Neurons in the monkey frontopolar cortex encode learning stage and goal during a fast learning task Article Swipe
Simon Nougaret
,
Lorenzo Ferrucci
,
Francesco Ceccarelli
,
Stefano Sacchetti
,
Danilo Benozzo
,
V. Fascianelli
,
Richard C. Saunders
,
Luc Renaud
,
Aldo Genovesio
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pbio.3002500
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pbio.3002500
The frontopolar cortex (FPC) is, to date, one of the least understood regions of the prefrontal cortex. The current understanding of its function suggests that it plays a role in the control of exploratory behaviors by coordinating the activities of other prefrontal cortex areas involved in decision-making and exploiting actions based on their outcomes. Based on this hypothesis, FPC would drive fast-learning processes through a valuation of the different alternatives. In our study, we used a modified version of a well-known paradigm, the object-in-place (OIP) task, to test this hypothesis in electrophysiology. This paradigm is designed to maximize learning, enabling monkeys to learn in one trial, which is an ability specifically impaired after a lesion of the FPC. We showed that FPC neurons presented an extremely specific pattern of activity by representing the learning stage, exploration versus exploitation, and the goal of the action. However, our results do not support the hypothesis that neurons in the frontal pole compute an evaluation of different alternatives. Indeed, the position of the chosen target was strongly encoded at its acquisition, but the position of the unchosen target was not. Once learned, this representation was also found at the problem presentation, suggesting a monitoring activity of the synthetic goal preceding its acquisition. Our results highlight important features of FPC neurons in fast-learning processes without confirming their role in the disengagement of cognitive control from the current goals.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pbio.3002500
- https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002500&type=printable
- OA Status
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- Cited By
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- OpenAlex ID
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- DOI
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https://doi.org/10.1371/journal.pbio.3002500Digital Object Identifier
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Neurons in the monkey frontopolar cortex encode learning stage and goal during a fast learning taskWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-02-16Full publication date if available
- Authors
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Simon Nougaret, Lorenzo Ferrucci, Francesco Ceccarelli, Stefano Sacchetti, Danilo Benozzo, V. Fascianelli, Richard C. Saunders, Luc Renaud, Aldo GenovesioList of authors in order
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https://doi.org/10.1371/journal.pbio.3002500Publisher landing page
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https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002500&type=printableDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002500&type=printableDirect OA link when available
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13Total citation count in OpenAlex
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2025: 11, 2024: 2Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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