New Developments in Exosomal lncRNAs in Cardiovascular Diseases Article Swipe

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YOU? · · 2021 · Open Access · · DOI: https://doi.org/10.3389/fcvm.2021.709169

Long non-coding RNAs (lncRNAs) are non-coding RNAs with lengths >200 nt and are involved in the occurrence and development of cardiovascular diseases (CVDs). Exosomes are secreted and produced by various cell types. Exosome contents include various ncRNAs, proteins and lipids. Exosomes are also important mediators of intercellular communication. The proportion of lncRNAs in exosomes is low, but increasing evidence suggests that exosomal lncRNAs play important roles in CVDs. We focused on research progress in exosomal lncRNAs in atherosclerosis, myocardial infarction, myocardial ischemia-reperfusion injury, cardiac angiogenesis, cardiac aging, rheumatic heart disease, and chronic kidney disease combined with CVD. The potential diagnostic and therapeutic effects of exosomal lncRNAs in CVDs are summarized based on preclinical studies involving animal and cell models and circulating exosomes in clinical patients. Finally, the challenges and possible prospects of exosomes and exosomal lncRNAs in clinical applications related to CVD are discussed.

Related Topics

Myocardial Infarction

Concepts

Microvesicles Exosome Medicine Angiogenesis Disease Bioinformatics Myocardial infarction microRNA Cancer research Biology Pathology Internal medicine Gene Biochemistry

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Type: review
Language: en
Landing Page: https://doi.org/10.3389/fcvm.2021.709169
PDF: https://www.frontiersin.org/articles/10.3389/fcvm.2021.709169/pdf
OA Status: gold
Cited By: 40
References: 110
Related Works: 10
OpenAlex ID: https://openalex.org/W3182120917

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OpenAlex ID: https://openalex.org/W3182120917

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DOI: https://doi.org/10.3389/fcvm.2021.709169

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Title: New Developments in Exosomal lncRNAs in Cardiovascular Diseases

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Type: review

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Language: en

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Publication year: 2021

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Publication date: 2021-07-08

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Authors: Zhu Yuan, Weiqiang Huang

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Landing page: https://doi.org/10.3389/fcvm.2021.709169

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PDF URL: https://www.frontiersin.org/articles/10.3389/fcvm.2021.709169/pdf

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OA URL: https://www.frontiersin.org/articles/10.3389/fcvm.2021.709169/pdf

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Concepts: Microvesicles, Exosome, Medicine, Angiogenesis, Disease, Bioinformatics, Myocardial infarction, microRNA, Cancer research, Biology, Pathology, Internal medicine, Gene, Biochemistry

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Cited by: 40

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Citations by year (recent): 2025: 6, 2024: 10, 2023: 6, 2022: 17, 2021: 1

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References (count): 110

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