Neoadjuvant Intra-arterial Cytoreductive Chemotherapy Improves Outcomes in Lacrimal Gland Adenoid Cystic Carcinoma Article Swipe
Philippos Apolinário Costa
,
David T. Tse
,
Pasquale Benedetto
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1093/oncolo/oyad346
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1093/oncolo/oyad346
Background Lacrimal gland adenoid cystic carcinoma (LGACC) has historically been associated with a poor prognosis even with localized disease, with a survival of 56% at 5 years. In 1988, we treated the first patient with neoadjuvant intra-arterial cytoreductive chemotherapy (IACC). Since then, we have used this protocol as the standard approach. We aim to analyze the outcomes of patients with LGACC treated with the protocol and compare them to a population-based cohort to assess if IACC can improve survival. Methods We prospectively assessed all non-metastatic patients with LGACC treated with IACC at a single institution between 1988 and 2021. For a comparison group, we identified all non-metastatic patients with LGACC treated with excision from the Surveillance, Epidemiology, and End Results (SEER) registry. We calculated disease-specific survival using the Kaplan-Meier and Cox proportional-hazards modeling methods. Results Thirty-five non-metastatic patients with LGACC treated with IACC were identified at a single institution, and 64 patients with non-metastatic LGACC treated with excision were identified in the SEER database. The 5- and 10-year disease-specific survival rates for patients treated with IACC were 84% (95%CI 71-97) and 76% (95%CI 60-92), respectively. While the 5- and 10-year disease-specific survival rates for the population-based cohort were 72% (95%CI 62-82) and 46% (95%CI 32-60). The survival analysis favored IACC, with a 60% lower risk of death (HR: 0.4; 95%CI 0.2-0.9). Conclusion IACC improves disease-specific survival in comparison to a population-based cohort treated with excision. Additional patients treated with IACC at multiple institutions are required to provide further external validity.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/oncolo/oyad346
- https://academic.oup.com/oncolo/advance-article-pdf/doi/10.1093/oncolo/oyad346/56148015/oyad346.pdf
- OA Status
- gold
- Cited By
- 3
- References
- 64
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4390904697
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4390904697Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/oncolo/oyad346Digital Object Identifier
- Title
-
Neoadjuvant Intra-arterial Cytoreductive Chemotherapy Improves Outcomes in Lacrimal Gland Adenoid Cystic CarcinomaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-01-16Full publication date if available
- Authors
-
Philippos Apolinário Costa, David T. Tse, Pasquale BenedettoList of authors in order
- Landing page
-
https://doi.org/10.1093/oncolo/oyad346Publisher landing page
- PDF URL
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https://academic.oup.com/oncolo/advance-article-pdf/doi/10.1093/oncolo/oyad346/56148015/oyad346.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://academic.oup.com/oncolo/advance-article-pdf/doi/10.1093/oncolo/oyad346/56148015/oyad346.pdfDirect OA link when available
- Concepts
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Medicine, Adenoid cystic carcinoma, Population, Internal medicine, Cohort, Oncology, Surgery, Survival analysis, Carcinoma, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 1Per-year citation counts (last 5 years)
- References (count)
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64Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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