Neferine Ameliorates Severe Acute Pancreatitis-Associated Intestinal Injury by Promoting NRF2-mediated Ferroptosis Article Swipe
Lilong Zhang
,
Kunpeng Wang
,
Wanrong Jiang
,
Ping’an Ding
,
Weixing Wang
,
Kailiang Zhao
,
Chen Chen
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.7150/ijbs.112888
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.7150/ijbs.112888
Severe acute pancreatitis (SAP) is a life-threatening abdominal condition often complicated by intestinal barrier dysfunction, which further exacerbates disease progression. Neferine has demonstrated potent anti-inflammatory and antioxidant properties; however, its role in ameliorating SAP and associated intestinal barrier damage remains unclear. In this study, we found that neferine administration significantly alleviates SAP severity by reducing pancreatic and ileal pathological damage, oxidative stress, inflammatory cell infiltration, and intestinal flora translocation. Additionally, neferine enhances the expression of tight junction proteins, increases short-chain fatty acid levels, and improves intestinal dysbiosis, thereby contributing to intestinal homeostasis restoration. Mechanistically, neferine upregulates Nrf2 expression and promotes its nuclear translocation by competitively binding to the Cys-288 site on Keap1. This activation enhances the Nrf2/FPN and Nrf2/xCT/GPX4 axes, thereby preventing ferroptosis and ultimately protecting against pancreatic and intestinal injury in SAP mice. Furthermore, the protective effects of neferine were largely reversed by the Nrf2 inhibitor ML385 and the ferroptosis inducer erastin. This study demonstrates that neferine effectively alleviates SAP by inhibiting ferroptosis and restoring intestinal homeostasis, providing insights into new treatment options for SAP.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.7150/ijbs.112888
- https://www.ijbs.com/v21p3247.pdf
- OA Status
- gold
- Cited By
- 1
- References
- 56
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4410305937Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.7150/ijbs.112888Digital Object Identifier
- Title
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Neferine Ameliorates Severe Acute Pancreatitis-Associated Intestinal Injury by Promoting NRF2-mediated FerroptosisWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-04-28Full publication date if available
- Authors
-
Lilong Zhang, Kunpeng Wang, Wanrong Jiang, Ping’an Ding, Weixing Wang, Kailiang Zhao, Chen ChenList of authors in order
- Landing page
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https://doi.org/10.7150/ijbs.112888Publisher landing page
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https://www.ijbs.com/v21p3247.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.ijbs.com/v21p3247.pdfDirect OA link when available
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Acute pancreatitis, Pancreatitis, Medicine, Chemistry, Internal medicineTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.restoration. | 92 |
| abstract_inverted_index.Additionally, | 69 |
| abstract_inverted_index.Nrf2/xCT/GPX4 | 118 |
| abstract_inverted_index.competitively | 104 |
| abstract_inverted_index.infiltration, | 64 |
| abstract_inverted_index.significantly | 49 |
| abstract_inverted_index.translocation | 102 |
| abstract_inverted_index.administration | 48 |
| abstract_inverted_index.translocation. | 68 |
| abstract_inverted_index.Mechanistically, | 93 |
| abstract_inverted_index.life-threatening | 6 |
| abstract_inverted_index.anti-inflammatory | 24 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 91 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 7 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6800000071525574 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.91145431 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |