Neuronal circuitry underlying female aggression inDrosophila Article Swipe
Catherine E. Schretter
,
Yoshinori Aso
,
Marisa Dreher
,
Alice A. Robie
,
Michael-John Dolan
,
Nan Chen
,
Masayoshi Ito
,
Tansy Yang
,
Ruchi Parekh
,
Gerald M. Rubin
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.05.27.118810
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.05.27.118810
Aggressive social interactions are used to compete for limited resources and are regulated by complex sensory cues and the organism’s internal state. While both sexes exhibit aggression, its neuronal underpinnings are understudied in females. Here, we describe a set of connected neurons in the adult Drosophila melanogaster central brain that drive female aggression. We identified a population of sexually dimorphic aIPg neurons whose optogenetic activation increased, and genetic inactivation reduced, female aggression. Analysis of GAL4 lines identified in an unbiased screen for increased female chasing behavior revealed the involvement of another sexually dimorphic neuron, pC1d, and implicated pC1d and aIPg neurons as core nodes regulating female aggression. pC1d activation increased female aggression and electron microscopy (EM) connectomic analysis demonstrated that aIPg neurons and pC1d have strong reciprocal connections. Our work reveals important regulatory components of the neuronal circuitry that underlies female aggressive social interactions and provides tools for their manipulation.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2020.05.27.118810
- https://www.biorxiv.org/content/biorxiv/early/2020/05/27/2020.05.27.118810.full.pdf
- OA Status
- green
- References
- 85
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3028842131
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3028842131Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2020.05.27.118810Digital Object Identifier
- Title
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Neuronal circuitry underlying female aggression inDrosophilaWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-05-27Full publication date if available
- Authors
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Catherine E. Schretter, Yoshinori Aso, Marisa Dreher, Alice A. Robie, Michael-John Dolan, Nan Chen, Masayoshi Ito, Tansy Yang, Ruchi Parekh, Gerald M. RubinList of authors in order
- Landing page
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https://doi.org/10.1101/2020.05.27.118810Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2020/05/27/2020.05.27.118810.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2020/05/27/2020.05.27.118810.full.pdfDirect OA link when available
- Concepts
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Aggression, Drosophila melanogaster, Optogenetics, Neuroscience, Population, Biology, Sexual dimorphism, Premovement neuronal activity, Psychology, Gene, Genetics, Developmental psychology, Medicine, Zoology, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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85Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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