Neoadjuvant Systemic Therapy in Early Breast Cancer: Results of a Prospective Observational Multicenter BRIDE Study Article Swipe
Stefania Gori
,
Alessandra Fabi
,
Catia Angiolini
,
Monica Turazza
,
Piermario Salvini
,
G. Ferretti
,
Elisabetta Cretella
,
Lorenzo Gianni
,
Claudia Bighin
,
Angela Toss
,
Claudio Zamagni
,
Patrizia Vici
,
Costanza De Rossi
,
Antonio Russo
,
Giancarlo Bisagni
,
Antonio Frassoldati
,
Lucia Borgato
,
Anna Cariello
,
C. Cappelletti
,
Roberto Bordonaro
,
Saverio Cinieri
,
Alessandra Modena
,
Matteo Valerio
,
M.F. Alvisi
,
Irene De Simone
,
Francesca Galli
,
Eliana Rulli
,
Anna Santoni
,
Fabrizio Nicolis
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/cancers15194852
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/cancers15194852
To evaluate the rate of early breast cancer (EBC) patients treated with neoadjuvant systemic therapy (NAT) in Italy, criteria of patient selection and types of therapies delivered, an analysis of 1276 patients with stage I-II-III was conducted out of 1633 patients enrolled in the multicenter prospective observational BRIDE study. A total of 177 patients (13.9%) were treated with NAT and 1099 (85.9%) with surgery; in multivariate analysis, menopausal status, cT, cN, grade, HER2-positive and Triple negative (TN) subgroups were significantly associated with the decision to administer NAT. The type of NAT delivered was influenced by EBC subtype. NAT was administered to 53.2% of HER2+/HR-negative, 27.9% of HER2+/HR+, 7.1% of HER2-negative/HR+ and 30.3% of TN EBC patients. The pCR rates were similar to the ones reported in the literature: 74.2% in HER2+/HR-negative, 52.3% in HER2+/HR+, 17.2% in HER2-negative/HR+ and 37.9% in TN. In clinical practice, patient and tumor characteristics influenced oncologists in the decision to administer NAT in EBC and in the choice of the type of systemic therapy, according to ESMO and AIOM Guidelines. Currently, it is recommended always to evaluate the use of NAT in EBC, mainly in HER2+ and TN patients, considering that pCR is associated with significantly better survival of the patient and that effective therapies are now available for residual disease.
Related Topics
Concepts
Medicine
Nat
Internal medicine
Breast cancer
Observational study
Neoadjuvant therapy
Systemic therapy
Prospective cohort study
Cancer
Oncology
Gastroenterology
Surgery
Computer network
Computer science
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/cancers15194852
- https://www.mdpi.com/2072-6694/15/19/4852/pdf?version=1696438091
- OA Status
- gold
- Cited By
- 6
- References
- 42
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4387370230
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4387370230Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/cancers15194852Digital Object Identifier
- Title
-
Neoadjuvant Systemic Therapy in Early Breast Cancer: Results of a Prospective Observational Multicenter BRIDE StudyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-10-04Full publication date if available
- Authors
-
Stefania Gori, Alessandra Fabi, Catia Angiolini, Monica Turazza, Piermario Salvini, G. Ferretti, Elisabetta Cretella, Lorenzo Gianni, Claudia Bighin, Angela Toss, Claudio Zamagni, Patrizia Vici, Costanza De Rossi, Antonio Russo, Giancarlo Bisagni, Antonio Frassoldati, Lucia Borgato, Anna Cariello, C. Cappelletti, Roberto Bordonaro, Saverio Cinieri, Alessandra Modena, Matteo Valerio, M.F. Alvisi, Irene De Simone, Francesca Galli, Eliana Rulli, Anna Santoni, Fabrizio NicolisList of authors in order
- Landing page
-
https://doi.org/10.3390/cancers15194852Publisher landing page
- PDF URL
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https://www.mdpi.com/2072-6694/15/19/4852/pdf?version=1696438091Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/2072-6694/15/19/4852/pdf?version=1696438091Direct OA link when available
- Concepts
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Medicine, Nat, Internal medicine, Breast cancer, Observational study, Neoadjuvant therapy, Systemic therapy, Prospective cohort study, Cancer, Oncology, Gastroenterology, Surgery, Computer network, Computer scienceTop concepts (fields/topics) attached by OpenAlex
- Cited by
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6Total citation count in OpenAlex
- Citations by year (recent)
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2025: 4, 2024: 2Per-year citation counts (last 5 years)
- References (count)
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42Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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