Navigating Lp(a) Measurement Challenges: From Guidelines to Laboratory Perspectives Article Swipe
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.62772/apfcb-news.2024.1.2
This comprehensive review delves into the evolving landscape of Lp(a) measurement standardsand examines the discordance and challenges in cardiovascular risk assessment in the contextof Lp(a). Acknowledging the shifting trends towards universal screening for Lp(a) endorsed by international societies working on risk assessment, management, and prevention of cardiovascular diseases, this review highlights the divergence in recommendations and the lackof consensus on Lp(a) risk thresholds. Ethnic variations in Lp(a) levels and ongoing clinical trial stargeting Lp(a) underscore the urgency of a unified and standardized approach to Lp(a) measurement. This article explores the intricacies of Lp(a) isoform size heterogeneity, availablemeasurement approaches, and the reporting unit challenge for the molecule. Emphasis is placed on collaborative efforts, transparent calibration, and the pivotal role of laboratories in ensuring the precision and reliability of Lp(a) measurements. The discussion encompasses thecall for unified calibration standards, highlighting the need for continuous external quality assessment and transparent reporting in clinical laboratories until a standardized Lp(a) measurement system is established.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- http://doi.org/10.62772/apfcb-news.2024.1.2
- https://doi.org/10.62772/apfcb-news.2024.1.2
- OA Status
- gold
- References
- 17
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4398788096
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4398788096Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.62772/apfcb-news.2024.1.2Digital Object Identifier
- Title
-
Navigating Lp(a) Measurement Challenges: From Guidelines to Laboratory PerspectivesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-01-01Full publication date if available
- Authors
-
Deepak Parchwani, Ragini Singh, C.D.S. KatochList of authors in order
- Landing page
-
https://doi.org/10.62772/apfcb-news.2024.1.2Publisher landing page
- PDF URL
-
https://doi.org/10.62772/apfcb-news.2024.1.2Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.62772/apfcb-news.2024.1.2Direct OA link when available
- Concepts
-
Computer scienceTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
17Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4398788096 |
|---|---|
| doi | https://doi.org/10.62772/apfcb-news.2024.1.2 |
| ids.doi | https://doi.org/10.62772/apfcb-news.2024.1.2 |
| ids.openalex | https://openalex.org/W4398788096 |
| fwci | 0.0 |
| type | article |
| title | Navigating Lp(a) Measurement Challenges: From Guidelines to Laboratory Perspectives |
| biblio.issue | 01 |
| biblio.volume | 2024 |
| biblio.last_page | 92 |
| biblio.first_page | 83 |
| topics[0].id | https://openalex.org/T10185 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9789000153541565 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2734 |
| topics[0].subfield.display_name | Pathology and Forensic Medicine |
| topics[0].display_name | Lymphoma Diagnosis and Treatment |
| topics[1].id | https://openalex.org/T10394 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9441999793052673 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2746 |
| topics[1].subfield.display_name | Surgery |
| topics[1].display_name | Lipoproteins and Cardiovascular Health |
| topics[2].id | https://openalex.org/T11395 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9262999892234802 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2741 |
| topics[2].subfield.display_name | Radiology, Nuclear Medicine and Imaging |
| topics[2].display_name | Radiopharmaceutical Chemistry and Applications |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C41008148 |
| concepts[0].level | 0 |
| concepts[0].score | 0.36665284633636475 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q21198 |
| concepts[0].display_name | Computer science |
| keywords[0].id | https://openalex.org/keywords/computer-science |
| keywords[0].score | 0.36665284633636475 |
| keywords[0].display_name | Computer science |
| language | en |
| locations[0].id | doi:10.62772/apfcb-news.2024.1.2 |
| locations[0].is_oa | True |
| locations[0].source | |
| locations[0].license | |
| locations[0].pdf_url | https://doi.org/10.62772/apfcb-news.2024.1.2 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Asia-Pacific Federation for Clinical Biochemistry and Laboratory Medicine |
| locations[0].landing_page_url | http://doi.org/10.62772/apfcb-news.2024.1.2 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5025282666 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-5024-970X |
| authorships[0].author.display_name | Deepak Parchwani |
| authorships[0].countries | IN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I63739035 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Biochemistry; All India Institute of Medical Sciences Rajkot, Gujarat, India |
| authorships[0].institutions[0].id | https://openalex.org/I63739035 |
| authorships[0].institutions[0].ror | https://ror.org/02dwcqs71 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I2799351866, https://openalex.org/I4210148677, https://openalex.org/I63739035 |
| authorships[0].institutions[0].country_code | IN |
| authorships[0].institutions[0].display_name | All India Institute of Medical Sciences |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Dr. Deepak N Parchwani |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Department of Biochemistry; All India Institute of Medical Sciences Rajkot, Gujarat, India |
| authorships[1].author.id | https://openalex.org/A5074839055 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-2397-9023 |
| authorships[1].author.display_name | Ragini Singh |
| authorships[1].countries | IN |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I63739035 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Biochemistry; All India Institute of Medical Sciences Rajkot, Gujarat, India |
| authorships[1].institutions[0].id | https://openalex.org/I63739035 |
| authorships[1].institutions[0].ror | https://ror.org/02dwcqs71 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I2799351866, https://openalex.org/I4210148677, https://openalex.org/I63739035 |
| authorships[1].institutions[0].country_code | IN |
| authorships[1].institutions[0].display_name | All India Institute of Medical Sciences |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Dr. Ragini D. Singh |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Biochemistry; All India Institute of Medical Sciences Rajkot, Gujarat, India |
| authorships[2].author.id | https://openalex.org/A5113377353 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | C.D.S. Katoch |
| authorships[2].author_position | last |
| authorships[2].raw_author_name | CDS Katoch |
| authorships[2].is_corresponding | False |
| has_content.pdf | True |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.62772/apfcb-news.2024.1.2 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Navigating Lp(a) Measurement Challenges: From Guidelines to Laboratory Perspectives |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10185 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9789000153541565 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2734 |
| primary_topic.subfield.display_name | Pathology and Forensic Medicine |
| primary_topic.display_name | Lymphoma Diagnosis and Treatment |
| related_works | https://openalex.org/W4391375266, https://openalex.org/W2748952813, https://openalex.org/W2390279801, https://openalex.org/W2358668433, https://openalex.org/W4396701345, https://openalex.org/W2376932109, https://openalex.org/W2001405890, https://openalex.org/W4396696052, https://openalex.org/W2382290278, https://openalex.org/W4395014643 |
| cited_by_count | 0 |
| locations_count | 1 |
| best_oa_location.id | doi:10.62772/apfcb-news.2024.1.2 |
| best_oa_location.is_oa | True |
| best_oa_location.source | |
| best_oa_location.license | |
| best_oa_location.pdf_url | https://doi.org/10.62772/apfcb-news.2024.1.2 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Asia-Pacific Federation for Clinical Biochemistry and Laboratory Medicine |
| best_oa_location.landing_page_url | http://doi.org/10.62772/apfcb-news.2024.1.2 |
| primary_location.id | doi:10.62772/apfcb-news.2024.1.2 |
| primary_location.is_oa | True |
| primary_location.source | |
| primary_location.license | |
| primary_location.pdf_url | https://doi.org/10.62772/apfcb-news.2024.1.2 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Asia-Pacific Federation for Clinical Biochemistry and Laboratory Medicine |
| primary_location.landing_page_url | http://doi.org/10.62772/apfcb-news.2024.1.2 |
| publication_date | 2024-01-01 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W4281250068, https://openalex.org/W4308599592, https://openalex.org/W3117215964, https://openalex.org/W1987023197, https://openalex.org/W2883271040, https://openalex.org/W1988877980, https://openalex.org/W4206573384, https://openalex.org/W2945006463, https://openalex.org/W2971008474, https://openalex.org/W1907534963, https://openalex.org/W2791021113, https://openalex.org/W2313206757, https://openalex.org/W2071679006, https://openalex.org/W3092575459, https://openalex.org/W2970669210, https://openalex.org/W3128300220, https://openalex.org/W1986030167 |
| referenced_works_count | 17 |
| abstract_inverted_index.a | 78, 152 |
| abstract_inverted_index.by | 35 |
| abstract_inverted_index.in | 17, 21, 53, 65, 120, 148 |
| abstract_inverted_index.is | 107, 157 |
