Neuroprotective effects of nanophytosome-encapsulated citral in a mouse model of chronic unpredictable mild stress through the suppression of oxidative stress and inflammation Article Swipe
Mohammad Amin Mashayekhpour
,
Akbar Hajizadeh Moghaddam
,
Mohaddeseh Abouhosseini Tabari
,
Mojtaba Ranjbar
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.biopha.2025.118280
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.biopha.2025.118280
This study investigated the neuroprotective effects of nanophytosomal citral against chronic unpredictable mild stress (CUMS)-induced depression in mice, with exploration of potential mechanisms. Following six weeks of CUMS exposure, mice received either fluoxetine (20 mg/kg) or nanophytosomal citral (10, 20, or 50 mg/kg) via oral gavage three times weekly for three consecutive weeks. Behavioral changes were evaluated using the forced swimming test (FST), open field test (OFT), tail suspension test (TST), and sucrose preference test (SPT). The mRNA expression levels of TNF-α, IL-6, and BDNF were quantified using real-time PCR. Serum cortisol levels and oxidative stress markers were assessed using ELISA kits. CUMS significantly reduced SP and BDNF mRNA levels while increasing immobility time, serum cortisol levels, TNF-α and IL-6 mRNA expression, and enhancing oxidative stress through reduced antioxidant enzyme activity. Notably, all CUMS-induced alterations were significantly reversed following treatment with fluoxetine or citral nanophytosome (20 and 50 mg/kg). These findings collectively suggest that citral nanophytosome produces antidepressant-like effects in the CUMS model, potentially through mechanisms involving attenuation of oxidative stress and inflammation, along with restoration of BDNF expression.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.biopha.2025.118280
- OA Status
- gold
- References
- 50
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411322934
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4411322934Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.biopha.2025.118280Digital Object Identifier
- Title
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Neuroprotective effects of nanophytosome-encapsulated citral in a mouse model of chronic unpredictable mild stress through the suppression of oxidative stress and inflammationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-06-15Full publication date if available
- Authors
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Mohammad Amin Mashayekhpour, Akbar Hajizadeh Moghaddam, Mohaddeseh Abouhosseini Tabari, Mojtaba RanjbarList of authors in order
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https://doi.org/10.1016/j.biopha.2025.118280Publisher landing page
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1016/j.biopha.2025.118280Direct OA link when available
- Concepts
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Neuroprotection, Oxidative stress, Inflammation, Citral, Pharmacology, Medicine, Chemistry, Immunology, Biochemistry, Chromatography, Essential oilTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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50Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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