Network pharmacology combined with untargeted metabolomics reveals the intervention mechanism and compatibility of chenpi-rougui herb pair in nonalcoholic fatty liver disease Article Swipe
Jinlin Xu
,
Sen Li
,
Yuehui Jin
,
Huiwen Yao
,
Xu Hu
,
Shan Cao
,
Huimin Zhou
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fmolb.2025.1553162
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fmolb.2025.1553162
Background Chenpi (the dried mature peel of Citrus reticulata Blanco) and Rougui (the dried bark of Cinnamomum cassia Presl) are both edible and medicinal plants, which have therapeutic effects on nonalcoholic fatty liver disease (NAFLD). However, the underlying mechanisms necessitate further exploration. This study evaluated the prevention effect of Chenpi-Rougui herb pair (CRP) on NAFLD using an integrated strategy that combined network pharmacology with metabolomics. Methods Initially, the components in CRP decoction were characterized by UPLC-QTOF-MS/MS. Subsequently, a high-fat diet induced NAFLD mouse model was used to assess the efficacy of CRP and its individual constituent, Chenpi and Rougui. Additionally, synergetic pathways and crucial targets for CRP therapy in NAFLD were identified using network pharmacology and serum metabolomics. Finally, real-time polymerase chain reaction (RT-PCR) was utilized to validate relevant genes. Results CRP exerted a more extensive prevention effect on NAFLD mice compared to the individual herb of Chenpi and Rougui. A total of 105 compounds were characterized from CRP, which were linked to 70 potential therapeutic targets for NAFLD. Thirty-two differential metabolites were identified by metabolomics, which were co-regulated by Chenpi, Rougui and CRP. Pathways associated with the intervention of herb pair in NAFLD included energy metabolism, fatty acid metabolism, glycerophospholipid metabolism, sphingolipids metabolism, arachidonic acid metabolism, sterol and bile acid metabolism. Finally, eight targets were screened through conjoint analysis and experimental verification showed that six of them including FASN, AKT1, CASP3, F2, PTGS2 and PRKCA, could be modulated by CRP in NAFLD mice. Besides, Chenpi primarily regulated FASN, AKT1, CASP3 and PRKCA, which were associated with reducing apoptosis in hepatocytes, while Rougui exceled in regulating F2 and PTGS2, closely linked to its anti-inflammatory properties. The combination of Chenpi and Rougui resulted in a broader influence on metabolites, pathways, and primary targets compared to their individual application. Conclusion These results provided valuable insights into the compatibility mechanism of CRP for treating NAFLD, and could also improve the value of its forthcoming application and development as a natural liver protective agent.
Related Topics
Concepts
Metabolomics
Pharmacology
Nonalcoholic fatty liver disease
Lipid metabolism
Glycerophospholipid
Evodiamine
Biology
Fatty acid metabolism
Traditional medicine
Fatty acid
Biochemistry
Fatty liver
Medicine
Disease
Bioinformatics
Internal medicine
Phospholipid
Membrane
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fmolb.2025.1553162
- https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2025.1553162/pdf
- OA Status
- gold
- References
- 38
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4408418950
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4408418950Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fmolb.2025.1553162Digital Object Identifier
- Title
-
Network pharmacology combined with untargeted metabolomics reveals the intervention mechanism and compatibility of chenpi-rougui herb pair in nonalcoholic fatty liver diseaseWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-03-13Full publication date if available
- Authors
-
Jinlin Xu, Sen Li, Yuehui Jin, Huiwen Yao, Xu Hu, Shan Cao, Huimin ZhouList of authors in order
- Landing page
-
https://doi.org/10.3389/fmolb.2025.1553162Publisher landing page
- PDF URL
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https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2025.1553162/pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2025.1553162/pdfDirect OA link when available
- Concepts
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Metabolomics, Pharmacology, Nonalcoholic fatty liver disease, Lipid metabolism, Glycerophospholipid, Evodiamine, Biology, Fatty acid metabolism, Traditional medicine, Fatty acid, Biochemistry, Fatty liver, Medicine, Disease, Bioinformatics, Internal medicine, Phospholipid, MembraneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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38Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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