Network Pharmacology Integrated with Transcriptomics Deciphered the Potential Mechanism of Codonopsis pilosula against Hepatocellular Carcinoma Article Swipe

PDF

Zhili Liu , Yuzhe Sun , Hefu Zhen , Chao Nie ·

YOU? · · 2022 · Open Access · · DOI: https://doi.org/10.1155/2022/1340194

Hepatocellular carcinoma (HCC) is the fourth main reason of cancer-related death. Codonopsis pilosula is a commonly used traditional Chinese medicine (TCM) for patients with HCC. However, its potential mechanism for treatment of HCC remains unclear. Here, we used transcriptomics and network pharmacology to explore the potential molecular mechanisms of Codonopsis pilosula. In our study, twelve differentially expressed genes (DEGs) (5 upregulated and 7 downregulated) of Codonopsis pilosula treating HepG2 cells (a kind of HCC cell) were identified. Among the 12 DEGs, HMOX1 may play an essential role. Codonopsis pilosula mainly affects the mineral absorption pathway in HCC. We acquired 2957, 1877, and 255 targets from TCMID, SymMap, and TCMSP, respectively. Codonopsis pilosula could upregulate HMOX1 via luteolin, capsaicin, and sulforaphane. Our study provided new understanding of the potential pharmacological mechanisms of Codonopsis pilosula in treating HCC and pointed out a direction for further experimental research.

Related Topics

Concepts

Mechanism (biology) Transcriptome Biology Medicine Cancer research Pharmacology Bioinformatics Gene expression Gene Genetics Epistemology Philosophy

Metadata

Type: article
Language: en
Landing Page: https://doi.org/10.1155/2022/1340194
PDF: https://downloads.hindawi.com/journals/ecam/2022/1340194.pdf
OA Status: hybrid
Cited By: 13
References: 65
Related Works: 10
OpenAlex ID: https://openalex.org/W4220664678

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W4220664678

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.1155/2022/1340194

Digital Object Identifier
Title: Network Pharmacology Integrated with Transcriptomics Deciphered the Potential Mechanism of Codonopsis pilosula against Hepatocellular Carcinoma

Work title
Type: article

OpenAlex work type
Language: en

Primary language
Publication year: 2022

Year of publication
Publication date: 2022-03-27

Full publication date if available
Authors: Zhili Liu, Yuzhe Sun, Hefu Zhen, Chao Nie

List of authors in order
Landing page: https://doi.org/10.1155/2022/1340194

Publisher landing page
PDF URL: https://downloads.hindawi.com/journals/ecam/2022/1340194.pdf

Direct link to full text PDF
Open access: Yes

Whether a free full text is available
OA status: hybrid

Open access status per OpenAlex
OA URL: https://downloads.hindawi.com/journals/ecam/2022/1340194.pdf

Direct OA link when available
Concepts: Mechanism (biology), Transcriptome, Biology, Medicine, Cancer research, Pharmacology, Bioinformatics, Gene expression, Gene, Genetics, Epistemology, Philosophy

Top concepts (fields/topics) attached by OpenAlex
Cited by: 13

Total citation count in OpenAlex
Citations by year (recent): 2025: 2, 2024: 6, 2023: 4, 2022: 1

Per-year citation counts (last 5 years)
References (count): 65

Number of works referenced by this work
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W4220664678
doi	https://doi.org/10.1155/2022/1340194
ids.doi	https://doi.org/10.1155/2022/1340194
ids.pmid	https://pubmed.ncbi.nlm.nih.gov/35388300
ids.openalex	https://openalex.org/W4220664678
fwci	2.64914027
type	article
title	Network Pharmacology Integrated with Transcriptomics Deciphered the Potential Mechanism of Codonopsis pilosula against Hepatocellular Carcinoma
awards[0].id	https://openalex.org/G3608752281
awards[0].funder_id	https://openalex.org/F4320326705
awards[0].display_name
awards[0].funder_award_id	JCYJ20180507183615145
awards[0].funder_display_name	Science, Technology and Innovation Commission of Shenzhen Municipality
awards[1].id	https://openalex.org/G8870742704
awards[1].funder_id	https://openalex.org/F4320326705
awards[1].display_name
awards[1].funder_award_id	2020YFC2002902
awards[1].funder_display_name	Science, Technology and Innovation Commission of Shenzhen Municipality
biblio.issue
biblio.volume	2022
biblio.last_page	10
biblio.first_page	1
topics[0].id	https://openalex.org/T12582
topics[0].field.id	https://openalex.org/fields/27
topics[0].field.display_name	Medicine
topics[0].score	0.9943000078201294
topics[0].domain.id	https://openalex.org/domains/4
topics[0].domain.display_name	Health Sciences
topics[0].subfield.id	https://openalex.org/subfields/2736
topics[0].subfield.display_name	Pharmacology
topics[0].display_name	Flavonoids in Medical Research
topics[1].id	https://openalex.org/T11385
topics[1].field.id	https://openalex.org/fields/13
topics[1].field.display_name	Biochemistry, Genetics and Molecular Biology
topics[1].score	0.9901999831199646
topics[1].domain.id	https://openalex.org/domains/1
topics[1].domain.display_name	Life Sciences
topics[1].subfield.id	https://openalex.org/subfields/1312
topics[1].subfield.display_name	Molecular Biology
topics[1].display_name	Natural product bioactivities and synthesis
topics[2].id	https://openalex.org/T11332
topics[2].field.id	https://openalex.org/fields/13
topics[2].field.display_name	Biochemistry, Genetics and Molecular Biology
topics[2].score	0.989799976348877
topics[2].domain.id	https://openalex.org/domains/1
topics[2].domain.display_name	Life Sciences
topics[2].subfield.id	https://openalex.org/subfields/1312
topics[2].subfield.display_name	Molecular Biology
topics[2].display_name	Genomics, phytochemicals, and oxidative stress
funders[0].id	https://openalex.org/F4320326705
funders[0].ror
funders[0].display_name	Science, Technology and Innovation Commission of Shenzhen Municipality
is_xpac	False
apc_list.value	2400
apc_list.currency	USD
apc_list.value_usd	2400
apc_paid.value	2400
apc_paid.currency	USD
apc_paid.value_usd	2400
concepts[0].id	https://openalex.org/C89611455
concepts[0].level	2
concepts[0].score	0.5560879111289978
concepts[0].wikidata	https://www.wikidata.org/wiki/Q6804646
concepts[0].display_name	Mechanism (biology)
concepts[1].id	https://openalex.org/C162317418
concepts[1].level	4
concepts[1].score	0.5513472557067871
concepts[1].wikidata	https://www.wikidata.org/wiki/Q252857
concepts[1].display_name	Transcriptome
concepts[2].id	https://openalex.org/C86803240
concepts[2].level	0
concepts[2].score	0.452075719833374
concepts[2].wikidata	https://www.wikidata.org/wiki/Q420
concepts[2].display_name	Biology
concepts[3].id	https://openalex.org/C71924100
concepts[3].level	0
concepts[3].score	0.4041631519794464
concepts[3].wikidata	https://www.wikidata.org/wiki/Q11190
concepts[3].display_name	Medicine
concepts[4].id	https://openalex.org/C502942594
concepts[4].level	1
concepts[4].score	0.36780697107315063
concepts[4].wikidata	https://www.wikidata.org/wiki/Q3421914
concepts[4].display_name	Cancer research
concepts[5].id	https://openalex.org/C98274493
concepts[5].level	1
concepts[5].score	0.3533658981323242
concepts[5].wikidata	https://www.wikidata.org/wiki/Q128406
concepts[5].display_name	Pharmacology
concepts[6].id	https://openalex.org/C60644358
concepts[6].level	1
concepts[6].score	0.3310219645500183
concepts[6].wikidata	https://www.wikidata.org/wiki/Q128570
concepts[6].display_name	Bioinformatics
concepts[7].id	https://openalex.org/C150194340
concepts[7].level	3
concepts[7].score	0.1814676821231842
concepts[7].wikidata	https://www.wikidata.org/wiki/Q26972
concepts[7].display_name	Gene expression
concepts[8].id	https://openalex.org/C104317684
concepts[8].level	2
concepts[8].score	0.16289576888084412
concepts[8].wikidata	https://www.wikidata.org/wiki/Q7187
concepts[8].display_name	Gene
concepts[9].id	https://openalex.org/C54355233
concepts[9].level	1
concepts[9].score	0.09345775842666626
concepts[9].wikidata	https://www.wikidata.org/wiki/Q7162
concepts[9].display_name	Genetics
concepts[10].id	https://openalex.org/C111472728
concepts[10].level	1
concepts[10].score	0.0
concepts[10].wikidata	https://www.wikidata.org/wiki/Q9471
concepts[10].display_name	Epistemology
concepts[11].id	https://openalex.org/C138885662
concepts[11].level	0
concepts[11].score	0.0
concepts[11].wikidata	https://www.wikidata.org/wiki/Q5891
concepts[11].display_name	Philosophy
keywords[0].id	https://openalex.org/keywords/mechanism
keywords[0].score	0.5560879111289978
keywords[0].display_name	Mechanism (biology)
keywords[1].id	https://openalex.org/keywords/transcriptome
keywords[1].score	0.5513472557067871
keywords[1].display_name	Transcriptome
keywords[2].id	https://openalex.org/keywords/biology
keywords[2].score	0.452075719833374
keywords[2].display_name	Biology
keywords[3].id	https://openalex.org/keywords/medicine
keywords[3].score	0.4041631519794464
keywords[3].display_name	Medicine
keywords[4].id	https://openalex.org/keywords/cancer-research
keywords[4].score	0.36780697107315063
keywords[4].display_name	Cancer research
keywords[5].id	https://openalex.org/keywords/pharmacology
keywords[5].score	0.3533658981323242
keywords[5].display_name	Pharmacology
keywords[6].id	https://openalex.org/keywords/bioinformatics
keywords[6].score	0.3310219645500183
keywords[6].display_name	Bioinformatics
keywords[7].id	https://openalex.org/keywords/gene-expression
keywords[7].score	0.1814676821231842
keywords[7].display_name	Gene expression
keywords[8].id	https://openalex.org/keywords/gene
keywords[8].score	0.16289576888084412
keywords[8].display_name	Gene
keywords[9].id	https://openalex.org/keywords/genetics
keywords[9].score	0.09345775842666626
keywords[9].display_name	Genetics
language	en
locations[0].id	doi:10.1155/2022/1340194
locations[0].is_oa	True
locations[0].source.id	https://openalex.org/S15444899
locations[0].source.issn	1741-427X, 1741-4288
locations[0].source.type	journal
locations[0].source.is_oa	False
locations[0].source.issn_l	1741-427X
locations[0].source.is_core	True
locations[0].source.is_in_doaj	False
locations[0].source.display_name	Evidence-based Complementary and Alternative Medicine
locations[0].source.host_organization	https://openalex.org/P4310319869
locations[0].source.host_organization_name	Hindawi Publishing Corporation
locations[0].source.host_organization_lineage	https://openalex.org/P4310319869
locations[0].source.host_organization_lineage_names	Hindawi Publishing Corporation
locations[0].license	cc-by
locations[0].pdf_url	https://downloads.hindawi.com/journals/ecam/2022/1340194.pdf
locations[0].version	publishedVersion
locations[0].raw_type	journal-article
locations[0].license_id	https://openalex.org/licenses/cc-by
locations[0].is_accepted	True
locations[0].is_published	True
locations[0].raw_source_name	Evidence-Based Complementary and Alternative Medicine
locations[0].landing_page_url	https://doi.org/10.1155/2022/1340194
locations[1].id	pmid:35388300
locations[1].is_oa	False
locations[1].source.id	https://openalex.org/S4306525036
locations[1].source.issn
locations[1].source.type	repository
locations[1].source.is_oa	False
locations[1].source.issn_l
locations[1].source.is_core	False
locations[1].source.is_in_doaj	False
locations[1].source.display_name	PubMed
locations[1].source.host_organization	https://openalex.org/I1299303238
locations[1].source.host_organization_name	National Institutes of Health
locations[1].source.host_organization_lineage	https://openalex.org/I1299303238
locations[1].license
locations[1].pdf_url
locations[1].version	publishedVersion
locations[1].raw_type
locations[1].license_id
locations[1].is_accepted	True
locations[1].is_published	True
locations[1].raw_source_name	Evidence-based complementary and alternative medicine : eCAM
locations[1].landing_page_url	https://pubmed.ncbi.nlm.nih.gov/35388300
locations[2].id	pmh:oai:doaj.org/article:54f01b80c63c47fdb7404bc1893ccf1b
locations[2].is_oa	True
locations[2].source.id	https://openalex.org/S4306401280
locations[2].source.issn
locations[2].source.type	repository
locations[2].source.is_oa	False
locations[2].source.issn_l
locations[2].source.is_core	False
locations[2].source.is_in_doaj	False
locations[2].source.display_name	DOAJ (DOAJ: Directory of Open Access Journals)
locations[2].source.host_organization
locations[2].source.host_organization_name
locations[2].license	cc-by-sa
locations[2].pdf_url
locations[2].version	submittedVersion
locations[2].raw_type	article
locations[2].license_id	https://openalex.org/licenses/cc-by-sa
locations[2].is_accepted	False
locations[2].is_published	False
locations[2].raw_source_name	Evidence-Based Complementary and Alternative Medicine, Vol 2022 (2022)
locations[2].landing_page_url	https://doaj.org/article/54f01b80c63c47fdb7404bc1893ccf1b
locations[3].id	pmh:oai:pubmedcentral.nih.gov:8977304
locations[3].is_oa	True
locations[3].source.id	https://openalex.org/S2764455111
locations[3].source.issn
locations[3].source.type	repository
locations[3].source.is_oa	False
locations[3].source.issn_l
locations[3].source.is_core	False
locations[3].source.is_in_doaj	False
locations[3].source.display_name	PubMed Central
locations[3].source.host_organization	https://openalex.org/I1299303238
locations[3].source.host_organization_name	National Institutes of Health
locations[3].source.host_organization_lineage	https://openalex.org/I1299303238
locations[3].license	other-oa
locations[3].pdf_url
locations[3].version	submittedVersion
locations[3].raw_type	Text
locations[3].license_id	https://openalex.org/licenses/other-oa
locations[3].is_accepted	False
locations[3].is_published	False
locations[3].raw_source_name	Evid Based Complement Alternat Med
locations[3].landing_page_url	https://www.ncbi.nlm.nih.gov/pmc/articles/8977304
indexed_in	crossref, doaj, pubmed
authorships[0].author.id	https://openalex.org/A5031785945
authorships[0].author.orcid	https://orcid.org/0000-0002-5983-630X
authorships[0].author.display_name	Zhili Liu
authorships[0].countries	CN
authorships[0].affiliations[0].institution_ids	https://openalex.org/I100135526
authorships[0].affiliations[0].raw_affiliation_string	BGI-Shenzhen, Shenzhen 518083, China
authorships[0].affiliations[1].institution_ids	https://openalex.org/I4210165038
authorships[0].affiliations[1].raw_affiliation_string	College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China
authorships[0].institutions[0].id	https://openalex.org/I100135526
authorships[0].institutions[0].ror	https://ror.org/045pn2j94
authorships[0].institutions[0].type	company
authorships[0].institutions[0].lineage	https://openalex.org/I100135526
authorships[0].institutions[0].country_code	CN
authorships[0].institutions[0].display_name	BGI Group (China)
authorships[0].institutions[1].id	https://openalex.org/I4210165038
authorships[0].institutions[1].ror	https://ror.org/05qbk4x57
authorships[0].institutions[1].type	education
authorships[0].institutions[1].lineage	https://openalex.org/I19820366, https://openalex.org/I4210165038
authorships[0].institutions[1].country_code	CN
authorships[0].institutions[1].display_name	University of Chinese Academy of Sciences
authorships[0].author_position	first
authorships[0].raw_author_name	Zhili Liu
authorships[0].is_corresponding	False
authorships[0].raw_affiliation_strings	BGI-Shenzhen, Shenzhen 518083, China, College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China
authorships[1].author.id	https://openalex.org/A5080744549
authorships[1].author.orcid	https://orcid.org/0000-0002-1891-7883
authorships[1].author.display_name	Yuzhe Sun
authorships[1].countries	CN
authorships[1].affiliations[0].institution_ids	https://openalex.org/I4210149137
authorships[1].affiliations[0].raw_affiliation_string	China National GeneBank, BGI-Shenzhen, Shenzhen 518120, China
authorships[1].affiliations[1].institution_ids	https://openalex.org/I100135526
authorships[1].affiliations[1].raw_affiliation_string	BGI-Shenzhen, Shenzhen 518083, China
authorships[1].institutions[0].id	https://openalex.org/I100135526
authorships[1].institutions[0].ror	https://ror.org/045pn2j94
authorships[1].institutions[0].type	company
authorships[1].institutions[0].lineage	https://openalex.org/I100135526
authorships[1].institutions[0].country_code	CN
authorships[1].institutions[0].display_name	BGI Group (China)
authorships[1].institutions[1].id	https://openalex.org/I4210149137
authorships[1].institutions[1].ror	https://ror.org/03n9hr695
authorships[1].institutions[1].type	archive
authorships[1].institutions[1].lineage	https://openalex.org/I4210149137
authorships[1].institutions[1].country_code	CN
authorships[1].institutions[1].display_name	China National GeneBank
authorships[1].author_position	middle
authorships[1].raw_author_name	Yuzhe Sun
authorships[1].is_corresponding	False
authorships[1].raw_affiliation_strings	BGI-Shenzhen, Shenzhen 518083, China, China National GeneBank, BGI-Shenzhen, Shenzhen 518120, China
authorships[2].author.id	https://openalex.org/A5014522956
authorships[2].author.orcid	https://orcid.org/0000-0003-3682-7934
authorships[2].author.display_name	Hefu Zhen
authorships[2].countries	CN
authorships[2].affiliations[0].institution_ids	https://openalex.org/I4210149137
authorships[2].affiliations[0].raw_affiliation_string	China National GeneBank, BGI-Shenzhen, Shenzhen 518120, China
authorships[2].affiliations[1].institution_ids	https://openalex.org/I100135526
authorships[2].affiliations[1].raw_affiliation_string	BGI-Shenzhen, Shenzhen 518083, China
authorships[2].institutions[0].id	https://openalex.org/I100135526
authorships[2].institutions[0].ror	https://ror.org/045pn2j94
authorships[2].institutions[0].type	company
authorships[2].institutions[0].lineage	https://openalex.org/I100135526
authorships[2].institutions[0].country_code	CN
authorships[2].institutions[0].display_name	BGI Group (China)
authorships[2].institutions[1].id	https://openalex.org/I4210149137
authorships[2].institutions[1].ror	https://ror.org/03n9hr695
authorships[2].institutions[1].type	archive
authorships[2].institutions[1].lineage	https://openalex.org/I4210149137
authorships[2].institutions[1].country_code	CN
authorships[2].institutions[1].display_name	China National GeneBank
authorships[2].author_position	middle
authorships[2].raw_author_name	Hefu Zhen
authorships[2].is_corresponding	True
authorships[2].raw_affiliation_strings	BGI-Shenzhen, Shenzhen 518083, China, China National GeneBank, BGI-Shenzhen, Shenzhen 518120, China
authorships[3].author.id	https://openalex.org/A5026620854
authorships[3].author.orcid	https://orcid.org/0000-0003-3536-0324
authorships[3].author.display_name	Chao Nie
authorships[3].countries	CN
authorships[3].affiliations[0].institution_ids	https://openalex.org/I100135526
authorships[3].affiliations[0].raw_affiliation_string	BGI-Shenzhen, Shenzhen 518083, China
authorships[3].affiliations[1].institution_ids	https://openalex.org/I4210149137
authorships[3].affiliations[1].raw_affiliation_string	China National GeneBank, BGI-Shenzhen, Shenzhen 518120, China
authorships[3].institutions[0].id	https://openalex.org/I100135526
authorships[3].institutions[0].ror	https://ror.org/045pn2j94
authorships[3].institutions[0].type	company
authorships[3].institutions[0].lineage	https://openalex.org/I100135526
authorships[3].institutions[0].country_code	CN
authorships[3].institutions[0].display_name	BGI Group (China)
authorships[3].institutions[1].id	https://openalex.org/I4210149137
authorships[3].institutions[1].ror	https://ror.org/03n9hr695
authorships[3].institutions[1].type	archive
authorships[3].institutions[1].lineage	https://openalex.org/I4210149137
authorships[3].institutions[1].country_code	CN
authorships[3].institutions[1].display_name	China National GeneBank
authorships[3].author_position	last
authorships[3].raw_author_name	Chao Nie
authorships[3].is_corresponding	True
authorships[3].raw_affiliation_strings	BGI-Shenzhen, Shenzhen 518083, China, China National GeneBank, BGI-Shenzhen, Shenzhen 518120, China
has_content.pdf	True
has_content.grobid_xml	True
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://downloads.hindawi.com/journals/ecam/2022/1340194.pdf
open_access.oa_status	hybrid
open_access.any_repository_has_fulltext	False
created_date	2022-04-03T00:00:00
display_name	Network Pharmacology Integrated with Transcriptomics Deciphered the Potential Mechanism of Codonopsis pilosula against Hepatocellular Carcinoma
has_fulltext	True
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T12582
primary_topic.field.id	https://openalex.org/fields/27
primary_topic.field.display_name	Medicine
primary_topic.score	0.9943000078201294
primary_topic.domain.id	https://openalex.org/domains/4
primary_topic.domain.display_name	Health Sciences
primary_topic.subfield.id	https://openalex.org/subfields/2736
primary_topic.subfield.display_name	Pharmacology
primary_topic.display_name	Flavonoids in Medical Research
related_works	https://openalex.org/W2399513595, https://openalex.org/W2028462563, https://openalex.org/W4388386498, https://openalex.org/W2982720988, https://openalex.org/W3150324899, https://openalex.org/W2523545060, https://openalex.org/W4229998356, https://openalex.org/W4379374180, https://openalex.org/W4388725868, https://openalex.org/W2382997850
cited_by_count	13
counts_by_year[0].year	2025
counts_by_year[0].cited_by_count	2
counts_by_year[1].year	2024
counts_by_year[1].cited_by_count	6
counts_by_year[2].year	2023
counts_by_year[2].cited_by_count	4
counts_by_year[3].year	2022
counts_by_year[3].cited_by_count	1
locations_count	4
best_oa_location.id	doi:10.1155/2022/1340194
best_oa_location.is_oa	True
best_oa_location.source.id	https://openalex.org/S15444899
best_oa_location.source.issn	1741-427X, 1741-4288
best_oa_location.source.type	journal
best_oa_location.source.is_oa	False
best_oa_location.source.issn_l	1741-427X
best_oa_location.source.is_core	True
best_oa_location.source.is_in_doaj	False
best_oa_location.source.display_name	Evidence-based Complementary and Alternative Medicine
best_oa_location.source.host_organization	https://openalex.org/P4310319869
best_oa_location.source.host_organization_name	Hindawi Publishing Corporation
best_oa_location.source.host_organization_lineage	https://openalex.org/P4310319869
best_oa_location.source.host_organization_lineage_names	Hindawi Publishing Corporation
best_oa_location.license	cc-by
best_oa_location.pdf_url	https://downloads.hindawi.com/journals/ecam/2022/1340194.pdf
best_oa_location.version	publishedVersion
best_oa_location.raw_type	journal-article
best_oa_location.license_id	https://openalex.org/licenses/cc-by
best_oa_location.is_accepted	True
best_oa_location.is_published	True
best_oa_location.raw_source_name	Evidence-Based Complementary and Alternative Medicine
best_oa_location.landing_page_url	https://doi.org/10.1155/2022/1340194
primary_location.id	doi:10.1155/2022/1340194
primary_location.is_oa	True
primary_location.source.id	https://openalex.org/S15444899
primary_location.source.issn	1741-427X, 1741-4288
primary_location.source.type	journal
primary_location.source.is_oa	False
primary_location.source.issn_l	1741-427X
primary_location.source.is_core	True
primary_location.source.is_in_doaj	False
primary_location.source.display_name	Evidence-based Complementary and Alternative Medicine
primary_location.source.host_organization	https://openalex.org/P4310319869
primary_location.source.host_organization_name	Hindawi Publishing Corporation
primary_location.source.host_organization_lineage	https://openalex.org/P4310319869
primary_location.source.host_organization_lineage_names	Hindawi Publishing Corporation
primary_location.license	cc-by
primary_location.pdf_url	https://downloads.hindawi.com/journals/ecam/2022/1340194.pdf
primary_location.version	publishedVersion
primary_location.raw_type	journal-article
primary_location.license_id	https://openalex.org/licenses/cc-by
primary_location.is_accepted	True
primary_location.is_published	True
primary_location.raw_source_name	Evidence-Based Complementary and Alternative Medicine
primary_location.landing_page_url	https://doi.org/10.1155/2022/1340194
publication_date	2022-03-27
publication_year	2022
referenced_works	https://openalex.org/W2990323558, https://openalex.org/W2563886529, https://openalex.org/W2905137137, https://openalex.org/W3034594171, https://openalex.org/W4232620598, https://openalex.org/W3005987050, https://openalex.org/W3152960122, https://openalex.org/W3108110268, https://openalex.org/W3185426724, https://openalex.org/W2944039552, https://openalex.org/W3012491782, https://openalex.org/W1975275493, https://openalex.org/W2211968863, https://openalex.org/W2160260402, https://openalex.org/W2136033624, https://openalex.org/W2944801277, https://openalex.org/W2891088504, https://openalex.org/W3136967973, https://openalex.org/W2937950765, https://openalex.org/W2124679671, https://openalex.org/W2766490148, https://openalex.org/W2899291554, https://openalex.org/W2146512944, https://openalex.org/W2900569176, https://openalex.org/W2159675211, https://openalex.org/W2035618305, https://openalex.org/W2736730167, https://openalex.org/W2130479394, https://openalex.org/W1757990252, https://openalex.org/W2105668062, https://openalex.org/W2984497827, https://openalex.org/W2342805349, https://openalex.org/W3047211571, https://openalex.org/W3088665686, https://openalex.org/W2008851677, https://openalex.org/W3044854927, https://openalex.org/W2241760375, https://openalex.org/W2044375122, https://openalex.org/W3098351509, https://openalex.org/W2318436667, https://openalex.org/W2901030744, https://openalex.org/W1910661068, https://openalex.org/W2964447635, https://openalex.org/W2885709068, https://openalex.org/W2897985606, https://openalex.org/W2083429514, https://openalex.org/W2893438768, https://openalex.org/W2801683799, https://openalex.org/W3008432654, https://openalex.org/W2807489487, https://openalex.org/W2597884957, https://openalex.org/W4206670923, https://openalex.org/W2082358366, https://openalex.org/W3211968758, https://openalex.org/W3195159703, https://openalex.org/W2893159429, https://openalex.org/W2961807409, https://openalex.org/W1981239378, https://openalex.org/W2069213289, https://openalex.org/W3153799043, https://openalex.org/W2259037852, https://openalex.org/W2968489920, https://openalex.org/W2283337148, https://openalex.org/W4210512211, https://openalex.org/W3217798540
referenced_works_count	65
abstract_inverted_index.7	62
abstract_inverted_index.a	14, 139
abstract_inverted_index.(5	59
abstract_inverted_index.(a	70
abstract_inverted_index.12	79
abstract_inverted_index.In	51
abstract_inverted_index.We	97
abstract_inverted_index.an	84
abstract_inverted_index.in	95, 133
abstract_inverted_index.is	3, 13
abstract_inverted_index.of	8, 31, 48, 64, 72, 125, 130
abstract_inverted_index.to	42
abstract_inverted_index.we	36
abstract_inverted_index.255	102
abstract_inverted_index.HCC	32, 73, 135
abstract_inverted_index.Our	120
abstract_inverted_index.and	39, 61, 101, 107, 118, 136
abstract_inverted_index.for	21, 29, 141
abstract_inverted_index.its	26
abstract_inverted_index.may	82
abstract_inverted_index.new	123
abstract_inverted_index.our	52
abstract_inverted_index.out	138
abstract_inverted_index.the	4, 44, 78, 91, 126
abstract_inverted_index.via	115
abstract_inverted_index.HCC.	24, 96
abstract_inverted_index.from	104
abstract_inverted_index.kind	71
abstract_inverted_index.main	6
abstract_inverted_index.play	83
abstract_inverted_index.used	16, 37
abstract_inverted_index.were	75
abstract_inverted_index.with	23
abstract_inverted_index.(HCC)	2
abstract_inverted_index.(TCM)	20
abstract_inverted_index.1877,	100
abstract_inverted_index.2957,	99
abstract_inverted_index.Among	77
abstract_inverted_index.DEGs,	80
abstract_inverted_index.HMOX1	81, 114
abstract_inverted_index.HepG2	68
abstract_inverted_index.Here,	35
abstract_inverted_index.cell)	74
abstract_inverted_index.cells	69
abstract_inverted_index.could	112
abstract_inverted_index.genes	57
abstract_inverted_index.role.	86
abstract_inverted_index.study	121
abstract_inverted_index.(DEGs)	58
abstract_inverted_index.TCMID,	105
abstract_inverted_index.TCMSP,	108
abstract_inverted_index.death.	10
abstract_inverted_index.fourth	5
abstract_inverted_index.mainly	89
abstract_inverted_index.reason	7
abstract_inverted_index.study,	53
abstract_inverted_index.twelve	54
abstract_inverted_index.Chinese	18
abstract_inverted_index.SymMap,	106
abstract_inverted_index.affects	90
abstract_inverted_index.explore	43
abstract_inverted_index.further	142
abstract_inverted_index.mineral	92
abstract_inverted_index.network	40
abstract_inverted_index.pathway	94
abstract_inverted_index.pointed	137
abstract_inverted_index.remains	33
abstract_inverted_index.targets	103
abstract_inverted_index.However,	25
abstract_inverted_index.acquired	98
abstract_inverted_index.commonly	15
abstract_inverted_index.medicine	19
abstract_inverted_index.patients	22
abstract_inverted_index.pilosula	12, 66, 88, 111, 132
abstract_inverted_index.provided	122
abstract_inverted_index.treating	67, 134
abstract_inverted_index.unclear.	34
abstract_inverted_index.carcinoma	1
abstract_inverted_index.direction	140
abstract_inverted_index.essential	85
abstract_inverted_index.expressed	56
abstract_inverted_index.luteolin,	116
abstract_inverted_index.mechanism	28
abstract_inverted_index.molecular	46
abstract_inverted_index.pilosula.	50
abstract_inverted_index.potential	27, 45, 127
abstract_inverted_index.research.	144
abstract_inverted_index.treatment	30
abstract_inverted_index.Codonopsis	11, 49, 65, 87, 110, 131
abstract_inverted_index.absorption	93
abstract_inverted_index.capsaicin,	117
abstract_inverted_index.mechanisms	47, 129
abstract_inverted_index.upregulate	113
abstract_inverted_index.identified.	76
abstract_inverted_index.traditional	17
abstract_inverted_index.upregulated	60
abstract_inverted_index.experimental	143
abstract_inverted_index.pharmacology	41
abstract_inverted_index.respectively.	109
abstract_inverted_index.sulforaphane.	119
abstract_inverted_index.understanding	124
abstract_inverted_index.Hepatocellular	0
abstract_inverted_index.cancer-related	9
abstract_inverted_index.differentially	55
abstract_inverted_index.downregulated)	63
abstract_inverted_index.pharmacological	128
abstract_inverted_index.transcriptomics	38
cited_by_percentile_year.max	98
cited_by_percentile_year.min	89
corresponding_author_ids	https://openalex.org/A5014522956, https://openalex.org/A5026620854
countries_distinct_count	1
institutions_distinct_count	4
corresponding_institution_ids	https://openalex.org/I100135526, https://openalex.org/I4210149137
sustainable_development_goals[0].id	https://metadata.un.org/sdg/3
sustainable_development_goals[0].score	0.7900000214576721
sustainable_development_goals[0].display_name	Good health and well-being
citation_normalized_percentile.value	0.87248155
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False