Neuron-specific enolase at admission as a predictor for stroke volume, severity and outcome in ischemic stroke patients: a prognostic biomarker review Article Swipe
Matheus Menão Mochetti
,
E.G. Silva
,
Adriana Aparecida Feltrin Correa
,
Marcela Rocha Cabette
,
Iago Navas Perissinotti
,
Lucas Oliveira J. e Silva
,
Adriano de Souza Pessôa
,
Rodrigo Cardoso de Oliveira
,
Luiz Fernando Ferraz da Silva
,
Heraldo Possolo de Souza
,
Júlio César Garcia de Alencar
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-024-53080-6
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-024-53080-6
An ideal blood biomarker for stroke should provide reliable results, enable fast diagnosis, and be readily accessible for practical use. Neuron-specific enolase (NSE), an enzyme released after neuronal damage, has been studied as a marker for brain injury, including cerebral infarction. However, different methodologies and limited sample sizes have restricted the applicability of any potential findings. This work aims to determine whether NSE levels at Emergency Department (ED) admission correlate with stroke severity, infarcted brain volume, functional outcome, and/or death rates. A systematic literature review was performed using PubMed, Embase, and Scopus databases. Each reviewer independently assessed all published studies identified as potentially relevant. All relevant original observational studies (cohort, case–control, and cross-sectional studies) were included. Eleven studies (1398 patients) met the inclusion criteria. Among these, six studies reported a significant correlation between NSE levels and stroke severity, while only one found no association. Four studies indicated a positive relationship between infarcted brain volume assessed by imaging and NSE levels, in contrast to the findings of only one study. Four studies identified an association related to functional outcome and death rates, while three others did not reach statistical significance in their findings. These data highlight that NSE levels at ED admissions proved to be a promising tool for predicting the outcome of ischemic stroke patients in most studies. However, they presented high discrepancies and low robustness. Therefore, further research is necessary to establish and define the role of NSE in clinical practice.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41598-024-53080-6
- https://www.nature.com/articles/s41598-024-53080-6.pdf
- OA Status
- gold
- Cited By
- 20
- References
- 26
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4391450351
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4391450351Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s41598-024-53080-6Digital Object Identifier
- Title
-
Neuron-specific enolase at admission as a predictor for stroke volume, severity and outcome in ischemic stroke patients: a prognostic biomarker reviewWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-02-01Full publication date if available
- Authors
-
Matheus Menão Mochetti, E.G. Silva, Adriana Aparecida Feltrin Correa, Marcela Rocha Cabette, Iago Navas Perissinotti, Lucas Oliveira J. e Silva, Adriano de Souza Pessôa, Rodrigo Cardoso de Oliveira, Luiz Fernando Ferraz da Silva, Heraldo Possolo de Souza, Júlio César Garcia de AlencarList of authors in order
- Landing page
-
https://doi.org/10.1038/s41598-024-53080-6Publisher landing page
- PDF URL
-
https://www.nature.com/articles/s41598-024-53080-6.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.nature.com/articles/s41598-024-53080-6.pdfDirect OA link when available
- Concepts
-
Medicine, Stroke (engine), Biomarker, Internal medicine, Enolase, Observational study, Cohort study, Bioinformatics, Oncology, Intensive care medicine, Immunohistochemistry, Engineering, Biochemistry, Mechanical engineering, Chemistry, BiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
20Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 11, 2024: 9Per-year citation counts (last 5 years)
- References (count)
-
26Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.studies) | 114 |
| abstract_inverted_index.studies. | 218 |
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| abstract_inverted_index.admission | 69 |
| abstract_inverted_index.biomarker | 4 |
| abstract_inverted_index.correlate | 70 |
| abstract_inverted_index.criteria. | 124 |
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| abstract_inverted_index.establish | 233 |
| abstract_inverted_index.findings. | 56, 192 |
| abstract_inverted_index.highlight | 195 |
| abstract_inverted_index.included. | 116 |
| abstract_inverted_index.including | 39 |
| abstract_inverted_index.inclusion | 123 |
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| abstract_inverted_index.patients) | 120 |
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| corresponding_author_ids | https://openalex.org/A5092208337 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 11 |
| corresponding_institution_ids | https://openalex.org/I17974374 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7699999809265137 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.9866732 |
| citation_normalized_percentile.is_in_top_1_percent | True |
| citation_normalized_percentile.is_in_top_10_percent | True |