Neurodegeneration rewires the tumor microenvironment via the neuro–immune–cancer axis Article Swipe

View

Jhommara Bautista , Emily C Coral-Riofrio , Salomé Suárez Urresta , David Palacios-Zavala , Carolina E. Echeverría , Salomé Araujo‐Abad , Andrés López‐Cortés ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.1016/j.isci.2025.113550

Related Topics

Truth And Reconciliation Commission Of Canada

Concepts

No concepts available.

Metadata

Type: review
Language: en
Landing Page: https://doi.org/10.1016/j.isci.2025.113550
OA Status: gold
Cited By: 3
References: 134
OpenAlex ID: https://openalex.org/W4414302215

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W4414302215

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.1016/j.isci.2025.113550

Digital Object Identifier
Title: Neurodegeneration rewires the tumor microenvironment via the neuro–immune–cancer axis

Work title
Type: review

OpenAlex work type
Language: en

Primary language
Publication year: 2025

Year of publication
Publication date: 2025-09-17

Full publication date if available
Authors: Jhommara Bautista, Emily C Coral-Riofrio, Salomé Suárez Urresta, David Palacios-Zavala, Carolina E. Echeverría, Salomé Araujo‐Abad, Andrés López‐Cortés

List of authors in order
Landing page: https://doi.org/10.1016/j.isci.2025.113550

Publisher landing page
Open access: Yes

Whether a free full text is available
OA status: gold

Open access status per OpenAlex
OA URL: https://doi.org/10.1016/j.isci.2025.113550

Direct OA link when available
Cited by: 3

Total citation count in OpenAlex
Citations by year (recent): 2025: 3

Per-year citation counts (last 5 years)
References (count): 134

Number of works referenced by this work

Full payload

id	https://openalex.org/W4414302215
doi	https://doi.org/10.1016/j.isci.2025.113550
ids.doi	https://doi.org/10.1016/j.isci.2025.113550
ids.pmid	https://pubmed.ncbi.nlm.nih.gov/41079621
ids.openalex	https://openalex.org/W4414302215
fwci	14.13962769
type	review
title	Neurodegeneration rewires the tumor microenvironment via the neuro–immune–cancer axis
biblio.issue	10
biblio.volume	28
biblio.last_page	113550
biblio.first_page	113550
topics[0].id	https://openalex.org/T12626
topics[0].field.id	https://openalex.org/fields/27
topics[0].field.display_name	Medicine
topics[0].score	0.9990000128746033
topics[0].domain.id	https://openalex.org/domains/4
topics[0].domain.display_name	Health Sciences
topics[0].subfield.id	https://openalex.org/subfields/2738
topics[0].subfield.display_name	Psychiatry and Mental health
topics[0].display_name	Cancer, Stress, Anesthesia, and Immune Response
topics[1].id	https://openalex.org/T11266
topics[1].field.id	https://openalex.org/fields/28
topics[1].field.display_name	Neuroscience
topics[1].score	0.9941999912261963
topics[1].domain.id	https://openalex.org/domains/1
topics[1].domain.display_name	Life Sciences
topics[1].subfield.id	https://openalex.org/subfields/2808
topics[1].subfield.display_name	Neurology
topics[1].display_name	Neuroinflammation and Neurodegeneration Mechanisms
topics[2].id	https://openalex.org/T11337
topics[2].field.id	https://openalex.org/fields/28
topics[2].field.display_name	Neuroscience
topics[2].score	0.9926999807357788
topics[2].domain.id	https://openalex.org/domains/1
topics[2].domain.display_name	Life Sciences
topics[2].subfield.id	https://openalex.org/subfields/2803
topics[2].subfield.display_name	Biological Psychiatry
topics[2].display_name	Tryptophan and brain disorders
is_xpac	False
apc_list.value	3000
apc_list.currency	USD
apc_list.value_usd	3000
apc_paid.value	3000
apc_paid.currency	USD
apc_paid.value_usd	3000
language	en
locations[0].id	doi:10.1016/j.isci.2025.113550
locations[0].is_oa	True
locations[0].source.id	https://openalex.org/S2898358376
locations[0].source.issn	2589-0042
locations[0].source.type	journal
locations[0].source.is_oa	True
locations[0].source.issn_l	2589-0042
locations[0].source.is_core	True
locations[0].source.is_in_doaj	True
locations[0].source.display_name	iScience
locations[0].source.host_organization	https://openalex.org/P4310315673
locations[0].source.host_organization_name	Cell Press
locations[0].source.host_organization_lineage	https://openalex.org/P4310315673
locations[0].license
locations[0].pdf_url
locations[0].version	publishedVersion
locations[0].raw_type	journal-article
locations[0].license_id
locations[0].is_accepted	True
locations[0].is_published	True
locations[0].raw_source_name	iScience
locations[0].landing_page_url	https://doi.org/10.1016/j.isci.2025.113550
locations[1].id	pmid:41079621
locations[1].is_oa	False
locations[1].source.id	https://openalex.org/S4306525036
locations[1].source.issn
locations[1].source.type	repository
locations[1].source.is_oa	False
locations[1].source.issn_l
locations[1].source.is_core	False
locations[1].source.is_in_doaj	False
locations[1].source.display_name	PubMed
locations[1].source.host_organization	https://openalex.org/I1299303238
locations[1].source.host_organization_name	National Institutes of Health
locations[1].source.host_organization_lineage	https://openalex.org/I1299303238
locations[1].license
locations[1].pdf_url
locations[1].version	publishedVersion
locations[1].raw_type
locations[1].license_id
locations[1].is_accepted	True
locations[1].is_published	True
locations[1].raw_source_name	iScience
locations[1].landing_page_url	https://pubmed.ncbi.nlm.nih.gov/41079621
locations[2].id	pmh:oai:europepmc.org:11316841
locations[2].is_oa	True
locations[2].source.id	https://openalex.org/S4306400806
locations[2].source.issn
locations[2].source.type	repository
locations[2].source.is_oa	False
locations[2].source.issn_l
locations[2].source.is_core	False
locations[2].source.is_in_doaj	False
locations[2].source.display_name	Europe PMC (PubMed Central)
locations[2].source.host_organization	https://openalex.org/I1303153112
locations[2].source.host_organization_name	European Bioinformatics Institute
locations[2].source.host_organization_lineage	https://openalex.org/I1303153112
locations[2].license	other-oa
locations[2].pdf_url
locations[2].version	submittedVersion
locations[2].raw_type	Text
locations[2].license_id	https://openalex.org/licenses/other-oa
locations[2].is_accepted	False
locations[2].is_published	False
locations[2].raw_source_name
locations[2].landing_page_url	https://www.ncbi.nlm.nih.gov/pmc/articles/12508874
locations[3].id	pmh:oai:doaj.org/article:c1fe43e0d5394d7d8793479b151b1d91
locations[3].is_oa	True
locations[3].source.id	https://openalex.org/S4306401280
locations[3].source.issn
locations[3].source.type	repository
locations[3].source.is_oa	False
locations[3].source.issn_l
locations[3].source.is_core	False
locations[3].source.is_in_doaj	False
locations[3].source.display_name	DOAJ (DOAJ: Directory of Open Access Journals)
locations[3].source.host_organization
locations[3].source.host_organization_name
locations[3].source.host_organization_lineage
locations[3].license	cc-by-sa
locations[3].pdf_url
locations[3].version	submittedVersion
locations[3].raw_type	article
locations[3].license_id	https://openalex.org/licenses/cc-by-sa
locations[3].is_accepted	False
locations[3].is_published	False
locations[3].raw_source_name	iScience, Vol 28, Iss 10, Pp 113550- (2025)
locations[3].landing_page_url	https://doaj.org/article/c1fe43e0d5394d7d8793479b151b1d91
indexed_in	crossref, doaj, pubmed
authorships[0].author.id	https://openalex.org/A5037503970
authorships[0].author.orcid	https://orcid.org/0000-0002-9717-8096
authorships[0].author.display_name	Jhommara Bautista
authorships[0].countries	EC, ES
authorships[0].affiliations[0].institution_ids	https://openalex.org/I11019714
authorships[0].affiliations[0].raw_affiliation_string	Facultade de Ciencias, Campus de A Zapateira, Universidade da Coruña, A Coruña, Spain.
authorships[0].affiliations[1].institution_ids	https://openalex.org/I4210102282
authorships[0].affiliations[1].raw_affiliation_string	Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador.
authorships[0].institutions[0].id	https://openalex.org/I4210102282
authorships[0].institutions[0].ror	https://ror.org/0198j4566
authorships[0].institutions[0].type	education
authorships[0].institutions[0].lineage	https://openalex.org/I4210102282
authorships[0].institutions[0].country_code	EC
authorships[0].institutions[0].display_name	Universidad de Las Américas
authorships[0].institutions[1].id	https://openalex.org/I11019714
authorships[0].institutions[1].ror	https://ror.org/01qckj285
authorships[0].institutions[1].type	education
authorships[0].institutions[1].lineage	https://openalex.org/I11019714
authorships[0].institutions[1].country_code	ES
authorships[0].institutions[1].display_name	Universidade da Coruña
authorships[0].author_position	first
authorships[0].raw_author_name	Jhommara Bautista
authorships[0].is_corresponding	False
authorships[0].raw_affiliation_strings	Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador., Facultade de Ciencias, Campus de A Zapateira, Universidade da Coruña, A Coruña, Spain.
authorships[1].author.id	https://openalex.org/A5119658757
authorships[1].author.orcid
authorships[1].author.display_name	Emily C Coral-Riofrio
authorships[1].countries	EC
authorships[1].affiliations[0].institution_ids	https://openalex.org/I4210102282
authorships[1].affiliations[0].raw_affiliation_string	Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador.
authorships[1].institutions[0].id	https://openalex.org/I4210102282
authorships[1].institutions[0].ror	https://ror.org/0198j4566
authorships[1].institutions[0].type	education
authorships[1].institutions[0].lineage	https://openalex.org/I4210102282
authorships[1].institutions[0].country_code	EC
authorships[1].institutions[0].display_name	Universidad de Las Américas
authorships[1].author_position	middle
authorships[1].raw_author_name	Emily C. Coral-Riofrio
authorships[1].is_corresponding	False
authorships[1].raw_affiliation_strings	Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador.
authorships[2].author.id	https://openalex.org/A5119658758
authorships[2].author.orcid
authorships[2].author.display_name	Salomé Suárez Urresta
authorships[2].countries	EC
authorships[2].affiliations[0].institution_ids	https://openalex.org/I4210102282
authorships[2].affiliations[0].raw_affiliation_string	Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador.
authorships[2].institutions[0].id	https://openalex.org/I4210102282
authorships[2].institutions[0].ror	https://ror.org/0198j4566
authorships[2].institutions[0].type	education
authorships[2].institutions[0].lineage	https://openalex.org/I4210102282
authorships[2].institutions[0].country_code	EC
authorships[2].institutions[0].display_name	Universidad de Las Américas
authorships[2].author_position	middle
authorships[2].raw_author_name	Salomé Suárez Urresta
authorships[2].is_corresponding	False
authorships[2].raw_affiliation_strings	Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador.
authorships[3].author.id	https://openalex.org/A5119014866
authorships[3].author.orcid
authorships[3].author.display_name	David Palacios-Zavala
authorships[3].countries	EC
authorships[3].affiliations[0].institution_ids	https://openalex.org/I4210102282
authorships[3].affiliations[0].raw_affiliation_string	Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador.
authorships[3].institutions[0].id	https://openalex.org/I4210102282
authorships[3].institutions[0].ror	https://ror.org/0198j4566
authorships[3].institutions[0].type	education
authorships[3].institutions[0].lineage	https://openalex.org/I4210102282
authorships[3].institutions[0].country_code	EC
authorships[3].institutions[0].display_name	Universidad de Las Américas
authorships[3].author_position	middle
authorships[3].raw_author_name	David Palacios-Zavala
authorships[3].is_corresponding	False
authorships[3].raw_affiliation_strings	Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador.
authorships[4].author.id	https://openalex.org/A5071779411
authorships[4].author.orcid	https://orcid.org/0000-0002-5298-1635
authorships[4].author.display_name	Carolina E. Echeverría
authorships[4].countries	US
authorships[4].affiliations[0].institution_ids	https://openalex.org/I57206974
authorships[4].affiliations[0].raw_affiliation_string	Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA.
authorships[4].institutions[0].id	https://openalex.org/I57206974
authorships[4].institutions[0].ror	https://ror.org/0190ak572
authorships[4].institutions[0].type	education
authorships[4].institutions[0].lineage	https://openalex.org/I57206974
authorships[4].institutions[0].country_code	US
authorships[4].institutions[0].display_name	New York University
authorships[4].author_position	middle
authorships[4].raw_author_name	Carolina E. Echeverría
authorships[4].is_corresponding	False
authorships[4].raw_affiliation_strings	Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA.
authorships[5].author.id	https://openalex.org/A5030802584
authorships[5].author.orcid	https://orcid.org/0000-0001-7387-0363
authorships[5].author.display_name	Salomé Araujo‐Abad
authorships[5].countries	EC
authorships[5].affiliations[0].institution_ids	https://openalex.org/I4210102282
authorships[5].affiliations[0].raw_affiliation_string	Cancer Research Group, Faculty of Engineering and Applied Sciences, Universidad de Las Américas, Quito, Ecuador.
authorships[5].institutions[0].id	https://openalex.org/I4210102282
authorships[5].institutions[0].ror	https://ror.org/0198j4566
authorships[5].institutions[0].type	education
authorships[5].institutions[0].lineage	https://openalex.org/I4210102282
authorships[5].institutions[0].country_code	EC
authorships[5].institutions[0].display_name	Universidad de Las Américas
authorships[5].author_position	middle
authorships[5].raw_author_name	Salomé Araujo-Abad
authorships[5].is_corresponding	False
authorships[5].raw_affiliation_strings	Cancer Research Group, Faculty of Engineering and Applied Sciences, Universidad de Las Américas, Quito, Ecuador.
authorships[6].author.id	https://openalex.org/A5029383178
authorships[6].author.orcid	https://orcid.org/0000-0003-1503-1929
authorships[6].author.display_name	Andrés López‐Cortés
authorships[6].countries	EC
authorships[6].affiliations[0].institution_ids	https://openalex.org/I4210102282
authorships[6].affiliations[0].raw_affiliation_string	Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador.
authorships[6].institutions[0].id	https://openalex.org/I4210102282
authorships[6].institutions[0].ror	https://ror.org/0198j4566
authorships[6].institutions[0].type	education
authorships[6].institutions[0].lineage	https://openalex.org/I4210102282
authorships[6].institutions[0].country_code	EC
authorships[6].institutions[0].display_name	Universidad de Las Américas
authorships[6].author_position	last
authorships[6].raw_author_name	Andrés López-Cortés
authorships[6].is_corresponding	False
authorships[6].raw_affiliation_strings	Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador.
has_content.pdf	False
has_content.grobid_xml	False
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://doi.org/10.1016/j.isci.2025.113550
open_access.oa_status	gold
open_access.any_repository_has_fulltext	False
created_date	2025-10-10T00:00:00
display_name	Neurodegeneration rewires the tumor microenvironment via the neuro–immune–cancer axis
has_fulltext	False
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T12626
primary_topic.field.id	https://openalex.org/fields/27
primary_topic.field.display_name	Medicine
primary_topic.score	0.9990000128746033
primary_topic.domain.id	https://openalex.org/domains/4
primary_topic.domain.display_name	Health Sciences
primary_topic.subfield.id	https://openalex.org/subfields/2738
primary_topic.subfield.display_name	Psychiatry and Mental health
primary_topic.display_name	Cancer, Stress, Anesthesia, and Immune Response
cited_by_count	3
counts_by_year[0].year	2025
counts_by_year[0].cited_by_count	3
locations_count	4
best_oa_location.id	doi:10.1016/j.isci.2025.113550
best_oa_location.is_oa	True
best_oa_location.source.id	https://openalex.org/S2898358376
best_oa_location.source.issn	2589-0042
best_oa_location.source.type	journal
best_oa_location.source.is_oa	True
best_oa_location.source.issn_l	2589-0042
best_oa_location.source.is_core	True
best_oa_location.source.is_in_doaj	True
best_oa_location.source.display_name	iScience
best_oa_location.source.host_organization	https://openalex.org/P4310315673
best_oa_location.source.host_organization_name	Cell Press
best_oa_location.source.host_organization_lineage	https://openalex.org/P4310315673
best_oa_location.license
best_oa_location.pdf_url
best_oa_location.version	publishedVersion
best_oa_location.raw_type	journal-article
best_oa_location.license_id
best_oa_location.is_accepted	True
best_oa_location.is_published	True
best_oa_location.raw_source_name	iScience
best_oa_location.landing_page_url	https://doi.org/10.1016/j.isci.2025.113550
primary_location.id	doi:10.1016/j.isci.2025.113550
primary_location.is_oa	True
primary_location.source.id	https://openalex.org/S2898358376
primary_location.source.issn	2589-0042
primary_location.source.type	journal
primary_location.source.is_oa	True
primary_location.source.issn_l	2589-0042
primary_location.source.is_core	True
primary_location.source.is_in_doaj	True
primary_location.source.display_name	iScience
primary_location.source.host_organization	https://openalex.org/P4310315673
primary_location.source.host_organization_name	Cell Press
primary_location.source.host_organization_lineage	https://openalex.org/P4310315673
primary_location.license
primary_location.pdf_url
primary_location.version	publishedVersion
primary_location.raw_type	journal-article
primary_location.license_id
primary_location.is_accepted	True
primary_location.is_published	True
primary_location.raw_source_name	iScience
primary_location.landing_page_url	https://doi.org/10.1016/j.isci.2025.113550
publication_date	2025-09-17
publication_year	2025
referenced_works	https://openalex.org/W4324046265, https://openalex.org/W3155267292, https://openalex.org/W2974724557, https://openalex.org/W4389558714, https://openalex.org/W2945540780, https://openalex.org/W4412686163, https://openalex.org/W2998698891, https://openalex.org/W4405832639, https://openalex.org/W3048236758, https://openalex.org/W2802814977, https://openalex.org/W3027255994, https://openalex.org/W4387473042, https://openalex.org/W4396769373, https://openalex.org/W4226250050, https://openalex.org/W3153173976, https://openalex.org/W4385498024, https://openalex.org/W3035853891, https://openalex.org/W2001650386, https://openalex.org/W4411347407, https://openalex.org/W4410427598, https://openalex.org/W2109491705, https://openalex.org/W4321019178, https://openalex.org/W4403464922, https://openalex.org/W4321372477, https://openalex.org/W4409436002, https://openalex.org/W4404702656, https://openalex.org/W4408996481, https://openalex.org/W4399258275, https://openalex.org/W4383894096, https://openalex.org/W4403236785, https://openalex.org/W2005182420, https://openalex.org/W1966163762, https://openalex.org/W4403825144, https://openalex.org/W2132413371, https://openalex.org/W2031588422, https://openalex.org/W2889021210, https://openalex.org/W4406745422, https://openalex.org/W4390664406, https://openalex.org/W1981859966, https://openalex.org/W4377939044, https://openalex.org/W4285084594, https://openalex.org/W1965029154, https://openalex.org/W4390508473, https://openalex.org/W4385498418, https://openalex.org/W4402143990, https://openalex.org/W4388483815, https://openalex.org/W4406505421, https://openalex.org/W4407751830, https://openalex.org/W4412745982, https://openalex.org/W4408225535, https://openalex.org/W4310211651, https://openalex.org/W3120090609, https://openalex.org/W3180882235, https://openalex.org/W4410934422, https://openalex.org/W3080773873, https://openalex.org/W4386084782, https://openalex.org/W1521729043, https://openalex.org/W4407225532, https://openalex.org/W2788455163, https://openalex.org/W4413345515, https://openalex.org/W4405264189, https://openalex.org/W4221019666, https://openalex.org/W2406188520, https://openalex.org/W4385551579, https://openalex.org/W4386225134, https://openalex.org/W4412637124, https://openalex.org/W4413799214, https://openalex.org/W4410068838, https://openalex.org/W4407878110, https://openalex.org/W4408419977, https://openalex.org/W3089667275, https://openalex.org/W4413867762, https://openalex.org/W4403674325, https://openalex.org/W4408063824, https://openalex.org/W4406489185, https://openalex.org/W4289048688, https://openalex.org/W4388540302, https://openalex.org/W4410506801, https://openalex.org/W2091495423, https://openalex.org/W2973754816, https://openalex.org/W4308773363, https://openalex.org/W4380550728, https://openalex.org/W4413345485, https://openalex.org/W4224305229, https://openalex.org/W4294238405, https://openalex.org/W3021978741, https://openalex.org/W2980652798, https://openalex.org/W4407625334, https://openalex.org/W4401214465, https://openalex.org/W3014837192, https://openalex.org/W3133822785, https://openalex.org/W2175804913, https://openalex.org/W4292835067, https://openalex.org/W2473586090, https://openalex.org/W2058148996, https://openalex.org/W1875921292, https://openalex.org/W2107207009, https://openalex.org/W4386776963, https://openalex.org/W2479269395, https://openalex.org/W4394996128, https://openalex.org/W4403432106, https://openalex.org/W4360600789, https://openalex.org/W1644377522, https://openalex.org/W4381943567, https://openalex.org/W2947021030, https://openalex.org/W4307228859, https://openalex.org/W2082425146, https://openalex.org/W4392232546, https://openalex.org/W4399890168, https://openalex.org/W3154342995, https://openalex.org/W4298149555, https://openalex.org/W2979979888, https://openalex.org/W3209276761, https://openalex.org/W2103079055, https://openalex.org/W3014903801, https://openalex.org/W2614627885, https://openalex.org/W4410873410, https://openalex.org/W4361224118, https://openalex.org/W4392965705, https://openalex.org/W4206157980, https://openalex.org/W4313531093, https://openalex.org/W4323858124, https://openalex.org/W4409411967, https://openalex.org/W4322216949, https://openalex.org/W2990179436, https://openalex.org/W4206662285, https://openalex.org/W2049959255, https://openalex.org/W2765161542, https://openalex.org/W2134164899, https://openalex.org/W2155636825, https://openalex.org/W4414253972, https://openalex.org/W4410873231, https://openalex.org/W4386289604, https://openalex.org/W3003912482
referenced_works_count	134
abstract_inverted_index
cited_by_percentile_year.max	97
cited_by_percentile_year.min	96
countries_distinct_count	3
institutions_distinct_count	7
citation_normalized_percentile.value	0.97161604
citation_normalized_percentile.is_in_top_1_percent	True
citation_normalized_percentile.is_in_top_10_percent	True