Navigating the complexity of BRAF mutations in non-small cell lung cancer: current insights and future prospects Article Swipe
Sufyan Ibrahim
,
Smita Shenoy
,
Ramya Kateel
,
Shreya Hegde
,
Amrita Parida
,
L. Samantaray
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.5826/mrm.2024.992
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.5826/mrm.2024.992
There are many challenges that are faced in the treatment of Non-Small Cell Lung Cancer (NSCLC) due to the complexities associated with the tumor. Association of different types of mutations are one of the major complexities. Among these mutations, BRAF mutations are significantly gathering more attention due to their impact on disease progression and therapeutic response. This review provides an analysis of the current understanding of BRAF mutations in NSCLC, focusing on the molecular intricacies, clinical implications, and therapeutic advancements. The article explores the diverse spectrum of BRAF mutations, highlighting the prevalence of specific mutations such as V600E and non-V600E alterations. The review also highlights the intricate signalling pathways influenced by BRAF mutations, shedding light on their role in tumorigenesis and metastasis. Therapeutically, we critically evaluate the existing targeted therapies tailored for BRAF-mutant NSCLC, addressing their efficacy, limitations, and emerging resistance mechanisms. Furthermore, we outline ongoing clinical trials and promising investigational agents that hold potential for reshaping the treatment of NSCLC. This review provides comprehensive current information about the role of BRAF mutations in NSCLC. Understanding the molecular diversity, clinical implications, and therapeutic strategies associated with BRAF-mutant NSCLC is crucial for optimizing patient outcomes and steering the direction of future research in this evolving field.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.5826/mrm.2024.992
- OA Status
- gold
- Cited By
- 2
- References
- 55
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4404415192Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.5826/mrm.2024.992Digital Object Identifier
- Title
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Navigating the complexity of BRAF mutations in non-small cell lung cancer: current insights and future prospectsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-11-15Full publication date if available
- Authors
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Sufyan Ibrahim, Smita Shenoy, Ramya Kateel, Shreya Hegde, Amrita Parida, L. SamantarayList of authors in order
- Landing page
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https://doi.org/10.5826/mrm.2024.992Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.5826/mrm.2024.992Direct OA link when available
- Concepts
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Lung cancer, Clinical trial, Targeted therapy, Carcinogenesis, Medicine, Metastasis, Mutation, Bioinformatics, Cancer research, Cancer, Biology, Oncology, Internal medicine, Gene, GeneticsTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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2025: 2Per-year citation counts (last 5 years)
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