Neural dissociation of attention and working memory through inhibitory control Article Swipe
Junrong Han
,
Bo Peng
,
Jinhao Huang
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41467-025-66553-7
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41467-025-66553-7
Attention and working memory (WM) have traditionally been considered closely linked processes with shared neural mechanisms. In information selection, attention is often conceptualized as a gatekeeper to WM, regulating which information is encoded and stored. Here, combining tasks specifically designed to separate attention from WM encoding with a multimodal approach, we provide converging neural and causal evidence that these processes are dissociable. Functional MRI identifies the supramarginal gyrus (SMG) as the key region enabling this dissociation, while dynamic causal modeling reveals the neural circuitry through which the SMG exerts inhibitory control over attentional representations, regulating their integration into WM. Furthermore, neuromodulation via transcranial direct current stimulation (tDCS) demonstrates that enhancing SMG activity strengthens this inhibitory control. A second tDCS experiment using varied stimuli confirms the generalizability of the effect. Finally, a transcranial magnetic stimulation (TMS) experiment provides further causal evidence with greater spatial precision. These findings challenge the long-standing view that attention and WM encoding form a continuous process, demonstrating instead that they constitute two dissociable neural processes of information selection.
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- https://doi.org/10.1038/s41467-025-66553-7
- https://www.nature.com/articles/s41467-025-66553-7_reference.pdf
- OA Status
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- 81
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Neural dissociation of attention and working memory through inhibitory controlWork title
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enPrimary language
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2025Year of publication
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2025-12-02Full publication date if available
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Junrong Han, Bo Peng, Jinhao HuangList of authors in order
- Landing page
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https://doi.org/10.1038/s41467-025-66553-7Publisher landing page
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https://www.nature.com/articles/s41467-025-66553-7_reference.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.nature.com/articles/s41467-025-66553-7_reference.pdfDirect OA link when available
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0Total citation count in OpenAlex
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81Number of works referenced by this work
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