| abstract_inverted_index.of | 8, 45, 77, 91, 118, 126 |
| abstract_inverted_index.on | 39, 59, 109 |
| abstract_inverted_index.to | 83 |
| abstract_inverted_index.The | 129 |
| abstract_inverted_index.and | 15, 43, 55, 68, 80, 98, 114, 124, 145 |
| abstract_inverted_index.for | 32, 103, 133, 140 |
| abstract_inverted_index.the | 5, 13, 22, 26, 51, 56, 75, 89, 99, 104, 115, 122, 138 |
| abstract_inverted_index.This | 0, 86 |
| abstract_inverted_index.into | 4 |
| abstract_inverted_index.need | 139 |
| abstract_inverted_index.risk | 19, 40, 61 |
| abstract_inverted_index.role | 117 |
| abstract_inverted_index.size | 94 |
| abstract_inverted_index.this | 48 |
| abstract_inverted_index.unit | 101 |
| abstract_inverted_index.Lp(a) | 9, 33, 60, 66, 73, 84, 92, 127, 154 |
| abstract_inverted_index.trial | 71 |
| abstract_inverted_index.until | 151 |
| abstract_inverted_index.Ethnic | 63 |
| abstract_inverted_index.Lp(a). | 24 |
| abstract_inverted_index.delves | 3 |
| abstract_inverted_index.lackof | 57 |
| abstract_inverted_index.levels | 67 |
| abstract_inverted_index.placed | 108 |
| abstract_inverted_index.review | 2, 49 |
| abstract_inverted_index.system | 156 |
| abstract_inverted_index.trends | 28 |
| abstract_inverted_index.article | 87 |
| abstract_inverted_index.isoform | 93 |
| abstract_inverted_index.ongoing | 69 |
| abstract_inverted_index.pivotal | 116 |
| abstract_inverted_index.quality | 143 |
| abstract_inverted_index.thecall | 132 |
| abstract_inverted_index.towards | 29 |
| abstract_inverted_index.unified | 79, 134 |
| abstract_inverted_index.urgency | 76 |
| abstract_inverted_index.working | 38 |
| abstract_inverted_index.Emphasis | 106 |
| abstract_inverted_index.approach | 82 |
| abstract_inverted_index.clinical | 70, 149 |
| abstract_inverted_index.efforts, | 111 |
| abstract_inverted_index.endorsed | 34 |
| abstract_inverted_index.ensuring | 121 |
| abstract_inverted_index.evolving | 6 |
| abstract_inverted_index.examines | 12 |
| abstract_inverted_index.explores | 88 |
| abstract_inverted_index.external | 142 |
| abstract_inverted_index.shifting | 27 |
| abstract_inverted_index.challenge | 102 |
| abstract_inverted_index.consensus | 58 |
| abstract_inverted_index.contextof | 23 |
| abstract_inverted_index.diseases, | 47 |
| abstract_inverted_index.landscape | 7 |
| abstract_inverted_index.molecule. | 105 |
| abstract_inverted_index.precision | 123 |
| abstract_inverted_index.reporting | 100, 147 |
| abstract_inverted_index.screening | 31 |
| abstract_inverted_index.societies | 37 |
| abstract_inverted_index.universal | 30 |
| abstract_inverted_index.assessment | 20, 144 |
| abstract_inverted_index.challenges | 16 |
| abstract_inverted_index.continuous | 141 |
| abstract_inverted_index.discussion | 130 |
| abstract_inverted_index.divergence | 52 |
| abstract_inverted_index.highlights | 50 |
| abstract_inverted_index.prevention | 44 |
| abstract_inverted_index.standards, | 136 |
| abstract_inverted_index.stargeting | 72 |
| abstract_inverted_index.underscore | 74 |
| abstract_inverted_index.variations | 64 |
| abstract_inverted_index.approaches, | 97 |
| abstract_inverted_index.assessment, | 41 |
| abstract_inverted_index.calibration | 135 |
| abstract_inverted_index.discordance | 14 |
| abstract_inverted_index.encompasses | 131 |
| abstract_inverted_index.intricacies | 90 |
| abstract_inverted_index.management, | 42 |
| abstract_inverted_index.measurement | 10, 155 |
| abstract_inverted_index.reliability | 125 |
| abstract_inverted_index.thresholds. | 62 |
| abstract_inverted_index.transparent | 112, 146 |
| abstract_inverted_index.calibration, | 113 |
| abstract_inverted_index.established. | 158 |
| abstract_inverted_index.highlighting | 137 |
| abstract_inverted_index.laboratories | 119, 150 |
| abstract_inverted_index.measurement. | 85 |
| abstract_inverted_index.standardized | 81, 153 |
| abstract_inverted_index.standardsand | 11 |
| abstract_inverted_index.Acknowledging | 25 |
| abstract_inverted_index.collaborative | 110 |
| abstract_inverted_index.comprehensive | 1 |
| abstract_inverted_index.international | 36 |
| abstract_inverted_index.measurements. | 128 |
| abstract_inverted_index.cardiovascular | 18, 46 |
| abstract_inverted_index.heterogeneity, | 95 |
| abstract_inverted_index.recommendations | 54 |
| abstract_inverted_index.availablemeasurement | 96 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5025282666 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 3 |
| corresponding_institution_ids | https://openalex.org/I63739035 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/17 |
| sustainable_development_goals[0].score | 0.5099999904632568 |
| sustainable_development_goals[0].display_name | Partnerships for the goals |
| citation_normalized_percentile.value | 0.13884512 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |