Neuropeptides in the Extracellular Space of the Mouse Cortex Measured In Vivo by Nanodialysis Probe Coupled with LC‐MS Article Swipe
Keyin Li
,
Weihua Shi
,
Yanqi Tan
,
Yu Ding
,
Alex G. Armstrong
,
Yurii A. Vlasov
,
Jonathan V. Sweedler
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/ange.202509490
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/ange.202509490
Neuropeptides are key neuromodulators in the central nervous system that shape sensory processing, yet their extracellular dynamics in the somatosensory cortex (S1) remain poorly understood. This study applies an innovative membrane‐free silicon nanodialysis (ND) probe coupled with liquid chromatography‐mass spectrometry (LC‐MS) to analyze the extracellular neuropeptidome in the mouse S1 with spatial resolution down to 100 µm. Localized in vivo sampling identified extracellular peptides from secretogranin‐1, ProSAAS, pro‐opiomelanocortin (POMC), and others. Minimal tissue damage, enabled by probe dimensions of 75 × 15 µm 2 , resulted in an absence of structural peptides in the dialysate indicating low intracellular contamination. Many detected secretory peptides correlated with strong local mRNA expression; however, the detection of POMC‐derived peptides, despite negligible local expression, suggests long‐distance peptide transport or extracellular processing. To expand peptide identification, a discovery‐to‐targeted peptidomic approach was developed, revealing 46 peptides from 24 proteins in dialysate samples, including 10 proteins with low local expression. Complementary S1 tissue analysis confirmed POMC peptides and showed that 17% of 304 prohormone‐derived peptides had low local expression. These results uncover a complex extracellular peptide landscape shaped by both local and long‐distance signaling. By overcoming the limitations of traditional microdialysis, this approach advances the understanding of neuropeptide signaling in cortical function.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/ange.202509490
- OA Status
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- References
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- Related Works
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- OpenAlex ID
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https://openalex.org/W4413221876Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/ange.202509490Digital Object Identifier
- Title
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Neuropeptides in the Extracellular Space of the Mouse Cortex Measured In Vivo by Nanodialysis Probe Coupled with LC‐MSWork title
- Type
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articleOpenAlex work type
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enPrimary language
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2025Year of publication
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2025-08-11Full publication date if available
- Authors
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Keyin Li, Weihua Shi, Yanqi Tan, Yu Ding, Alex G. Armstrong, Yurii A. Vlasov, Jonathan V. SweedlerList of authors in order
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https://doi.org/10.1002/ange.202509490Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1002/ange.202509490Direct OA link when available
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Extracellular, Peptide, Neuropeptide, Microdialysis, In vivo, Intracellular, Chemistry, Cell biology, Biochemistry, Biology, Biophysics, Receptor, BiotechnologyTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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