Neopterin extends C. elegans lifespan in an ATFS-1-dependent manner Article Swipe
Miina Pitkänen
,
Geoffray Monteuuis
,
Christopher B. Jackson
,
Olli Matilainen
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.17912/micropub.biology.001543
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.17912/micropub.biology.001543
Neopterin, a byproduct of tetrahydrobiopterin synthesis, is commonly used as a biomarker for immune system activation. In addition to its role in immune responses, neopterin levels are known to increase with age. Its impact on longevity, however, remains unclear. Here, we demonstrate that neopterin supplementation extends lifespan in Caenorhabditis elegans. Additionally, neopterin shows moderate activation of the mitochondrial unfolded protein response (UPRmt), and that the neopterin-mediated lifespan extension is dependent on ATFS-1, the primary transcription factor regulating UPRmt. These findings highlight the need for further investigation into the biological functions and health-promoting effects of neopterin.
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https://doi.org/10.17912/micropub.biology.001543Digital Object Identifier
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Neopterin extends C. elegans lifespan in an ATFS-1-dependent mannerWork title
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articleOpenAlex work type
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enPrimary language
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2025Year of publication
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2025-02-12Full publication date if available
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Miina Pitkänen, Geoffray Monteuuis, Christopher B. Jackson, Olli MatilainenList of authors in order
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.ncbi.nlm.nih.gov/pmc/articles/11971658Direct OA link when available
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Neopterin, Medicine, ImmunologyTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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