Neurological disability and brain grey matter atrophy in primary progressive multiple sclerosis are determined by microstructural lesional changes, but not by lesion load Article Swipe
Theodoros Ladopoulos
,
Zainab Abbas
,
Britta Krieger
,
Barbara Bellenberg
,
Jeyanthan Charles James
,
Jan Bauer
,
Ralf Gold
,
Carsten Lukas
,
Ruth Schneider
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1007/s00415-025-13043-x
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1007/s00415-025-13043-x
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1007/s00415-025-13043-x
- OA Status
- hybrid
- References
- 45
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409086279
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4409086279Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1007/s00415-025-13043-xDigital Object Identifier
- Title
-
Neurological disability and brain grey matter atrophy in primary progressive multiple sclerosis are determined by microstructural lesional changes, but not by lesion loadWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-04-01Full publication date if available
- Authors
-
Theodoros Ladopoulos, Zainab Abbas, Britta Krieger, Barbara Bellenberg, Jeyanthan Charles James, Jan Bauer, Ralf Gold, Carsten Lukas, Ruth SchneiderList of authors in order
- Landing page
-
https://doi.org/10.1007/s00415-025-13043-xPublisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1007/s00415-025-13043-xDirect OA link when available
- Concepts
-
Atrophy, Multiple sclerosis, Medicine, Grey matter, White matter, Lesion, Neuroradiology, Pathology, Fluid-attenuated inversion recovery, Expanded Disability Status Scale, Magnetic resonance imaging, Neurology, Radiology, PsychiatryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
45Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4409086279 |
|---|---|
| doi | https://doi.org/10.1007/s00415-025-13043-x |
| ids.doi | https://doi.org/10.1007/s00415-025-13043-x |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/40167785 |
| ids.openalex | https://openalex.org/W4409086279 |
| fwci | 0.0 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D008297 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Male |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D005260 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Female |
| mesh[3].qualifier_ui | Q000473 |
| mesh[3].descriptor_ui | D066128 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | pathology |
| mesh[3].descriptor_name | Gray Matter |
| mesh[4].qualifier_ui | Q000000981 |
| mesh[4].descriptor_ui | D066128 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | diagnostic imaging |
| mesh[4].descriptor_name | Gray Matter |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D008875 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Middle Aged |
| mesh[6].qualifier_ui | Q000473 |
| mesh[6].descriptor_ui | D001284 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | pathology |
| mesh[6].descriptor_name | Atrophy |
| mesh[7].qualifier_ui | Q000000981 |
| mesh[7].descriptor_ui | D020528 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | diagnostic imaging |
| mesh[7].descriptor_name | Multiple Sclerosis, Chronic Progressive |
| mesh[8].qualifier_ui | Q000473 |
| mesh[8].descriptor_ui | D020528 |
| mesh[8].is_major_topic | True |
| mesh[8].qualifier_name | pathology |
| mesh[8].descriptor_name | Multiple Sclerosis, Chronic Progressive |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D000328 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Adult |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D008279 |
| mesh[10].is_major_topic | True |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Magnetic Resonance Imaging |
| mesh[11].qualifier_ui | Q000473 |
| mesh[11].descriptor_ui | D001921 |
| mesh[11].is_major_topic | True |
| mesh[11].qualifier_name | pathology |
| mesh[11].descriptor_name | Brain |
| mesh[12].qualifier_ui | Q000000981 |
| mesh[12].descriptor_ui | D001921 |
| mesh[12].is_major_topic | True |
| mesh[12].qualifier_name | diagnostic imaging |
| mesh[12].descriptor_name | Brain |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D004185 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Disability Evaluation |
| mesh[14].qualifier_ui | Q000000981 |
| mesh[14].descriptor_ui | D066127 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | diagnostic imaging |
| mesh[14].descriptor_name | White Matter |
| mesh[15].qualifier_ui | Q000473 |
| mesh[15].descriptor_ui | D066127 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | pathology |
| mesh[15].descriptor_name | White Matter |
| mesh[16].qualifier_ui | Q000473 |
| mesh[16].descriptor_ui | D020529 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | pathology |
| mesh[16].descriptor_name | Multiple Sclerosis, Relapsing-Remitting |
| mesh[17].qualifier_ui | Q000000981 |
| mesh[17].descriptor_ui | D020529 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | diagnostic imaging |
| mesh[17].descriptor_name | Multiple Sclerosis, Relapsing-Remitting |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D000368 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Aged |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D007091 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Image Processing, Computer-Assisted |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D006801 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Humans |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D008297 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Male |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D005260 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Female |
| mesh[23].qualifier_ui | Q000473 |
| mesh[23].descriptor_ui | D066128 |
| mesh[23].is_major_topic | True |
| mesh[23].qualifier_name | pathology |
| mesh[23].descriptor_name | Gray Matter |
| mesh[24].qualifier_ui | Q000000981 |
| mesh[24].descriptor_ui | D066128 |
| mesh[24].is_major_topic | True |
| mesh[24].qualifier_name | diagnostic imaging |
| mesh[24].descriptor_name | Gray Matter |
| mesh[25].qualifier_ui | Q000473 |
| mesh[25].descriptor_ui | D001284 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | pathology |
| mesh[25].descriptor_name | Atrophy |
| mesh[26].qualifier_ui | |
| mesh[26].descriptor_ui | D008279 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | |
| mesh[26].descriptor_name | Magnetic Resonance Imaging |
| mesh[27].qualifier_ui | Q000473 |
| mesh[27].descriptor_ui | D020528 |
| mesh[27].is_major_topic | True |
| mesh[27].qualifier_name | pathology |
| mesh[27].descriptor_name | Multiple Sclerosis, Chronic Progressive |
| mesh[28].qualifier_ui | Q000000981 |
| mesh[28].descriptor_ui | D020528 |
| mesh[28].is_major_topic | True |
| mesh[28].qualifier_name | diagnostic imaging |
| mesh[28].descriptor_name | Multiple Sclerosis, Chronic Progressive |
| mesh[29].qualifier_ui | Q000503 |
| mesh[29].descriptor_ui | D020528 |
| mesh[29].is_major_topic | True |
| mesh[29].qualifier_name | physiopathology |
| mesh[29].descriptor_name | Multiple Sclerosis, Chronic Progressive |
| mesh[30].qualifier_ui | |
| mesh[30].descriptor_ui | D008875 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | |
| mesh[30].descriptor_name | Middle Aged |
| mesh[31].qualifier_ui | |
| mesh[31].descriptor_ui | D000328 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | |
| mesh[31].descriptor_name | Adult |
| mesh[32].qualifier_ui | Q000473 |
| mesh[32].descriptor_ui | D001921 |
| mesh[32].is_major_topic | True |
| mesh[32].qualifier_name | pathology |
| mesh[32].descriptor_name | Brain |
| mesh[33].qualifier_ui | Q000000981 |
| mesh[33].descriptor_ui | D001921 |
| mesh[33].is_major_topic | True |
| mesh[33].qualifier_name | diagnostic imaging |
| mesh[33].descriptor_name | Brain |
| mesh[34].qualifier_ui | Q000473 |
| mesh[34].descriptor_ui | D020529 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | pathology |
| mesh[34].descriptor_name | Multiple Sclerosis, Relapsing-Remitting |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D004185 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | Disability Evaluation |
| mesh[36].qualifier_ui | |
| mesh[36].descriptor_ui | D007091 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | |
| mesh[36].descriptor_name | Image Processing, Computer-Assisted |
| mesh[37].qualifier_ui | |
| mesh[37].descriptor_ui | D006801 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | |
| mesh[37].descriptor_name | Humans |
| mesh[38].qualifier_ui | |
| mesh[38].descriptor_ui | D008297 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | |
| mesh[38].descriptor_name | Male |
| mesh[39].qualifier_ui | |
| mesh[39].descriptor_ui | D005260 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | |
| mesh[39].descriptor_name | Female |
| mesh[40].qualifier_ui | Q000473 |
| mesh[40].descriptor_ui | D066128 |
| mesh[40].is_major_topic | True |
| mesh[40].qualifier_name | pathology |
| mesh[40].descriptor_name | Gray Matter |
| mesh[41].qualifier_ui | Q000000981 |
| mesh[41].descriptor_ui | D066128 |
| mesh[41].is_major_topic | True |
| mesh[41].qualifier_name | diagnostic imaging |
| mesh[41].descriptor_name | Gray Matter |
| mesh[42].qualifier_ui | |
| mesh[42].descriptor_ui | D008875 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | |
| mesh[42].descriptor_name | Middle Aged |
| mesh[43].qualifier_ui | Q000473 |
| mesh[43].descriptor_ui | D001284 |
| mesh[43].is_major_topic | True |
| mesh[43].qualifier_name | pathology |
| mesh[43].descriptor_name | Atrophy |
| mesh[44].qualifier_ui | Q000000981 |
| mesh[44].descriptor_ui | D020528 |
| mesh[44].is_major_topic | True |
| mesh[44].qualifier_name | diagnostic imaging |
| mesh[44].descriptor_name | Multiple Sclerosis, Chronic Progressive |
| mesh[45].qualifier_ui | Q000473 |
| mesh[45].descriptor_ui | D020528 |
| mesh[45].is_major_topic | True |
| mesh[45].qualifier_name | pathology |
| mesh[45].descriptor_name | Multiple Sclerosis, Chronic Progressive |
| mesh[46].qualifier_ui | |
| mesh[46].descriptor_ui | D000328 |
| mesh[46].is_major_topic | False |
| mesh[46].qualifier_name | |
| mesh[46].descriptor_name | Adult |
| mesh[47].qualifier_ui | |
| mesh[47].descriptor_ui | D008279 |
| mesh[47].is_major_topic | True |
| mesh[47].qualifier_name | |
| mesh[47].descriptor_name | Magnetic Resonance Imaging |
| mesh[48].qualifier_ui | Q000473 |
| mesh[48].descriptor_ui | D001921 |
| mesh[48].is_major_topic | True |
| mesh[48].qualifier_name | pathology |
| mesh[48].descriptor_name | Brain |
| mesh[49].qualifier_ui | Q000000981 |
| mesh[49].descriptor_ui | D001921 |
| mesh[49].is_major_topic | True |
| mesh[49].qualifier_name | diagnostic imaging |
| mesh[49].descriptor_name | Brain |
| type | article |
| title | Neurological disability and brain grey matter atrophy in primary progressive multiple sclerosis are determined by microstructural lesional changes, but not by lesion load |
| biblio.issue | 4 |
| biblio.volume | 272 |
| biblio.last_page | 302 |
| biblio.first_page | 302 |
| grants[0].funder | https://openalex.org/F4320323715 |
| grants[0].award_id | |
| grants[0].funder_display_name | Ruhr-Universität Bochum |
| topics[0].id | https://openalex.org/T10137 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2734 |
| topics[0].subfield.display_name | Pathology and Forensic Medicine |
| topics[0].display_name | Multiple Sclerosis Research Studies |
| topics[1].id | https://openalex.org/T11330 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9656000137329102 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2734 |
| topics[1].subfield.display_name | Pathology and Forensic Medicine |
| topics[1].display_name | Systemic Sclerosis and Related Diseases |
| topics[2].id | https://openalex.org/T10727 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.947700023651123 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2741 |
| topics[2].subfield.display_name | Radiology, Nuclear Medicine and Imaging |
| topics[2].display_name | Ultrasound Imaging and Elastography |
| funders[0].id | https://openalex.org/F4320323715 |
| funders[0].ror | https://ror.org/04tsk2644 |
| funders[0].display_name | Ruhr-Universität Bochum |
| is_xpac | False |
| apc_list.value | 3290 |
| apc_list.currency | EUR |
| apc_list.value_usd | 4190 |
| apc_paid.value | 3290 |
| apc_paid.currency | EUR |
| apc_paid.value_usd | 4190 |
| concepts[0].id | https://openalex.org/C2781172350 |
| concepts[0].level | 2 |
| concepts[0].score | 0.8078995943069458 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q194520 |
| concepts[0].display_name | Atrophy |
| concepts[1].id | https://openalex.org/C2780640218 |
| concepts[1].level | 2 |
| concepts[1].score | 0.7740725874900818 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q8277 |
| concepts[1].display_name | Multiple sclerosis |
| concepts[2].id | https://openalex.org/C71924100 |
| concepts[2].level | 0 |
| concepts[2].score | 0.684768795967102 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[2].display_name | Medicine |
| concepts[3].id | https://openalex.org/C2778013878 |
| concepts[3].level | 4 |
| concepts[3].score | 0.6833569407463074 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q646150 |
| concepts[3].display_name | Grey matter |
| concepts[4].id | https://openalex.org/C2781192897 |
| concepts[4].level | 3 |
| concepts[4].score | 0.6654744744300842 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q822050 |
| concepts[4].display_name | White matter |
| concepts[5].id | https://openalex.org/C2781156865 |
| concepts[5].level | 2 |
| concepts[5].score | 0.6357040405273438 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q827023 |
| concepts[5].display_name | Lesion |
| concepts[6].id | https://openalex.org/C2779889316 |
| concepts[6].level | 3 |
| concepts[6].score | 0.5499632954597473 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q642836 |
| concepts[6].display_name | Neuroradiology |
| concepts[7].id | https://openalex.org/C142724271 |
| concepts[7].level | 1 |
| concepts[7].score | 0.54345703125 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[7].display_name | Pathology |
| concepts[8].id | https://openalex.org/C101070640 |
| concepts[8].level | 3 |
| concepts[8].score | 0.5254977345466614 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q3737215 |
| concepts[8].display_name | Fluid-attenuated inversion recovery |
| concepts[9].id | https://openalex.org/C2780892749 |
| concepts[9].level | 3 |
| concepts[9].score | 0.523724377155304 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q929518 |
| concepts[9].display_name | Expanded Disability Status Scale |
| concepts[10].id | https://openalex.org/C143409427 |
| concepts[10].level | 2 |
| concepts[10].score | 0.49533191323280334 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q161238 |
| concepts[10].display_name | Magnetic resonance imaging |
| concepts[11].id | https://openalex.org/C16568411 |
| concepts[11].level | 2 |
| concepts[11].score | 0.47423359751701355 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q83042 |
| concepts[11].display_name | Neurology |
| concepts[12].id | https://openalex.org/C126838900 |
| concepts[12].level | 1 |
| concepts[12].score | 0.30150362849235535 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q77604 |
| concepts[12].display_name | Radiology |
| concepts[13].id | https://openalex.org/C118552586 |
| concepts[13].level | 1 |
| concepts[13].score | 0.0 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q7867 |
| concepts[13].display_name | Psychiatry |
| keywords[0].id | https://openalex.org/keywords/atrophy |
| keywords[0].score | 0.8078995943069458 |
| keywords[0].display_name | Atrophy |
| keywords[1].id | https://openalex.org/keywords/multiple-sclerosis |
| keywords[1].score | 0.7740725874900818 |
| keywords[1].display_name | Multiple sclerosis |
| keywords[2].id | https://openalex.org/keywords/medicine |
| keywords[2].score | 0.684768795967102 |
| keywords[2].display_name | Medicine |
| keywords[3].id | https://openalex.org/keywords/grey-matter |
| keywords[3].score | 0.6833569407463074 |
| keywords[3].display_name | Grey matter |
| keywords[4].id | https://openalex.org/keywords/white-matter |
| keywords[4].score | 0.6654744744300842 |
| keywords[4].display_name | White matter |
| keywords[5].id | https://openalex.org/keywords/lesion |
| keywords[5].score | 0.6357040405273438 |
| keywords[5].display_name | Lesion |
| keywords[6].id | https://openalex.org/keywords/neuroradiology |
| keywords[6].score | 0.5499632954597473 |
| keywords[6].display_name | Neuroradiology |
| keywords[7].id | https://openalex.org/keywords/pathology |
| keywords[7].score | 0.54345703125 |
| keywords[7].display_name | Pathology |
| keywords[8].id | https://openalex.org/keywords/fluid-attenuated-inversion-recovery |
| keywords[8].score | 0.5254977345466614 |
| keywords[8].display_name | Fluid-attenuated inversion recovery |
| keywords[9].id | https://openalex.org/keywords/expanded-disability-status-scale |
| keywords[9].score | 0.523724377155304 |
| keywords[9].display_name | Expanded Disability Status Scale |
| keywords[10].id | https://openalex.org/keywords/magnetic-resonance-imaging |
| keywords[10].score | 0.49533191323280334 |
| keywords[10].display_name | Magnetic resonance imaging |
| keywords[11].id | https://openalex.org/keywords/neurology |
| keywords[11].score | 0.47423359751701355 |
| keywords[11].display_name | Neurology |
| keywords[12].id | https://openalex.org/keywords/radiology |
| keywords[12].score | 0.30150362849235535 |
| keywords[12].display_name | Radiology |
| language | en |
| locations[0].id | doi:10.1007/s00415-025-13043-x |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S175814247 |
| locations[0].source.issn | 0340-5354, 1432-1459 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0340-5354 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Journal of Neurology |
| locations[0].source.host_organization | https://openalex.org/P4310319900 |
| locations[0].source.host_organization_name | Springer Science+Business Media |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310319900 |
| locations[0].license | cc-by |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Journal of Neurology |
| locations[0].landing_page_url | https://doi.org/10.1007/s00415-025-13043-x |
| locations[1].id | pmid:40167785 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Journal of neurology |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/40167785 |
| locations[2].id | pmh:oai:europepmc.org:10775010 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306400806 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | Europe PMC (PubMed Central) |
| locations[2].source.host_organization | https://openalex.org/I1303153112 |
| locations[2].source.host_organization_name | European Bioinformatics Institute |
| locations[2].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11961454 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5025376883 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Theodoros Ladopoulos |
| authorships[0].countries | DE |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210138993 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Neurology, St Josef Hospital, Ruhr University, Gudrunstr. 56, 44791, Bochum, Germany. [email protected]. |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I4210138993, https://openalex.org/I904495901 |
| authorships[0].affiliations[1].raw_affiliation_string | Institute of Neuroradiology, St Josef Hospital, Ruhr University, Bochum, Germany. [email protected]. |
| authorships[0].institutions[0].id | https://openalex.org/I904495901 |
| authorships[0].institutions[0].ror | https://ror.org/04tsk2644 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I904495901 |
| authorships[0].institutions[0].country_code | DE |
| authorships[0].institutions[0].display_name | Ruhr University Bochum |
| authorships[0].institutions[1].id | https://openalex.org/I4210138993 |
| authorships[0].institutions[1].ror | https://ror.org/046vare28 |
| authorships[0].institutions[1].type | healthcare |
| authorships[0].institutions[1].lineage | https://openalex.org/I2799784675, https://openalex.org/I4210138993, https://openalex.org/I4210153564 |
| authorships[0].institutions[1].country_code | DE |
| authorships[0].institutions[1].display_name | St. Josef-Hospital |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Theodoros Ladopoulos |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Neurology, St Josef Hospital, Ruhr University, Gudrunstr. 56, 44791, Bochum, Germany. [email protected]., Institute of Neuroradiology, St Josef Hospital, Ruhr University, Bochum, Germany. [email protected]. |
| authorships[1].author.id | https://openalex.org/A5072204163 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-2948-7401 |
| authorships[1].author.display_name | Zainab Abbas |
| authorships[1].countries | DE |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4210138993 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Neurology, St Josef Hospital, Ruhr University, Gudrunstr. 56, 44791, Bochum, Germany. |
| authorships[1].institutions[0].id | https://openalex.org/I4210138993 |
| authorships[1].institutions[0].ror | https://ror.org/046vare28 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I2799784675, https://openalex.org/I4210138993, https://openalex.org/I4210153564 |
| authorships[1].institutions[0].country_code | DE |
| authorships[1].institutions[0].display_name | St. Josef-Hospital |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Zainab Abbas |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Neurology, St Josef Hospital, Ruhr University, Gudrunstr. 56, 44791, Bochum, Germany. |
| authorships[2].author.id | https://openalex.org/A5072573822 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Britta Krieger |
| authorships[2].countries | DE |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210138993, https://openalex.org/I904495901 |
| authorships[2].affiliations[0].raw_affiliation_string | Institute of Neuroradiology, St Josef Hospital, Ruhr University, Bochum, Germany. |
| authorships[2].institutions[0].id | https://openalex.org/I904495901 |
| authorships[2].institutions[0].ror | https://ror.org/04tsk2644 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I904495901 |
| authorships[2].institutions[0].country_code | DE |
| authorships[2].institutions[0].display_name | Ruhr University Bochum |
| authorships[2].institutions[1].id | https://openalex.org/I4210138993 |
| authorships[2].institutions[1].ror | https://ror.org/046vare28 |
| authorships[2].institutions[1].type | healthcare |
| authorships[2].institutions[1].lineage | https://openalex.org/I2799784675, https://openalex.org/I4210138993, https://openalex.org/I4210153564 |
| authorships[2].institutions[1].country_code | DE |
| authorships[2].institutions[1].display_name | St. Josef-Hospital |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Britta Krieger |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Institute of Neuroradiology, St Josef Hospital, Ruhr University, Bochum, Germany. |
| authorships[3].author.id | https://openalex.org/A5088023477 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-7484-6787 |
| authorships[3].author.display_name | Barbara Bellenberg |
| authorships[3].countries | DE |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210138993, https://openalex.org/I904495901 |
| authorships[3].affiliations[0].raw_affiliation_string | Institute of Neuroradiology, St Josef Hospital, Ruhr University, Bochum, Germany. |
| authorships[3].institutions[0].id | https://openalex.org/I904495901 |
| authorships[3].institutions[0].ror | https://ror.org/04tsk2644 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I904495901 |
| authorships[3].institutions[0].country_code | DE |
| authorships[3].institutions[0].display_name | Ruhr University Bochum |
| authorships[3].institutions[1].id | https://openalex.org/I4210138993 |
| authorships[3].institutions[1].ror | https://ror.org/046vare28 |
| authorships[3].institutions[1].type | healthcare |
| authorships[3].institutions[1].lineage | https://openalex.org/I2799784675, https://openalex.org/I4210138993, https://openalex.org/I4210153564 |
| authorships[3].institutions[1].country_code | DE |
| authorships[3].institutions[1].display_name | St. Josef-Hospital |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Barbara Bellenberg |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Institute of Neuroradiology, St Josef Hospital, Ruhr University, Bochum, Germany. |
| authorships[4].author.id | https://openalex.org/A5035137000 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-7192-2120 |
| authorships[4].author.display_name | Jeyanthan Charles James |
| authorships[4].countries | DE |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210138993 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Neurology, St Josef Hospital, Ruhr University, Gudrunstr. 56, 44791, Bochum, Germany. |
| authorships[4].institutions[0].id | https://openalex.org/I4210138993 |
| authorships[4].institutions[0].ror | https://ror.org/046vare28 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I2799784675, https://openalex.org/I4210138993, https://openalex.org/I4210153564 |
| authorships[4].institutions[0].country_code | DE |
| authorships[4].institutions[0].display_name | St. Josef-Hospital |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Jeyanthan Charles James |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Neurology, St Josef Hospital, Ruhr University, Gudrunstr. 56, 44791, Bochum, Germany. |
| authorships[5].author.id | https://openalex.org/A5003170013 |
| authorships[5].author.orcid | https://orcid.org/0000-0001-5802-8047 |
| authorships[5].author.display_name | Jan Bauer |
| authorships[5].countries | DE |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I4210138993 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Neurology, St Josef Hospital, Ruhr University, Gudrunstr. 56, 44791, Bochum, Germany. |
| authorships[5].institutions[0].id | https://openalex.org/I4210138993 |
| authorships[5].institutions[0].ror | https://ror.org/046vare28 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I2799784675, https://openalex.org/I4210138993, https://openalex.org/I4210153564 |
| authorships[5].institutions[0].country_code | DE |
| authorships[5].institutions[0].display_name | St. Josef-Hospital |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Jana Bauer |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Neurology, St Josef Hospital, Ruhr University, Gudrunstr. 56, 44791, Bochum, Germany. |
| authorships[6].author.id | https://openalex.org/A5062220148 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-7223-3052 |
| authorships[6].author.display_name | Ralf Gold |
| authorships[6].countries | DE |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I4210138993 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Neurology, St Josef Hospital, Ruhr University, Gudrunstr. 56, 44791, Bochum, Germany. |
| authorships[6].institutions[0].id | https://openalex.org/I4210138993 |
| authorships[6].institutions[0].ror | https://ror.org/046vare28 |
| authorships[6].institutions[0].type | healthcare |
| authorships[6].institutions[0].lineage | https://openalex.org/I2799784675, https://openalex.org/I4210138993, https://openalex.org/I4210153564 |
| authorships[6].institutions[0].country_code | DE |
| authorships[6].institutions[0].display_name | St. Josef-Hospital |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Ralf Gold |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Neurology, St Josef Hospital, Ruhr University, Gudrunstr. 56, 44791, Bochum, Germany. |
| authorships[7].author.id | https://openalex.org/A5009536414 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-8562-9697 |
| authorships[7].author.display_name | Carsten Lukas |
| authorships[7].countries | DE |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I4210138993 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Neurology, St Josef Hospital, Ruhr University, Gudrunstr. 56, 44791, Bochum, Germany. |
| authorships[7].affiliations[1].institution_ids | https://openalex.org/I4210138993, https://openalex.org/I904495901 |
| authorships[7].affiliations[1].raw_affiliation_string | Institute of Neuroradiology, St Josef Hospital, Ruhr University, Bochum, Germany. |
| authorships[7].institutions[0].id | https://openalex.org/I904495901 |
| authorships[7].institutions[0].ror | https://ror.org/04tsk2644 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I904495901 |
| authorships[7].institutions[0].country_code | DE |
| authorships[7].institutions[0].display_name | Ruhr University Bochum |
| authorships[7].institutions[1].id | https://openalex.org/I4210138993 |
| authorships[7].institutions[1].ror | https://ror.org/046vare28 |
| authorships[7].institutions[1].type | healthcare |
| authorships[7].institutions[1].lineage | https://openalex.org/I2799784675, https://openalex.org/I4210138993, https://openalex.org/I4210153564 |
| authorships[7].institutions[1].country_code | DE |
| authorships[7].institutions[1].display_name | St. Josef-Hospital |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Carsten Lukas |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Neurology, St Josef Hospital, Ruhr University, Gudrunstr. 56, 44791, Bochum, Germany., Institute of Neuroradiology, St Josef Hospital, Ruhr University, Bochum, Germany. |
| authorships[8].author.id | https://openalex.org/A5051943352 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-0997-2725 |
| authorships[8].author.display_name | Ruth Schneider |
| authorships[8].countries | DE |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I4210138993, https://openalex.org/I904495901 |
| authorships[8].affiliations[0].raw_affiliation_string | Institute of Neuroradiology, St Josef Hospital, Ruhr University, Bochum, Germany. |
| authorships[8].affiliations[1].institution_ids | https://openalex.org/I4210138993 |
| authorships[8].affiliations[1].raw_affiliation_string | Department of Neurology, St Josef Hospital, Ruhr University, Gudrunstr. 56, 44791, Bochum, Germany. |
| authorships[8].institutions[0].id | https://openalex.org/I904495901 |
| authorships[8].institutions[0].ror | https://ror.org/04tsk2644 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I904495901 |
| authorships[8].institutions[0].country_code | DE |
| authorships[8].institutions[0].display_name | Ruhr University Bochum |
| authorships[8].institutions[1].id | https://openalex.org/I4210138993 |
| authorships[8].institutions[1].ror | https://ror.org/046vare28 |
| authorships[8].institutions[1].type | healthcare |
| authorships[8].institutions[1].lineage | https://openalex.org/I2799784675, https://openalex.org/I4210138993, https://openalex.org/I4210153564 |
| authorships[8].institutions[1].country_code | DE |
| authorships[8].institutions[1].display_name | St. Josef-Hospital |
| authorships[8].author_position | last |
| authorships[8].raw_author_name | Ruth Schneider |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Neurology, St Josef Hospital, Ruhr University, Gudrunstr. 56, 44791, Bochum, Germany., Institute of Neuroradiology, St Josef Hospital, Ruhr University, Bochum, Germany. |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.1007/s00415-025-13043-x |
| open_access.oa_status | hybrid |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Neurological disability and brain grey matter atrophy in primary progressive multiple sclerosis are determined by microstructural lesional changes, but not by lesion load |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10137 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2734 |
| primary_topic.subfield.display_name | Pathology and Forensic Medicine |
| primary_topic.display_name | Multiple Sclerosis Research Studies |
| related_works | https://openalex.org/W2028814883, https://openalex.org/W4205866527, https://openalex.org/W2997548647, https://openalex.org/W2071001789, https://openalex.org/W1595276058, https://openalex.org/W2049932968, https://openalex.org/W2044166387, https://openalex.org/W2017977110, https://openalex.org/W4253937632, https://openalex.org/W3003967560 |
| cited_by_count | 0 |
| locations_count | 3 |
| best_oa_location.id | doi:10.1007/s00415-025-13043-x |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S175814247 |
| best_oa_location.source.issn | 0340-5354, 1432-1459 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 0340-5354 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Journal of Neurology |
| best_oa_location.source.host_organization | https://openalex.org/P4310319900 |
| best_oa_location.source.host_organization_name | Springer Science+Business Media |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310319900 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Journal of Neurology |
| best_oa_location.landing_page_url | https://doi.org/10.1007/s00415-025-13043-x |
| primary_location.id | doi:10.1007/s00415-025-13043-x |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S175814247 |
| primary_location.source.issn | 0340-5354, 1432-1459 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0340-5354 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Journal of Neurology |
| primary_location.source.host_organization | https://openalex.org/P4310319900 |
| primary_location.source.host_organization_name | Springer Science+Business Media |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310319900 |
| primary_location.license | cc-by |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Journal of Neurology |
| primary_location.landing_page_url | https://doi.org/10.1007/s00415-025-13043-x |
| publication_date | 2025-04-01 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W1990040006, https://openalex.org/W2777074421, https://openalex.org/W2061110874, https://openalex.org/W2227745747, https://openalex.org/W2046748764, https://openalex.org/W2752554587, https://openalex.org/W4213065380, https://openalex.org/W2015040716, https://openalex.org/W1763205699, https://openalex.org/W2037151367, https://openalex.org/W4304957527, https://openalex.org/W2038460807, https://openalex.org/W2051500859, https://openalex.org/W3162013124, https://openalex.org/W2123328938, https://openalex.org/W2321220444, https://openalex.org/W2607407713, https://openalex.org/W3006512435, https://openalex.org/W2832769012, https://openalex.org/W4283649730, https://openalex.org/W4293045865, https://openalex.org/W2514101822, https://openalex.org/W3021605584, https://openalex.org/W4241074797, https://openalex.org/W3120208800, https://openalex.org/W2162978315, https://openalex.org/W2788632940, https://openalex.org/W2909270098, https://openalex.org/W4401589663, https://openalex.org/W2047062145, https://openalex.org/W4320487060, https://openalex.org/W2899415108, https://openalex.org/W3082954545, https://openalex.org/W2125068099, https://openalex.org/W2603095844, https://openalex.org/W2545154663, https://openalex.org/W4296248769, https://openalex.org/W2765467523, https://openalex.org/W2885021343, https://openalex.org/W2168989684, https://openalex.org/W2906069075, https://openalex.org/W4297996478, https://openalex.org/W2972993728, https://openalex.org/W4210508368, https://openalex.org/W4226485794 |
| referenced_works_count | 45 |
| abstract_inverted_index | |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| citation_normalized_percentile.value | 0.14646305 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |