Neurometabolic abnormalities in schizophrenia and depression observed with magnetic resonance spectroscopy at 7 T Article Swipe
Reggie Taylor
,
Elizabeth Osuch
,
Betsy Schaefer
,
Nagalingam Rajakumar
,
Richard W. J. Neufeld
,
Jean Théberge
,
Peter Williamson
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1192/bjpo.bp.116.003756
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1192/bjpo.bp.116.003756
Background Examining neurometabolic abnormalities in critical brain areas in schizophrenia and major depressive disorder (MDD) may help guide future pharmacological interventions including glutamate-modulating treatments. Aims To measure metabolite concentrations within the anterior cingulate cortex (ACC) and thalamus of people with schizophrenia and people with MDD. Methods Spectra were acquired from 16 volunteers with schizophrenia, 17 with MDD and 18 healthy controls using magnetic resonance spectroscopy on a 7 Tesla scanner. Results In the thalamus, there were lower glycine concentrations in the schizophrenia group relative to control ( P =0.017) and MDD groups ( P =0.012), and higher glutamine concentrations relative to healthy controls ( P =0.009). In the thalamus and the ACC, the MDD group had lower myo -inositol concentrations than the control ( P =0.014, P =0.009, respectively) and schizophrenia ( P =0.004, P =0.002, respectively) groups. Conclusion These results support the glutamatergic theory of schizophrenia and indicate a potential glycine deficiency in the thalamus. In addition, reduced myo -inositol concentrations in MDD suggest its involvement in the disorder.
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- https://www.cambridge.org/core/services/aop-cambridge-core/content/view/864567C0645C893B8AEE5408C1A08604/S2056472400001952a.pdf/div-class-title-neurometabolic-abnormalities-in-schizophrenia-and-depression-observed-with-magnetic-resonance-spectroscopy-at-7-t-div.pdf
- OA Status
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- Cited By
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- References
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- OpenAlex ID
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- DOI
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https://doi.org/10.1192/bjpo.bp.116.003756Digital Object Identifier
- Title
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Neurometabolic abnormalities in schizophrenia and depression observed with magnetic resonance spectroscopy at 7 TWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2017Year of publication
- Publication date
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2017-01-01Full publication date if available
- Authors
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Reggie Taylor, Elizabeth Osuch, Betsy Schaefer, Nagalingam Rajakumar, Richard W. J. Neufeld, Jean Théberge, Peter WilliamsonList of authors in order
- Landing page
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https://doi.org/10.1192/bjpo.bp.116.003756Publisher landing page
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https://www.cambridge.org/core/services/aop-cambridge-core/content/view/864567C0645C893B8AEE5408C1A08604/S2056472400001952a.pdf/div-class-title-neurometabolic-abnormalities-in-schizophrenia-and-depression-observed-with-magnetic-resonance-spectroscopy-at-7-t-div.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.cambridge.org/core/services/aop-cambridge-core/content/view/864567C0645C893B8AEE5408C1A08604/S2056472400001952a.pdf/div-class-title-neurometabolic-abnormalities-in-schizophrenia-and-depression-observed-with-magnetic-resonance-spectroscopy-at-7-t-div.pdfDirect OA link when available
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Thalamus, Anterior cingulate cortex, Schizophrenia (object-oriented programming), Major depressive disorder, Psychology, Psychiatry, Glutamine, Neuroscience, Glutamate receptor, Internal medicine, Medicine, Chemistry, Mood, Cognition, Biochemistry, Amino acid, ReceptorTop concepts (fields/topics) attached by OpenAlex
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27Total citation count in OpenAlex
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2024: 2, 2023: 2, 2022: 3, 2021: 5, 2020: 3Per-year citation counts (last 5 years)
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47Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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