Neuronalinjury and roles of apoptosis and autophagy in a neonatal rat model of hypoxia-ischemia-induced periventricular leukomalacia Article Swipe
Qiao Lin
,
Jianhua Fu
,
Xindong Xue
,
Yongyan Shi
,
Li Yao
,
Wanjie Huang
,
Jun Li
,
Dan Zhang
,
Na Liu
,
Xin Tong
,
Yanna Du
,
Yu‐Qing Pan
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3892/mmr.2018.8570
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3892/mmr.2018.8570
As research into periventricular leukomalacia (PVL) gradually increases, concerns are emerging about long‑term neuron injury. The present study aimed to investigate neuronal injury and the relevant alterations in apoptosis and autophagy in a PVL model established previously. A rat model of hypoxia‑ischemia‑induced PVL was established. In the model group, Sprague‑Dawley (SD) rats [postnatal day 3 (P3)] were subjected to right common carotid artery ligation followed by suturing and exposed to 6‑8% oxygen for 2 h; in the control group, SD rats (P3) were subjected to right common carotid artery dissection followed by suturing, without ligation and hypoxic exposure. At 1, 3, 7 and 14 days following modeling, brain tissue samples were collected and stained with hematoxylin and eosin. Cellular apoptosis was detected by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay and the protein and mRNA expression alterations of neuronal nuclei (NeuN), caspase‑3 and Beclin 1 in the model group were detected by western blot analysis and reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) analyses. Compared with the control group, the protein and mRNA expression levels of NeuN (a marker of mature neurons) were markedly reduced, the number of positive cells was increased as detected by TUNEL, and the protein and mRNA expression levels of caspase‑3 and Beclin 1 were elevated in the model group. In the rat model of hypoxia‑ischemia‑induced PVL, oligodendrocyte injury and myelinization disorders were observed, in addition to neuron injury, a decrease in mature neurons and the co‑presence of apoptosis and autophagy. However, apoptosis and autophagy exist in different phases: Apoptosis is involved in neuron injury, while autophagy is likely to have a protective role.
Related Topics
Concepts
TUNEL assay
NeuN
Periventricular leukomalacia
Apoptosis
Biology
Ischemia
Pathology
Terminal deoxynucleotidyl transferase
Andrology
Molecular biology
Internal medicine
Medicine
Immunohistochemistry
Biochemistry
Gestational age
Genetics
Pregnancy
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3892/mmr.2018.8570
- http://www.spandidos-publications.com/10.3892/mmr.2018.8570/download
- OA Status
- hybrid
- Cited By
- 20
- References
- 50
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2792736366
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2792736366Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3892/mmr.2018.8570Digital Object Identifier
- Title
-
Neuronalinjury and roles of apoptosis and autophagy in a neonatal rat model of hypoxia-ischemia-induced periventricular leukomalaciaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-02-07Full publication date if available
- Authors
-
Qiao Lin, Jianhua Fu, Xindong Xue, Yongyan Shi, Li Yao, Wanjie Huang, Jun Li, Dan Zhang, Na Liu, Xin Tong, Yanna Du, Yu‐Qing PanList of authors in order
- Landing page
-
https://doi.org/10.3892/mmr.2018.8570Publisher landing page
- PDF URL
-
https://www.spandidos-publications.com/10.3892/mmr.2018.8570/downloadDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://www.spandidos-publications.com/10.3892/mmr.2018.8570/downloadDirect OA link when available
- Concepts
-
TUNEL assay, NeuN, Periventricular leukomalacia, Apoptosis, Biology, Ischemia, Pathology, Terminal deoxynucleotidyl transferase, Andrology, Molecular biology, Internal medicine, Medicine, Immunohistochemistry, Biochemistry, Gestational age, Genetics, PregnancyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
20Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 1, 2023: 3, 2022: 1, 2021: 1Per-year citation counts (last 5 years)
- References (count)
-
50Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| referenced_works_count | 50 |
| abstract_inverted_index.1 | 146, 208 |
| abstract_inverted_index.2 | 73 |
| abstract_inverted_index.3 | 54 |
| abstract_inverted_index.7 | 101 |
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| abstract_inverted_index.(a | 178 |
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| abstract_inverted_index.3, | 100 |
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| abstract_inverted_index.h; | 74 |
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| abstract_inverted_index.is | 255, 262 |
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| abstract_inverted_index.(SD) | 50 |
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| abstract_inverted_index.were | 56, 82, 110, 151, 183, 209, 227 |
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| abstract_inverted_index.6‑8% | 70 |
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| abstract_inverted_index.common | 60, 86 |
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| abstract_inverted_index.group. | 214 |
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| abstract_inverted_index.marker | 179 |
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| abstract_inverted_index.oxygen | 71 |
| abstract_inverted_index.tissue | 108 |
| abstract_inverted_index.(NeuN), | 142 |
| abstract_inverted_index.(TUNEL) | 130 |
| abstract_inverted_index.carotid | 61, 87 |
| abstract_inverted_index.control | 77, 168 |
| abstract_inverted_index.exposed | 68 |
| abstract_inverted_index.hypoxic | 96 |
| abstract_inverted_index.injury, | 233, 259 |
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| abstract_inverted_index.neurons | 238 |
| abstract_inverted_index.phases: | 253 |
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| abstract_inverted_index.samples | 109 |
| abstract_inverted_index.stained | 113 |
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| abstract_inverted_index.Cellular | 118 |
| abstract_inverted_index.Compared | 165 |
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| abstract_inverted_index.addition | 230 |
| abstract_inverted_index.analysis | 156 |
| abstract_inverted_index.concerns | 8 |
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| abstract_inverted_index.elevated | 210 |
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| abstract_inverted_index.markedly | 184 |
| abstract_inverted_index.neuronal | 21, 140 |
| abstract_inverted_index.neurons) | 182 |
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| abstract_inverted_index.terminal | 123 |
| abstract_inverted_index.Apoptosis | 254 |
| abstract_inverted_index.analyses. | 164 |
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| abstract_inverted_index.collected | 111 |
| abstract_inverted_index.different | 252 |
| abstract_inverted_index.disorders | 226 |
| abstract_inverted_index.exposure. | 97 |
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| abstract_inverted_index.modeling, | 106 |
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| abstract_inverted_index.protective | 267 |
| abstract_inverted_index.(RT‑qPCR) | 163 |
| abstract_inverted_index.alterations | 26, 138 |
| abstract_inverted_index.caspase‑3 | 143, 205 |
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| abstract_inverted_index.deoxynucleotidyl | 124 |
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| abstract_inverted_index.transcription‑quantitative | 159 |
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| countries_distinct_count | 1 |
| institutions_distinct_count | 12 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7599999904632568 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.93868579 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |