676904, https://openalex.org/W2093234904, https://openalex.org/W2335169054, https://openalex.org/W2746807303, https://openalex.org/W1965536028, https://openalex.org/W2886572205, https://openalex.org/W2557512586, https://openalex.org/W4232043845, https://openalex.org/W2127366175, https://openalex.org/W2009546792, https://openalex.org/W2085475094, https://openalex.org/W2096436797, https://openalex.org/W2101785219, https://openalex.org/W2950847316, https://openalex.org/W2063150904, https://openalex.org/W3008653361, https://openalex.org/W3043706855, https://openalex.org/W3005662976, https://openalex.org/W3000957888, https://openalex.org/W2917912064, https://openalex.org/W4256503849, https://openalex.org/W2151709132, https://openalex.org/W2947079937, https://openalex.org/W2810724953, https://openalex.org/W2999977264, https://openalex.org/W3005728616, https://openalex.org/W3091157204, https://openalex.org/W2950352950, https://openalex.org/W2729329687, https://openalex.org/W3088983575, https://openalex.org/W2032545978, https://openalex.org/W2087191734, https://openalex.org/W2053869569, https://openalex.org/W2065675602, https://openalex.org/W1967018847, https://openalex.org/W2089850803, https://openalex.org/W2036727958, https://openalex.org/W2093450038, https://openalex.org/W3002094750, https://openalex.org/W1964272339, https://openalex.org/W2165546237, https://openalex.org/W2481500357, https://openalex.org/W2026433653, https://openalex.org/W3128935390, https://openalex.org/W1973845595, https://openalex.org/W3155177878, https://openalex.org/W2899430976, https://openalex.org/W2146893495, https://openalex.org/W2119039945, https://openalex.org/W2586761071, https://openalex.org/W3195995841, https://openalex.org/W3196906344, https://openalex.org/W1590106858, https://openalex.org/W3137247471, https://openalex.org/W2950799264, https://openalex.org/W2256636826, https://openalex.org/W573478681, https://openalex.org/W3088566624, https://openalex.org/W2929312703, https://openalex.org/W2052731133, https://openalex.org/W1991094657 |
| referenced_works_count | 108 |
| abstract_inverted_index.a | 39 |
| abstract_inverted_index.In | 97 |
| abstract_inverted_index.To | 74 |
| abstract_inverted_index.an | 151 |
| abstract_inverted_index.as | 4, 35, 139, 141 |
| abstract_inverted_index.at | 116 |
| abstract_inverted_index.be | 75, 156 |
| abstract_inverted_index.in | 38, 57, 158 |
| abstract_inverted_index.is | 164 |
| abstract_inverted_index.of | 26, 71, 80, 119, 128, 173 |
| abstract_inverted_index.to | 23, 90, 125, 144 |
| abstract_inverted_index.we | 5, 100 |
| abstract_inverted_index.and | 21, 60, 94, 122, 135, 147 |
| abstract_inverted_index.are | 30, 44, 137 |
| abstract_inverted_index.but | 49 |
| abstract_inverted_index.for | 14, 112 |
| abstract_inverted_index.has | 65 |
| abstract_inverted_index.it. | 7 |
| abstract_inverted_index.may | 155 |
| abstract_inverted_index.not | 66 |
| abstract_inverted_index.our | 105 |
| abstract_inverted_index.the | 12, 24, 69, 78, 117, 126, 159, 171, 174 |
| abstract_inverted_index.tip | 172 |
| abstract_inverted_index.P(V) | 72, 113, 162 |
| abstract_inverted_index.cell | 19 |
| abstract_inverted_index.from | 18, 104 |
| abstract_inverted_index.high | 47 |
| abstract_inverted_index.into | 153 |
| abstract_inverted_index.just | 170 |
| abstract_inverted_index.know | 6 |
| abstract_inverted_index.life | 3 |
| abstract_inverted_index.many | 15 |
| abstract_inverted_index.that | 108 |
| abstract_inverted_index.they | 43 |
| abstract_inverted_index.this | 98 |
| abstract_inverted_index.well | 140 |
| abstract_inverted_index.what | 154 |
| abstract_inverted_index.with | 46, 161 |
| abstract_inverted_index.Their | 8 |
| abstract_inverted_index.exist | 115 |
| abstract_inverted_index.fully | 67 |
| abstract_inverted_index.ideal | 31 |
| abstract_inverted_index.nexus | 118 |
| abstract_inverted_index.sure, | 76 |
| abstract_inverted_index.their | 95 |
| abstract_inverted_index.these | 167 |
| abstract_inverted_index.world | 79 |
| abstract_inverted_index.P(III) | 87 |
| abstract_inverted_index.acids. | 28, 149 |
| abstract_inverted_index.create | 91 |
| abstract_inverted_index.cyclic | 132 |
| abstract_inverted_index.future | 160 |
| abstract_inverted_index.govern | 2 |
| abstract_inverted_index.modern | 84 |
| abstract_inverted_index.recent | 102 |
| abstract_inverted_index.stable | 40 |
| abstract_inverted_index.state, | 42 |
| abstract_inverted_index.unique | 9 |
| abstract_inverted_index.within | 77 |
| abstract_inverted_index.Despite | 54 |
| abstract_inverted_index.biology | 20 |
| abstract_inverted_index.endowed | 45 |
| abstract_inverted_index.exhibit | 50 |
| abstract_inverted_index.intense | 55 |
| abstract_inverted_index.ionized | 36 |
| abstract_inverted_index.natural | 16, 32 |
| abstract_inverted_index.nucleic | 27, 148 |
| abstract_inverted_index.organic | 63, 120 |
| abstract_inverted_index.outlook | 152 |
| abstract_inverted_index.present | 101 |
| abstract_inverted_index.provide | 11 |
| abstract_inverted_index.reagent | 88 |
| abstract_inverted_index.species | 37 |
| abstract_inverted_index.studies | 103 |
| abstract_inverted_index.systems | 17, 89 |
| abstract_inverted_index.utilize | 86 |
| abstract_inverted_index.Finally, | 150 |
| abstract_inverted_index.Outlook, | 99 |
| abstract_inverted_index.analogs. | 96 |
| abstract_inverted_index.backbone | 25 |
| abstract_inverted_index.chemical | 81 |
| abstract_inverted_index.embraced | 68 |
| abstract_inverted_index.examples | 168 |
| abstract_inverted_index.exciting | 110 |
| abstract_inverted_index.existing | 34 |
| abstract_inverted_index.iceberg. | 175 |
| abstract_inverted_index.interest | 56 |
| abstract_inverted_index.linkages | 1, 93 |
| abstract_inverted_index.numerous | 109 |
| abstract_inverted_index.possible | 157 |
| abstract_inverted_index.reviewed | 138 |
| abstract_inverted_index.Phosphate | 0 |
| abstract_inverted_index.antisense | 130 |
| abstract_inverted_index.catalysis | 59 |
| abstract_inverted_index.chemistry | 64, 114, 163 |
| abstract_inverted_index.moieties; | 33 |
| abstract_inverted_index.peptides, | 145 |
| abstract_inverted_index.phosphate | 92 |
| abstract_inverted_index.potential | 70 |
| abstract_inverted_index.proteins, | 146 |
| abstract_inverted_index.reagents. | 73 |
| abstract_inverted_index.represent | 169 |
| abstract_inverted_index.stability | 48 |
| abstract_inverted_index.synthesis | 121, 127 |
| abstract_inverted_index.Phosphates | 29 |
| abstract_inverted_index.approaches | 85 |
| abstract_inverted_index.chemistry, | 62 |
| abstract_inverted_index.foundation | 13 |
| abstract_inverted_index.phosphines | 136 |
| abstract_inverted_index.phosphorus | 58 |
| abstract_inverted_index.potential. | 53 |
| abstract_inverted_index.previewed, | 165 |
| abstract_inverted_index.properties | 10 |
| abstract_inverted_index.stereopure | 129 |
| abstract_inverted_index.suggesting | 107, 166 |
| abstract_inverted_index.synthesis, | 83 |
| abstract_inverted_index.unlockable | 52 |
| abstract_inverted_index.Applications | 124 |
| abstract_inverted_index.biosynthesis | 22 |
| abstract_inverted_index.condensation | 61 |
| abstract_inverted_index.laboratories | 106 |
| abstract_inverted_index.modification | 143 |
| abstract_inverted_index.biochemistry. | 123 |
| abstract_inverted_index.enzymatically | 51 |
| abstract_inverted_index.opportunities | 111 |
| abstract_inverted_index.P(V)-oxidation | 41 |
| abstract_inverted_index.chemoselective | 142 |
| abstract_inverted_index.dinucleotides, | 133 |
| abstract_inverted_index.oligonucleotide | 82 |
| abstract_inverted_index.oligonucleotides, | 131 |
| abstract_inverted_index.methylphosphonates, | 134 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5051379973 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 7 |
| corresponding_institution_ids | https://openalex.org/I150209017, https://openalex.org/I40399489, https://openalex.org/I4210140114 |
| citation_normalized_percentile.value | 0.97660497 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |