Neuroblastoma Patients’ Outcome and Chromosomal Instability Article Swipe
Marzia Ognibene
,
Patrizia De Marco
,
Loredana Amoroso
,
Martina Fragola
,
Federico Zara
,
Stefano Parodi
,
Annalisa Pezzolo
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/ijms242115514
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/ijms242115514
Chromosomal instability (CIN) induces a high rate of losses or gains of whole chromosomes or parts of chromosomes. It is a hallmark of most human cancers and one of the causes of aneuploidy and intra-tumor heterogeneity. The present study aimed to evaluate the potential prognostic role of CIN in NB patients at diagnosis. We performed array comparative genomic hybridization analyses on 451 primary NB patients at the onset of the disease. To assess global chromosomal instability with high precision, we focused on the total number of DNA breakpoints of gains or losses of chromosome arms. For each tumor, an array-CGH-based breakpoint instability index (BPI) was assigned which defined the total number of chromosomal breakpoints per genome. This approach allowed us to quantify CIN related to whole genome disruption in all NB cases analyzed. We found differences in chromosomal breakages among the NB clinical risk groups. High BPI values are negatively associated with survival of NB patients. This association remains significant when correcting for stage, age, and MYCN status in the Cox model. Stratified analysis confirms the prognostic effect of BPI index in low-risk NB patients with non-amplified MYCN and with segmental chromosome aberrations.
Related Topics
Concepts
Chromosome instability
Genome instability
Breakpoint
Comparative genomic hybridization
Aneuploidy
Biology
Chromosome
Neuroblastoma
Oncology
Cancer research
Genetics
Internal medicine
DNA
Medicine
Gene
DNA damage
Cell culture
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms242115514
- https://www.mdpi.com/1422-0067/24/21/15514/pdf?version=1698132805
- OA Status
- gold
- Cited By
- 3
- References
- 63
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4387907537
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4387907537Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/ijms242115514Digital Object Identifier
- Title
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Neuroblastoma Patients’ Outcome and Chromosomal InstabilityWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-10-24Full publication date if available
- Authors
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Marzia Ognibene, Patrizia De Marco, Loredana Amoroso, Martina Fragola, Federico Zara, Stefano Parodi, Annalisa PezzoloList of authors in order
- Landing page
-
https://doi.org/10.3390/ijms242115514Publisher landing page
- PDF URL
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https://www.mdpi.com/1422-0067/24/21/15514/pdf?version=1698132805Direct link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1422-0067/24/21/15514/pdf?version=1698132805Direct OA link when available
- Concepts
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Chromosome instability, Genome instability, Breakpoint, Comparative genomic hybridization, Aneuploidy, Biology, Chromosome, Neuroblastoma, Oncology, Cancer research, Genetics, Internal medicine, DNA, Medicine, Gene, DNA damage, Cell cultureTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
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2025: 3Per-year citation counts (last 5 years)
- References (count)
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63Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| citation_normalized_percentile.value | 0.73709361 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |