Neuroprotective effect of Src kinase in hypoxia-ischemia: A systematic review Article Swipe
Panagiotis Christidis
,
Abhya Vij
,
Stamatios Petousis
,
Javid Ghaemmaghami
,
Bhairav V. Shah
,
Ioannis Koutroulis
,
Panagiotis Kratimenos
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fnins.2022.1049655
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fnins.2022.1049655
Background Hypoxic-ischemic encephalopathy (HIE) is a major cause of neonatal morbidity and mortality worldwide. While the application of therapeutic hypothermia has improved neurodevelopmental outcomes for some survivors of HIE, this lone treatment option is only available to a subset of affected neonates. Src kinase, an enzyme central to the apoptotic cascade, is a potential pharmacologic target to preserve typical brain development after HIE. Here, we present evidence of the neuroprotective effects of targeting Src kinase in preclinical models of HIE. Methods We performed a comprehensive literature search using the National Library of Medicine's MEDLINE database to compile studies examining the impact of Src kinase regulation on neurodevelopment in animal models. Each eligible study was assessed for bias. Results Twenty studies met the inclusion criteria, and most studies had an intermediate risk for bias. Together, these studies showed that targeting Src kinase resulted in a neuroprotective effect as assessed by neuropathology, enzymatic activity, and neurobehavioral outcomes. Conclusion Src kinase is an effective neuroprotective target in the setting of acute hypoxic injury. Src kinase inhibition triggers multiple signaling pathways of the sub-membranous focal adhesions and the nucleus, resulting in modulation of calcium signaling and prevention of cell death. Despite the significant heterogeneity of the research studies that we examined, the available evidence can serve as proof-of-concept for further studies on this promising therapeutic strategy.
Related Topics
Concepts
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fnins.2022.1049655
- OA Status
- gold
- Cited By
- 5
- References
- 91
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4309857308
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4309857308Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fnins.2022.1049655Digital Object Identifier
- Title
-
Neuroprotective effect of Src kinase in hypoxia-ischemia: A systematic reviewWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-11-24Full publication date if available
- Authors
-
Panagiotis Christidis, Abhya Vij, Stamatios Petousis, Javid Ghaemmaghami, Bhairav V. Shah, Ioannis Koutroulis, Panagiotis KratimenosList of authors in order
- Landing page
-
https://doi.org/10.3389/fnins.2022.1049655Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3389/fnins.2022.1049655Direct OA link when available
- Concepts
-
Neuroprotection, Medicine, Proto-oncogene tyrosine-protein kinase Src, Neuropathology, Kinase, Hypoxia (environmental), Encephalopathy, Bioinformatics, Neuroscience, Pharmacology, Internal medicine, Biology, Chemistry, Cell biology, Receptor, Disease, Oxygen, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
5Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 1, 2023: 2Per-year citation counts (last 5 years)
- References (count)
-
91Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4309857308 |
|---|---|
| doi | https://doi.org/10.3389/fnins.2022.1049655 |
| ids.doi | https://doi.org/10.3389/fnins.2022.1049655 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/36507364 |
| ids.openalex | https://openalex.org/W4309857308 |
| fwci | 4.54860805 |
| type | review |
| title | Neuroprotective effect of Src kinase in hypoxia-ischemia: A systematic review |
| biblio.issue | |
| biblio.volume | 16 |
| biblio.last_page | 1049655 |
| biblio.first_page | 1049655 |
| topics[0].id | https://openalex.org/T11184 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2735 |
| topics[0].subfield.display_name | Pediatrics, Perinatology and Child Health |
| topics[0].display_name | Neonatal and fetal brain pathology |
| topics[1].id | https://openalex.org/T10077 |
| topics[1].field.id | https://openalex.org/fields/28 |
| topics[1].field.display_name | Neuroscience |
| topics[1].score | 0.9925000071525574 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2804 |
| topics[1].subfield.display_name | Cellular and Molecular Neuroscience |
| topics[1].display_name | Neuroscience and Neuropharmacology Research |
| topics[2].id | https://openalex.org/T11266 |
| topics[2].field.id | https://openalex.org/fields/28 |
| topics[2].field.display_name | Neuroscience |
| topics[2].score | 0.9847999811172485 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2808 |
| topics[2].subfield.display_name | Neurology |
| topics[2].display_name | Neuroinflammation and Neurodegeneration Mechanisms |
| funders[0].id | https://openalex.org/F4320337364 |
| funders[0].ror | https://ror.org/04byxyr05 |
| funders[0].display_name | National Institute of Child Health and Human Development |
| is_xpac | False |
| apc_list.value | 2950 |
| apc_list.currency | USD |
| apc_list.value_usd | 2950 |
| apc_paid.value | 2950 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 2950 |
| concepts[0].id | https://openalex.org/C25498285 |
| concepts[0].level | 2 |
| concepts[0].score | 0.8323029279708862 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q1981368 |
| concepts[0].display_name | Neuroprotection |
| concepts[1].id | https://openalex.org/C71924100 |
| concepts[1].level | 0 |
| concepts[1].score | 0.6697591543197632 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[1].display_name | Medicine |
| concepts[2].id | https://openalex.org/C108636557 |
| concepts[2].level | 3 |
| concepts[2].score | 0.588561475276947 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q21109354 |
| concepts[2].display_name | Proto-oncogene tyrosine-protein kinase Src |
| concepts[3].id | https://openalex.org/C2780130745 |
| concepts[3].level | 3 |
| concepts[3].score | 0.5005910396575928 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q1650750 |
| concepts[3].display_name | Neuropathology |
| concepts[4].id | https://openalex.org/C184235292 |
| concepts[4].level | 2 |
| concepts[4].score | 0.47355785965919495 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q421851 |
| concepts[4].display_name | Kinase |
| concepts[5].id | https://openalex.org/C7836513 |
| concepts[5].level | 3 |
| concepts[5].score | 0.4509791433811188 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q1641506 |
| concepts[5].display_name | Hypoxia (environmental) |
| concepts[6].id | https://openalex.org/C2778621155 |
| concepts[6].level | 2 |
| concepts[6].score | 0.4360349476337433 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q576349 |
| concepts[6].display_name | Encephalopathy |
| concepts[7].id | https://openalex.org/C60644358 |
| concepts[7].level | 1 |
| concepts[7].score | 0.39873063564300537 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q128570 |
| concepts[7].display_name | Bioinformatics |
| concepts[8].id | https://openalex.org/C169760540 |
| concepts[8].level | 1 |
| concepts[8].score | 0.3954314589500427 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q207011 |
| concepts[8].display_name | Neuroscience |
| concepts[9].id | https://openalex.org/C98274493 |
| concepts[9].level | 1 |
| concepts[9].score | 0.3577750325202942 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q128406 |
| concepts[9].display_name | Pharmacology |
| concepts[10].id | https://openalex.org/C126322002 |
| concepts[10].level | 1 |
| concepts[10].score | 0.22029262781143188 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[10].display_name | Internal medicine |
| concepts[11].id | https://openalex.org/C86803240 |
| concepts[11].level | 0 |
| concepts[11].score | 0.1847856342792511 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[11].display_name | Biology |
| concepts[12].id | https://openalex.org/C185592680 |
| concepts[12].level | 0 |
| concepts[12].score | 0.11224502325057983 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[12].display_name | Chemistry |
| concepts[13].id | https://openalex.org/C95444343 |
| concepts[13].level | 1 |
| concepts[13].score | 0.10208046436309814 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[13].display_name | Cell biology |
| concepts[14].id | https://openalex.org/C170493617 |
| concepts[14].level | 2 |
| concepts[14].score | 0.0756884515285492 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q208467 |
| concepts[14].display_name | Receptor |
| concepts[15].id | https://openalex.org/C2779134260 |
| concepts[15].level | 2 |
| concepts[15].score | 0.0 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q12136 |
| concepts[15].display_name | Disease |
| concepts[16].id | https://openalex.org/C540031477 |
| concepts[16].level | 2 |
| concepts[16].score | 0.0 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q629 |
| concepts[16].display_name | Oxygen |
| concepts[17].id | https://openalex.org/C178790620 |
| concepts[17].level | 1 |
| concepts[17].score | 0.0 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q11351 |
| concepts[17].display_name | Organic chemistry |
| keywords[0].id | https://openalex.org/keywords/neuroprotection |
| keywords[0].score | 0.8323029279708862 |
| keywords[0].display_name | Neuroprotection |
| keywords[1].id | https://openalex.org/keywords/medicine |
| keywords[1].score | 0.6697591543197632 |
| keywords[1].display_name | Medicine |
| keywords[2].id | https://openalex.org/keywords/proto-oncogene-tyrosine-protein-kinase-src |
| keywords[2].score | 0.588561475276947 |
| keywords[2].display_name | Proto-oncogene tyrosine-protein kinase Src |
| keywords[3].id | https://openalex.org/keywords/neuropathology |
| keywords[3].score | 0.5005910396575928 |
| keywords[3].display_name | Neuropathology |
| keywords[4].id | https://openalex.org/keywords/kinase |
| keywords[4].score | 0.47355785965919495 |
| keywords[4].display_name | Kinase |
| keywords[5].id | https://openalex.org/keywords/hypoxia |
| keywords[5].score | 0.4509791433811188 |
| keywords[5].display_name | Hypoxia (environmental) |
| keywords[6].id | https://openalex.org/keywords/encephalopathy |
| keywords[6].score | 0.4360349476337433 |
| keywords[6].display_name | Encephalopathy |
| keywords[7].id | https://openalex.org/keywords/bioinformatics |
| keywords[7].score | 0.39873063564300537 |
| keywords[7].display_name | Bioinformatics |
| keywords[8].id | https://openalex.org/keywords/neuroscience |
| keywords[8].score | 0.3954314589500427 |
| keywords[8].display_name | Neuroscience |
| keywords[9].id | https://openalex.org/keywords/pharmacology |
| keywords[9].score | 0.3577750325202942 |
| keywords[9].display_name | Pharmacology |
| keywords[10].id | https://openalex.org/keywords/internal-medicine |
| keywords[10].score | 0.22029262781143188 |
| keywords[10].display_name | Internal medicine |
| keywords[11].id | https://openalex.org/keywords/biology |
| keywords[11].score | 0.1847856342792511 |
| keywords[11].display_name | Biology |
| keywords[12].id | https://openalex.org/keywords/chemistry |
| keywords[12].score | 0.11224502325057983 |
| keywords[12].display_name | Chemistry |
| keywords[13].id | https://openalex.org/keywords/cell-biology |
| keywords[13].score | 0.10208046436309814 |
| keywords[13].display_name | Cell biology |
| keywords[14].id | https://openalex.org/keywords/receptor |
| keywords[14].score | 0.0756884515285492 |
| keywords[14].display_name | Receptor |
| language | en |
| locations[0].id | doi:10.3389/fnins.2022.1049655 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S115201632 |
| locations[0].source.issn | 1662-453X, 1662-4548 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1662-453X |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Frontiers in Neuroscience |
| locations[0].source.host_organization | https://openalex.org/P4310320527 |
| locations[0].source.host_organization_name | Frontiers Media |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320527 |
| locations[0].source.host_organization_lineage_names | Frontiers Media |
| locations[0].license | cc-by |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Frontiers in Neuroscience |
| locations[0].landing_page_url | https://doi.org/10.3389/fnins.2022.1049655 |
| locations[1].id | pmid:36507364 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Frontiers in neuroscience |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/36507364 |
| locations[2].id | pmh:oai:doaj.org/article:9b5722c5bb5f440cb916002f75ae8a20 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].license | cc-by-sa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Frontiers in Neuroscience, Vol 16 (2022) |
| locations[2].landing_page_url | https://doaj.org/article/9b5722c5bb5f440cb916002f75ae8a20 |
| locations[3].id | pmh:oai:pubmedcentral.nih.gov:9730728 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S2764455111 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | PubMed Central |
| locations[3].source.host_organization | https://openalex.org/I1299303238 |
| locations[3].source.host_organization_name | National Institutes of Health |
| locations[3].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[3].license | other-oa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/other-oa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Front Neurosci |
| locations[3].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/9730728 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5030026838 |
| authorships[0].author.orcid | https://orcid.org/0000-0003-4324-5051 |
| authorships[0].author.display_name | Panagiotis Christidis |
| authorships[0].countries | GR |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I21370196 |
| authorships[0].affiliations[0].raw_affiliation_string | Laboratory of Physiology, Faculty of Health Sciences, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece |
| authorships[0].institutions[0].id | https://openalex.org/I21370196 |
| authorships[0].institutions[0].ror | https://ror.org/02j61yw88 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I21370196 |
| authorships[0].institutions[0].country_code | GR |
| authorships[0].institutions[0].display_name | Aristotle University of Thessaloniki |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Panagiotis Christidis |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Laboratory of Physiology, Faculty of Health Sciences, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece |
| authorships[1].author.id | https://openalex.org/A5033330963 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-3461-9138 |
| authorships[1].author.display_name | Abhya Vij |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I1288882113, https://openalex.org/I136199984 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States |
| authorships[1].institutions[0].id | https://openalex.org/I1288882113 |
| authorships[1].institutions[0].ror | https://ror.org/00dvg7y05 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I1288882113 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | Boston Children's Hospital |
| authorships[1].institutions[1].id | https://openalex.org/I136199984 |
| authorships[1].institutions[1].ror | https://ror.org/03vek6s52 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I136199984 |
| authorships[1].institutions[1].country_code | US |
| authorships[1].institutions[1].display_name | Harvard University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Abhya Vij |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States |
| authorships[2].author.id | https://openalex.org/A5027313730 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-5564-0406 |
| authorships[2].author.display_name | Stamatios Petousis |
| authorships[2].countries | GR |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I21370196, https://openalex.org/I4210116665 |
| authorships[2].affiliations[0].raw_affiliation_string | 2nd Department of Obstetrics and Gynecology, "Hippokrateion" General Hospital of Thessaloniki, Aristotle University of Thessaloniki, Thessaloniki, Greece |
| authorships[2].institutions[0].id | https://openalex.org/I21370196 |
| authorships[2].institutions[0].ror | https://ror.org/02j61yw88 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I21370196 |
| authorships[2].institutions[0].country_code | GR |
| authorships[2].institutions[0].display_name | Aristotle University of Thessaloniki |
| authorships[2].institutions[1].id | https://openalex.org/I4210116665 |
| authorships[2].institutions[1].ror | https://ror.org/02kpyrm37 |
| authorships[2].institutions[1].type | healthcare |
| authorships[2].institutions[1].lineage | https://openalex.org/I4210116665 |
| authorships[2].institutions[1].country_code | GR |
| authorships[2].institutions[1].display_name | Ippokrateio General Hospital of Thessaloniki |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Stamatios Petousis |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | 2nd Department of Obstetrics and Gynecology, "Hippokrateion" General Hospital of Thessaloniki, Aristotle University of Thessaloniki, Thessaloniki, Greece |
| authorships[3].author.id | https://openalex.org/A5070902994 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Javid Ghaemmaghami |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I1336742384 |
| authorships[3].affiliations[0].raw_affiliation_string | Center for Neuroscience Research, Children's National Research Institute, Washington, DC, United States |
| authorships[3].institutions[0].id | https://openalex.org/I1336742384 |
| authorships[3].institutions[0].ror | https://ror.org/03wa2q724 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I1336742384 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | Children's National |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Javid Ghaemmaghami |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Center for Neuroscience Research, Children's National Research Institute, Washington, DC, United States |
| authorships[4].author.id | https://openalex.org/A5052642053 |
| authorships[4].author.orcid | https://orcid.org/0000-0001-7051-1680 |
| authorships[4].author.display_name | Bhairav V. Shah |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I1283654650, https://openalex.org/I155781252 |
| authorships[4].affiliations[0].raw_affiliation_string | Division of Pediatric Surgery, Department of Pediatrics, School of Medicine, Prisma Health Children's Hospital-Midlands, University of South Carolina, Columbia, SC, United States |
| authorships[4].institutions[0].id | https://openalex.org/I1283654650 |
| authorships[4].institutions[0].ror | https://ror.org/03n7vd314 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I1283654650 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | Prisma Health |
| authorships[4].institutions[1].id | https://openalex.org/I155781252 |
| authorships[4].institutions[1].ror | https://ror.org/02b6qw903 |
| authorships[4].institutions[1].type | education |
| authorships[4].institutions[1].lineage | https://openalex.org/I155781252 |
| authorships[4].institutions[1].country_code | US |
| authorships[4].institutions[1].display_name | University of South Carolina |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Bhairav V. Shah |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Division of Pediatric Surgery, Department of Pediatrics, School of Medicine, Prisma Health Children's Hospital-Midlands, University of South Carolina, Columbia, SC, United States |
| authorships[5].author.id | https://openalex.org/A5013171416 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-8396-9022 |
| authorships[5].author.display_name | Ioannis Koutroulis |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I193531525 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Pediatrics, Division of Emergency Medicine, Children's National Hospital, George Washington University School of Medicine and Health Sciences, Washington, DC, United States |
| authorships[5].institutions[0].id | https://openalex.org/I193531525 |
| authorships[5].institutions[0].ror | https://ror.org/00y4zzh67 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I193531525 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | George Washington University |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Ioannis Koutroulis |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Pediatrics, Division of Emergency Medicine, Children's National Hospital, George Washington University School of Medicine and Health Sciences, Washington, DC, United States |
| authorships[6].author.id | https://openalex.org/A5013647206 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-7368-0436 |
| authorships[6].author.display_name | Panagiotis Kratimenos |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I1336742384 |
| authorships[6].affiliations[0].raw_affiliation_string | Center for Neuroscience Research, Children's National Research Institute, Washington, DC, United States |
| authorships[6].affiliations[1].institution_ids | https://openalex.org/I193531525 |
| authorships[6].affiliations[1].raw_affiliation_string | Division of Neonatology, Department of Pediatrics, Children's National Hospital, George Washington University School of Medicine and Health Sciences, Washington, DC, United States |
| authorships[6].institutions[0].id | https://openalex.org/I1336742384 |
| authorships[6].institutions[0].ror | https://ror.org/03wa2q724 |
| authorships[6].institutions[0].type | healthcare |
| authorships[6].institutions[0].lineage | https://openalex.org/I1336742384 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | Children's National |
| authorships[6].institutions[1].id | https://openalex.org/I193531525 |
| authorships[6].institutions[1].ror | https://ror.org/00y4zzh67 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I193531525 |
| authorships[6].institutions[1].country_code | US |
| authorships[6].institutions[1].display_name | George Washington University |
| authorships[6].author_position | last |
| authorships[6].raw_author_name | Panagiotis Kratimenos |
| authorships[6].is_corresponding | True |
| authorships[6].raw_affiliation_strings | Center for Neuroscience Research, Children's National Research Institute, Washington, DC, United States, Division of Neonatology, Department of Pediatrics, Children's National Hospital, George Washington University School of Medicine and Health Sciences, Washington, DC, United States |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.3389/fnins.2022.1049655 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Neuroprotective effect of Src kinase in hypoxia-ischemia: A systematic review |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11184 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2735 |
| primary_topic.subfield.display_name | Pediatrics, Perinatology and Child Health |
| primary_topic.display_name | Neonatal and fetal brain pathology |
| related_works | https://openalex.org/W2409174684, https://openalex.org/W1978954528, https://openalex.org/W139999544, https://openalex.org/W1836775371, https://openalex.org/W3136021439, https://openalex.org/W2171645631, https://openalex.org/W3206582313, https://openalex.org/W2001050739, https://openalex.org/W4249345063, https://openalex.org/W4240553834 |
| cited_by_count | 5 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 2 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 1 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 2 |
| locations_count | 4 |
| best_oa_location.id | doi:10.3389/fnins.2022.1049655 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S115201632 |
| best_oa_location.source.issn | 1662-453X, 1662-4548 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1662-453X |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Frontiers in Neuroscience |
| best_oa_location.source.host_organization | https://openalex.org/P4310320527 |
| best_oa_location.source.host_organization_name | Frontiers Media |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| best_oa_location.source.host_organization_lineage_names | Frontiers Media |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Frontiers in Neuroscience |
| best_oa_location.landing_page_url | https://doi.org/10.3389/fnins.2022.1049655 |
| primary_location.id | doi:10.3389/fnins.2022.1049655 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S115201632 |
| primary_location.source.issn | 1662-453X, 1662-4548 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1662-453X |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Frontiers in Neuroscience |
| primary_location.source.host_organization | https://openalex.org/P4310320527 |
| primary_location.source.host_organization_name | Frontiers Media |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| primary_location.source.host_organization_lineage_names | Frontiers Media |
| primary_location.license | cc-by |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Frontiers in Neuroscience |
| primary_location.landing_page_url | https://doi.org/10.3389/fnins.2022.1049655 |
| publication_date | 2022-11-24 |
| publication_year | 2022 |
| referenced_works | https://openalex.org/W2730506647, https://openalex.org/W2620268346, https://openalex.org/W1276705959, https://openalex.org/W2045129792, https://openalex.org/W2146150933, https://openalex.org/W1976696624, https://openalex.org/W2011855358, https://openalex.org/W1966507725, https://openalex.org/W1971409408, https://openalex.org/W1977424168, https://openalex.org/W1976141746, https://openalex.org/W6638581556, https://openalex.org/W2081328612, https://openalex.org/W1969790007, https://openalex.org/W2159030941, https://openalex.org/W1918204060, https://openalex.org/W2108737419, https://openalex.org/W2145195758, https://openalex.org/W2074187761, https://openalex.org/W4210988681, https://openalex.org/W2002135364, https://openalex.org/W1969821944, https://openalex.org/W2022770324, https://openalex.org/W2912578903, https://openalex.org/W1996248256, https://openalex.org/W2041646472, https://openalex.org/W1990978819, https://openalex.org/W2094617144, https://openalex.org/W2129108032, https://openalex.org/W2058571677, https://openalex.org/W2040409273, https://openalex.org/W2026623398, https://openalex.org/W2152394340, https://openalex.org/W2001280219, https://openalex.org/W2022532556, https://openalex.org/W1830337612, https://openalex.org/W2088126601, https://openalex.org/W2030767981, https://openalex.org/W2112408952, https://openalex.org/W1991004364, https://openalex.org/W2770092297, https://openalex.org/W2763811597, https://openalex.org/W4225568572, https://openalex.org/W2132797770, https://openalex.org/W92838330, https://openalex.org/W2019091990, https://openalex.org/W2136573391, https://openalex.org/W1769055698, https://openalex.org/W1987107961, https://openalex.org/W2113679122, https://openalex.org/W1881368483, https://openalex.org/W1977609384, https://openalex.org/W2047061818, https://openalex.org/W4294215472, https://openalex.org/W2087826252, https://openalex.org/W2139877152, https://openalex.org/W1986361769, https://openalex.org/W2006585182, https://openalex.org/W1514513302, https://openalex.org/W1965626286, https://openalex.org/W2100192087, https://openalex.org/W2159491492, https://openalex.org/W2075235814, https://openalex.org/W6681276876, https://openalex.org/W1972195239, https://openalex.org/W2081331892, https://openalex.org/W1983828429, https://openalex.org/W2030756376, https://openalex.org/W2042846502, https://openalex.org/W2009297045, https://openalex.org/W2089648703, https://openalex.org/W1994288348, https://openalex.org/W2015983536, https://openalex.org/W2111681808, https://openalex.org/W1987007217, https://openalex.org/W2035535900, https://openalex.org/W2168914736, https://openalex.org/W2141210606, https://openalex.org/W2285862104, https://openalex.org/W1976553968, https://openalex.org/W1999112375, https://openalex.org/W1973342484, https://openalex.org/W2142218314, https://openalex.org/W2048383379, https://openalex.org/W2055235177, https://openalex.org/W2037532427, https://openalex.org/W2053204649, https://openalex.org/W1837631563, https://openalex.org/W2156098321, https://openalex.org/W246286872, https://openalex.org/W2082429191 |
| referenced_works_count | 91 |
| abstract_inverted_index.a | 5, 37, 52, 83, 143 |
| abstract_inverted_index.We | 81 |
| abstract_inverted_index.an | 44, 128, 159 |
| abstract_inverted_index.as | 146, 212 |
| abstract_inverted_index.by | 148 |
| abstract_inverted_index.in | 75, 107, 142, 163, 186 |
| abstract_inverted_index.is | 4, 33, 51, 158 |
| abstract_inverted_index.of | 8, 17, 27, 39, 67, 71, 78, 91, 101, 166, 177, 188, 193, 200 |
| abstract_inverted_index.on | 105, 217 |
| abstract_inverted_index.to | 36, 47, 56, 95 |
| abstract_inverted_index.we | 64, 205 |
| abstract_inverted_index.Src | 42, 73, 102, 139, 156, 170 |
| abstract_inverted_index.and | 11, 124, 152, 182, 191 |
| abstract_inverted_index.can | 210 |
| abstract_inverted_index.for | 24, 115, 131, 214 |
| abstract_inverted_index.had | 127 |
| abstract_inverted_index.has | 20 |
| abstract_inverted_index.met | 120 |
| abstract_inverted_index.the | 15, 48, 68, 88, 99, 121, 164, 178, 183, 197, 201, 207 |
| abstract_inverted_index.was | 113 |
| abstract_inverted_index.Each | 110 |
| abstract_inverted_index.HIE, | 28 |
| abstract_inverted_index.HIE. | 62, 79 |
| abstract_inverted_index.cell | 194 |
| abstract_inverted_index.lone | 30 |
| abstract_inverted_index.most | 125 |
| abstract_inverted_index.only | 34 |
| abstract_inverted_index.risk | 130 |
| abstract_inverted_index.some | 25 |
| abstract_inverted_index.that | 137, 204 |
| abstract_inverted_index.this | 29, 218 |
| abstract_inverted_index.(HIE) | 3 |
| abstract_inverted_index.Here, | 63 |
| abstract_inverted_index.While | 14 |
| abstract_inverted_index.acute | 167 |
| abstract_inverted_index.after | 61 |
| abstract_inverted_index.bias. | 116, 132 |
| abstract_inverted_index.brain | 59 |
| abstract_inverted_index.cause | 7 |
| abstract_inverted_index.focal | 180 |
| abstract_inverted_index.major | 6 |
| abstract_inverted_index.serve | 211 |
| abstract_inverted_index.study | 112 |
| abstract_inverted_index.these | 134 |
| abstract_inverted_index.using | 87 |
| abstract_inverted_index.Twenty | 118 |
| abstract_inverted_index.animal | 108 |
| abstract_inverted_index.death. | 195 |
| abstract_inverted_index.effect | 145 |
| abstract_inverted_index.enzyme | 45 |
| abstract_inverted_index.impact | 100 |
| abstract_inverted_index.kinase | 74, 103, 140, 157, 171 |
| abstract_inverted_index.models | 77 |
| abstract_inverted_index.option | 32 |
| abstract_inverted_index.search | 86 |
| abstract_inverted_index.showed | 136 |
| abstract_inverted_index.subset | 38 |
| abstract_inverted_index.target | 55, 162 |
| abstract_inverted_index.Despite | 196 |
| abstract_inverted_index.Library | 90 |
| abstract_inverted_index.MEDLINE | 93 |
| abstract_inverted_index.Methods | 80 |
| abstract_inverted_index.Results | 117 |
| abstract_inverted_index.calcium | 189 |
| abstract_inverted_index.central | 46 |
| abstract_inverted_index.compile | 96 |
| abstract_inverted_index.effects | 70 |
| abstract_inverted_index.further | 215 |
| abstract_inverted_index.hypoxic | 168 |
| abstract_inverted_index.injury. | 169 |
| abstract_inverted_index.kinase, | 43 |
| abstract_inverted_index.models. | 109 |
| abstract_inverted_index.present | 65 |
| abstract_inverted_index.setting | 165 |
| abstract_inverted_index.studies | 97, 119, 126, 135, 203, 216 |
| abstract_inverted_index.typical | 58 |
| abstract_inverted_index.National | 89 |
| abstract_inverted_index.affected | 40 |
| abstract_inverted_index.assessed | 114, 147 |
| abstract_inverted_index.cascade, | 50 |
| abstract_inverted_index.database | 94 |
| abstract_inverted_index.eligible | 111 |
| abstract_inverted_index.evidence | 66, 209 |
| abstract_inverted_index.improved | 21 |
| abstract_inverted_index.multiple | 174 |
| abstract_inverted_index.neonatal | 9 |
| abstract_inverted_index.nucleus, | 184 |
| abstract_inverted_index.outcomes | 23 |
| abstract_inverted_index.pathways | 176 |
| abstract_inverted_index.preserve | 57 |
| abstract_inverted_index.research | 202 |
| abstract_inverted_index.resulted | 141 |
| abstract_inverted_index.triggers | 173 |
| abstract_inverted_index.Together, | 133 |
| abstract_inverted_index.activity, | 151 |
| abstract_inverted_index.adhesions | 181 |
| abstract_inverted_index.apoptotic | 49 |
| abstract_inverted_index.available | 35, 208 |
| abstract_inverted_index.criteria, | 123 |
| abstract_inverted_index.effective | 160 |
| abstract_inverted_index.enzymatic | 150 |
| abstract_inverted_index.examined, | 206 |
| abstract_inverted_index.examining | 98 |
| abstract_inverted_index.inclusion | 122 |
| abstract_inverted_index.morbidity | 10 |
| abstract_inverted_index.mortality | 12 |
| abstract_inverted_index.neonates. | 41 |
| abstract_inverted_index.outcomes. | 154 |
| abstract_inverted_index.performed | 82 |
| abstract_inverted_index.potential | 53 |
| abstract_inverted_index.promising | 219 |
| abstract_inverted_index.resulting | 185 |
| abstract_inverted_index.signaling | 175, 190 |
| abstract_inverted_index.strategy. | 221 |
| abstract_inverted_index.survivors | 26 |
| abstract_inverted_index.targeting | 72, 138 |
| abstract_inverted_index.treatment | 31 |
| abstract_inverted_index.Background | 0 |
| abstract_inverted_index.Conclusion | 155 |
| abstract_inverted_index.Medicine's | 92 |
| abstract_inverted_index.inhibition | 172 |
| abstract_inverted_index.literature | 85 |
| abstract_inverted_index.modulation | 187 |
| abstract_inverted_index.prevention | 192 |
| abstract_inverted_index.regulation | 104 |
| abstract_inverted_index.worldwide. | 13 |
| abstract_inverted_index.application | 16 |
| abstract_inverted_index.development | 60 |
| abstract_inverted_index.hypothermia | 19 |
| abstract_inverted_index.preclinical | 76 |
| abstract_inverted_index.significant | 198 |
| abstract_inverted_index.therapeutic | 18, 220 |
| abstract_inverted_index.intermediate | 129 |
| abstract_inverted_index.comprehensive | 84 |
| abstract_inverted_index.heterogeneity | 199 |
| abstract_inverted_index.pharmacologic | 54 |
| abstract_inverted_index.encephalopathy | 2 |
| abstract_inverted_index.sub-membranous | 179 |
| abstract_inverted_index.neurobehavioral | 153 |
| abstract_inverted_index.neuropathology, | 149 |
| abstract_inverted_index.neuroprotective | 69, 144, 161 |
| abstract_inverted_index.Hypoxic-ischemic | 1 |
| abstract_inverted_index.neurodevelopment | 106 |
| abstract_inverted_index.proof-of-concept | 213 |
| abstract_inverted_index.neurodevelopmental | 22 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5013647206 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 7 |
| corresponding_institution_ids | https://openalex.org/I1336742384, https://openalex.org/I193531525 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8199999928474426 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.87030635 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |